Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ08_LEIBR

TriTrypDb:

LbrM.35.5160 , LBRM2903_350062500

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.570
CLV_NRD_NRD_1	15	17	PF00675	0.482
CLV_NRD_NRD_1	220	222	PF00675	0.472
CLV_NRD_NRD_1	263	265	PF00675	0.483
CLV_NRD_NRD_1	274	276	PF00675	0.442
CLV_NRD_NRD_1	295	297	PF00675	0.592
CLV_NRD_NRD_1	332	334	PF00675	0.459
CLV_NRD_NRD_1	336	338	PF00675	0.467
CLV_NRD_NRD_1	34	36	PF00675	0.494
CLV_NRD_NRD_1	62	64	PF00675	0.675
CLV_NRD_NRD_1	94	96	PF00675	0.630
CLV_PCSK_FUR_1	261	265	PF00082	0.505
CLV_PCSK_KEX2_1	113	115	PF00082	0.534
CLV_PCSK_KEX2_1	15	17	PF00082	0.482
CLV_PCSK_KEX2_1	183	185	PF00082	0.512
CLV_PCSK_KEX2_1	220	222	PF00082	0.454
CLV_PCSK_KEX2_1	263	265	PF00082	0.464
CLV_PCSK_KEX2_1	295	297	PF00082	0.670
CLV_PCSK_KEX2_1	332	334	PF00082	0.502
CLV_PCSK_KEX2_1	34	36	PF00082	0.368
CLV_PCSK_KEX2_1	52	54	PF00082	0.595
CLV_PCSK_KEX2_1	94	96	PF00082	0.511
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.534
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.505
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.530
CLV_PCSK_PC7_1	179	185	PF00082	0.358
CLV_PCSK_PC7_1	48	54	PF00082	0.583
CLV_PCSK_SKI1_1	131	135	PF00082	0.572
CLV_PCSK_SKI1_1	223	227	PF00082	0.493
CLV_PCSK_SKI1_1	263	267	PF00082	0.527
CLV_PCSK_SKI1_1	319	323	PF00082	0.562
CLV_PCSK_SKI1_1	43	47	PF00082	0.553
CLV_PCSK_SKI1_1	52	56	PF00082	0.375
DEG_APCC_DBOX_1	15	23	PF00400	0.581
DEG_APCC_DBOX_1	171	179	PF00400	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.497
DOC_CYCLIN_RxL_1	221	235	PF00134	0.491
DOC_PIKK_1	141	149	PF02985	0.362
DOC_USP7_MATH_1	314	318	PF00917	0.464
DOC_USP7_MATH_1	5	9	PF00917	0.617
DOC_USP7_MATH_1	66	70	PF00917	0.697
DOC_USP7_MATH_1	74	78	PF00917	0.677
DOC_USP7_UBL2_3	238	242	PF12436	0.389
LIG_14-3-3_CanoR_1	24	32	PF00244	0.570
LIG_14-3-3_CanoR_1	244	252	PF00244	0.369
LIG_14-3-3_CanoR_1	295	303	PF00244	0.564
LIG_14-3-3_CanoR_1	351	358	PF00244	0.480
LIG_FHA_1	224	230	PF00498	0.633
LIG_FHA_1	99	105	PF00498	0.608
LIG_FHA_2	264	270	PF00498	0.523
LIG_FHA_2	351	357	PF00498	0.650
LIG_FHA_2	45	51	PF00498	0.448
LIG_LIR_Apic_2	297	303	PF02991	0.500
LIG_LIR_Gen_1	115	124	PF02991	0.558
LIG_LIR_Nem_3	115	119	PF02991	0.572
LIG_LIR_Nem_3	317	321	PF02991	0.574
LIG_PCNA_yPIPBox_3	220	229	PF02747	0.362
LIG_Pex14_2	280	284	PF04695	0.459
