RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HPZ4_LEIBR

TriTrypDb:

LbrM.35.5020 , LBRM2903_350061100

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005759	mitochondrial matrix	5	1
GO:0020023	kinetoplast	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ4

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0000963	mitochondrial RNA processing	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010467	gene expression	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044528	regulation of mitochondrial mRNA stability	5	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140053	mitochondrial gene expression	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.393
CLV_MEL_PAP_1	353	359	PF00089	0.303
CLV_NRD_NRD_1	100	102	PF00675	0.549
CLV_NRD_NRD_1	140	142	PF00675	0.505
CLV_NRD_NRD_1	147	149	PF00675	0.447
CLV_NRD_NRD_1	218	220	PF00675	0.453
CLV_PCSK_KEX2_1	100	102	PF00082	0.600
CLV_PCSK_KEX2_1	185	187	PF00082	0.404
CLV_PCSK_KEX2_1	218	220	PF00082	0.473
CLV_PCSK_KEX2_1	287	289	PF00082	0.533
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.424
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.553
CLV_PCSK_SKI1_1	185	189	PF00082	0.436
CLV_PCSK_SKI1_1	218	222	PF00082	0.441
CLV_PCSK_SKI1_1	474	478	PF00082	0.515
CLV_PCSK_SKI1_1	525	529	PF00082	0.515
CLV_Separin_Metazoa	145	149	PF03568	0.312
CLV_Separin_Metazoa	70	74	PF03568	0.535
DEG_APCC_DBOX_1	36	44	PF00400	0.437
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DOC_AGCK_PIF_1	452	457	PF00069	0.427
DOC_CDC14_PxL_1	147	155	PF14671	0.463
DOC_CKS1_1	482	487	PF01111	0.276
DOC_CYCLIN_RxL_1	182	192	PF00134	0.549
DOC_MAPK_DCC_7	453	463	PF00069	0.392
DOC_MAPK_gen_1	287	293	PF00069	0.437
DOC_MAPK_gen_1	37	45	PF00069	0.417
DOC_MAPK_gen_1	408	416	PF00069	0.437
DOC_MAPK_MEF2A_6	408	416	PF00069	0.448
DOC_PP4_FxxP_1	346	349	PF00568	0.473
DOC_PP4_FxxP_1	457	460	PF00568	0.390
DOC_PP4_FxxP_1	482	485	PF00568	0.430
DOC_USP7_MATH_1	330	334	PF00917	0.528
DOC_WW_Pin1_4	104	109	PF00397	0.633
DOC_WW_Pin1_4	117	122	PF00397	0.396
DOC_WW_Pin1_4	155	160	PF00397	0.425
DOC_WW_Pin1_4	345	350	PF00397	0.268
DOC_WW_Pin1_4	481	486	PF00397	0.499
DOC_WW_Pin1_4	525	530	PF00397	0.537
LIG_14-3-3_CanoR_1	227	233	PF00244	0.379
LIG_14-3-3_CanoR_1	27	32	PF00244	0.569
LIG_14-3-3_CanoR_1	337	343	PF00244	0.506
LIG_14-3-3_CanoR_1	356	365	PF00244	0.317
LIG_Actin_WH2_2	159	175	PF00022	0.436
LIG_Actin_WH2_2	87	102	PF00022	0.556
LIG_APCC_ABBA_1	291	296	PF00400	0.359
LIG_BRCT_BRCA1_1	250	254	PF00533	0.486
LIG_BRCT_BRCA1_2	250	256	PF00533	0.491
LIG_CtBP_PxDLS_1	419	423	PF00389	0.265
LIG_deltaCOP1_diTrp_1	454	457	PF00928	0.417
LIG_EH_1	87	91	PF12763	0.597
