Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ15_LEIBR

TriTrypDb:

LbrM.35.5230 , LBRM2903_350063200

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	168	174	PF00089	0.440
CLV_NRD_NRD_1	252	254	PF00675	0.555
CLV_NRD_NRD_1	263	265	PF00675	0.441
CLV_PCSK_FUR_1	66	70	PF00082	0.546
CLV_PCSK_KEX2_1	68	70	PF00082	0.672
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.596
CLV_PCSK_SKI1_1	127	131	PF00082	0.634
CLV_PCSK_SKI1_1	182	186	PF00082	0.638
CLV_PCSK_SKI1_1	211	215	PF00082	0.486
CLV_PCSK_SKI1_1	286	290	PF00082	0.351
DEG_SPOP_SBC_1	147	151	PF00917	0.555
DEG_SPOP_SBC_1	18	22	PF00917	0.520
DOC_CDC14_PxL_1	231	239	PF14671	0.473
DOC_CYCLIN_yCln2_LP_2	10	13	PF00134	0.516
DOC_MAPK_FxFP_2	318	321	PF00069	0.474
DOC_PP1_RVXF_1	209	216	PF00149	0.445
DOC_PP1_RVXF_1	284	291	PF00149	0.369
DOC_PP2B_LxvP_1	10	13	PF13499	0.614
DOC_PP4_FxxP_1	177	180	PF00568	0.383
DOC_PP4_FxxP_1	295	298	PF00568	0.378
DOC_PP4_FxxP_1	318	321	PF00568	0.474
DOC_USP7_MATH_1	105	109	PF00917	0.770
DOC_USP7_MATH_1	146	150	PF00917	0.576
DOC_USP7_MATH_1	158	162	PF00917	0.493
DOC_USP7_MATH_1	42	46	PF00917	0.480
DOC_USP7_UBL2_3	68	72	PF12436	0.615
DOC_WW_Pin1_4	224	229	PF00397	0.483
DOC_WW_Pin1_4	3	8	PF00397	0.592
DOC_WW_Pin1_4	57	62	PF00397	0.638
LIG_14-3-3_CanoR_1	164	169	PF00244	0.385
LIG_14-3-3_CanoR_1	286	291	PF00244	0.383
LIG_Actin_WH2_2	270	288	PF00022	0.370
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_3	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	166	170	PF00533	0.412
LIG_BRCT_BRCA1_1	173	177	PF00533	0.468
LIG_FHA_1	287	293	PF00498	0.417
LIG_FHA_1	317	323	PF00498	0.482
LIG_FHA_2	115	121	PF00498	0.595
LIG_FHA_2	246	252	PF00498	0.543
LIG_GBD_Chelix_1	300	308	PF00786	0.425
LIG_IBAR_NPY_1	27	29	PF08397	0.556
LIG_LIR_Apic_2	174	180	PF02991	0.398
LIG_LIR_Apic_2	222	228	PF02991	0.485
LIG_LIR_Apic_2	315	321	PF02991	0.467
LIG_LIR_Nem_3	44	49	PF02991	0.552
LIG_PCNA_PIPBox_1	92	101	PF02747	0.557
LIG_Pex14_2	172	176	PF04695	0.443
LIG_Pex14_2	177	181	PF04695	0.401
LIG_SH2_CRK	165	169	PF00017	0.381
LIG_SH2_CRK	50	54	PF00017	0.705
LIG_SH2_NCK_1	165	169	PF00017	0.381
LIG_SH2_SRC	48	51	PF00017	0.571
LIG_SH2_STAP1	125	129	PF00017	0.619
LIG_SH2_STAP1	29	33	PF00017	0.555
LIG_SH2_STAT5	125	128	PF00017	0.502
LIG_SH2_STAT5	216	219	PF00017	0.518
LIG_SH2_STAT5	225	228	PF00017	0.528
LIG_SH2_STAT5	48	51	PF00017	0.571
LIG_SH2_STAT5	99	102	PF00017	0.500
LIG_SH3_3	188	194	PF00018	0.430
LIG_TRAF2_1	227	230	PF00917	0.473
LIG_TRAF2_1	309	312	PF00917	0.436
LIG_TYR_ITIM	163	168	PF00017	0.375
LIG_WRC_WIRS_1	181	186	PF05994	0.498
LIG_WW_3	11	15	PF00397	0.515
MOD_CK1_1	115	121	PF00069	0.655
MOD_CK1_1	123	129	PF00069	0.723
MOD_CK1_1	135	141	PF00069	0.724
MOD_CK1_1	20	26	PF00069	0.523
MOD_CK1_1	205	211	PF00069	0.416
MOD_CK1_1	51	57	PF00069	0.584
MOD_CK1_1	6	12	PF00069	0.510
MOD_CK2_1	224	230	PF00069	0.497
MOD_CK2_1	245	251	PF00069	0.450
MOD_Cter_Amidation	66	69	PF01082	0.546
MOD_GlcNHglycan	101	104	PF01048	0.611
MOD_GlcNHglycan	134	137	PF01048	0.611
MOD_GlcNHglycan	150	153	PF01048	0.563
MOD_GlcNHglycan	173	176	PF01048	0.429
MOD_GlcNHglycan	204	207	PF01048	0.474
MOD_GlcNHglycan	256	260	PF01048	0.358
MOD_GlcNHglycan	78	81	PF01048	0.527
MOD_GSK3_1	112	119	PF00069	0.622
MOD_GSK3_1	135	142	PF00069	0.582
MOD_GSK3_1	202	209	PF00069	0.418
MOD_GSK3_1	316	323	PF00069	0.507
MOD_NEK2_1	129	134	PF00069	0.489
MOD_NEK2_1	137	142	PF00069	0.545
MOD_NEK2_2	42	47	PF00069	0.411
MOD_PK_1	164	170	PF00069	0.387
MOD_PKA_1	68	74	PF00069	0.544
MOD_PKA_2	68	74	PF00069	0.544
MOD_Plk_1	255	261	PF00069	0.507
MOD_Plk_4	158	164	PF00069	0.475
MOD_Plk_4	286	292	PF00069	0.425
MOD_Plk_4	48	54	PF00069	0.510
MOD_Plk_4	6	12	PF00069	0.509
MOD_ProDKin_1	224	230	PF00069	0.477
MOD_ProDKin_1	3	9	PF00069	0.591
MOD_ProDKin_1	57	63	PF00069	0.644
MOD_SUMO_rev_2	243	250	PF00179	0.490
TRG_DiLeu_BaEn_1	269	274	PF01217	0.354
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.464
TRG_ENDOCYTIC_2	165	168	PF00928	0.364
TRG_ENDOCYTIC_2	50	53	PF00928	0.712
TRG_NES_CRM1_1	299	312	PF08389	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG8	Leptomonas seymouri	59%	98%
A0A3Q8IJQ3	Leishmania donovani	77%	99%
A4IDS1	Leishmania infantum	77%	99%
E9ATT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%
Q4Q0R4	Leishmania major	76%	100%