PIG-P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PIG-P, putative

Species:

Leishmania braziliensis

UniProt:

A4HPZ2_LEIBR

TriTrypDb:

LbrM.35.5000 , LBRM2903_350060900

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HPZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	4
GO:0006505	GPI anchor metabolic process	6	4
GO:0006506	GPI anchor biosynthetic process	6	4
GO:0006629	lipid metabolic process	3	4
GO:0006643	membrane lipid metabolic process	4	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0006664	glycolipid metabolic process	5	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009247	glycolipid biosynthetic process	5	4
GO:0009987	cellular process	1	4
GO:0019538	protein metabolic process	3	4
GO:0019637	organophosphate metabolic process	3	4
GO:0036211	protein modification process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046467	membrane lipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901137	carbohydrate derivative biosynthetic process	4	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901576	organic substance biosynthetic process	3	4
GO:1903509	liposaccharide metabolic process	4	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008194	UDP-glycosyltransferase activity	4	4
GO:0008375	acetylglucosaminyltransferase activity	5	4
GO:0016740	transferase activity	2	4
GO:0016757	glycosyltransferase activity	3	4
GO:0016758	hexosyltransferase activity	4	4
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	162	166	PF00082	0.377
DEG_MDM2_SWIB_1	144	152	PF02201	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.446
DOC_PP2B_LxvP_1	34	37	PF13499	0.316
DOC_PP2B_PxIxI_1	132	138	PF00149	0.447
DOC_USP7_MATH_1	66	70	PF00917	0.556
DOC_USP7_MATH_1	72	76	PF00917	0.545
DOC_WW_Pin1_4	39	44	PF00397	0.587
DOC_WW_Pin1_4	68	73	PF00397	0.563
LIG_14-3-3_CanoR_1	117	123	PF00244	0.439
LIG_14-3-3_CanoR_1	162	171	PF00244	0.639
LIG_14-3-3_CanoR_1	26	31	PF00244	0.243
LIG_14-3-3_CanoR_1	48	58	PF00244	0.579
LIG_14-3-3_CanoR_1	63	73	PF00244	0.560
LIG_BRCT_BRCA1_1	69	73	PF00533	0.560
LIG_eIF4E_1	18	24	PF01652	0.331
LIG_FHA_1	11	17	PF00498	0.231
LIG_FHA_1	144	150	PF00498	0.447
LIG_FHA_1	153	159	PF00498	0.497
LIG_FHA_1	26	32	PF00498	0.227
LIG_FHA_2	163	169	PF00498	0.608
LIG_FHA_2	171	177	PF00498	0.473
LIG_GBD_Chelix_1	98	106	PF00786	0.418
LIG_LIR_Gen_1	145	153	PF02991	0.447
LIG_LIR_Gen_1	28	38	PF02991	0.243
LIG_LIR_Gen_1	70	77	PF02991	0.574
LIG_LIR_Nem_3	125	130	PF02991	0.377
LIG_LIR_Nem_3	145	151	PF02991	0.199
LIG_LIR_Nem_3	28	33	PF02991	0.243
LIG_LIR_Nem_3	70	76	PF02991	0.575
LIG_PCNA_yPIPBox_3	78	92	PF02747	0.520
LIG_Pex14_2	144	148	PF04695	0.447
LIG_REV1ctd_RIR_1	22	30	PF16727	0.243
LIG_SH2_CRK	2	6	PF00017	0.380
LIG_SH2_NCK_1	2	6	PF00017	0.380
LIG_SH2_STAP1	12	16	PF00017	0.231
LIG_SH2_STAT5	104	107	PF00017	0.447
LIG_SH2_STAT5	12	15	PF00017	0.265
LIG_SH2_STAT5	143	146	PF00017	0.447
LIG_SH2_STAT5	18	21	PF00017	0.311
LIG_SH2_STAT5	59	62	PF00017	0.562
LIG_SH3_3	127	133	PF00018	0.377
LIG_SH3_3	188	194	PF00018	0.577
LIG_SH3_3	3	9	PF00018	0.367
LIG_SH3_3	34	40	PF00018	0.520
LIG_SUMO_SIM_anti_2	145	155	PF11976	0.447
LIG_SUMO_SIM_anti_2	94	101	PF11976	0.474
LIG_SUMO_SIM_par_1	145	155	PF11976	0.447
LIG_SUMO_SIM_par_1	192	199	PF11976	0.577
LIG_SUMO_SIM_par_1	94	101	PF11976	0.447
LIG_WRC_WIRS_1	27	32	PF05994	0.243
LIG_WRC_WIRS_1	62	67	PF05994	0.595
MOD_CK1_1	183	189	PF00069	0.577
MOD_CK1_1	196	202	PF00069	0.461
MOD_CK1_1	42	48	PF00069	0.602
MOD_CK1_1	64	70	PF00069	0.593
MOD_CK2_1	170	176	PF00069	0.441
MOD_GlcNHglycan	182	185	PF01048	0.241
MOD_GSK3_1	152	159	PF00069	0.577
MOD_GSK3_1	162	169	PF00069	0.488
MOD_GSK3_1	64	71	PF00069	0.558
MOD_NEK2_1	1	6	PF00069	0.402
MOD_NEK2_1	118	123	PF00069	0.377
MOD_NEK2_1	144	149	PF00069	0.447
MOD_NEK2_1	152	157	PF00069	0.506
MOD_NEK2_1	180	185	PF00069	0.611
MOD_NEK2_1	25	30	PF00069	0.322
MOD_NEK2_1	91	96	PF00069	0.400
MOD_PIKK_1	42	48	PF00454	0.602
MOD_PIKK_1	78	84	PF00454	0.669
MOD_PKA_2	25	31	PF00069	0.243
MOD_Plk_4	118	124	PF00069	0.335
MOD_Plk_4	144	150	PF00069	0.447
MOD_Plk_4	26	32	PF00069	0.300
MOD_Plk_4	72	78	PF00069	0.562
MOD_Plk_4	91	97	PF00069	0.406
MOD_Plk_4	98	104	PF00069	0.258
MOD_ProDKin_1	39	45	PF00069	0.589
MOD_ProDKin_1	68	74	PF00069	0.560
MOD_SUMO_rev_2	166	171	PF00179	0.577
TRG_ENDOCYTIC_2	127	130	PF00928	0.377
TRG_ENDOCYTIC_2	2	5	PF00928	0.445
TRG_ENDOCYTIC_2	59	62	PF00928	0.562
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILG4	Leishmania donovani	89%	100%
A4IDQ3	Leishmania infantum	89%	100%
E9ATQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0T8	Leishmania major	86%	100%