Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPZ6_LEIBR

TriTrypDb:

LbrM.35.5040 , LBRM2903_350061300

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.514
CLV_C14_Caspase3-7	480	484	PF00656	0.530
CLV_C14_Caspase3-7	902	906	PF00656	0.665
CLV_NRD_NRD_1	141	143	PF00675	0.602
CLV_NRD_NRD_1	149	151	PF00675	0.570
CLV_NRD_NRD_1	199	201	PF00675	0.497
CLV_NRD_NRD_1	235	237	PF00675	0.619
CLV_NRD_NRD_1	320	322	PF00675	0.603
CLV_NRD_NRD_1	335	337	PF00675	0.488
CLV_NRD_NRD_1	394	396	PF00675	0.569
CLV_NRD_NRD_1	442	444	PF00675	0.621
CLV_NRD_NRD_1	452	454	PF00675	0.611
CLV_NRD_NRD_1	531	533	PF00675	0.746
CLV_NRD_NRD_1	547	549	PF00675	0.565
CLV_NRD_NRD_1	584	586	PF00675	0.649
CLV_NRD_NRD_1	618	620	PF00675	0.582
CLV_NRD_NRD_1	672	674	PF00675	0.535
CLV_NRD_NRD_1	688	690	PF00675	0.641
CLV_NRD_NRD_1	714	716	PF00675	0.705
CLV_NRD_NRD_1	761	763	PF00675	0.719
CLV_NRD_NRD_1	780	782	PF00675	0.456
CLV_NRD_NRD_1	891	893	PF00675	0.726
CLV_PCSK_KEX2_1	140	142	PF00082	0.580
CLV_PCSK_KEX2_1	149	151	PF00082	0.513
CLV_PCSK_KEX2_1	234	236	PF00082	0.561
CLV_PCSK_KEX2_1	320	322	PF00082	0.601
CLV_PCSK_KEX2_1	394	396	PF00082	0.537
CLV_PCSK_KEX2_1	403	405	PF00082	0.530
CLV_PCSK_KEX2_1	451	453	PF00082	0.572
CLV_PCSK_KEX2_1	488	490	PF00082	0.608
CLV_PCSK_KEX2_1	618	620	PF00082	0.680
CLV_PCSK_KEX2_1	688	690	PF00082	0.701
CLV_PCSK_KEX2_1	714	716	PF00082	0.705
CLV_PCSK_KEX2_1	761	763	PF00082	0.693
CLV_PCSK_KEX2_1	830	832	PF00082	0.681
CLV_PCSK_KEX2_1	889	891	PF00082	0.739
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.630
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.597
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.504
CLV_PCSK_PC1ET2_1	889	891	PF00082	0.749
CLV_PCSK_SKI1_1	105	109	PF00082	0.520
CLV_PCSK_SKI1_1	124	128	PF00082	0.646
CLV_PCSK_SKI1_1	157	161	PF00082	0.613
CLV_PCSK_SKI1_1	25	29	PF00082	0.711
CLV_PCSK_SKI1_1	395	399	PF00082	0.561
CLV_PCSK_SKI1_1	473	477	PF00082	0.667
CLV_PCSK_SKI1_1	488	492	PF00082	0.576
CLV_PCSK_SKI1_1	496	500	PF00082	0.726
CLV_PCSK_SKI1_1	50	54	PF00082	0.479
CLV_PCSK_SKI1_1	537	541	PF00082	0.541
CLV_PCSK_SKI1_1	666	670	PF00082	0.524
CLV_Separin_Metazoa	679	683	PF03568	0.692
DEG_APCC_DBOX_1	665	673	PF00400	0.396
DEG_APCC_DBOX_1	830	838	PF00400	0.742
DEG_Kelch_Keap1_1	343	348	PF01344	0.555
