Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ03_LEIBR

TriTrypDb:

LbrM.35.5110 , LBRM2903_350062000

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 7
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQ03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.508
CLV_NRD_NRD_1	51	53	PF00675	0.554
CLV_NRD_NRD_1	86	88	PF00675	0.480
CLV_PCSK_SKI1_1	155	159	PF00082	0.405
CLV_PCSK_SKI1_1	88	92	PF00082	0.534
CLV_Separin_Metazoa	77	81	PF03568	0.462
DEG_SPOP_SBC_1	21	25	PF00917	0.532
DOC_MAPK_DCC_7	115	124	PF00069	0.489
DOC_MAPK_gen_1	115	124	PF00069	0.489
DOC_MAPK_MEF2A_6	115	124	PF00069	0.489
DOC_PP2B_PxIxI_1	119	125	PF00149	0.355
DOC_USP7_MATH_1	21	25	PF00917	0.532
DOC_WW_Pin1_4	124	129	PF00397	0.474
LIG_14-3-3_CanoR_1	217	226	PF00244	0.551
LIG_Actin_WH2_2	58	75	PF00022	0.296
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BRCT_BRCA1_1	11	15	PF00533	0.338
LIG_CaM_IQ_9	60	75	PF13499	0.439
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.484
LIG_deltaCOP1_diTrp_1	81	86	PF00928	0.421
LIG_FHA_1	125	131	PF00498	0.548
LIG_FHA_2	108	114	PF00498	0.508
LIG_LIR_Gen_1	12	22	PF02991	0.477
LIG_LIR_Gen_1	228	234	PF02991	0.499
LIG_LIR_Gen_1	81	91	PF02991	0.387
LIG_LIR_LC3C_4	215	220	PF02991	0.369
LIG_LIR_Nem_3	12	18	PF02991	0.468
LIG_LIR_Nem_3	228	233	PF02991	0.434
LIG_LIR_Nem_3	81	86	PF02991	0.465
LIG_Pex14_1	173	177	PF04695	0.359
LIG_Pex14_2	158	162	PF04695	0.413
LIG_Pex14_2	226	230	PF04695	0.452
LIG_SH2_SRC	186	189	PF00017	0.280
LIG_SH3_3	114	120	PF00018	0.471
LIG_SH3_3	15	21	PF00018	0.488
LIG_SUMO_SIM_par_1	27	34	PF11976	0.617
LIG_TRFH_1	42	46	PF08558	0.552
LIG_WRC_WIRS_1	174	179	PF05994	0.478
MOD_CK1_1	168	174	PF00069	0.427
MOD_CK1_1	176	182	PF00069	0.468
MOD_CK1_1	93	99	PF00069	0.479
MOD_CK2_1	209	215	PF00069	0.437
MOD_CK2_1	225	231	PF00069	0.382
MOD_GlcNHglycan	12	15	PF01048	0.377
MOD_GlcNHglycan	155	158	PF01048	0.533
MOD_GlcNHglycan	167	170	PF01048	0.409
MOD_GSK3_1	120	127	PF00069	0.442
MOD_GSK3_1	175	182	PF00069	0.446
MOD_GSK3_1	93	100	PF00069	0.542
MOD_N-GLC_1	120	125	PF02516	0.428
MOD_N-GLC_1	165	170	PF02516	0.552
MOD_N-GLC_2	225	227	PF02516	0.370
MOD_N-GLC_2	7	9	PF02516	0.298
MOD_NEK2_1	10	15	PF00069	0.447
MOD_NEK2_1	133	138	PF00069	0.400
MOD_NEK2_1	175	180	PF00069	0.288
MOD_NEK2_1	218	223	PF00069	0.435
MOD_NEK2_1	22	27	PF00069	0.419
MOD_NEK2_1	97	102	PF00069	0.405
MOD_PIKK_1	176	182	PF00454	0.279
MOD_PKA_2	79	85	PF00069	0.417
MOD_Plk_1	120	126	PF00069	0.444
MOD_Plk_1	209	215	PF00069	0.394
MOD_Plk_1	35	41	PF00069	0.537
MOD_Plk_4	133	139	PF00069	0.425
MOD_Plk_4	58	64	PF00069	0.430
MOD_Plk_4	79	85	PF00069	0.484
MOD_Plk_4	93	99	PF00069	0.427
MOD_ProDKin_1	124	130	PF00069	0.468
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB92	Leptomonas seymouri	69%	100%
A0A1X0P0Q7	Trypanosomatidae	47%	100%
A0A3Q8IPJ6	Leishmania donovani	92%	100%
A0A3R7NWI3	Trypanosoma rangeli	44%	91%
A4IDR4	Leishmania infantum	92%	100%
E9ATS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0S7	Leishmania major	90%	100%
V5BQ42	Trypanosoma cruzi	45%	100%