ATG11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQ02_LEIBR

TriTrypDb:

LbrM.35.5100 , LBRM2903_350061900

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQ02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQ02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.548
CLV_C14_Caspase3-7	575	579	PF00656	0.382
CLV_NRD_NRD_1	395	397	PF00675	0.443
CLV_NRD_NRD_1	434	436	PF00675	0.371
CLV_NRD_NRD_1	439	441	PF00675	0.378
CLV_NRD_NRD_1	443	445	PF00675	0.442
CLV_PCSK_KEX2_1	395	397	PF00082	0.417
CLV_PCSK_KEX2_1	434	436	PF00082	0.370
CLV_PCSK_KEX2_1	439	441	PF00082	0.372
CLV_PCSK_KEX2_1	443	445	PF00082	0.428
CLV_PCSK_PC7_1	435	441	PF00082	0.383
CLV_PCSK_SKI1_1	132	136	PF00082	0.373
CLV_PCSK_SKI1_1	226	230	PF00082	0.476
CLV_PCSK_SKI1_1	321	325	PF00082	0.470
CLV_PCSK_SKI1_1	379	383	PF00082	0.484
CLV_PCSK_SKI1_1	395	399	PF00082	0.401
CLV_PCSK_SKI1_1	435	439	PF00082	0.445
CLV_PCSK_SKI1_1	444	448	PF00082	0.536
CLV_PCSK_SKI1_1	531	535	PF00082	0.559
CLV_PCSK_SKI1_1	538	542	PF00082	0.568
CLV_PCSK_SKI1_1	79	83	PF00082	0.371
DEG_APCC_DBOX_1	325	333	PF00400	0.309
DEG_APCC_DBOX_1	413	421	PF00400	0.486
DEG_APCC_DBOX_1	482	490	PF00400	0.524
DEG_SPOP_SBC_1	289	293	PF00917	0.422
DEG_SPOP_SBC_1	590	594	PF00917	0.541
DOC_AGCK_PIF_2	118	123	PF00069	0.513
DOC_CYCLIN_RxL_1	324	336	PF00134	0.469
DOC_CYCLIN_RxL_1	392	399	PF00134	0.587
DOC_CYCLIN_RxL_1	535	544	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.484
DOC_MAPK_gen_1	321	329	PF00069	0.296
DOC_MAPK_gen_1	400	407	PF00069	0.462
DOC_MAPK_gen_1	439	449	PF00069	0.452
DOC_MAPK_JIP1_4	210	216	PF00069	0.458
DOC_MAPK_MEF2A_6	210	218	PF00069	0.463
DOC_PP1_RVXF_1	475	481	PF00149	0.505
DOC_PP2B_LxvP_1	181	184	PF13499	0.496
DOC_PP2B_LxvP_1	482	485	PF13499	0.497
DOC_PP4_FxxP_1	101	104	PF00568	0.585
DOC_PP4_FxxP_1	108	111	PF00568	0.605
DOC_PP4_FxxP_1	112	115	PF00568	0.590
DOC_PP4_FxxP_1	44	47	PF00568	0.501
DOC_USP7_MATH_1	342	346	PF00917	0.477
DOC_USP7_MATH_1	40	44	PF00917	0.569
DOC_USP7_MATH_1	47	51	PF00917	0.616
DOC_USP7_MATH_1	524	528	PF00917	0.605
DOC_USP7_MATH_1	553	557	PF00917	0.511
DOC_USP7_UBL2_3	324	328	PF12436	0.438
DOC_WW_Pin1_4	102	107	PF00397	0.711
DOC_WW_Pin1_4	264	269	PF00397	0.534
DOC_WW_Pin1_4	27	32	PF00397	0.640
DOC_WW_Pin1_4	57	62	PF00397	0.695
DOC_WW_Pin1_4	579	584	PF00397	0.668
LIG_14-3-3_CanoR_1	176	182	PF00244	0.669
LIG_14-3-3_CanoR_1	270	275	PF00244	0.556
LIG_14-3-3_CanoR_1	290	298	PF00244	0.360
LIG_14-3-3_CanoR_1	337	343	PF00244	0.489
LIG_14-3-3_CanoR_1	385	391	PF00244	0.384
LIG_14-3-3_CanoR_1	414	418	PF00244	0.529
LIG_14-3-3_CanoR_1	520	529	PF00244	0.623
LIG_14-3-3_CanoR_1	545	551	PF00244	0.559
LIG_14-3-3_CanoR_1	554	558	PF00244	0.574
LIG_14-3-3_CanoR_1	79	85	PF00244	0.516
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	104	108	PF00533	0.507