DEG_SPOP_SBC_1	114	118	PF00917	0.522
DEG_SPOP_SBC_1	81	85	PF00917	0.636
DOC_MAPK_gen_1	585	592	PF00069	0.497
DOC_MAPK_gen_1	781	788	PF00069	0.513
DOC_MAPK_gen_1	878	886	PF00069	0.769
DOC_MAPK_gen_1	889	899	PF00069	0.728
DOC_PP1_RVXF_1	893	900	PF00149	0.732
DOC_PP4_FxxP_1	773	776	PF00568	0.726
DOC_PP4_FxxP_1	788	791	PF00568	0.713
DOC_USP7_MATH_1	109	113	PF00917	0.776
DOC_USP7_MATH_1	212	216	PF00917	0.624
DOC_USP7_MATH_1	250	254	PF00917	0.555
DOC_USP7_MATH_1	455	459	PF00917	0.675
DOC_USP7_MATH_1	554	558	PF00917	0.701
DOC_USP7_MATH_1	81	85	PF00917	0.636
DOC_USP7_MATH_1	852	856	PF00917	0.748
DOC_USP7_MATH_1	872	876	PF00917	0.452
DOC_USP7_MATH_1	904	908	PF00917	0.725
DOC_USP7_UBL2_3	377	381	PF12436	0.452
DOC_USP7_UBL2_3	428	432	PF12436	0.654
DOC_USP7_UBL2_3	533	537	PF12436	0.756
DOC_WW_Pin1_4	116	121	PF00397	0.699
DOC_WW_Pin1_4	304	309	PF00397	0.485
DOC_WW_Pin1_4	34	39	PF00397	0.551
DOC_WW_Pin1_4	466	471	PF00397	0.658
DOC_WW_Pin1_4	511	516	PF00397	0.584
DOC_WW_Pin1_4	695	700	PF00397	0.690
DOC_WW_Pin1_4	718	723	PF00397	0.636
DOC_WW_Pin1_4	781	786	PF00397	0.512
DOC_WW_Pin1_4	787	792	PF00397	0.477
DOC_WW_Pin1_4	836	841	PF00397	0.747
DOC_WW_Pin1_4	870	875	PF00397	0.638
LIG_14-3-3_CanoR_1	284	291	PF00244	0.607
LIG_14-3-3_CanoR_1	320	328	PF00244	0.638
LIG_14-3-3_CanoR_1	489	498	PF00244	0.573
LIG_14-3-3_CanoR_1	500	510	PF00244	0.585
LIG_14-3-3_CanoR_1	532	539	PF00244	0.740
LIG_14-3-3_CanoR_1	589	593	PF00244	0.708
LIG_14-3-3_CanoR_1	635	644	PF00244	0.667
LIG_14-3-3_CanoR_1	74	78	PF00244	0.672
LIG_14-3-3_CanoR_1	762	772	PF00244	0.530
LIG_14-3-3_CanoR_1	892	898	PF00244	0.719
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.643
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	726	730	PF00533	0.533
LIG_BRCT_BRCA1_1	75	79	PF00533	0.708
LIG_BRCT_BRCA1_1	895	899	PF00533	0.737
LIG_EH_1	704	708	PF12763	0.606
LIG_eIF4E_1	829	835	PF01652	0.742
LIG_FHA_1	121	127	PF00498	0.599
LIG_FHA_1	165	171	PF00498	0.687
LIG_FHA_1	286	292	PF00498	0.540
LIG_FHA_1	429	435	PF00498	0.611
LIG_FHA_1	470	476	PF00498	0.555
LIG_FHA_1	485	491	PF00498	0.594
LIG_FHA_1	497	503	PF00498	0.684
LIG_FHA_1	538	544	PF00498	0.786
LIG_FHA_1	681	687	PF00498	0.690
LIG_FHA_1	699	705	PF00498	0.646
LIG_FHA_1	7	13	PF00498	0.806
