Putative delta tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin delta chain

Species:

Leishmania braziliensis

UniProt:

A4HQ16_LEIBR

TriTrypDb:

LbrM.35.5240 , LBRM2903_350063300

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:0005634	nucleus	5	2
GO:0005814	centriole	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HQ16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ16

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005198	structural molecule activity	1	4
GO:0005200	structural constituent of cytoskeleton	2	4
GO:0005488	binding	1	4
GO:0005525	GTP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0019001	guanyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032561	guanyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.558
CLV_C14_Caspase3-7	319	323	PF00656	0.408
CLV_C14_Caspase3-7	36	40	PF00656	0.402
CLV_PCSK_SKI1_1	114	118	PF00082	0.744
CLV_PCSK_SKI1_1	133	137	PF00082	0.576
CLV_PCSK_SKI1_1	151	155	PF00082	0.212
CLV_PCSK_SKI1_1	60	64	PF00082	0.677
DEG_APCC_DBOX_1	219	227	PF00400	0.399
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.540
DOC_MAPK_DCC_7	76	86	PF00069	0.540
DOC_MAPK_gen_1	60	70	PF00069	0.654
DOC_MAPK_MEF2A_6	76	84	PF00069	0.454
DOC_PIKK_1	46	53	PF02985	0.548
DOC_PP2B_LxvP_1	80	83	PF13499	0.452
DOC_PP2B_LxvP_1	84	87	PF13499	0.463
DOC_PP4_FxxP_1	183	186	PF00568	0.648
DOC_PP4_FxxP_1	257	260	PF00568	0.544
DOC_USP7_MATH_1	135	139	PF00917	0.493
DOC_USP7_MATH_1	179	183	PF00917	0.472
DOC_USP7_MATH_1	210	214	PF00917	0.663
DOC_USP7_MATH_1	252	256	PF00917	0.559
DOC_USP7_MATH_1	266	270	PF00917	0.538
DOC_USP7_UBL2_3	98	102	PF12436	0.646
DOC_WW_Pin1_4	187	192	PF00397	0.725
DOC_WW_Pin1_4	246	251	PF00397	0.458
DOC_WW_Pin1_4	256	261	PF00397	0.372
DOC_WW_Pin1_4	264	269	PF00397	0.484
DOC_WW_Pin1_4	280	285	PF00397	0.272
DOC_WW_Pin1_4	92	97	PF00397	0.542
LIG_14-3-3_CanoR_1	133	141	PF00244	0.453
LIG_14-3-3_CanoR_1	4	8	PF00244	0.566
LIG_14-3-3_CanoR_1	76	84	PF00244	0.490
LIG_APCC_ABBA_1	189	194	PF00400	0.739
LIG_BIR_III_4	292	296	PF00653	0.553
LIG_BRCT_BRCA1_1	247	251	PF00533	0.615
LIG_FHA_1	152	158	PF00498	0.509
LIG_FHA_1	231	237	PF00498	0.550
LIG_FHA_1	281	287	PF00498	0.410
LIG_FHA_2	134	140	PF00498	0.558
LIG_FHA_2	269	275	PF00498	0.656
LIG_FHA_2	31	37	PF00498	0.522
LIG_LIR_Apic_2	182	186	PF02991	0.639
LIG_LIR_Apic_2	254	260	PF02991	0.414
LIG_LIR_Apic_2	267	273	PF02991	0.551
LIG_LIR_Gen_1	165	176	PF02991	0.483
LIG_LIR_Gen_1	190	196	PF02991	0.744
LIG_LIR_Gen_1	22	31	PF02991	0.345
