Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPZ3_LEIBR

TriTrypDb:

LbrM.35.5010 , LBRM2903_350061000

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.725
CLV_C14_Caspase3-7	82	86	PF00656	0.424
CLV_NRD_NRD_1	157	159	PF00675	0.508
CLV_NRD_NRD_1	194	196	PF00675	0.429
CLV_NRD_NRD_1	225	227	PF00675	0.355
CLV_NRD_NRD_1	236	238	PF00675	0.346
CLV_NRD_NRD_1	303	305	PF00675	0.278
CLV_NRD_NRD_1	578	580	PF00675	0.633
CLV_NRD_NRD_1	582	584	PF00675	0.628
CLV_PCSK_FUR_1	579	583	PF00082	0.705
CLV_PCSK_KEX2_1	225	227	PF00082	0.355
CLV_PCSK_KEX2_1	235	237	PF00082	0.359
CLV_PCSK_KEX2_1	519	521	PF00082	0.462
CLV_PCSK_KEX2_1	581	583	PF00082	0.671
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.361
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.364
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.763
CLV_PCSK_SKI1_1	219	223	PF00082	0.472
CLV_PCSK_SKI1_1	316	320	PF00082	0.329
CLV_PCSK_SKI1_1	351	355	PF00082	0.343
CLV_PCSK_SKI1_1	545	549	PF00082	0.479
CLV_PCSK_SKI1_1	556	560	PF00082	0.378
CLV_PCSK_SKI1_1	81	85	PF00082	0.464
CLV_Separin_Metazoa	506	510	PF03568	0.483
DEG_APCC_DBOX_1	235	243	PF00400	0.437
DEG_APCC_DBOX_1	251	259	PF00400	0.528
DEG_APCC_DBOX_1	315	323	PF00400	0.447
DEG_APCC_DBOX_1	32	40	PF00400	0.533
DEG_APCC_DBOX_1	544	552	PF00400	0.364
DEG_APCC_DBOX_1	555	563	PF00400	0.369
DOC_CYCLIN_RxL_1	313	321	PF00134	0.439
DOC_CYCLIN_RxL_1	78	85	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	294	300	PF00134	0.438
DOC_MAPK_gen_1	235	244	PF00069	0.464
DOC_MAPK_MEF2A_6	545	553	PF00069	0.443
DOC_MIT_MIM_1	373	382	PF04212	0.370
DOC_PP2B_LxvP_1	294	297	PF13499	0.351
DOC_USP7_MATH_1	153	157	PF00917	0.665
DOC_USP7_MATH_1	346	350	PF00917	0.410
DOC_USP7_MATH_1	359	363	PF00917	0.298
DOC_USP7_MATH_1	447	451	PF00917	0.455
DOC_USP7_UBL2_3	207	211	PF12436	0.471
DOC_WW_Pin1_4	112	117	PF00397	0.700
DOC_WW_Pin1_4	120	125	PF00397	0.603
DOC_WW_Pin1_4	195	200	PF00397	0.522
DOC_WW_Pin1_4	308	313	PF00397	0.481
DOC_WW_Pin1_4	509	514	PF00397	0.292
DOC_WW_Pin1_4	74	79	PF00397	0.429
LIG_14-3-3_CanoR_1	154	162	PF00244	0.621
LIG_14-3-3_CanoR_1	347	354	PF00244	0.418
LIG_14-3-3_CanoR_1	378	386	PF00244	0.488
LIG_14-3-3_CanoR_1	4	12	PF00244	0.588
LIG_14-3-3_CanoR_1	423	427	PF00244	0.369
LIG_Actin_WH2_2	180	197	PF00022	0.319
LIG_APCC_ABBA_1	477	482	PF00400	0.408
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_Clathr_ClatBox_1	400	404	PF01394	0.305