LIG_FHA_1	802	808	PF00498	0.758
LIG_FHA_1	83	89	PF00498	0.656
LIG_FHA_2	634	640	PF00498	0.597
LIG_FHA_2	745	751	PF00498	0.649
LIG_FHA_2	9	15	PF00498	0.686
LIG_FHA_2	91	97	PF00498	0.755
LIG_LIR_Apic_2	804	809	PF02991	0.509
LIG_LIR_Apic_2	828	832	PF02991	0.492
LIG_LIR_Apic_2	918	922	PF02991	0.755
LIG_LIR_Gen_1	833	843	PF02991	0.705
LIG_LIR_Nem_3	833	838	PF02991	0.702
LIG_MYND_1	466	470	PF01753	0.560
LIG_NRBOX	295	301	PF00104	0.645
LIG_PCNA_yPIPBox_3	33	43	PF02747	0.444
LIG_Pex14_2	388	392	PF04695	0.524
LIG_REV1ctd_RIR_1	385	393	PF16727	0.409
LIG_SH2_CRK	829	833	PF00017	0.744
LIG_SH2_PTP2	806	809	PF00017	0.507
LIG_SH2_SRC	399	402	PF00017	0.638
LIG_SH2_SRC	806	809	PF00017	0.507
LIG_SH2_SRC	919	922	PF00017	0.501
LIG_SH2_STAP1	171	175	PF00017	0.694
LIG_SH2_STAP1	326	330	PF00017	0.631
LIG_SH2_STAT3	601	604	PF00017	0.535
LIG_SH2_STAT5	10	13	PF00017	0.689
LIG_SH2_STAT5	778	781	PF00017	0.629
LIG_SH2_STAT5	806	809	PF00017	0.750
LIG_SH3_3	103	109	PF00018	0.636
LIG_SH3_3	363	369	PF00018	0.719
LIG_SH3_3	460	466	PF00018	0.600
LIG_SH3_3	700	706	PF00018	0.547
LIG_SH3_3	72	78	PF00018	0.617
LIG_SH3_3	768	774	PF00018	0.716
LIG_TRAF2_1	623	626	PF00917	0.545
LIG_TRAF2_1	756	759	PF00917	0.617
LIG_TRAF2_1	795	798	PF00917	0.504
LIG_TYR_ITIM	188	193	PF00017	0.387
MOD_CDK_SPxxK_3	34	41	PF00069	0.616
MOD_CDK_SPxxK_3	466	473	PF00069	0.696
MOD_CK1_1	116	122	PF00069	0.747
MOD_CK1_1	2	8	PF00069	0.689
MOD_CK1_1	274	280	PF00069	0.631
MOD_CK1_1	312	318	PF00069	0.705
MOD_CK1_1	421	427	PF00069	0.652
MOD_CK1_1	469	475	PF00069	0.651
MOD_CK1_1	513	519	PF00069	0.631
MOD_CK1_1	698	704	PF00069	0.713
MOD_CK1_1	726	732	PF00069	0.639
MOD_CK1_1	810	816	PF00069	0.738
MOD_CK1_1	833	839	PF00069	0.700
MOD_CK1_1	84	90	PF00069	0.730
MOD_CK1_1	885	891	PF00069	0.784
MOD_CK1_1	915	921	PF00069	0.698
MOD_CK2_1	342	348	PF00069	0.517
MOD_CK2_1	455	461	PF00069	0.665
MOD_CK2_1	535	541	PF00069	0.543
MOD_CK2_1	567	573	PF00069	0.732
MOD_CK2_1	744	750	PF00069	0.660
MOD_CK2_1	8	14	PF00069	0.757
MOD_CK2_1	895	901	PF00069	0.778
MOD_GlcNHglycan	111	114	PF01048	0.785
MOD_GlcNHglycan	273	276	PF01048	0.634
MOD_GlcNHglycan	314	317	PF01048	0.749
MOD_GlcNHglycan	420	423	PF01048	0.723
MOD_GlcNHglycan	440	443	PF01048	0.392
MOD_GlcNHglycan	457	460	PF01048	0.663
