J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ14_LEIBR

TriTrypDb:

LbrM.35.5220 , LBRM2903_350063100

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.589
CLV_NRD_NRD_1	118	120	PF00675	0.524
CLV_NRD_NRD_1	203	205	PF00675	0.385
CLV_NRD_NRD_1	222	224	PF00675	0.441
CLV_NRD_NRD_1	253	255	PF00675	0.689
CLV_NRD_NRD_1	278	280	PF00675	0.536
CLV_NRD_NRD_1	332	334	PF00675	0.532
CLV_NRD_NRD_1	43	45	PF00675	0.577
CLV_PCSK_FUR_1	116	120	PF00082	0.554
CLV_PCSK_KEX2_1	116	118	PF00082	0.559
CLV_PCSK_KEX2_1	203	205	PF00082	0.385
CLV_PCSK_KEX2_1	222	224	PF00082	0.441
CLV_PCSK_KEX2_1	253	255	PF00082	0.642
CLV_PCSK_KEX2_1	280	282	PF00082	0.574
CLV_PCSK_KEX2_1	332	334	PF00082	0.532
CLV_PCSK_KEX2_1	347	349	PF00082	0.598
CLV_PCSK_KEX2_1	43	45	PF00082	0.577
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.459
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.656
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.598
CLV_PCSK_SKI1_1	104	108	PF00082	0.565
CLV_PCSK_SKI1_1	167	171	PF00082	0.495
CLV_PCSK_SKI1_1	196	200	PF00082	0.481
CLV_PCSK_SKI1_1	253	257	PF00082	0.688
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DOC_CYCLIN_RxL_1	18	26	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.484
DOC_MAPK_gen_1	291	301	PF00069	0.622
DOC_USP7_MATH_1	226	230	PF00917	0.630
DOC_USP7_MATH_1	232	236	PF00917	0.667
DOC_USP7_MATH_1	32	36	PF00917	0.626
DOC_USP7_MATH_1	331	335	PF00917	0.517
DOC_WW_Pin1_4	242	247	PF00397	0.689
DOC_WW_Pin1_4	256	261	PF00397	0.742
DOC_WW_Pin1_4	30	35	PF00397	0.411
DOC_WW_Pin1_4	311	316	PF00397	0.677
DOC_WW_Pin1_4	324	329	PF00397	0.717
LIG_14-3-3_CanoR_1	167	172	PF00244	0.396
LIG_14-3-3_CanoR_1	182	188	PF00244	0.426
LIG_14-3-3_CanoR_1	240	246	PF00244	0.685
LIG_14-3-3_CanoR_1	296	302	PF00244	0.519
LIG_14-3-3_CanoR_1	332	339	PF00244	0.516
LIG_BIR_III_4	94	98	PF00653	0.518
LIG_BRCT_BRCA1_1	165	169	PF00533	0.470
LIG_deltaCOP1_diTrp_1	282	290	PF00928	0.607
LIG_FHA_1	145	151	PF00498	0.573
LIG_FHA_2	134	140	PF00498	0.634
LIG_FHA_2	149	155	PF00498	0.614
LIG_FHA_2	168	174	PF00498	0.436
LIG_FHA_2	197	203	PF00498	0.403
LIG_FHA_2	298	304	PF00498	0.521
LIG_FHA_2	68	74	PF00498	0.375
LIG_LIR_Apic_2	289	293	PF02991	0.658
LIG_LIR_Apic_2	84	88	PF02991	0.505
LIG_LIR_Gen_1	137	144	PF02991	0.534
LIG_LIR_Gen_1	70	80	PF02991	0.407
LIG_LIR_Nem_3	166	171	PF02991	0.448
LIG_LIR_Nem_3	176	181	PF02991	0.426
LIG_LIR_Nem_3	342	346	PF02991	0.514
LIG_LIR_Nem_3	70	75	PF02991	0.381
LIG_MAD2	21	29	PF02301	0.536
LIG_MLH1_MIPbox_1	165	169	PF16413	0.455
LIG_NRBOX	306	312	PF00104	0.630
LIG_PCNA_yPIPBox_3	304	316	PF02747	0.636
LIG_PDZ_Class_1	348	353	PF00595	0.448
LIG_Pex14_1	283	287	PF04695	0.664
LIG_PTB_Apo_2	204	211	PF02174	0.394
LIG_PTB_Apo_2	66	73	PF02174	0.385
LIG_PTB_Phospho_1	66	72	PF10480	0.382
LIG_SH2_CRK	178	182	PF00017	0.421
LIG_SH2_CRK	346	350	PF00017	0.573
LIG_SH2_CRK	85	89	PF00017	0.579
LIG_SH2_GRB2like	343	346	PF00017	0.493