LIG_EH1_1	308	316	PF00400	0.292
LIG_FHA_1	189	195	PF00498	0.515
LIG_FHA_1	201	207	PF00498	0.443
LIG_FHA_1	236	242	PF00498	0.363
LIG_FHA_1	272	278	PF00498	0.405
LIG_FHA_1	359	365	PF00498	0.479
LIG_FHA_1	388	394	PF00498	0.394
LIG_FHA_1	424	430	PF00498	0.377
LIG_FHA_1	473	479	PF00498	0.486
LIG_FHA_1	90	96	PF00498	0.465
LIG_FHA_2	135	141	PF00498	0.594
LIG_FHA_2	270	276	PF00498	0.477
LIG_FHA_2	279	285	PF00498	0.481
LIG_FHA_2	454	460	PF00498	0.404
LIG_HCF-1_HBM_1	510	513	PF13415	0.489
LIG_LIR_Apic_2	343	349	PF02991	0.489
LIG_LIR_Apic_2	454	460	PF02991	0.404
LIG_LIR_Apic_2	481	485	PF02991	0.436
LIG_LIR_Gen_1	234	243	PF02991	0.389
LIG_LIR_Gen_1	251	262	PF02991	0.194
LIG_LIR_Gen_1	279	285	PF02991	0.490
LIG_LIR_Gen_1	32	43	PF02991	0.485
LIG_LIR_Gen_1	325	336	PF02991	0.480
LIG_LIR_Gen_1	454	463	PF02991	0.381
LIG_LIR_Nem_3	234	239	PF02991	0.394
LIG_LIR_Nem_3	251	257	PF02991	0.199
LIG_LIR_Nem_3	279	283	PF02991	0.429
LIG_LIR_Nem_3	32	38	PF02991	0.576
LIG_LIR_Nem_3	325	331	PF02991	0.484
LIG_LIR_Nem_3	415	420	PF02991	0.554
LIG_LIR_Nem_3	454	458	PF02991	0.394
LIG_LIR_Nem_3	510	516	PF02991	0.500
LIG_MAD2	477	485	PF02301	0.297
LIG_PDZ_Class_1	545	550	PF00595	0.583
LIG_Pex14_2	276	280	PF04695	0.434
LIG_Pex14_2	402	406	PF04695	0.262
LIG_Pex14_2	448	452	PF04695	0.414
LIG_SH2_CRK	214	218	PF00017	0.530
LIG_SH2_CRK	513	517	PF00017	0.495
LIG_SH2_NCK_1	440	444	PF00017	0.411
LIG_SH2_PTP2	236	239	PF00017	0.382
LIG_SH2_STAP1	250	254	PF00017	0.501
LIG_SH2_STAP1	338	342	PF00017	0.438
LIG_SH2_STAP1	440	444	PF00017	0.407
LIG_SH2_STAT3	33	36	PF00017	0.554
LIG_SH2_STAT3	439	442	PF00017	0.493
LIG_SH2_STAT3	501	504	PF00017	0.436
LIG_SH2_STAT5	236	239	PF00017	0.366
LIG_SH2_STAT5	33	36	PF00017	0.537
LIG_SH2_STAT5	501	504	PF00017	0.498
LIG_SH3_3	108	114	PF00018	0.513
LIG_SH3_3	413	419	PF00018	0.288
LIG_SH3_3	526	532	PF00018	0.518
LIG_SH3_3	83	89	PF00018	0.465
LIG_Sin3_3	295	302	PF02671	0.403
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.550
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.261
LIG_SUMO_SIM_par_1	13	20	PF11976	0.413
LIG_SUMO_SIM_par_1	238	245	PF11976	0.523
LIG_SUMO_SIM_par_1	296	304	PF11976	0.434
LIG_TRAF2_1	114	117	PF00917	0.605
LIG_TYR_ITIM	432	437	PF00017	0.535
LIG_UBA3_1	240	248	PF00899	0.524
LIG_UBA3_1	461	469	PF00899	0.368
LIG_WRC_WIRS_1	277	282	PF05994	0.479
LIG_WRC_WIRS_1	479	484	PF05994	0.502
MOD_CDK_SPK_2	104	109	PF00069	0.577
MOD_CDK_SPxxK_3	481	488	PF00069	0.290
MOD_CK1_1	120	126	PF00069	0.428
MOD_CK1_1	20	26	PF00069	0.515
MOD_CK1_1	200	206	PF00069	0.501
MOD_CK1_1	355	361	PF00069	0.527
MOD_CK1_1	481	487	PF00069	0.534
MOD_CK2_1	104	110	PF00069	0.533
