Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ09_LEIBR

TriTrypDb:

LbrM.35.5170 , LBRM2903_350062600

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005938	cell cortex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQ09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.373
CLV_C14_Caspase3-7	287	291	PF00656	0.295
CLV_C14_Caspase3-7	707	711	PF00656	0.335
CLV_C14_Caspase3-7	93	97	PF00656	0.498
CLV_NRD_NRD_1	102	104	PF00675	0.526
CLV_NRD_NRD_1	188	190	PF00675	0.392
CLV_NRD_NRD_1	273	275	PF00675	0.331
CLV_NRD_NRD_1	457	459	PF00675	0.635
CLV_NRD_NRD_1	607	609	PF00675	0.595
CLV_NRD_NRD_1	682	684	PF00675	0.564
CLV_NRD_NRD_1	691	693	PF00675	0.423
CLV_PCSK_KEX2_1	188	190	PF00082	0.392
CLV_PCSK_KEX2_1	253	255	PF00082	0.527
CLV_PCSK_KEX2_1	272	274	PF00082	0.216
CLV_PCSK_KEX2_1	607	609	PF00082	0.508
CLV_PCSK_KEX2_1	66	68	PF00082	0.507
CLV_PCSK_KEX2_1	682	684	PF00082	0.564
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.385
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.209
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.365
CLV_PCSK_SKI1_1	66	70	PF00082	0.377
CLV_PCSK_SKI1_1	683	687	PF00082	0.347
CLV_PCSK_SKI1_1	692	696	PF00082	0.410
CLV_PCSK_SKI1_1	90	94	PF00082	0.530
CLV_PCSK_SKI1_1	95	99	PF00082	0.452
DEG_APCC_DBOX_1	188	196	PF00400	0.515
DEG_APCC_DBOX_1	200	208	PF00400	0.274
DEG_APCC_DBOX_1	335	343	PF00400	0.541
DEG_APCC_DBOX_1	94	102	PF00400	0.494
DEG_SCF_FBW7_1	515	520	PF00400	0.627
DEG_SCF_FBW7_2	474	480	PF00400	0.564
DEG_SCF_TRCP1_1	441	446	PF00400	0.582
DEG_SPOP_SBC_1	665	669	PF00917	0.405
DOC_CKS1_1	452	457	PF01111	0.549
DOC_CKS1_1	474	479	PF01111	0.574
DOC_CKS1_1	514	519	PF01111	0.631
DOC_CYCLIN_RxL_1	61	73	PF00134	0.362
DOC_CYCLIN_RxL_1	688	699	PF00134	0.337
DOC_MAPK_gen_1	138	148	PF00069	0.513
DOC_MAPK_gen_1	24	34	PF00069	0.501
DOC_MAPK_gen_1	682	689	PF00069	0.465
DOC_MAPK_MEF2A_6	227	236	PF00069	0.385
DOC_MAPK_MEF2A_6	315	322	PF00069	0.460
DOC_MAPK_MEF2A_6	635	644	PF00069	0.504
DOC_MAPK_MEF2A_6	682	689	PF00069	0.465
DOC_MAPK_MEF2A_6	701	708	PF00069	0.370
DOC_MAPK_NFAT4_5	227	235	PF00069	0.243
DOC_PP1_RVXF_1	612	618	PF00149	0.660
DOC_PP1_RVXF_1	680	687	PF00149	0.467
DOC_PP2B_LxvP_1	217	220	PF13499	0.265
DOC_PP2B_LxvP_1	249	252	PF13499	0.385
DOC_PP2B_LxvP_1	379	382	PF13499	0.530
DOC_PP2B_PxIxI_1	317	323	PF00149	0.433
DOC_PP2B_PxIxI_1	703	709	PF00149	0.349