MOD_GlcNHglycan	503	506	PF01048	0.704
MOD_GlcNHglycan	545	548	PF01048	0.617
MOD_GlcNHglycan	556	560	PF01048	0.573
MOD_GlcNHglycan	569	572	PF01048	0.696
MOD_GlcNHglycan	645	648	PF01048	0.746
MOD_GlcNHglycan	765	768	PF01048	0.584
MOD_GlcNHglycan	843	846	PF01048	0.723
MOD_GlcNHglycan	868	871	PF01048	0.807
MOD_GlcNHglycan	874	877	PF01048	0.642
MOD_GlcNHglycan	914	917	PF01048	0.758
MOD_GlcNHglycan	928	931	PF01048	0.685
MOD_GSK3_1	109	116	PF00069	0.719
MOD_GSK3_1	2	9	PF00069	0.792
MOD_GSK3_1	212	219	PF00069	0.630
MOD_GSK3_1	300	307	PF00069	0.689
MOD_GSK3_1	312	319	PF00069	0.687
MOD_GSK3_1	368	375	PF00069	0.603
MOD_GSK3_1	484	491	PF00069	0.648
MOD_GSK3_1	513	520	PF00069	0.655
MOD_GSK3_1	522	529	PF00069	0.744
MOD_GSK3_1	531	538	PF00069	0.767
MOD_GSK3_1	548	555	PF00069	0.799
MOD_GSK3_1	563	570	PF00069	0.657
MOD_GSK3_1	643	650	PF00069	0.553
MOD_GSK3_1	691	698	PF00069	0.667
MOD_GSK3_1	726	733	PF00069	0.688
MOD_GSK3_1	80	87	PF00069	0.680
MOD_GSK3_1	807	814	PF00069	0.758
MOD_GSK3_1	866	873	PF00069	0.764
MOD_GSK3_1	900	907	PF00069	0.528
MOD_N-GLC_1	164	169	PF02516	0.722
MOD_N-GLC_1	309	314	PF02516	0.650
MOD_N-GLC_1	316	321	PF02516	0.487
MOD_N-GLC_1	342	347	PF02516	0.670
MOD_N-GLC_1	522	527	PF02516	0.604
MOD_N-GLC_1	567	572	PF02516	0.554
MOD_N-GLC_1	893	898	PF02516	0.772
MOD_NEK2_1	207	212	PF00069	0.492
MOD_NEK2_1	309	314	PF00069	0.714
MOD_NEK2_1	409	414	PF00069	0.686
MOD_NEK2_1	438	443	PF00069	0.651
MOD_NEK2_1	680	685	PF00069	0.709
MOD_NEK2_1	73	78	PF00069	0.630
MOD_NEK2_1	730	735	PF00069	0.610
MOD_NEK2_1	877	882	PF00069	0.773
MOD_NEK2_1	884	889	PF00069	0.714
MOD_NEK2_1	893	898	PF00069	0.662
MOD_PIKK_1	213	219	PF00454	0.667
MOD_PIKK_1	225	231	PF00454	0.735
MOD_PIKK_1	294	300	PF00454	0.641
MOD_PIKK_1	411	417	PF00454	0.493
MOD_PIKK_1	44	50	PF00454	0.508
MOD_PIKK_1	489	495	PF00454	0.684
MOD_PIKK_1	513	519	PF00454	0.796
MOD_PIKK_1	526	532	PF00454	0.761
MOD_PIKK_1	730	736	PF00454	0.697
MOD_PIKK_1	765	771	PF00454	0.756
MOD_PKA_1	488	494	PF00069	0.676
MOD_PKA_1	548	554	PF00069	0.807
MOD_PKA_1	585	591	PF00069	0.618
MOD_PKA_1	830	836	PF00069	0.487
MOD_PKA_2	285	291	PF00069	0.563
MOD_PKA_2	319	325	PF00069	0.644
MOD_PKA_2	488	494	PF00069	0.676
MOD_PKA_2	531	537	PF00069	0.778
MOD_PKA_2	552	558	PF00069	0.760
MOD_PKA_2	588	594	PF00069	0.525
