Putative exosome-associated protein 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ06_LEIBR

TriTrypDb:

LbrM.35.5140 , LBRM2903_350062300

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0005730	nucleolus	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

Previous1 2Next

Expansion

Sequence features

A4HQ06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ06

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1

Previous1 2 3 4 5 6Next

Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.374
CLV_PCSK_KEX2_1	2	4	PF00082	0.522
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DOC_CDC14_PxL_1	96	104	PF14671	0.452
DOC_MAPK_MEF2A_6	98	106	PF00069	0.433
DOC_USP7_MATH_1	165	169	PF00917	0.449
DOC_WW_Pin1_4	6	11	PF00397	0.492
LIG_14-3-3_CanoR_1	66	74	PF00244	0.462
LIG_FHA_1	120	126	PF00498	0.540

Previous1 2 3 4 5Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R2	Leptomonas seymouri	80%	100%
A0A0N1ILN0	Leptomonas seymouri	25%	90%
A0A1X0P328	Trypanosomatidae	55%	97%
A0A3S7XB24	Leishmania donovani	28%	90%
A0A3S7XBS2	Leishmania donovani	90%	100%
A0A422NC95	Trypanosoma rangeli	52%	97%
A0RXU1	Cenarchaeum symbiosum (strain A)	30%	91%
A1RST0	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	31%	90%
A2BKC0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	30%	87%
A3MUP1	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	90%

Previous1 2 3 4 5Next