DOC_USP7_MATH_1	125	129	PF00917	0.599
DOC_USP7_MATH_1	137	141	PF00917	0.607
DOC_USP7_MATH_1	170	174	PF00917	0.573
DOC_USP7_MATH_1	225	229	PF00917	0.399
DOC_USP7_MATH_1	375	379	PF00917	0.663
DOC_USP7_MATH_1	450	454	PF00917	0.733
DOC_USP7_MATH_1	482	486	PF00917	0.590
DOC_USP7_MATH_1	517	521	PF00917	0.668
DOC_USP7_MATH_1	593	597	PF00917	0.535
DOC_USP7_MATH_1	666	670	PF00917	0.388
DOC_USP7_MATH_1	70	74	PF00917	0.378
DOC_WW_Pin1_4	349	354	PF00397	0.524
DOC_WW_Pin1_4	38	43	PF00397	0.499
DOC_WW_Pin1_4	390	395	PF00397	0.583
DOC_WW_Pin1_4	423	428	PF00397	0.569
DOC_WW_Pin1_4	448	453	PF00397	0.673
DOC_WW_Pin1_4	457	462	PF00397	0.675
DOC_WW_Pin1_4	473	478	PF00397	0.544
DOC_WW_Pin1_4	513	518	PF00397	0.656
DOC_WW_Pin1_4	619	624	PF00397	0.628
DOC_WW_Pin1_4	655	660	PF00397	0.504
LIG_14-3-3_CanoR_1	138	144	PF00244	0.518
LIG_14-3-3_CanoR_1	295	304	PF00244	0.449
LIG_14-3-3_CanoR_1	306	316	PF00244	0.506
LIG_14-3-3_CanoR_1	423	427	PF00244	0.617
LIG_14-3-3_CanoR_1	429	438	PF00244	0.608
LIG_14-3-3_CanoR_1	472	477	PF00244	0.574
LIG_14-3-3_CanoR_1	486	494	PF00244	0.515
LIG_14-3-3_CanoR_1	661	666	PF00244	0.559
LIG_14-3-3_CanoR_1	85	92	PF00244	0.503
LIG_Actin_WH2_1	682	699	PF00022	0.472
LIG_Actin_WH2_2	212	229	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_4	710	714	PF00653	0.332
LIG_BRCT_BRCA1_1	1	5	PF00533	0.582
LIG_FHA_1	29	35	PF00498	0.366
LIG_FHA_1	311	317	PF00498	0.328
LIG_FHA_1	350	356	PF00498	0.538
LIG_FHA_1	375	381	PF00498	0.546
LIG_FHA_1	452	458	PF00498	0.563
LIG_FHA_1	474	480	PF00498	0.834
LIG_FHA_1	489	495	PF00498	0.565
LIG_FHA_2	127	133	PF00498	0.551
LIG_FHA_2	155	161	PF00498	0.600
LIG_FHA_2	282	288	PF00498	0.385
LIG_FHA_2	333	339	PF00498	0.543
LIG_FHA_2	39	45	PF00498	0.485
LIG_FHA_2	431	437	PF00498	0.614
LIG_FHA_2	537	543	PF00498	0.722
LIG_FHA_2	666	672	PF00498	0.510
LIG_FHA_2	74	80	PF00498	0.499
LIG_FHA_2	91	97	PF00498	0.356
LIG_LIR_Gen_1	44	53	PF02991	0.471
LIG_LIR_Nem_3	14	20	PF02991	0.470
LIG_LIR_Nem_3	44	49	PF02991	0.466
LIG_LIR_Nem_3	634	640	PF02991	0.526
LIG_LIR_Nem_3	669	675	PF02991	0.469
LIG_NRBOX	231	237	PF00104	0.385
LIG_PDZ_Class_2	715	720	PF00595	0.526
LIG_REV1ctd_RIR_1	256	265	PF16727	0.385
LIG_RPA_C_Fungi	677	689	PF08784	0.443
LIG_SH2_CRK	675	679	PF00017	0.396
LIG_SH2_NCK_1	275	279	PF00017	0.385
LIG_SH2_STAP1	323	327	PF00017	0.495
LIG_SH2_STAT3	105	108	PF00017	0.551
LIG_SH2_STAT5	575	578	PF00017	0.585
LIG_SH2_STAT5	585	588	PF00017	0.620
