PABS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPZ7_LEIBR

TriTrypDb:

LbrM.35.5050 , LBRM2903_350061400

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.569
CLV_C14_Caspase3-7	258	262	PF00656	0.592
CLV_C14_Caspase3-7	274	278	PF00656	0.519
CLV_NRD_NRD_1	101	103	PF00675	0.592
CLV_NRD_NRD_1	211	213	PF00675	0.411
CLV_NRD_NRD_1	23	25	PF00675	0.649
CLV_PCSK_KEX2_1	21	23	PF00082	0.633
CLV_PCSK_KEX2_1	286	288	PF00082	0.510
CLV_PCSK_KEX2_1	63	65	PF00082	0.413
CLV_PCSK_KEX2_1	7	9	PF00082	0.638
CLV_PCSK_KEX2_1	78	80	PF00082	0.395
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.621
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.510
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.480
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.554
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.395
CLV_PCSK_SKI1_1	323	327	PF00082	0.419
CLV_PCSK_SKI1_1	403	407	PF00082	0.479
CLV_PCSK_SKI1_1	52	56	PF00082	0.417
CLV_PCSK_SKI1_1	75	79	PF00082	0.418
DOC_MAPK_DCC_7	86	96	PF00069	0.361
DOC_MAPK_gen_1	7	17	PF00069	0.586
DOC_MAPK_JIP1_4	407	413	PF00069	0.428
DOC_MAPK_MEF2A_6	46	53	PF00069	0.448
DOC_MAPK_NFAT4_5	46	54	PF00069	0.455
DOC_PP4_MxPP_1	134	137	PF00568	0.523
DOC_USP7_MATH_1	113	117	PF00917	0.604
DOC_USP7_MATH_1	262	266	PF00917	0.570
DOC_USP7_UBL2_3	129	133	PF12436	0.530
DOC_USP7_UBL2_3	282	286	PF12436	0.543
DOC_WW_Pin1_4	451	456	PF00397	0.302
LIG_14-3-3_CanoR_1	212	219	PF00244	0.427
LIG_14-3-3_CanoR_1	22	30	PF00244	0.479
LIG_14-3-3_CanoR_1	287	294	PF00244	0.459
LIG_14-3-3_CanoR_1	443	451	PF00244	0.468
LIG_14-3-3_CanoR_1	64	72	PF00244	0.350
LIG_14-3-3_CanoR_1	8	17	PF00244	0.586
LIG_14-3-3_CanoR_1	86	90	PF00244	0.412
LIG_14-3-3_CterR_2	507	511	PF00244	0.375
LIG_Actin_WH2_2	191	206	PF00022	0.326
LIG_Actin_WH2_2	76	94	PF00022	0.366
LIG_BIR_III_4	261	265	PF00653	0.555
LIG_BRCT_BRCA1_1	174	178	PF00533	0.291
LIG_BRCT_BRCA1_1	193	197	PF00533	0.201
LIG_FHA_1	214	220	PF00498	0.392
LIG_FHA_1	304	310	PF00498	0.459
LIG_FHA_1	53	59	PF00498	0.530
LIG_FHA_1	64	70	PF00498	0.293
LIG_FHA_1	86	92	PF00498	0.453
LIG_FHA_2	137	143	PF00498	0.620
LIG_FHA_2	163	169	PF00498	0.476
LIG_FHA_2	256	262	PF00498	0.601
LIG_FHA_2	272	278	PF00498	0.508
LIG_FHA_2	348	354	PF00498	0.416
LIG_FHA_2	452	458	PF00498	0.401
LIG_FHA_2	468	474	PF00498	0.429
LIG_FHA_2	9	15	PF00498	0.606
LIG_FHA_2	96	102	PF00498	0.643
LIG_LIR_Gen_1	194	203	PF02991	0.329
LIG_LIR_Gen_1	378	388	PF02991	0.343
LIG_LIR_Nem_3	194	200	PF02991	0.331
LIG_LIR_Nem_3	378	384	PF02991	0.328
LIG_LIR_Nem_3	473	479	PF02991	0.416
LIG_Pex14_1	486	490	PF04695	0.337
LIG_Pex14_2	44	48	PF04695	0.432
LIG_SH2_CRK	200	204	PF00017	0.408
LIG_SH2_CRK	377	381	PF00017	0.327
LIG_SH2_CRK	428	432	PF00017	0.445
LIG_SH2_NCK_1	428	432	PF00017	0.445
LIG_SH2_STAP1	377	381	PF00017	0.327
LIG_SH2_STAP1	428	432	PF00017	0.445
