Sugar transporter SWEET

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania braziliensis

UniProt:

A4HQ04_LEIBR

TriTrypDb:

LbrM.35.5120 , LBRM2903_280009100

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HQ04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ04

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0015144	carbohydrate transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0051119	sugar transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.262
CLV_PCSK_KEX2_1	221	223	PF00082	0.244
DEG_SPOP_SBC_1	97	101	PF00917	0.522
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.305
DOC_MAPK_gen_1	221	229	PF00069	0.525
DOC_MAPK_MEF2A_6	193	200	PF00069	0.251
DOC_PP2B_PxIxI_1	22	28	PF00149	0.370
DOC_PP2B_PxIxI_1	5	11	PF00149	0.332
DOC_USP7_MATH_1	32	36	PF00917	0.434
DOC_WW_Pin1_4	151	156	PF00397	0.264
DOC_WW_Pin1_4	19	24	PF00397	0.302
DOC_WW_Pin1_4	231	236	PF00397	0.699
LIG_14-3-3_CanoR_1	104	108	PF00244	0.363
LIG_14-3-3_CanoR_1	221	229	PF00244	0.525
LIG_14-3-3_CanoR_1	31	37	PF00244	0.434
LIG_BRCT_BRCA1_1	108	112	PF00533	0.165
LIG_Clathr_ClatBox_1	191	195	PF01394	0.234
LIG_FHA_1	111	117	PF00498	0.260
LIG_FHA_1	134	140	PF00498	0.373
LIG_FHA_1	157	163	PF00498	0.156
LIG_FHA_1	59	65	PF00498	0.354
LIG_LIR_Gen_1	109	120	PF02991	0.275
LIG_LIR_Gen_1	175	185	PF02991	0.312
LIG_LIR_Gen_1	195	204	PF02991	0.216
LIG_LIR_Gen_1	210	219	PF02991	0.205
LIG_LIR_Gen_1	76	87	PF02991	0.263
LIG_LIR_Nem_3	109	115	PF02991	0.275
LIG_LIR_Nem_3	175	181	PF02991	0.315
LIG_LIR_Nem_3	183	189	PF02991	0.296
LIG_LIR_Nem_3	195	200	PF02991	0.202
LIG_LIR_Nem_3	210	214	PF02991	0.205
LIG_LIR_Nem_3	52	57	PF02991	0.287
LIG_LIR_Nem_3	76	82	PF02991	0.226
LIG_LIR_Nem_3	83	87	PF02991	0.262
LIG_NRBOX	118	124	PF00104	0.242
LIG_NRBOX	187	193	PF00104	0.369
LIG_SH2_CRK	189	193	PF00017	0.275
LIG_SH2_CRK	79	83	PF00017	0.286
LIG_SH2_PTP2	197	200	PF00017	0.369
LIG_SH2_STAT3	57	60	PF00017	0.348
LIG_SH2_STAT5	126	129	PF00017	0.484
LIG_SH2_STAT5	197	200	PF00017	0.369
LIG_SH2_STAT5	79	82	PF00017	0.286
LIG_SH3_3	167	173	PF00018	0.484
LIG_SH3_3	17	23	PF00018	0.240
LIG_TYR_ITIM	187	192	PF00017	0.199
LIG_WRC_WIRS_1	81	86	PF05994	0.315
MOD_CK1_1	106	112	PF00069	0.290
MOD_CK1_1	177	183	PF00069	0.311
MOD_CK1_1	99	105	PF00069	0.614
MOD_Cter_Amidation	219	222	PF01082	0.238
MOD_GlcNHglycan	108	111	PF01048	0.315
MOD_GlcNHglycan	73	76	PF01048	0.336
MOD_GSK3_1	106	113	PF00069	0.268
MOD_GSK3_1	19	26	PF00069	0.275
MOD_GSK3_1	203	210	PF00069	0.412
MOD_GSK3_1	98	105	PF00069	0.614
MOD_N-GLC_1	131	136	PF02516	0.539
MOD_N-GLC_1	49	54	PF02516	0.156
