Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPZ3_LEIBR

TriTrypDb:

LbrM.35.5010 , LBRM2903_350061000

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HPZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ3

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.725
CLV_C14_Caspase3-7	82	86	PF00656	0.424
CLV_NRD_NRD_1	157	159	PF00675	0.508
CLV_NRD_NRD_1	194	196	PF00675	0.429
CLV_NRD_NRD_1	225	227	PF00675	0.355
CLV_NRD_NRD_1	236	238	PF00675	0.346
CLV_NRD_NRD_1	303	305	PF00675	0.278
CLV_NRD_NRD_1	578	580	PF00675	0.633
CLV_NRD_NRD_1	582	584	PF00675	0.628
CLV_PCSK_FUR_1	579	583	PF00082	0.705

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX5	Leptomonas seymouri	53%	92%
A0A1X0P0I1	Trypanosomatidae	36%	100%
A0A3Q8IKW8	Leishmania donovani	78%	96%
A0A3R7LEP3	Trypanosoma rangeli	36%	100%
A4IDQ4	Leishmania infantum	78%	96%
D0A4E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	92%
Q4Q0T7	Leishmania major	77%	100%
V5B501	Trypanosoma cruzi	34%	97%

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