Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HPZ9_LEIBR

TriTrypDb:

LbrM.35.5070 , LBRM2903_350061600

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HPZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.503
CLV_NRD_NRD_1	453	455	PF00675	0.552
CLV_PCSK_KEX2_1	120	122	PF00082	0.596
CLV_PCSK_KEX2_1	133	135	PF00082	0.517
CLV_PCSK_KEX2_1	453	455	PF00082	0.534
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.596
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.517
CLV_PCSK_SKI1_1	152	156	PF00082	0.502
CLV_PCSK_SKI1_1	177	181	PF00082	0.315
CLV_PCSK_SKI1_1	264	268	PF00082	0.317
CLV_PCSK_SKI1_1	430	434	PF00082	0.385
CLV_PCSK_SKI1_1	492	496	PF00082	0.221
CLV_PCSK_SKI1_1	500	504	PF00082	0.211
CLV_Separin_Metazoa	261	265	PF03568	0.391
DEG_Nend_UBRbox_1	1	4	PF02207	0.485
DEG_SIAH_1	402	410	PF03145	0.459
DOC_CYCLIN_RxL_1	352	363	PF00134	0.479
DOC_MAPK_gen_1	150	157	PF00069	0.603
DOC_MAPK_gen_1	175	183	PF00069	0.391
DOC_MAPK_gen_1	352	362	PF00069	0.344
DOC_PP1_RVXF_1	356	363	PF00149	0.460
DOC_PP2B_LxvP_1	26	29	PF13499	0.576
DOC_USP7_MATH_1	124	128	PF00917	0.663
DOC_USP7_MATH_1	230	234	PF00917	0.515
DOC_USP7_MATH_1	278	282	PF00917	0.460
DOC_USP7_MATH_1	368	372	PF00917	0.444
DOC_USP7_MATH_1	403	407	PF00917	0.628
DOC_USP7_MATH_1	434	438	PF00917	0.334
DOC_USP7_MATH_1	91	95	PF00917	0.688
DOC_WW_Pin1_4	120	125	PF00397	0.588
DOC_WW_Pin1_4	142	147	PF00397	0.384
DOC_WW_Pin1_4	168	173	PF00397	0.505
DOC_WW_Pin1_4	237	242	PF00397	0.411
DOC_WW_Pin1_4	342	347	PF00397	0.268
DOC_WW_Pin1_4	425	430	PF00397	0.328
LIG_14-3-3_CanoR_1	232	237	PF00244	0.435
LIG_14-3-3_CanoR_1	402	408	PF00244	0.547
LIG_14-3-3_CanoR_1	421	429	PF00244	0.324
LIG_14-3-3_CanoR_1	44	52	PF00244	0.686
LIG_BIR_III_2	34	38	PF00653	0.478
LIG_BRCT_BRCA1_1	331	335	PF00533	0.515
LIG_BRCT_BRCA1_1	383	387	PF00533	0.500
LIG_FHA_1	215	221	PF00498	0.340
LIG_FHA_1	291	297	PF00498	0.454
LIG_FHA_1	310	316	PF00498	0.443
LIG_FHA_1	391	397	PF00498	0.541
LIG_FHA_1	466	472	PF00498	0.413
LIG_FHA_1	483	489	PF00498	0.424
LIG_FHA_1	73	79	PF00498	0.712
LIG_FHA_2	2	8	PF00498	0.658
LIG_LIR_Apic_2	446	450	PF02991	0.432
LIG_LIR_Gen_1	203	212	PF02991	0.515
LIG_LIR_Gen_1	332	342	PF02991	0.536
LIG_LIR_LC3C_4	153	157	PF02991	0.602
LIG_LIR_LC3C_4	317	320	PF02991	0.478
LIG_LIR_Nem_3	203	209	PF02991	0.515
LIG_LIR_Nem_3	332	338	PF02991	0.536
LIG_MYND_1	29	33	PF01753	0.457
LIG_NRBOX	5	11	PF00104	0.375
LIG_PCNA_yPIPBox_3	2	10	PF02747	0.393
LIG_PCNA_yPIPBox_3	253	267	PF02747	0.515
LIG_Pex14_1	63	67	PF04695	0.646
LIG_Pex14_2	335	339	PF04695	0.515
LIG_REV1ctd_RIR_1	264	274	PF16727	0.515