LIG_SH2_STAT5	672	675	PF00017	0.453
LIG_SH3_3	449	455	PF00018	0.582
LIG_SH3_3	502	508	PF00018	0.600
LIG_SH3_3	587	593	PF00018	0.556
LIG_SH3_3	617	623	PF00018	0.505
LIG_SUMO_SIM_par_1	29	36	PF11976	0.368
LIG_TRAF2_1	348	351	PF00917	0.509
LIG_TRAF2_1	540	543	PF00917	0.698
LIG_TRAF2_1	562	565	PF00917	0.661
LIG_TRAF2_1	598	601	PF00917	0.637
LIG_TYR_ITIM	673	678	PF00017	0.470
LIG_UBA3_1	16	24	PF00899	0.486
LIG_UBA3_1	231	238	PF00899	0.363
LIG_UBA3_1	45	51	PF00899	0.462
LIG_UBA3_1	52	57	PF00899	0.428
LIG_WRC_WIRS_1	264	269	PF05994	0.385
LIG_WW_1	629	632	PF00397	0.530
LIG_WW_3	628	632	PF00397	0.546
MOD_CDC14_SPxK_1	658	661	PF00782	0.473
MOD_CDK_SPxK_1	423	429	PF00069	0.546
MOD_CDK_SPxK_1	513	519	PF00069	0.654
MOD_CDK_SPxK_1	655	661	PF00069	0.500
MOD_CDK_SPxxK_3	451	458	PF00069	0.558
MOD_CK1_1	118	124	PF00069	0.668
MOD_CK1_1	152	158	PF00069	0.657
MOD_CK1_1	173	179	PF00069	0.645
MOD_CK1_1	181	187	PF00069	0.515
MOD_CK1_1	310	316	PF00069	0.422
MOD_CK1_1	332	338	PF00069	0.401
MOD_CK1_1	374	380	PF00069	0.545
MOD_CK1_1	399	405	PF00069	0.658
MOD_CK1_1	451	457	PF00069	0.609
MOD_CK1_1	460	466	PF00069	0.573
MOD_CK1_1	470	476	PF00069	0.541
MOD_CK1_1	489	495	PF00069	0.679
MOD_CK1_1	664	670	PF00069	0.384
MOD_CK1_1	73	79	PF00069	0.370
MOD_CK2_1	125	131	PF00069	0.555
MOD_CK2_1	154	160	PF00069	0.530
MOD_CK2_1	38	44	PF00069	0.499
MOD_CK2_1	536	542	PF00069	0.692
MOD_CK2_1	594	600	PF00069	0.631
MOD_CK2_1	665	671	PF00069	0.526
MOD_GlcNHglycan	115	118	PF01048	0.540
MOD_GlcNHglycan	123	126	PF01048	0.536
MOD_GlcNHglycan	160	164	PF01048	0.672
MOD_GlcNHglycan	183	186	PF01048	0.574
MOD_GlcNHglycan	227	230	PF01048	0.399
MOD_GlcNHglycan	309	312	PF01048	0.476
MOD_GlcNHglycan	373	376	PF01048	0.525
MOD_GlcNHglycan	398	401	PF01048	0.661
MOD_GlcNHglycan	440	444	PF01048	0.698
MOD_GlcNHglycan	488	491	PF01048	0.649
MOD_GlcNHglycan	519	522	PF01048	0.602
MOD_GlcNHglycan	550	554	PF01048	0.654
MOD_GlcNHglycan	596	599	PF01048	0.490
MOD_GlcNHglycan	668	671	PF01048	0.513
MOD_GlcNHglycan	81	84	PF01048	0.334
MOD_GSK3_1	109	116	PF00069	0.505
MOD_GSK3_1	121	128	PF00069	0.528
MOD_GSK3_1	28	35	PF00069	0.358
MOD_GSK3_1	296	303	PF00069	0.385
MOD_GSK3_1	349	356	PF00069	0.528
MOD_GSK3_1	371	378	PF00069	0.647
MOD_GSK3_1	380	387	PF00069	0.601
MOD_GSK3_1	395	402	PF00069	0.567
MOD_GSK3_1	423	430	PF00069	0.587
MOD_GSK3_1	439	446	PF00069	0.597
MOD_GSK3_1	482	489	PF00069	0.642
