RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized protein family UPF0029, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ11_LEIBR

TriTrypDb:

LbrM.35.5190 , LBRM2903_350062800

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HQ11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ11

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	8
GO:0009889	regulation of biosynthetic process	4	8
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0010608	post-transcriptional regulation of gene expression	6	8
GO:0019222	regulation of metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0034248	regulation of amide metabolic process	5	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0080090	regulation of primary metabolic process	4	8
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	8
GO:0006446	regulation of translational initiation	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.183
CLV_NRD_NRD_1	76	78	PF00675	0.396
CLV_PCSK_KEX2_1	144	146	PF00082	0.271
CLV_PCSK_KEX2_1	266	268	PF00082	0.609
CLV_PCSK_KEX2_1	76	78	PF00082	0.452
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.601
CLV_PCSK_SKI1_1	104	108	PF00082	0.453
CLV_PCSK_SKI1_1	169	173	PF00082	0.353
CLV_PCSK_SKI1_1	209	213	PF00082	0.226
CLV_PCSK_SKI1_1	248	252	PF00082	0.265
DEG_APCC_DBOX_1	247	255	PF00400	0.385
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.337
DOC_MAPK_gen_1	239	246	PF00069	0.414
DOC_MAPK_gen_1	76	86	PF00069	0.354
DOC_MAPK_HePTP_8	74	86	PF00069	0.464
DOC_MAPK_MEF2A_6	25	33	PF00069	0.237
DOC_MAPK_MEF2A_6	77	86	PF00069	0.466
DOC_MAPK_NFAT4_5	79	87	PF00069	0.474
DOC_PP2B_LxvP_1	84	87	PF13499	0.418
DOC_PP2B_LxvP_1	91	94	PF13499	0.379
DOC_USP7_MATH_1	49	53	PF00917	0.410
LIG_14-3-3_CanoR_1	186	194	PF00244	0.445
LIG_Actin_WH2_2	236	254	PF00022	0.356
LIG_APCC_ABBA_1	12	17	PF00400	0.430
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BIR_III_4	189	193	PF00653	0.485
LIG_eIF4E_1	53	59	PF01652	0.414
LIG_FHA_1	117	123	PF00498	0.357
LIG_FHA_1	245	251	PF00498	0.502
LIG_FHA_2	129	135	PF00498	0.360
LIG_FHA_2	251	257	PF00498	0.481
LIG_LIR_Gen_1	220	226	PF02991	0.445
LIG_LIR_Nem_3	220	225	PF02991	0.423
LIG_LIR_Nem_3	227	233	PF02991	0.403
LIG_LIR_Nem_3	238	243	PF02991	0.448
LIG_LIR_Nem_3	50	56	PF02991	0.420
LIG_LYPXL_yS_3	53	56	PF13949	0.385
LIG_SH2_PTP2	222	225	PF00017	0.410
LIG_SH2_STAP1	183	187	PF00017	0.414
LIG_SH2_STAT5	167	170	PF00017	0.423
LIG_SH2_STAT5	222	225	PF00017	0.410
LIG_SH2_STAT5	57	60	PF00017	0.477
LIG_SH3_3	28	34	PF00018	0.365
LIG_SH3_3	38	44	PF00018	0.362
LIG_SUMO_SIM_par_1	222	227	PF11976	0.410
LIG_TRAF2_1	157	160	PF00917	0.442
LIG_TRAF2_1	3	6	PF00917	0.411
MOD_CK1_1	13	19	PF00069	0.498
MOD_CK1_1	170	176	PF00069	0.535
MOD_CK1_1	204	210	PF00069	0.508
MOD_CK1_1	68	74	PF00069	0.491
MOD_CK2_1	1	7	PF00069	0.395
MOD_CK2_1	154	160	PF00069	0.550
MOD_CK2_1	250	256	PF00069	0.586
MOD_CK2_1	95	101	PF00069	0.449
MOD_Cter_Amidation	264	267	PF01082	0.481
MOD_GlcNHglycan	1	4	PF01048	0.592
MOD_GlcNHglycan	136	139	PF01048	0.455
MOD_GlcNHglycan	203	206	PF01048	0.278
MOD_GlcNHglycan	263	266	PF01048	0.518
MOD_GlcNHglycan	59	62	PF01048	0.353
MOD_GlcNHglycan	67	70	PF01048	0.453
MOD_GSK3_1	139	146	PF00069	0.304
MOD_NEK2_1	10	15	PF00069	0.395
MOD_NEK2_1	244	249	PF00069	0.481
MOD_NEK2_1	261	266	PF00069	0.508
MOD_NEK2_1	39	44	PF00069	0.334
MOD_NEK2_1	95	100	PF00069	0.420
MOD_NEK2_2	167	172	PF00069	0.423
MOD_PIKK_1	68	74	PF00454	0.390
MOD_PK_1	154	160	PF00069	0.448
MOD_PK_1	25	31	PF00069	0.241
MOD_PKA_2	128	134	PF00069	0.488
MOD_PKA_2	143	149	PF00069	0.187
MOD_PKA_2	185	191	PF00069	0.438
MOD_Plk_1	49	55	PF00069	0.478
MOD_Plk_4	10	16	PF00069	0.445
MOD_Plk_4	178	184	PF00069	0.418
MOD_Plk_4	25	31	PF00069	0.340
MOD_SUMO_rev_2	17	26	PF00179	0.286
MOD_SUMO_rev_2	98	106	PF00179	0.483
TRG_DiLeu_BaEn_3	5	11	PF01217	0.468
TRG_DiLeu_BaEn_4	101	107	PF01217	0.460
TRG_ENDOCYTIC_2	222	225	PF00928	0.414
TRG_ENDOCYTIC_2	53	56	PF00928	0.385
TRG_ER_diArg_1	144	147	PF00400	0.513
TRG_ER_diArg_1	76	79	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ9	Leptomonas seymouri	70%	99%
A0A0S4JCX3	Bodo saltans	46%	91%
A0A1X0P3C9	Trypanosomatidae	49%	98%
A0A3Q8IHS6	Leishmania donovani	81%	99%
A0A422NC53	Trypanosoma rangeli	50%	98%
A4ICE6	Leishmania infantum	81%	99%
E9ATS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
P25637	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4Q0R8	Leishmania major	83%	100%
Q9XWF4	Caenorhabditis elegans	37%	100%
V5B4H2	Trypanosoma cruzi	51%	87%