LIG_SH2_CRK	170	174	PF00017	0.500
LIG_SH2_NCK_1	170	174	PF00017	0.552
LIG_SH2_STAP1	418	422	PF00017	0.442
LIG_SH2_STAT5	337	340	PF00017	0.449
LIG_SH3_2	33	38	PF14604	0.616
LIG_SH3_3	27	33	PF00018	0.582
LIG_SH3_CIN85_PxpxPR_1	33	38	PF14604	0.474
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.411
LIG_SUMO_SIM_par_1	105	111	PF11976	0.598
LIG_SUMO_SIM_par_1	139	145	PF11976	0.426
LIG_SUMO_SIM_par_1	431	437	PF11976	0.312
LIG_TRAF2_1	161	164	PF00917	0.606
LIG_TRAF2_1	5	8	PF00917	0.495
LIG_WW_3	35	39	PF00397	0.551
MOD_CDK_SPK_2	425	430	PF00069	0.347
MOD_CDK_SPxxK_3	168	175	PF00069	0.489
MOD_CDK_SPxxK_3	342	349	PF00069	0.268
MOD_CK1_1	111	117	PF00069	0.645
MOD_CK1_1	119	125	PF00069	0.502
MOD_CK1_1	237	243	PF00069	0.415
MOD_CK1_1	314	320	PF00069	0.412
MOD_CK1_1	329	335	PF00069	0.406
MOD_CK1_1	498	504	PF00069	0.422
MOD_CK1_1	81	87	PF00069	0.685
MOD_CK2_1	1	7	PF00069	0.554
MOD_GlcNHglycan	126	129	PF01048	0.703
MOD_GlcNHglycan	152	155	PF01048	0.609
MOD_GlcNHglycan	286	289	PF01048	0.178
MOD_GlcNHglycan	328	331	PF01048	0.211
MOD_GlcNHglycan	342	345	PF01048	0.334
MOD_GlcNHglycan	383	386	PF01048	0.459
MOD_GlcNHglycan	403	406	PF01048	0.659
MOD_GlcNHglycan	47	50	PF01048	0.561
MOD_GlcNHglycan	487	491	PF01048	0.211
MOD_GlcNHglycan	93	96	PF01048	0.627
MOD_GSK3_1	116	123	PF00069	0.641
MOD_GSK3_1	124	131	PF00069	0.625
MOD_GSK3_1	230	237	PF00069	0.472
MOD_GSK3_1	244	251	PF00069	0.386
MOD_GSK3_1	286	293	PF00069	0.484
MOD_GSK3_1	36	43	PF00069	0.680
MOD_GSK3_1	386	393	PF00069	0.461
MOD_GSK3_1	416	423	PF00069	0.450
MOD_GSK3_1	463	470	PF00069	0.362
MOD_GSK3_1	482	489	PF00069	0.418
MOD_GSK3_1	67	74	PF00069	0.703
MOD_GSK3_1	78	85	PF00069	0.774
MOD_GSK3_1	89	96	PF00069	0.657
MOD_N-GLC_1	111	116	PF02516	0.604
MOD_N-GLC_1	222	227	PF02516	0.222
MOD_N-GLC_1	389	394	PF02516	0.399
MOD_N-GLC_1	44	49	PF02516	0.570
MOD_N-GLC_2	115	117	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.583
MOD_NEK2_1	155	160	PF00069	0.546
MOD_NEK2_1	222	227	PF00069	0.414
MOD_NEK2_1	360	365	PF00069	0.393
MOD_PIKK_1	434	440	PF00454	0.324
MOD_PIKK_1	89	95	PF00454	0.726
MOD_PKA_2	348	354	PF00069	0.360
MOD_PKA_2	401	407	PF00069	0.489
MOD_PKA_2	420	426	PF00069	0.330
MOD_PKA_2	98	104	PF00069	0.457
MOD_PKB_1	42	50	PF00069	0.445
MOD_Plk_1	248	254	PF00069	0.422
MOD_Plk_1	290	296	PF00069	0.422
MOD_Plk_1	416	422	PF00069	0.597
MOD_Plk_1	498	504	PF00069	0.438
MOD_Plk_1	82	88	PF00069	0.472
MOD_Plk_4	105	111	PF00069	0.670
MOD_Plk_4	304	310	PF00069	0.474
MOD_Plk_4	311	317	PF00069	0.417
MOD_ProDKin_1	120	126	PF00069	0.588
MOD_ProDKin_1	142	148	PF00069	0.381
MOD_ProDKin_1	168	174	PF00069	0.495