LIG_SH2_STAP1	463	467	PF00017	0.370
LIG_SH2_STAP1	479	483	PF00017	0.350
LIG_SH2_STAT5	148	151	PF00017	0.354
LIG_SH2_STAT5	200	203	PF00017	0.404
LIG_SH2_STAT5	361	364	PF00017	0.315
LIG_SH3_3	325	331	PF00018	0.316
LIG_SUMO_SIM_par_1	329	336	PF11976	0.368
LIG_TRAF2_1	98	101	PF00917	0.598
LIG_TYR_ITIM	198	203	PF00017	0.404
LIG_WRC_WIRS_1	192	197	PF05994	0.331
LIG_WW_3	1	5	PF00397	0.558
LIG_WW_3	107	111	PF00397	0.668
MOD_CK1_1	167	173	PF00069	0.423
MOD_CK1_1	191	197	PF00069	0.466
MOD_CK1_1	233	239	PF00069	0.732
MOD_CK1_1	247	253	PF00069	0.612
MOD_CK1_1	265	271	PF00069	0.591
MOD_CK2_1	8	14	PF00069	0.522
MOD_CK2_1	95	101	PF00069	0.635
MOD_Cter_Amidation	284	287	PF01082	0.483
MOD_GlcNHglycan	111	114	PF01048	0.522
MOD_GlcNHglycan	115	118	PF01048	0.497
MOD_GlcNHglycan	126	129	PF01048	0.572
MOD_GlcNHglycan	142	145	PF01048	0.413
MOD_GlcNHglycan	246	249	PF01048	0.722
MOD_GlcNHglycan	294	297	PF01048	0.345
MOD_GlcNHglycan	420	423	PF01048	0.403
MOD_GSK3_1	109	116	PF00069	0.489
MOD_GSK3_1	136	143	PF00069	0.530
MOD_GSK3_1	231	238	PF00069	0.701
MOD_GSK3_1	240	247	PF00069	0.646
MOD_GSK3_1	265	272	PF00069	0.758
MOD_GSK3_1	285	292	PF00069	0.473
MOD_GSK3_1	457	464	PF00069	0.386
MOD_LATS_1	284	290	PF00433	0.445
MOD_N-GLC_1	103	108	PF02516	0.478
MOD_N-GLC_1	230	235	PF02516	0.649
MOD_NEK2_1	17	22	PF00069	0.607
MOD_NEK2_1	237	242	PF00069	0.581
MOD_NEK2_1	38	43	PF00069	0.366
MOD_PIKK_1	2	8	PF00454	0.549
MOD_PIKK_1	269	275	PF00454	0.696
MOD_PIKK_1	63	69	PF00454	0.414
MOD_PKA_1	162	168	PF00069	0.455
MOD_PKA_1	212	218	PF00069	0.365
MOD_PKA_1	23	29	PF00069	0.555
MOD_PKA_1	286	292	PF00069	0.466
MOD_PKA_1	63	69	PF00069	0.314
MOD_PKA_2	109	115	PF00069	0.658
MOD_PKA_2	23	29	PF00069	0.522
MOD_PKA_2	286	292	PF00069	0.485
MOD_PKA_2	63	69	PF00069	0.368
MOD_PKA_2	85	91	PF00069	0.406
MOD_PKB_1	8	16	PF00069	0.589
MOD_Plk_1	167	173	PF00069	0.423
MOD_Plk_1	38	44	PF00069	0.369
MOD_Plk_1	472	478	PF00069	0.258
MOD_Plk_2-3	461	467	PF00069	0.354
MOD_Plk_4	172	178	PF00069	0.383
MOD_Plk_4	188	194	PF00069	0.347
MOD_Plk_4	445	451	PF00069	0.371
MOD_Plk_4	478	484	PF00069	0.432
MOD_ProDKin_1	451	457	PF00069	0.304
MOD_SUMO_rev_2	13	17	PF00179	0.632
MOD_SUMO_rev_2	353	358	PF00179	0.506
TRG_ENDOCYTIC_2	200	203	PF00928	0.404
TRG_ENDOCYTIC_2	377	380	PF00928	0.328
TRG_ENDOCYTIC_2	381	384	PF00928	0.340
TRG_ENDOCYTIC_2	428	431	PF00928	0.376
TRG_ENDOCYTIC_2	479	482	PF00928	0.350
TRG_ER_diArg_1	105	108	PF00400	0.490
TRG_ER_diArg_1	22	24	PF00400	0.640
TRG_ER_diArg_1	504	507	PF00400	0.429
TRG_NLS_Bipartite_1	7	25	PF00514	0.554
TRG_NLS_MonoCore_2	20	25	PF00514	0.571
TRG_NLS_MonoExtN_4	4	11	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ0	Leptomonas seymouri	54%	100%
A0A3S7XBN4	Leishmania donovani	77%	100%
A4IDQ8	Leishmania infantum	77%	100%
E9ATR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q0T3	Leishmania major	77%	100%