LIG_BRCT_BRCA1_1	40	44	PF00533	0.636
LIG_BRCT_BRCA1_2	108	114	PF00533	0.485
LIG_Clathr_ClatBox_1	540	544	PF01394	0.556
LIG_FHA_1	115	121	PF00498	0.531
LIG_FHA_1	148	154	PF00498	0.555
LIG_FHA_1	178	184	PF00498	0.523
LIG_FHA_1	243	249	PF00498	0.378
LIG_FHA_1	3	9	PF00498	0.533
LIG_FHA_1	376	382	PF00498	0.476
LIG_FHA_1	450	456	PF00498	0.483
LIG_FHA_1	545	551	PF00498	0.583
LIG_FHA_2	191	197	PF00498	0.538
LIG_FHA_2	230	236	PF00498	0.379
LIG_FHA_2	276	282	PF00498	0.557
LIG_FHA_2	496	502	PF00498	0.581
LIG_FHA_2	91	97	PF00498	0.524
LIG_GBD_Chelix_1	407	415	PF00786	0.450
LIG_GBD_Chelix_1	496	504	PF00786	0.549
LIG_LIR_Apic_2	105	111	PF02991	0.482
LIG_LIR_Apic_2	41	47	PF02991	0.499
LIG_LIR_Apic_2	98	104	PF02991	0.516
LIG_LIR_Gen_1	117	126	PF02991	0.484
LIG_LIR_Gen_1	160	168	PF02991	0.587
LIG_LIR_Nem_3	117	121	PF02991	0.442
LIG_LIR_Nem_3	122	126	PF02991	0.487
LIG_LIR_Nem_3	160	164	PF02991	0.632
LIG_LIR_Nem_3	273	277	PF02991	0.486
LIG_LIR_Nem_3	451	457	PF02991	0.499
LIG_MYND_1	487	491	PF01753	0.513
LIG_Pex14_1	161	165	PF04695	0.633
LIG_Pex14_2	108	112	PF04695	0.496
LIG_SH2_CRK	123	127	PF00017	0.402
LIG_SH2_CRK	165	169	PF00017	0.578
LIG_SH2_NCK_1	574	578	PF00017	0.536
LIG_SH2_STAT3	390	393	PF00017	0.449
LIG_SH2_STAT5	19	22	PF00017	0.623
LIG_SH2_STAT5	355	358	PF00017	0.517
LIG_SH2_STAT5	390	393	PF00017	0.449
LIG_SH2_STAT5	481	484	PF00017	0.475
LIG_SH3_3	165	171	PF00018	0.524
LIG_SH3_3	298	304	PF00018	0.354
LIG_SH3_3	536	542	PF00018	0.584
LIG_SH3_3	58	64	PF00018	0.675
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.548
LIG_SUMO_SIM_par_1	140	147	PF11976	0.647
LIG_SUMO_SIM_par_1	445	453	PF11976	0.621
LIG_TRAF2_1	193	196	PF00917	0.557
LIG_TRAF2_1	338	341	PF00917	0.535
LIG_TRAF2_1	549	552	PF00917	0.361
LIG_UBA3_1	76	82	PF00899	0.520
LIG_WRC_WIRS_1	461	466	PF05994	0.468
MOD_CDC14_SPxK_1	267	270	PF00782	0.456
MOD_CDC14_SPxK_1	30	33	PF00782	0.665
MOD_CDK_SPxK_1	264	270	PF00069	0.475
MOD_CDK_SPxK_1	27	33	PF00069	0.663
MOD_CDK_SPxxK_3	107	114	PF00069	0.488
MOD_CK1_1	175	181	PF00069	0.695
MOD_CK1_1	2	8	PF00069	0.582
MOD_CK1_1	242	248	PF00069	0.501
MOD_CK1_1	264	270	PF00069	0.554
MOD_CK1_1	413	419	PF00069	0.586
MOD_CK1_1	465	471	PF00069	0.331
MOD_CK1_1	56	62	PF00069	0.563
MOD_CK1_1	594	600	PF00069	0.754
MOD_CK2_1	190	196	PF00069	0.595
MOD_CK2_1	229	235	PF00069	0.377
MOD_CK2_1	275	281	PF00069	0.462
MOD_CK2_1	361	367	PF00069	0.506
MOD_CK2_1	546	552	PF00069	0.462
MOD_CK2_1	559	565	PF00069	0.611
MOD_CK2_1	590	596	PF00069	0.553
MOD_CK2_1	600	606	PF00069	0.735
MOD_GlcNHglycan	1	4	PF01048	0.724
MOD_GlcNHglycan	165	168	PF01048	0.626
MOD_GlcNHglycan	256	259	PF01048	0.735
MOD_GlcNHglycan	294	297	PF01048	0.535
MOD_GlcNHglycan	344	347	PF01048	0.475
MOD_GlcNHglycan	362	366	PF01048	0.513
MOD_GlcNHglycan	602	605	PF01048	0.631
MOD_GSK3_1	144	151	PF00069	0.429