MOD_PKA_2	73	79	PF00069	0.682
MOD_PKA_2	830	836	PF00069	0.739
MOD_PKB_1	494	502	PF00069	0.639
MOD_PKB_1	524	532	PF00069	0.560
MOD_PKB_1	633	641	PF00069	0.637
MOD_Plk_1	207	213	PF00069	0.611
MOD_Plk_1	294	300	PF00069	0.656
MOD_Plk_1	347	353	PF00069	0.526
MOD_Plk_1	5	11	PF00069	0.774
MOD_Plk_1	628	634	PF00069	0.654
MOD_Plk_1	893	899	PF00069	0.762
MOD_Plk_2-3	535	541	PF00069	0.543
MOD_Plk_2-3	92	98	PF00069	0.534
MOD_Plk_4	216	222	PF00069	0.694
MOD_Plk_4	471	477	PF00069	0.445
MOD_Plk_4	699	705	PF00069	0.524
MOD_Plk_4	802	808	PF00069	0.505
MOD_Plk_4	830	836	PF00069	0.698
MOD_Plk_4	84	90	PF00069	0.529
MOD_Plk_4	895	901	PF00069	0.680
MOD_ProDKin_1	116	122	PF00069	0.713
MOD_ProDKin_1	304	310	PF00069	0.490
MOD_ProDKin_1	34	40	PF00069	0.540
MOD_ProDKin_1	466	472	PF00069	0.656
MOD_ProDKin_1	511	517	PF00069	0.585
MOD_ProDKin_1	695	701	PF00069	0.690
MOD_ProDKin_1	718	724	PF00069	0.639
MOD_ProDKin_1	781	787	PF00069	0.512
MOD_ProDKin_1	836	842	PF00069	0.747
MOD_ProDKin_1	870	876	PF00069	0.638
MOD_SUMO_for_1	402	405	PF00179	0.525
MOD_SUMO_rev_2	424	434	PF00179	0.468
MOD_SUMO_rev_2	529	539	PF00179	0.758
TRG_DiLeu_BaEn_1	295	300	PF01217	0.643
TRG_DiLeu_BaEn_1	405	410	PF01217	0.406
TRG_DiLeu_BaEn_1	676	681	PF01217	0.672
TRG_DiLeu_BaEn_4	405	411	PF01217	0.407
TRG_DiLeu_BaEn_4	797	803	PF01217	0.500
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.502
TRG_DiLeu_BaLyEn_6	714	719	PF01217	0.494
TRG_ENDOCYTIC_2	190	193	PF00928	0.637
TRG_ENDOCYTIC_2	399	402	PF00928	0.497
TRG_ENDOCYTIC_2	42	45	PF00928	0.634
TRG_ER_diArg_1	139	142	PF00400	0.628
TRG_ER_diArg_1	234	236	PF00400	0.578
TRG_ER_diArg_1	393	395	PF00400	0.574
TRG_ER_diArg_1	451	453	PF00400	0.649
TRG_ER_diArg_1	632	635	PF00400	0.592
TRG_ER_diArg_1	687	689	PF00400	0.623
TRG_ER_diArg_1	713	715	PF00400	0.693
TRG_ER_diArg_1	890	892	PF00400	0.758
TRG_NES_CRM1_1	173	185	PF08389	0.630
TRG_NLS_Bipartite_1	532	552	PF00514	0.549
TRG_NLS_MonoCore_2	888	893	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T1	Leptomonas seymouri	43%	97%
A0A3S7XBQ9	Leishmania donovani	69%	100%
A0A422P5F8	Trypanosoma rangeli	26%	100%
A4IDQ7	Leishmania infantum	69%	100%
D0A4F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q0T4	Leishmania major	68%	99%
V5BQ47	Trypanosoma cruzi	27%	100%