2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ12_LEIBR

TriTrypDb:

LbrM.35.5200 , LBRM2903_350062900

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	198	200	PF00675	0.444
CLV_NRD_NRD_1	214	216	PF00675	0.601
CLV_NRD_NRD_1	292	294	PF00675	0.408
CLV_NRD_NRD_1	297	299	PF00675	0.431
CLV_NRD_NRD_1	30	32	PF00675	0.690
CLV_NRD_NRD_1	478	480	PF00675	0.479
CLV_NRD_NRD_1	526	528	PF00675	0.456
CLV_NRD_NRD_1	637	639	PF00675	0.368
CLV_NRD_NRD_1	705	707	PF00675	0.679
CLV_PCSK_FUR_1	703	707	PF00082	0.416
CLV_PCSK_KEX2_1	179	181	PF00082	0.417
CLV_PCSK_KEX2_1	198	200	PF00082	0.305
CLV_PCSK_KEX2_1	214	216	PF00082	0.671
CLV_PCSK_KEX2_1	292	294	PF00082	0.367
CLV_PCSK_KEX2_1	297	299	PF00082	0.393
CLV_PCSK_KEX2_1	30	32	PF00082	0.690
CLV_PCSK_KEX2_1	363	365	PF00082	0.348
CLV_PCSK_KEX2_1	453	455	PF00082	0.306
CLV_PCSK_KEX2_1	478	480	PF00082	0.479
CLV_PCSK_KEX2_1	526	528	PF00082	0.508
CLV_PCSK_KEX2_1	566	568	PF00082	0.307
CLV_PCSK_KEX2_1	616	618	PF00082	0.641
CLV_PCSK_KEX2_1	705	707	PF00082	0.703
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.419
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.348
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.304
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.307
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.641
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.703
CLV_PCSK_PC7_1	293	299	PF00082	0.435
CLV_PCSK_SKI1_1	179	183	PF00082	0.493
CLV_PCSK_SKI1_1	20	24	PF00082	0.570
CLV_PCSK_SKI1_1	490	494	PF00082	0.325
CLV_PCSK_SKI1_1	526	530	PF00082	0.425
CLV_PCSK_SKI1_1	707	711	PF00082	0.605
DEG_APCC_DBOX_1	478	486	PF00400	0.495
DEG_Nend_UBRbox_1	1	4	PF02207	0.451
DEG_SPOP_SBC_1	618	622	PF00917	0.495
DOC_CKS1_1	351	356	PF01111	0.440
DOC_CKS1_1	403	408	PF01111	0.325
DOC_CKS1_1	581	586	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	581	587	PF00134	0.404
DOC_MAPK_MEF2A_6	97	106	PF00069	0.332
DOC_PP2B_LxvP_1	575	578	PF13499	0.418
DOC_PP4_FxxP_1	23	26	PF00568	0.454
DOC_PP4_FxxP_1	664	667	PF00568	0.399
DOC_USP7_MATH_1	183	187	PF00917	0.546
DOC_USP7_MATH_1	222	226	PF00917	0.510
DOC_USP7_MATH_1	39	43	PF00917	0.554
DOC_USP7_MATH_1	481	485	PF00917	0.381
DOC_USP7_MATH_1	576	580	PF00917	0.527
DOC_USP7_MATH_1	592	596	PF00917	0.444
DOC_USP7_MATH_1	625	629	PF00917	0.628
DOC_USP7_MATH_2	354	360	PF00917	0.459
DOC_WW_Pin1_4	224	229	PF00397	0.638
DOC_WW_Pin1_4	253	258	PF00397	0.415
DOC_WW_Pin1_4	350	355	PF00397	0.370
DOC_WW_Pin1_4	402	407	PF00397	0.314
DOC_WW_Pin1_4	580	585	PF00397	0.418
DOC_WW_Pin1_4	61	66	PF00397	0.504
LIG_14-3-3_CanoR_1	180	188	PF00244	0.524
LIG_14-3-3_CanoR_1	202	210	PF00244	0.535
LIG_14-3-3_CanoR_1	297	306	PF00244	0.426
LIG_14-3-3_CanoR_1	542	551	PF00244	0.346
LIG_14-3-3_CanoR_1	652	656	PF00244	0.349
LIG_14-3-3_CanoR_1	706	710	PF00244	0.528
LIG_Actin_WH2_2	630	647	PF00022	0.462
LIG_APCC_ABBA_1	424	429	PF00400	0.384
LIG_BRCT_BRCA1_1	246	250	PF00533	0.431
LIG_BRCT_BRCA1_1	578	582	PF00533	0.438
LIG_EH1_1	171	179	PF00400	0.484
LIG_FHA_1	105	111	PF00498	0.499
LIG_FHA_1	148	154	PF00498	0.376