MOD_ProDKin_1	237	243	PF00069	0.411
MOD_ProDKin_1	342	348	PF00069	0.269
MOD_ProDKin_1	425	431	PF00069	0.331
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.435
TRG_ER_diArg_1	299	302	PF00400	0.365
TRG_ER_diArg_1	452	454	PF00400	0.531
TRG_ER_diArg_1	55	58	PF00400	0.565
TRG_NES_CRM1_1	18	32	PF08389	0.584
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N2	Leptomonas seymouri	69%	99%
A0A0N1I6C2	Leptomonas seymouri	22%	100%
A0A0N1IHN2	Leptomonas seymouri	24%	98%
A0A0S4IWG1	Bodo saltans	43%	100%
A0A0S4JE21	Bodo saltans	28%	100%
A0A0S4JL38	Bodo saltans	24%	95%
A0A0S4KJ87	Bodo saltans	26%	85%
A0A1X0NQ96	Trypanosomatidae	24%	100%
A0A1X0NVZ7	Trypanosomatidae	24%	98%
A0A1X0P0F0	Trypanosomatidae	52%	100%
A0A3Q8IGC4	Leishmania donovani	23%	98%
A0A3R7KUH0	Trypanosoma rangeli	26%	100%
A0A3R7MCP0	Trypanosoma rangeli	52%	100%
A0A3R7N6M9	Trypanosoma rangeli	22%	98%
A0A3S5H5M7	Leishmania donovani	25%	75%
A0A3S7WR72	Leishmania donovani	23%	100%
A0A3S7XBP3	Leishmania donovani	86%	100%
A4H4H1	Leishmania braziliensis	26%	77%
A4H666	Leishmania braziliensis	23%	100%
A4HDT7	Leishmania braziliensis	24%	98%
A4HSP6	Leishmania infantum	25%	75%
A4HUJ0	Leishmania infantum	23%	100%
A4I135	Leishmania infantum	23%	98%
A4IBS6	Leishmania infantum	23%	100%
A4IDR0	Leishmania infantum	86%	100%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
D0A4F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D3Z902	Rattus norvegicus	26%	71%
E9AFL2	Leishmania major	24%	100%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O60907	Homo sapiens	21%	88%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P0CS48	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	100%
P0CS49	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
Q12417	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
Q4Q0T1	Leishmania major	85%	100%
Q4QAA4	Leishmania major	23%	100%
Q4QHD6	Leishmania major	23%	100%
Q4R8H1	Macaca fascicularis	21%	89%
Q4WT34	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	100%
Q5A7Q3	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	100%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q6BU94	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	100%
Q6CKE8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q75BY3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q86TI4	Homo sapiens	25%	100%
Q8K450	Mus musculus	23%	80%
Q8VBV4	Mus musculus	26%	72%
Q969H0	Homo sapiens	26%	72%
Q9BQ87	Homo sapiens	21%	98%
Q9QXE7	Mus musculus	21%	97%
V5B4Z8	Trypanosoma cruzi	53%	100%
V5BEB2	Trypanosoma cruzi	22%	94%
V5BP59	Trypanosoma cruzi	25%	100%