LIG_PTB_Apo_2	230	237	PF02174	0.514
LIG_SH2_CRK	116	120	PF00017	0.576
LIG_SH2_CRK	318	322	PF00017	0.507
LIG_SH2_NCK_1	252	256	PF00017	0.525
LIG_SH2_NCK_1	300	304	PF00017	0.468
LIG_SH2_SRC	252	255	PF00017	0.529
LIG_SH2_SRC	300	303	PF00017	0.516
LIG_SH2_STAP1	120	124	PF00017	0.553
LIG_SH2_STAP1	252	256	PF00017	0.623
LIG_SH2_STAT3	102	105	PF00017	0.500
LIG_SH2_STAT5	174	177	PF00017	0.482
LIG_SH2_STAT5	18	21	PF00017	0.461
LIG_TRAF2_1	167	170	PF00917	0.570
LIG_TRAF2_1	257	260	PF00917	0.512
LIG_TRAF2_1	266	269	PF00917	0.516
LIG_TRAF2_1	47	50	PF00917	0.444
LIG_UBA3_1	340	347	PF00899	0.433
MOD_CK2_1	263	269	PF00069	0.522
MOD_CK2_1	44	50	PF00069	0.622
MOD_Cter_Amidation	92	95	PF01082	0.497
MOD_GlcNHglycan	7	10	PF01048	0.626
MOD_GlcNHglycan	76	79	PF01048	0.718
MOD_GlcNHglycan	91	94	PF01048	0.628
MOD_GSK3_1	346	353	PF00069	0.606
MOD_GSK3_1	85	92	PF00069	0.694
MOD_GSK3_1	94	101	PF00069	0.703
MOD_N-GLC_1	223	228	PF02516	0.516
MOD_NEK2_1	178	183	PF00069	0.478
MOD_NEK2_1	25	30	PF00069	0.573
MOD_NEK2_1	89	94	PF00069	0.721
MOD_PIKK_1	25	31	PF00454	0.514
MOD_PIKK_1	57	63	PF00454	0.466
MOD_PK_1	94	100	PF00069	0.473
MOD_PKA_1	263	269	PF00069	0.620
MOD_PKA_1	94	100	PF00069	0.576
MOD_PKA_2	178	184	PF00069	0.374
MOD_PKA_2	25	31	PF00069	0.570
MOD_PKA_2	263	269	PF00069	0.457
MOD_PKA_2	294	300	PF00069	0.603
MOD_PKA_2	350	356	PF00069	0.562
MOD_PKA_2	94	100	PF00069	0.591
MOD_PKB_1	261	269	PF00069	0.650
MOD_Plk_1	131	137	PF00069	0.482
MOD_Plk_1	223	229	PF00069	0.515
MOD_Plk_1	98	104	PF00069	0.672
TRG_DiLeu_BaEn_4	170	176	PF01217	0.364
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.353
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.462
TRG_ENDOCYTIC_2	116	119	PF00928	0.579
TRG_ENDOCYTIC_2	252	255	PF00928	0.529
TRG_ENDOCYTIC_2	318	321	PF00928	0.511
TRG_ER_diArg_1	24	27	PF00400	0.486
TRG_ER_diArg_1	261	264	PF00400	0.582
TRG_ER_diArg_1	294	296	PF00400	0.572
TRG_ER_diArg_1	94	96	PF00400	0.491
TRG_NLS_Bipartite_1	52	67	PF00514	0.400
TRG_NLS_MonoExtC_3	62	68	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM7	Leptomonas seymouri	69%	100%
A0A1X0P2Z9	Trypanosomatidae	40%	100%
A0A3Q8ILH7	Leishmania donovani	82%	100%
A0A3R7KX10	Trypanosoma rangeli	37%	100%
A4IDR9	Leishmania infantum	82%	100%
D0A8W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q0S1	Leishmania major	81%	100%
V5B8Z3	Trypanosoma cruzi	40%	100%