LIG_FHA_1	169	175	PF00498	0.380
LIG_FHA_1	188	194	PF00498	0.251
LIG_FHA_1	46	52	PF00498	0.660
LIG_FHA_1	545	551	PF00498	0.343
LIG_FHA_2	351	357	PF00498	0.389
LIG_FHA_2	363	369	PF00498	0.329
LIG_FHA_2	370	376	PF00498	0.337
LIG_FHA_2	644	650	PF00498	0.480
LIG_LIR_Apic_2	21	26	PF02991	0.453
LIG_LIR_Apic_2	498	504	PF02991	0.349
LIG_LIR_Gen_1	185	196	PF02991	0.366
LIG_LIR_Gen_1	336	344	PF02991	0.416
LIG_LIR_Gen_1	393	400	PF02991	0.347
LIG_LIR_Gen_1	69	79	PF02991	0.399
LIG_LIR_Nem_3	119	124	PF02991	0.405
LIG_LIR_Nem_3	185	191	PF02991	0.383
LIG_LIR_Nem_3	3	7	PF02991	0.641
LIG_LIR_Nem_3	336	340	PF02991	0.414
LIG_LIR_Nem_3	498	503	PF02991	0.374
LIG_LIR_Nem_3	579	585	PF02991	0.589
LIG_LIR_Nem_3	695	701	PF02991	0.364
LIG_MYND_1	207	211	PF01753	0.518
LIG_PAM2_1	258	270	PF00658	0.467
LIG_PCNA_yPIPBox_3	265	277	PF02747	0.453
LIG_Pex14_1	390	394	PF04695	0.350
LIG_Pex14_2	277	281	PF04695	0.366
LIG_PTB_Apo_2	522	529	PF02174	0.486
LIG_SH2_CRK	400	404	PF00017	0.374
LIG_SH2_CRK	501	505	PF00017	0.464
LIG_SH2_CRK	572	576	PF00017	0.312
LIG_SH2_GRB2like	457	460	PF00017	0.599
LIG_SH2_PTP2	337	340	PF00017	0.345
LIG_SH2_SRC	457	460	PF00017	0.505
LIG_SH2_STAT3	156	159	PF00017	0.498
LIG_SH2_STAT5	188	191	PF00017	0.475
LIG_SH2_STAT5	333	336	PF00017	0.314
LIG_SH2_STAT5	337	340	PF00017	0.306
LIG_SH2_STAT5	433	436	PF00017	0.313
LIG_SH2_STAT5	570	573	PF00017	0.377
LIG_SH3_1	254	260	PF00018	0.447
LIG_SH3_3	254	260	PF00018	0.439
LIG_SH3_3	263	269	PF00018	0.412
LIG_SH3_3	449	455	PF00018	0.406
LIG_SH3_3	483	489	PF00018	0.315
LIG_SH3_3	511	517	PF00018	0.527
LIG_SH3_3	583	589	PF00018	0.469
LIG_SUMO_SIM_par_1	435	441	PF11976	0.288
LIG_TRAF2_1	353	356	PF00917	0.441
LIG_TRAF2_1	365	368	PF00917	0.332
LIG_TRAF2_1	646	649	PF00917	0.571
LIG_TRAF2_1	654	657	PF00917	0.569
LIG_WRC_WIRS_1	1	6	PF05994	0.422
LIG_WRC_WIRS_1	188	193	PF05994	0.361
LIG_WRC_WIRS_1	447	452	PF05994	0.448
MOD_CK1_1	186	192	PF00069	0.405
MOD_CK1_1	227	233	PF00069	0.745
MOD_CK1_1	359	365	PF00069	0.435
MOD_CK1_1	380	386	PF00069	0.330
MOD_CK1_1	40	46	PF00069	0.583
MOD_CK1_1	441	447	PF00069	0.363
MOD_CK1_1	544	550	PF00069	0.344
MOD_CK1_1	588	594	PF00069	0.525
MOD_CK1_1	595	601	PF00069	0.584
MOD_CK1_1	620	626	PF00069	0.611
MOD_CK1_1	628	634	PF00069	0.538
MOD_CK2_1	306	312	PF00069	0.405
MOD_CK2_1	336	342	PF00069	0.364
MOD_CK2_1	350	356	PF00069	0.414
MOD_CK2_1	362	368	PF00069	0.344
MOD_CK2_1	369	375	PF00069	0.313
MOD_CK2_1	643	649	PF00069	0.432
MOD_CK2_1	651	657	PF00069	0.414
MOD_Cter_Amidation	476	479	PF01082	0.477
MOD_Cter_Amidation	703	706	PF01082	0.442
MOD_GlcNHglycan	216	219	PF01048	0.626
MOD_GlcNHglycan	223	227	PF01048	0.683
MOD_GlcNHglycan	246	249	PF01048	0.458
MOD_GlcNHglycan	260	263	PF01048	0.466
MOD_GlcNHglycan	308	311	PF01048	0.553
MOD_GlcNHglycan	495	498	PF01048	0.450
MOD_GlcNHglycan	590	593	PF01048	0.571
MOD_GlcNHglycan	599	602	PF01048	0.609
MOD_GlcNHglycan	607	611	PF01048	0.651
MOD_GlcNHglycan	622	625	PF01048	0.583
MOD_GlcNHglycan	627	630	PF01048	0.428
MOD_GSK3_1	168	175	PF00069	0.367
MOD_GSK3_1	179	186	PF00069	0.332