MOD_CK2_1	134	140	PF00069	0.573
MOD_CK2_1	192	198	PF00069	0.550
MOD_CK2_1	269	275	PF00069	0.442
MOD_CK2_1	453	459	PF00069	0.405
MOD_CK2_1	488	494	PF00069	0.466
MOD_CK2_1	64	70	PF00069	0.574
MOD_Cter_Amidation	285	288	PF01082	0.544
MOD_GlcNHglycan	134	137	PF01048	0.607
MOD_GlcNHglycan	19	22	PF01048	0.586
MOD_GlcNHglycan	328	331	PF01048	0.468
MOD_GSK3_1	16	23	PF00069	0.613
MOD_GSK3_1	172	179	PF00069	0.398
MOD_GSK3_1	188	195	PF00069	0.462
MOD_GSK3_1	326	333	PF00069	0.367
MOD_N-GLC_1	104	109	PF02516	0.609
MOD_N-GLC_1	59	64	PF02516	0.571
MOD_NEK2_1	17	22	PF00069	0.512
MOD_NEK2_1	172	177	PF00069	0.366
MOD_NEK2_1	197	202	PF00069	0.386
MOD_NEK2_1	206	211	PF00069	0.406
MOD_NEK2_1	276	281	PF00069	0.470
MOD_NEK2_1	310	315	PF00069	0.424
MOD_NEK2_1	486	491	PF00069	0.423
MOD_NEK2_1	90	95	PF00069	0.520
MOD_NEK2_2	213	218	PF00069	0.554
MOD_NEK2_2	472	477	PF00069	0.536
MOD_PIKK_1	157	163	PF00454	0.394
MOD_PKA_2	172	178	PF00069	0.411
MOD_PKA_2	226	232	PF00069	0.387
MOD_PKA_2	355	361	PF00069	0.315
MOD_PKA_2	423	429	PF00069	0.483
MOD_Plk_1	192	198	PF00069	0.447
MOD_Plk_1	453	459	PF00069	0.405
MOD_Plk_1	59	65	PF00069	0.530
MOD_Plk_2-3	192	198	PF00069	0.534
MOD_Plk_2-3	269	275	PF00069	0.285
MOD_Plk_2-3	300	306	PF00069	0.522
MOD_Plk_4	120	126	PF00069	0.433
MOD_Plk_4	192	198	PF00069	0.509
MOD_Plk_4	235	241	PF00069	0.252
MOD_Plk_4	310	316	PF00069	0.429
MOD_Plk_4	478	484	PF00069	0.474
MOD_Plk_4	52	58	PF00069	0.528
MOD_Plk_4	534	540	PF00069	0.338
MOD_Plk_4	90	96	PF00069	0.468
MOD_ProDKin_1	104	110	PF00069	0.638
MOD_ProDKin_1	117	123	PF00069	0.386
MOD_ProDKin_1	155	161	PF00069	0.422
MOD_ProDKin_1	345	351	PF00069	0.265
MOD_ProDKin_1	481	487	PF00069	0.495
MOD_ProDKin_1	525	531	PF00069	0.525
MOD_SUMO_for_1	505	508	PF00179	0.536
MOD_SUMO_rev_2	135	143	PF00179	0.388
TRG_DiLeu_BaEn_1	534	539	PF01217	0.483
TRG_ENDOCYTIC_2	214	217	PF00928	0.472
TRG_ENDOCYTIC_2	236	239	PF00928	0.398
TRG_ENDOCYTIC_2	434	437	PF00928	0.483
TRG_ENDOCYTIC_2	513	516	PF00928	0.398
TRG_ER_diArg_1	217	219	PF00400	0.476
TRG_ER_diArg_1	37	40	PF00400	0.497
TRG_ER_diArg_1	411	414	PF00400	0.429
TRG_ER_diArg_1	99	101	PF00400	0.590
TRG_NES_CRM1_1	312	325	PF08389	0.523
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I018	Leptomonas seymouri	67%	100%
A0A0S4KHA2	Bodo saltans	51%	100%
A0A1X0P0I1	Trypanosomatidae	21%	94%
A0A1X0P129	Trypanosomatidae	55%	100%
A0A3R7P546	Trypanosoma rangeli	54%	100%
A0A3S7XBP0	Leishmania donovani	87%	100%
A4IDQ5	Leishmania infantum	87%	100%
D0A4E7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ATR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0T6	Leishmania major	87%	100%
V5BKI7	Trypanosoma cruzi	57%	100%