MOD_GSK3_1	497	504	PF00069	0.617
MOD_GSK3_1	513	520	PF00069	0.587
MOD_GSK3_1	537	544	PF00069	0.697
MOD_GSK3_1	602	609	PF00069	0.537
MOD_GSK3_1	619	626	PF00069	0.448
MOD_GSK3_1	661	668	PF00069	0.523
MOD_N-GLC_1	359	364	PF02516	0.564
MOD_N-GLC_1	501	506	PF02516	0.648
MOD_N-GLC_1	567	572	PF02516	0.596
MOD_N-GLC_1	678	683	PF02516	0.413
MOD_N-GLC_1	73	78	PF02516	0.518
MOD_NEK2_1	115	120	PF00069	0.685
MOD_NEK2_1	422	427	PF00069	0.540
MOD_NEK2_1	462	467	PF00069	0.704
MOD_NEK2_1	624	629	PF00069	0.606
MOD_NEK2_1	678	683	PF00069	0.578
MOD_NEK2_1	696	701	PF00069	0.355
MOD_NEK2_2	139	144	PF00069	0.656
MOD_PIKK_1	118	124	PF00454	0.548
MOD_PK_1	501	507	PF00069	0.572
MOD_PK_1	661	667	PF00069	0.370
MOD_PKA_1	253	259	PF00069	0.385
MOD_PKA_2	118	124	PF00069	0.668
MOD_PKA_2	137	143	PF00069	0.471
MOD_PKA_2	253	259	PF00069	0.385
MOD_PKA_2	332	338	PF00069	0.640
MOD_PKA_2	422	428	PF00069	0.618
MOD_PKA_2	60	66	PF00069	0.497
MOD_PKA_2	606	612	PF00069	0.504
MOD_PKA_2	696	702	PF00069	0.368
MOD_PKA_2	84	90	PF00069	0.483
MOD_Plk_1	149	155	PF00069	0.655
MOD_Plk_1	28	34	PF00069	0.503
MOD_Plk_1	470	476	PF00069	0.669
MOD_Plk_1	495	501	PF00069	0.701
MOD_Plk_4	170	176	PF00069	0.647
MOD_Plk_4	263	269	PF00069	0.385
MOD_Plk_4	375	381	PF00069	0.532
MOD_ProDKin_1	349	355	PF00069	0.527
MOD_ProDKin_1	38	44	PF00069	0.499
MOD_ProDKin_1	390	396	PF00069	0.585
MOD_ProDKin_1	423	429	PF00069	0.573
MOD_ProDKin_1	448	454	PF00069	0.674
MOD_ProDKin_1	457	463	PF00069	0.674
MOD_ProDKin_1	473	479	PF00069	0.543
MOD_ProDKin_1	513	519	PF00069	0.656
MOD_ProDKin_1	619	625	PF00069	0.629
MOD_ProDKin_1	655	661	PF00069	0.500
MOD_SUMO_rev_2	246	252	PF00179	0.378
MOD_SUMO_rev_2	596	604	PF00179	0.491
MOD_SUMO_rev_2	82	92	PF00179	0.494
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.354
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.344
TRG_ENDOCYTIC_2	275	278	PF00928	0.385
TRG_ENDOCYTIC_2	50	53	PF00928	0.480
TRG_ENDOCYTIC_2	675	678	PF00928	0.476
TRG_ER_diArg_1	156	159	PF00400	0.532
TRG_ER_diArg_1	187	189	PF00400	0.396
TRG_ER_diArg_1	273	275	PF00400	0.331
TRG_ER_diArg_1	682	684	PF00400	0.556
TRG_NES_CRM1_1	224	240	PF08389	0.385
TRG_NES_CRM1_1	44	56	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBQ1	Leishmania donovani	65%	100%
A4IDS0	Leishmania infantum	65%	100%
E9ATS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q0S0	Leishmania major	65%	99%