LIG_SH2_NCK_1	72	76	PF00017	0.504
LIG_SH2_NCK_1	85	89	PF00017	0.659
LIG_SH2_STAT3	295	298	PF00017	0.624
LIG_SH2_STAT5	216	219	PF00017	0.389
LIG_SH3_3	26	32	PF00018	0.526
LIG_SH3_3	282	288	PF00018	0.569
LIG_SH3_3	322	328	PF00018	0.625
LIG_SUMO_SIM_par_1	146	154	PF11976	0.443
LIG_TRAF2_1	151	154	PF00917	0.540
LIG_TRAF2_1	300	303	PF00917	0.470
LIG_TYR_ITSM	174	181	PF00017	0.436
LIG_TYR_ITSM	68	75	PF00017	0.502
LIG_WRC_WIRS_1	168	173	PF05994	0.391
MOD_CDK_SPK_2	311	316	PF00069	0.677
MOD_CDK_SPxK_1	30	36	PF00069	0.406
MOD_CK1_1	146	152	PF00069	0.538
MOD_CK1_1	235	241	PF00069	0.678
MOD_CK1_1	274	280	PF00069	0.638
MOD_CK1_1	327	333	PF00069	0.695
MOD_CK1_1	334	340	PF00069	0.610
MOD_CK2_1	148	154	PF00069	0.522
MOD_CK2_1	196	202	PF00069	0.397
MOD_CK2_1	283	289	PF00069	0.641
MOD_CK2_1	297	303	PF00069	0.484
MOD_CK2_1	67	73	PF00069	0.381
MOD_DYRK1A_RPxSP_1	30	34	PF00069	0.410
MOD_GlcNHglycan	125	128	PF01048	0.689
MOD_GlcNHglycan	329	332	PF01048	0.700
MOD_GlcNHglycan	333	336	PF01048	0.643
MOD_GlcNHglycan	58	61	PF01048	0.478
MOD_GlcNHglycan	77	80	PF01048	0.548
MOD_GlcNHglycan	8	11	PF01048	0.388
MOD_GSK3_1	100	107	PF00069	0.585
MOD_GSK3_1	123	130	PF00069	0.610
MOD_GSK3_1	144	151	PF00069	0.596
MOD_GSK3_1	163	170	PF00069	0.483
MOD_GSK3_1	2	9	PF00069	0.464
MOD_GSK3_1	235	242	PF00069	0.646
MOD_GSK3_1	327	334	PF00069	0.637
MOD_LATS_1	165	171	PF00433	0.437
MOD_N-GLC_1	144	149	PF02516	0.567
MOD_N-GLC_1	318	323	PF02516	0.495
MOD_NEK2_1	163	168	PF00069	0.477
MOD_NEK2_1	2	7	PF00069	0.587
MOD_NEK2_1	23	28	PF00069	0.496
MOD_NEK2_1	239	244	PF00069	0.791
MOD_NEK2_1	74	79	PF00069	0.424
MOD_NEK2_2	183	188	PF00069	0.420
MOD_PKA_2	239	245	PF00069	0.640
MOD_PKA_2	331	337	PF00069	0.519
MOD_Plk_1	127	133	PF00069	0.666
MOD_Plk_1	173	179	PF00069	0.375
MOD_Plk_2-3	148	154	PF00069	0.644
MOD_Plk_4	173	179	PF00069	0.375
MOD_Plk_4	196	202	PF00069	0.397
MOD_ProDKin_1	242	248	PF00069	0.686
MOD_ProDKin_1	256	262	PF00069	0.742
MOD_ProDKin_1	30	36	PF00069	0.406
MOD_ProDKin_1	311	317	PF00069	0.680
MOD_ProDKin_1	324	330	PF00069	0.715
MOD_SUMO_rev_2	148	158	PF00179	0.594
TRG_DiLeu_BaEn_4	302	308	PF01217	0.585
TRG_ENDOCYTIC_2	178	181	PF00928	0.410
TRG_ENDOCYTIC_2	346	349	PF00928	0.502
TRG_ENDOCYTIC_2	46	49	PF00928	0.449
TRG_ENDOCYTIC_2	72	75	PF00928	0.366
TRG_ER_diArg_1	116	119	PF00400	0.560
TRG_ER_diArg_1	203	205	PF00400	0.385
TRG_ER_diArg_1	278	281	PF00400	0.659
TRG_ER_diArg_1	36	39	PF00400	0.592
TRG_ER_diArg_1	42	44	PF00400	0.545
TRG_NLS_Bipartite_1	332	351	PF00514	0.490
TRG_PTS1	350	353	PF00515	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P554	Leptomonas seymouri	67%	94%
A0A1X0P394	Trypanosomatidae	40%	89%
A0A3Q8IRL6	Leishmania donovani	81%	100%
A0A3R7NA51	Trypanosoma rangeli	48%	99%
A4ICE4	Leishmania infantum	81%	100%
D0A8V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q0R5	Leishmania major	82%	98%
V5BDN3	Trypanosoma cruzi	47%	100%