LIG_LIR_Gen_1	67	77	PF02991	0.431
LIG_LIR_Nem_3	165	171	PF02991	0.451
LIG_LIR_Nem_3	190	195	PF02991	0.691
LIG_LIR_Nem_3	22	28	PF02991	0.339
LIG_LRP6_Inhibitor_1	231	237	PF00058	0.556
LIG_PDZ_Class_2	331	336	PF00595	0.569
LIG_Pex14_2	306	310	PF04695	0.459
LIG_SH2_CRK	25	29	PF00017	0.380
LIG_SH2_CRK	91	95	PF00017	0.572
LIG_SH2_NCK_1	134	138	PF00017	0.486
LIG_SH2_NCK_1	192	196	PF00017	0.750
LIG_SH2_NCK_1	270	274	PF00017	0.662
LIG_SH2_NCK_1	328	332	PF00017	0.547
LIG_SH2_NCK_1	91	95	PF00017	0.572
LIG_SH2_STAP1	192	196	PF00017	0.750
LIG_SH2_STAP1	328	332	PF00017	0.547
LIG_SH2_STAT5	270	273	PF00017	0.609
LIG_SH2_STAT5	91	94	PF00017	0.563
LIG_SH3_3	8	14	PF00018	0.386
LIG_SH3_3	90	96	PF00018	0.572
LIG_TRAF2_1	260	263	PF00917	0.555
MOD_CDC14_SPxK_1	95	98	PF00782	0.614
MOD_CDK_SPxK_1	92	98	PF00069	0.598
MOD_CK1_1	187	193	PF00069	0.674
MOD_CK1_1	197	203	PF00069	0.638
MOD_CK1_1	246	252	PF00069	0.469
MOD_CK2_1	121	127	PF00069	0.705
MOD_CK2_1	256	262	PF00069	0.480
MOD_CK2_1	313	319	PF00069	0.569
MOD_GlcNHglycan	108	111	PF01048	0.702
MOD_GlcNHglycan	186	189	PF01048	0.591
MOD_GlcNHglycan	199	202	PF01048	0.594
MOD_GlcNHglycan	211	215	PF01048	0.512
MOD_GlcNHglycan	245	248	PF01048	0.543
MOD_GSK3_1	160	167	PF00069	0.621
MOD_GSK3_1	190	197	PF00069	0.687
MOD_GSK3_1	218	225	PF00069	0.470
MOD_GSK3_1	252	259	PF00069	0.424
MOD_GSK3_1	264	271	PF00069	0.621
MOD_GSK3_1	3	10	PF00069	0.573
MOD_NEK2_1	106	111	PF00069	0.536
MOD_NEK2_1	116	121	PF00069	0.598
MOD_NEK2_1	153	158	PF00069	0.498
MOD_NEK2_1	243	248	PF00069	0.512
MOD_NEK2_1	29	34	PF00069	0.392
MOD_NEK2_1	327	332	PF00069	0.400
MOD_NEK2_1	7	12	PF00069	0.405
MOD_NEK2_1	89	94	PF00069	0.552
MOD_NEK2_2	222	227	PF00069	0.515
MOD_NEK2_2	252	257	PF00069	0.554
MOD_PIKK_1	19	25	PF00454	0.362
MOD_PKA_2	3	9	PF00069	0.577
MOD_PKA_2	75	81	PF00069	0.486
MOD_Plk_1	210	216	PF00069	0.662
MOD_Plk_1	66	72	PF00069	0.466
MOD_Plk_4	167	173	PF00069	0.439
MOD_Plk_4	252	258	PF00069	0.487
MOD_Plk_4	275	281	PF00069	0.409
MOD_Plk_4	3	9	PF00069	0.503
MOD_ProDKin_1	187	193	PF00069	0.728
MOD_ProDKin_1	246	252	PF00069	0.450
MOD_ProDKin_1	256	262	PF00069	0.379
MOD_ProDKin_1	264	270	PF00069	0.486
MOD_ProDKin_1	280	286	PF00069	0.270
MOD_ProDKin_1	92	98	PF00069	0.548
TRG_DiLeu_BaEn_1	238	243	PF01217	0.562
TRG_ENDOCYTIC_2	192	195	PF00928	0.752
TRG_ENDOCYTIC_2	25	28	PF00928	0.376
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NC27	Trypanosoma rangeli	35%	69%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	69%