MOD_NEK2_1	150	155	PF00069	0.321
MOD_NEK2_1	156	161	PF00069	0.357
MOD_NEK2_1	196	201	PF00069	0.250
MOD_NEK2_1	207	212	PF00069	0.322
MOD_NEK2_1	49	54	PF00069	0.305
MOD_NEK2_1	98	103	PF00069	0.623
MOD_NEK2_2	145	150	PF00069	0.281
MOD_NEK2_2	39	44	PF00069	0.264
MOD_PKA_2	103	109	PF00069	0.441
MOD_PKA_2	220	226	PF00069	0.537
MOD_Plk_1	49	55	PF00069	0.156
MOD_Plk_4	145	151	PF00069	0.290
MOD_Plk_4	180	186	PF00069	0.297
MOD_Plk_4	49	55	PF00069	0.259
MOD_Plk_4	80	86	PF00069	0.301
MOD_ProDKin_1	151	157	PF00069	0.264
MOD_ProDKin_1	19	25	PF00069	0.302
MOD_ProDKin_1	231	237	PF00069	0.697
TRG_ENDOCYTIC_2	189	192	PF00928	0.274
TRG_ENDOCYTIC_2	197	200	PF00928	0.258
TRG_ENDOCYTIC_2	79	82	PF00928	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	66%	100%
A0A0N1HZ27	Leptomonas seymouri	43%	99%
A0A0S4JK63	Bodo saltans	29%	100%
A0A0S4JP06	Bodo saltans	37%	83%
A0A1X0NHK1	Trypanosomatidae	46%	100%
A0A3Q8IJU9	Leishmania donovani	73%	100%
A0A3R7RTY4	Trypanosoma rangeli	48%	100%
A0A3S7X189	Leishmania donovani	40%	99%
A2WR31	Oryza sativa subsp. indica	30%	98%
A2WSD3	Oryza sativa subsp. indica	25%	94%
A2WSD8	Oryza sativa subsp. indica	26%	92%
A2X3S3	Oryza sativa subsp. indica	28%	92%
A2X5B4	Oryza sativa subsp. indica	29%	75%
A2YZ24	Oryza sativa subsp. indica	30%	90%
A3BWJ9	Oryza sativa subsp. japonica	30%	93%
A4HG76	Leishmania braziliensis	41%	100%
A4I3B9	Leishmania infantum	40%	99%
A4IDR5	Leishmania infantum	72%	100%
B9G2E6	Oryza sativa subsp. japonica	30%	87%
E9ATS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9AZJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
O82587	Arabidopsis thaliana	26%	84%
P0DKJ4	Sorghum bicolor	28%	98%
P0DKJ5	Vitis vinifera	26%	83%
Q0J349	Oryza sativa subsp. japonica	29%	90%
Q290X1	Drosophila pseudoobscura pseudoobscura	28%	100%
Q4Q0S5	Leishmania major	70%	100%
Q4Q8N5	Leishmania major	42%	100%
Q54JW5	Dictyostelium discoideum	24%	100%
Q5JJY5	Oryza sativa subsp. japonica	30%	98%
Q5NAZ9	Oryza sativa subsp. japonica	25%	95%
Q6K4V2	Oryza sativa subsp. japonica	28%	92%
Q6K602	Oryza sativa subsp. japonica	27%	75%
Q6L568	Oryza sativa subsp. japonica	24%	100%
Q6NQN5	Arabidopsis thaliana	23%	91%
Q8LBF7	Arabidopsis thaliana	29%	93%
Q8LR09	Oryza sativa subsp. japonica	26%	92%
Q8W0K2	Oryza sativa subsp. japonica	25%	94%
Q944M5	Arabidopsis thaliana	29%	95%
Q9C9M9	Arabidopsis thaliana	27%	92%
Q9FGQ2	Arabidopsis thaliana	23%	81%
Q9FM10	Arabidopsis thaliana	27%	100%
Q9FY94	Arabidopsis thaliana	24%	82%
Q9LUE3	Arabidopsis thaliana	27%	83%
Q9SMM5	Arabidopsis thaliana	28%	83%
Q9SW25	Arabidopsis thaliana	25%	85%