MOD_GSK3_1	172	179	PF00069	0.611
MOD_GSK3_1	22	29	PF00069	0.589
MOD_GSK3_1	222	229	PF00069	0.448
MOD_GSK3_1	235	242	PF00069	0.542
MOD_GSK3_1	250	257	PF00069	0.544
MOD_GSK3_1	260	267	PF00069	0.482
MOD_GSK3_1	288	295	PF00069	0.484
MOD_GSK3_1	342	349	PF00069	0.582
MOD_GSK3_1	516	523	PF00069	0.505
MOD_GSK3_1	53	60	PF00069	0.725
MOD_GSK3_1	585	592	PF00069	0.668
MOD_GSK3_1	600	607	PF00069	0.762
MOD_GSK3_1	65	72	PF00069	0.600
MOD_GSK3_1	80	87	PF00069	0.470
MOD_GSK3_1	95	102	PF00069	0.637
MOD_LATS_1	174	180	PF00433	0.631
MOD_NEK2_1	12	17	PF00069	0.560
MOD_NEK2_1	144	149	PF00069	0.447
MOD_NEK2_1	214	219	PF00069	0.526
MOD_NEK2_1	240	245	PF00069	0.457
MOD_NEK2_1	254	259	PF00069	0.467
MOD_NEK2_1	288	293	PF00069	0.526
MOD_NEK2_1	410	415	PF00069	0.457
MOD_NEK2_1	534	539	PF00069	0.448
MOD_NEK2_1	585	590	PF00069	0.740
MOD_NEK2_1	88	93	PF00069	0.561
MOD_PIKK_1	148	154	PF00454	0.357
MOD_PIKK_1	229	235	PF00454	0.422
MOD_PIKK_1	261	267	PF00454	0.496
MOD_PIKK_1	389	395	PF00454	0.452
MOD_PIKK_1	462	468	PF00454	0.502
MOD_PIKK_1	594	600	PF00454	0.501
MOD_PKA_2	175	181	PF00069	0.512
MOD_PKA_2	240	246	PF00069	0.352
MOD_PKA_2	289	295	PF00069	0.445
MOD_PKA_2	336	342	PF00069	0.595
MOD_PKA_2	413	419	PF00069	0.503
MOD_PKA_2	544	550	PF00069	0.458
MOD_PKA_2	553	559	PF00069	0.492
MOD_Plk_1	226	232	PF00069	0.452
MOD_Plk_1	516	522	PF00069	0.593
MOD_Plk_2-3	336	342	PF00069	0.486
MOD_Plk_4	214	220	PF00069	0.545
MOD_Plk_4	314	320	PF00069	0.434
MOD_Plk_4	485	491	PF00069	0.529
MOD_Plk_4	495	501	PF00069	0.463
MOD_Plk_4	585	591	PF00069	0.581
MOD_ProDKin_1	102	108	PF00069	0.712
MOD_ProDKin_1	264	270	PF00069	0.527
MOD_ProDKin_1	27	33	PF00069	0.643
MOD_ProDKin_1	57	63	PF00069	0.696
MOD_ProDKin_1	579	585	PF00069	0.675
MOD_SUMO_rev_2	125	134	PF00179	0.382
MOD_SUMO_rev_2	562	571	PF00179	0.412
TRG_DiLeu_BaEn_1	138	143	PF01217	0.485
TRG_DiLeu_BaEn_1	427	432	PF01217	0.445
TRG_DiLeu_BaEn_1	511	516	PF01217	0.589
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.542
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.358
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.441
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.345
TRG_ENDOCYTIC_2	123	126	PF00928	0.512
TRG_ENDOCYTIC_2	165	168	PF00928	0.632
TRG_ER_diArg_1	394	396	PF00400	0.400
TRG_ER_diArg_1	420	423	PF00400	0.499
TRG_ER_diArg_1	434	436	PF00400	0.367
TRG_ER_diArg_1	438	440	PF00400	0.366
TRG_NES_CRM1_1	206	222	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	548	552	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N7	Leptomonas seymouri	49%	98%
A0A1X0P1Y3	Trypanosomatidae	26%	100%
A0A3Q8IJM8	Leishmania donovani	78%	100%
A4IDR3	Leishmania infantum	78%	100%
D0A4F5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ATR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q0S8	Leishmania major	78%	100%