LIG_CtBP_PxDLS_1	402	406	PF00389	0.440
LIG_deltaCOP1_diTrp_1	339	344	PF00928	0.483
LIG_eIF4E_1	217	223	PF01652	0.377
LIG_eIF4E_1	314	320	PF01652	0.315
LIG_eIF4E_1	40	46	PF01652	0.387
LIG_FHA_1	11	17	PF00498	0.483
LIG_FHA_1	178	184	PF00498	0.476
LIG_FHA_1	200	206	PF00498	0.450
LIG_FHA_1	383	389	PF00498	0.447
LIG_FHA_1	444	450	PF00498	0.517
LIG_FHA_1	462	468	PF00498	0.306
LIG_FHA_1	57	63	PF00498	0.544
LIG_FHA_2	124	130	PF00498	0.494
LIG_FHA_2	186	192	PF00498	0.447
LIG_FHA_2	213	219	PF00498	0.510
LIG_FHA_2	268	274	PF00498	0.454
LIG_GBD_Chelix_1	16	24	PF00786	0.378
LIG_GBD_Chelix_1	258	266	PF00786	0.254
LIG_LIR_LC3C_4	13	17	PF02991	0.404
LIG_LIR_Nem_3	129	134	PF02991	0.503
LIG_LIR_Nem_3	144	149	PF02991	0.574
LIG_LIR_Nem_3	481	487	PF02991	0.314
LIG_NRBOX	19	25	PF00104	0.589
LIG_OCRL_FandH_1	242	254	PF00620	0.410
LIG_PCNA_yPIPBox_3	334	347	PF02747	0.475
LIG_SH2_CRK	325	329	PF00017	0.350
LIG_SH2_CRK	69	73	PF00017	0.531
LIG_SH2_GRB2like	214	217	PF00017	0.509
LIG_SH2_NCK_1	325	329	PF00017	0.292
LIG_SH2_STAP1	217	221	PF00017	0.443
LIG_SH2_STAP1	453	457	PF00017	0.475
LIG_SH2_STAP1	480	484	PF00017	0.425
LIG_SH2_STAT5	130	133	PF00017	0.445
LIG_SH2_STAT5	214	217	PF00017	0.429
LIG_SH2_STAT5	480	483	PF00017	0.400
LIG_SH3_1	304	310	PF00018	0.434
LIG_SH3_3	304	310	PF00018	0.434
LIG_SH3_3	324	330	PF00018	0.226
LIG_SH3_3	454	460	PF00018	0.282
LIG_SUMO_SIM_anti_2	253	260	PF11976	0.418
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.279
LIG_SUMO_SIM_par_1	51	57	PF11976	0.447
LIG_TRAF2_1	503	506	PF00917	0.427
LIG_UBA3_1	134	139	PF00899	0.435
LIG_UBA3_1	205	211	PF00899	0.463
LIG_UBA3_1	242	248	PF00899	0.439
LIG_UBA3_1	262	268	PF00899	0.219
LIG_WRC_WIRS_1	146	151	PF05994	0.382
LIG_WRC_WIRS_1	498	503	PF05994	0.383
MOD_CDK_SPxxK_3	74	81	PF00069	0.438
MOD_CK1_1	163	169	PF00069	0.677
MOD_CK1_1	177	183	PF00069	0.574
MOD_CK1_1	288	294	PF00069	0.478
MOD_CK1_1	362	368	PF00069	0.462
MOD_CK1_1	461	467	PF00069	0.419
MOD_CK1_1	56	62	PF00069	0.631
MOD_CK1_1	561	567	PF00069	0.407
MOD_CK2_1	123	129	PF00069	0.516
MOD_CK2_1	185	191	PF00069	0.599
MOD_CK2_1	195	201	PF00069	0.346
MOD_CK2_1	364	370	PF00069	0.515
MOD_CK2_1	54	60	PF00069	0.508
MOD_CK2_1	88	94	PF00069	0.528
MOD_GlcNHglycan	164	169	PF01048	0.638
MOD_GlcNHglycan	229	233	PF01048	0.428
MOD_GlcNHglycan	288	291	PF01048	0.390
MOD_GlcNHglycan	364	367	PF01048	0.485
MOD_GlcNHglycan	440	443	PF01048	0.371
MOD_GlcNHglycan	96	101	PF01048	0.766
