Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ05_LEIBR

TriTrypDb:

LbrM.35.5130 , LBRM2903_350062200

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	13
GO:0110165	cellular anatomical entity	1	14
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HQ05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ05

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0036158	outer dynein arm assembly	7	13
GO:0036159	inner dynein arm assembly	7	13
GO:0043933	protein-containing complex organization	4	13
GO:0065003	protein-containing complex assembly	5	13
GO:0070286	axonemal dynein complex assembly	6	13
GO:0071840	cellular component organization or biogenesis	2	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0044877	protein-containing complex binding	2	13
GO:0070840	dynein complex binding	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.517
CLV_C14_Caspase3-7	92	96	PF00656	0.520
CLV_NRD_NRD_1	192	194	PF00675	0.317
CLV_NRD_NRD_1	25	27	PF00675	0.519
CLV_NRD_NRD_1	264	266	PF00675	0.579
CLV_PCSK_KEX2_1	263	265	PF00082	0.544
CLV_PCSK_PC7_1	260	266	PF00082	0.585
CLV_PCSK_SKI1_1	176	180	PF00082	0.399
CLV_PCSK_SKI1_1	240	244	PF00082	0.375
DEG_APCC_DBOX_1	171	179	PF00400	0.459
DEG_Nend_UBRbox_2	1	3	PF02207	0.687
DOC_CDC14_PxL_1	197	205	PF14671	0.231
DOC_CDC14_PxL_1	94	102	PF14671	0.421
DOC_CKS1_1	31	36	PF01111	0.386
DOC_WW_Pin1_4	186	191	PF00397	0.488
DOC_WW_Pin1_4	267	272	PF00397	0.659
DOC_WW_Pin1_4	30	35	PF00397	0.389
LIG_14-3-3_CanoR_1	172	176	PF00244	0.451
LIG_14-3-3_CanoR_1	240	249	PF00244	0.446
LIG_APCC_ABBA_1	60	65	PF00400	0.344
LIG_BIR_III_4	290	294	PF00653	0.452
LIG_Clathr_ClatBox_1	148	152	PF01394	0.449
LIG_FHA_1	103	109	PF00498	0.542
LIG_FHA_1	126	132	PF00498	0.389
LIG_FHA_1	15	21	PF00498	0.377
LIG_FHA_1	175	181	PF00498	0.379
LIG_FHA_1	278	284	PF00498	0.699
LIG_FHA_1	31	37	PF00498	0.208
LIG_FHA_1	55	61	PF00498	0.353
LIG_FHA_2	13	19	PF00498	0.529
LIG_FHA_2	77	83	PF00498	0.473
LIG_LIR_Nem_3	2	7	PF02991	0.540
LIG_LIR_Nem_3	207	212	PF02991	0.406
LIG_LIR_Nem_3	247	252	PF02991	0.451
LIG_NRBOX	125	131	PF00104	0.449
LIG_NRBOX	174	180	PF00104	0.449
LIG_SH2_CRK	252	256	PF00017	0.279
LIG_SH2_NCK_1	31	35	PF00017	0.425
LIG_SH2_SRC	41	44	PF00017	0.424
LIG_SH2_SRC	63	66	PF00017	0.355
LIG_SH2_STAT5	41	44	PF00017	0.347
LIG_SH2_STAT5	63	66	PF00017	0.336
LIG_SH2_STAT5	85	88	PF00017	0.449
LIG_SH3_2	274	279	PF14604	0.416
LIG_SH3_3	268	274	PF00018	0.562
LIG_SH3_3	293	299	PF00018	0.595
LIG_SH3_3	95	101	PF00018	0.449
LIG_SUMO_SIM_par_1	146	152	PF11976	0.494
MOD_CDK_SPxxK_3	186	193	PF00069	0.475
MOD_CK1_1	147	153	PF00069	0.379
MOD_CK1_1	170	176	PF00069	0.512
MOD_CK2_1	12	18	PF00069	0.437
MOD_CK2_1	29	35	PF00069	0.414
MOD_CK2_1	308	314	PF00069	0.648
MOD_GlcNHglycan	234	237	PF01048	0.509
MOD_GlcNHglycan	299	302	PF01048	0.470
MOD_GlcNHglycan	310	313	PF01048	0.457
MOD_GSK3_1	12	19	PF00069	0.486
MOD_GSK3_1	143	150	PF00069	0.504
MOD_GSK3_1	167	174	PF00069	0.280
MOD_GSK3_1	278	285	PF00069	0.631
MOD_GSK3_1	297	304	PF00069	0.470
MOD_GSK3_1	76	83	PF00069	0.490
MOD_GSK3_1	89	96	PF00069	0.393
MOD_LATS_1	238	244	PF00433	0.292
MOD_NEK2_1	151	156	PF00069	0.475
MOD_NEK2_1	16	21	PF00069	0.506
MOD_NEK2_1	84	89	PF00069	0.480
MOD_NEK2_2	301	306	PF00069	0.472
MOD_PKA_2	171	177	PF00069	0.458
MOD_PKA_2	278	284	PF00069	0.626
MOD_PKA_2	301	307	PF00069	0.565
MOD_Plk_1	160	166	PF00069	0.336
MOD_Plk_4	125	131	PF00069	0.451
MOD_Plk_4	144	150	PF00069	0.431
MOD_Plk_4	16	22	PF00069	0.398
MOD_Plk_4	80	86	PF00069	0.445
MOD_ProDKin_1	186	192	PF00069	0.481
MOD_ProDKin_1	267	273	PF00069	0.659
MOD_ProDKin_1	30	36	PF00069	0.390
MOD_SUMO_rev_2	154	164	PF00179	0.418
TRG_ENDOCYTIC_2	209	212	PF00928	0.453
TRG_ENDOCYTIC_2	252	255	PF00928	0.472
TRG_ER_diArg_1	263	265	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJD4	Leptomonas seymouri	60%	98%
A0A0S4JHJ7	Bodo saltans	35%	83%
A0A1X0NUQ9	Trypanosomatidae	36%	73%
A0A1X0P4D9	Trypanosomatidae	51%	100%
A0A3Q8IWC9	Leishmania donovani	78%	100%
A0A3R7KFT3	Trypanosoma rangeli	35%	70%
A0A422NC68	Trypanosoma rangeli	45%	100%
A4IDR6	Leishmania infantum	77%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	72%
E9ATS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q09JZ4	Chlamydomonas reinhardtii	32%	74%
Q15435	Homo sapiens	25%	88%
Q3T0W4	Bos taurus	25%	88%
Q3UM45	Mus musculus	24%	88%
Q4Q0S4	Leishmania major	75%	100%
Q5RFS7	Pongo abelii	24%	88%