Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania braziliensis

UniProt:

A4HPZ5_LEIBR

TriTrypDb:

LbrM.35.5030 , LBRM2903_350061200

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HPZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.331
CLV_NRD_NRD_1	159	161	PF00675	0.363
CLV_NRD_NRD_1	264	266	PF00675	0.316
CLV_NRD_NRD_1	291	293	PF00675	0.432
CLV_PCSK_FUR_1	305	309	PF00082	0.305
CLV_PCSK_KEX2_1	159	161	PF00082	0.432
CLV_PCSK_KEX2_1	264	266	PF00082	0.318
CLV_PCSK_KEX2_1	307	309	PF00082	0.347
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.351
CLV_PCSK_SKI1_1	124	128	PF00082	0.285
CLV_PCSK_SKI1_1	182	186	PF00082	0.516
CLV_PCSK_SKI1_1	209	213	PF00082	0.488
CLV_PCSK_SKI1_1	241	245	PF00082	0.287
CLV_PCSK_SKI1_1	26	30	PF00082	0.281
CLV_PCSK_SKI1_1	264	268	PF00082	0.420
CLV_PCSK_SKI1_1	4	8	PF00082	0.434
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DOC_CKS1_1	39	44	PF01111	0.411
DOC_MAPK_DCC_7	209	218	PF00069	0.415
DOC_MAPK_gen_1	143	151	PF00069	0.316
DOC_MAPK_gen_1	179	188	PF00069	0.489
DOC_MAPK_gen_1	264	275	PF00069	0.308
DOC_MAPK_MEF2A_6	209	218	PF00069	0.343
DOC_PP4_FxxP_1	39	42	PF00568	0.295
DOC_USP7_MATH_1	134	138	PF00917	0.428
DOC_WW_Pin1_4	130	135	PF00397	0.336
DOC_WW_Pin1_4	173	178	PF00397	0.328
DOC_WW_Pin1_4	38	43	PF00397	0.411
LIG_14-3-3_CanoR_1	182	187	PF00244	0.455
LIG_14-3-3_CanoR_1	209	214	PF00244	0.412
LIG_14-3-3_CanoR_1	4	9	PF00244	0.460
LIG_Actin_WH2_2	103	120	PF00022	0.189
LIG_BIR_III_4	242	246	PF00653	0.423
LIG_BRCT_BRCA1_1	136	140	PF00533	0.360
LIG_EH1_1	91	99	PF00400	0.213
LIG_FHA_1	121	127	PF00498	0.332
LIG_FHA_1	183	189	PF00498	0.432
LIG_FHA_1	213	219	PF00498	0.487
LIG_FHA_1	246	252	PF00498	0.524
LIG_FHA_1	42	48	PF00498	0.446
LIG_FHA_1	93	99	PF00498	0.264
LIG_FHA_2	185	191	PF00498	0.338
LIG_FHA_2	256	262	PF00498	0.391
LIG_FHA_2	275	281	PF00498	0.300
LIG_Integrin_RGD_1	160	162	PF01839	0.411
LIG_LIR_Apic_2	36	42	PF02991	0.295
LIG_LIR_Nem_3	190	196	PF02991	0.432
LIG_PCNA_yPIPBox_3	230	241	PF02747	0.279
LIG_PDZ_Class_2	312	317	PF00595	0.481
LIG_SH2_STAP1	171	175	PF00017	0.473
LIG_SH2_STAP1	225	229	PF00017	0.412
LIG_SH2_STAP1	43	47	PF00017	0.295
LIG_SH2_STAT3	43	46	PF00017	0.322
LIG_SH2_STAT5	225	228	PF00017	0.575
LIG_SH2_STAT5	43	46	PF00017	0.300
LIG_SH3_3	189	195	PF00018	0.452
LIG_SH3_3	208	214	PF00018	0.532
LIG_SUMO_SIM_par_1	184	190	PF11976	0.463
LIG_SUMO_SIM_par_1	27	33	PF11976	0.413
LIG_TRAF2_1	187	190	PF00917	0.308
MOD_CDK_SPxK_1	173	179	PF00069	0.326
MOD_CK1_1	220	226	PF00069	0.539
MOD_CK2_1	184	190	PF00069	0.364
MOD_CK2_1	256	262	PF00069	0.372
MOD_CK2_1	30	36	PF00069	0.348
MOD_GlcNHglycan	101	104	PF01048	0.441
MOD_GlcNHglycan	136	139	PF01048	0.189
MOD_GlcNHglycan	20	23	PF01048	0.363
MOD_GSK3_1	130	137	PF00069	0.391
MOD_GSK3_1	138	145	PF00069	0.297
MOD_GSK3_1	14	21	PF00069	0.361
MOD_GSK3_1	200	207	PF00069	0.439
MOD_GSK3_1	217	224	PF00069	0.414
MOD_GSK3_1	241	248	PF00069	0.360
MOD_GSK3_1	251	258	PF00069	0.401
MOD_N-GLC_1	182	187	PF02516	0.417
MOD_N-GLC_1	92	97	PF02516	0.189
MOD_NEK2_1	113	118	PF00069	0.252
MOD_NEK2_1	20	25	PF00069	0.482
MOD_NEK2_1	62	67	PF00069	0.431
MOD_NEK2_1	99	104	PF00069	0.276
MOD_NEK2_2	138	143	PF00069	0.189
MOD_NEK2_2	200	205	PF00069	0.549
MOD_PIKK_1	30	36	PF00454	0.411
MOD_PIKK_1	41	47	PF00454	0.432
MOD_Plk_1	171	177	PF00069	0.428
MOD_Plk_1	182	188	PF00069	0.519
MOD_Plk_1	221	227	PF00069	0.455
MOD_Plk_4	14	20	PF00069	0.440
MOD_Plk_4	212	218	PF00069	0.492
MOD_Plk_4	232	238	PF00069	0.254
MOD_Plk_4	251	257	PF00069	0.391
MOD_ProDKin_1	130	136	PF00069	0.336
MOD_ProDKin_1	173	179	PF00069	0.326
MOD_ProDKin_1	38	44	PF00069	0.411
TRG_DiLeu_BaEn_2	261	267	PF01217	0.310
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.420
TRG_ER_diArg_1	264	266	PF00400	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFN3	Leptomonas seymouri	56%	100%
A0A0S4KFB4	Bodo saltans	38%	100%
A0A1X0P0E6	Trypanosomatidae	38%	97%
A0A3Q8IHR7	Leishmania donovani	72%	100%
A0A3R7MXS0	Trypanosoma rangeli	34%	98%
A4IDQ6	Leishmania infantum	71%	100%
D0A4E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9ATR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q0T5	Leishmania major	73%	100%
V5BUR3	Trypanosoma cruzi	34%	98%