MOD_GSK3_1	160	167	PF00069	0.743
MOD_GSK3_1	195	202	PF00069	0.509
MOD_GSK3_1	284	291	PF00069	0.519
MOD_GSK3_1	434	441	PF00069	0.537
MOD_GSK3_1	443	450	PF00069	0.400
MOD_GSK3_1	466	473	PF00069	0.427
MOD_LATS_1	145	151	PF00433	0.374
MOD_LATS_1	343	349	PF00433	0.371
MOD_N-GLC_1	212	217	PF02516	0.502
MOD_N-GLC_1	285	290	PF02516	0.536
MOD_NEK2_1	15	20	PF00069	0.529
MOD_NEK2_1	175	180	PF00069	0.573
MOD_NEK2_1	212	217	PF00069	0.476
MOD_NEK2_1	221	226	PF00069	0.440
MOD_NEK2_1	3	8	PF00069	0.573
MOD_NEK2_1	318	323	PF00069	0.443
MOD_NEK2_1	364	369	PF00069	0.416
MOD_NEK2_1	405	410	PF00069	0.487
MOD_NEK2_1	435	440	PF00069	0.369
MOD_NEK2_1	515	520	PF00069	0.458
MOD_NEK2_1	53	58	PF00069	0.596
MOD_NEK2_1	79	84	PF00069	0.405
MOD_NEK2_2	453	458	PF00069	0.414
MOD_PIKK_1	288	294	PF00454	0.484
MOD_PIKK_1	490	496	PF00454	0.557
MOD_PIKK_1	88	94	PF00454	0.668
MOD_PKA_2	153	159	PF00069	0.603
MOD_PKA_2	251	257	PF00069	0.493
MOD_PKA_2	3	9	PF00069	0.543
MOD_PKA_2	346	352	PF00069	0.300
MOD_PKA_2	377	383	PF00069	0.482
MOD_PKA_2	422	428	PF00069	0.427
MOD_Plk_2-3	463	469	PF00069	0.471
MOD_Plk_4	114	120	PF00069	0.487
MOD_Plk_4	251	257	PF00069	0.372
MOD_Plk_4	359	365	PF00069	0.419
MOD_Plk_4	396	402	PF00069	0.427
MOD_Plk_4	466	472	PF00069	0.417
MOD_Plk_4	558	564	PF00069	0.276
MOD_Plk_4	79	85	PF00069	0.476
MOD_ProDKin_1	112	118	PF00069	0.696
MOD_ProDKin_1	120	126	PF00069	0.587
MOD_ProDKin_1	195	201	PF00069	0.517
MOD_ProDKin_1	308	314	PF00069	0.475
MOD_ProDKin_1	509	515	PF00069	0.285
MOD_ProDKin_1	74	80	PF00069	0.423
MOD_SUMO_rev_2	152	161	PF00179	0.453
TRG_DiLeu_BaEn_1	201	206	PF01217	0.335
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.587
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.482
TRG_ENDOCYTIC_2	146	149	PF00928	0.653
TRG_ENDOCYTIC_2	325	328	PF00928	0.349
TRG_ENDOCYTIC_2	586	589	PF00928	0.626
TRG_ENDOCYTIC_2	69	72	PF00928	0.431
TRG_NES_CRM1_1	35	48	PF08389	0.526
TRG_NES_CRM1_1	465	478	PF08389	0.448
TRG_NLS_MonoCore_2	578	583	PF00514	0.704
TRG_NLS_MonoExtC_3	578	583	PF00514	0.516
TRG_NLS_MonoExtN_4	579	585	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX5	Leptomonas seymouri	53%	92%
A0A1X0P0I1	Trypanosomatidae	36%	100%
A0A3Q8IKW8	Leishmania donovani	78%	96%
A0A3R7LEP3	Trypanosoma rangeli	36%	100%
A4IDQ4	Leishmania infantum	78%	96%
D0A4E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	92%
Q4Q0T7	Leishmania major	77%	100%
V5B501	Trypanosoma cruzi	34%	97%