MOD_GSK3_1	222	229	PF00069	0.768
MOD_GSK3_1	369	376	PF00069	0.429
MOD_GSK3_1	405	412	PF00069	0.351
MOD_GSK3_1	438	445	PF00069	0.382
MOD_GSK3_1	533	540	PF00069	0.525
MOD_GSK3_1	576	583	PF00069	0.477
MOD_GSK3_1	588	595	PF00069	0.496
MOD_GSK3_1	606	613	PF00069	0.572
MOD_GSK3_1	628	635	PF00069	0.467
MOD_GSK3_1	66	73	PF00069	0.615
MOD_GSK3_1	667	674	PF00069	0.590
MOD_GSK3_1	705	712	PF00069	0.614
MOD_N-GLC_1	231	236	PF02516	0.517
MOD_N-GLC_1	45	50	PF02516	0.566
MOD_N-GLC_1	465	470	PF02516	0.432
MOD_N-GLC_2	11	13	PF02516	0.431
MOD_NEK2_1	172	177	PF00069	0.398
MOD_NEK2_1	306	311	PF00069	0.522
MOD_NEK2_1	373	378	PF00069	0.501
MOD_NEK2_1	442	447	PF00069	0.351
MOD_NEK2_1	60	65	PF00069	0.503
MOD_NEK2_1	608	613	PF00069	0.551
MOD_NEK2_1	683	688	PF00069	0.480
MOD_NEK2_2	446	451	PF00069	0.422
MOD_NEK2_2	465	470	PF00069	0.321
MOD_OFUCOSY	371	377	PF10250	0.437
MOD_PIKK_1	209	215	PF00454	0.649
MOD_PIKK_1	297	303	PF00454	0.466
MOD_PKA_1	179	185	PF00069	0.512
MOD_PKA_1	214	220	PF00069	0.467
MOD_PKA_1	297	303	PF00069	0.415
MOD_PKA_1	705	711	PF00069	0.584
MOD_PKA_2	179	185	PF00069	0.512
MOD_PKA_2	201	207	PF00069	0.575
MOD_PKA_2	214	220	PF00069	0.706
MOD_PKA_2	297	303	PF00069	0.402
MOD_PKA_2	541	547	PF00069	0.347
MOD_PKA_2	651	657	PF00069	0.459
MOD_PKA_2	705	711	PF00069	0.584
MOD_PKB_1	284	292	PF00069	0.441
MOD_Plk_1	186	192	PF00069	0.385
MOD_Plk_1	465	471	PF00069	0.428
MOD_Plk_2-3	336	342	PF00069	0.355
MOD_Plk_4	160	166	PF00069	0.493
MOD_Plk_4	377	383	PF00069	0.347
MOD_Plk_4	435	441	PF00069	0.302
MOD_Plk_4	446	452	PF00069	0.367
MOD_Plk_4	481	487	PF00069	0.372
MOD_Plk_4	675	681	PF00069	0.458
MOD_Plk_4	683	689	PF00069	0.435
MOD_ProDKin_1	224	230	PF00069	0.638
MOD_ProDKin_1	253	259	PF00069	0.421
MOD_ProDKin_1	350	356	PF00069	0.376
MOD_ProDKin_1	402	408	PF00069	0.314
MOD_ProDKin_1	580	586	PF00069	0.429
MOD_ProDKin_1	61	67	PF00069	0.500
MOD_SUMO_rev_2	654	661	PF00179	0.568
MOD_SUMO_rev_2	685	694	PF00179	0.466
TRG_DiLeu_BaEn_1	488	493	PF01217	0.300
TRG_DiLeu_BaEn_1	657	662	PF01217	0.522
TRG_DiLeu_BaEn_4	342	348	PF01217	0.386
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.466
TRG_ENDOCYTIC_2	158	161	PF00928	0.368
TRG_ENDOCYTIC_2	188	191	PF00928	0.354
TRG_ENDOCYTIC_2	337	340	PF00928	0.404
TRG_ENDOCYTIC_2	400	403	PF00928	0.359
TRG_ENDOCYTIC_2	433	436	PF00928	0.337
TRG_ENDOCYTIC_2	572	575	PF00928	0.380
TRG_ER_diArg_1	197	199	PF00400	0.510
TRG_ER_diArg_1	284	287	PF00400	0.496
TRG_ER_diArg_1	291	293	PF00400	0.446
TRG_ER_diArg_1	30	32	PF00400	0.614
TRG_ER_diArg_1	478	480	PF00400	0.479
TRG_ER_diArg_1	526	528	PF00400	0.508
TRG_NES_CRM1_1	656	669	PF08389	0.516
TRG_NLS_MonoExtN_4	703	709	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL8	Leptomonas seymouri	66%	100%
A0A0S4JGT6	Bodo saltans	43%	100%
A0A1X0P422	Trypanosomatidae	46%	100%
A0A3S7XBU8	Leishmania donovani	79%	100%
A0A422NC22	Trypanosoma rangeli	48%	100%
A4ICE7	Leishmania infantum	79%	100%
D0A8V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q0R7	Leishmania major	79%	100%
V5AP55	Trypanosoma cruzi	47%	100%