Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPY8_LEIBR

TriTrypDb:

LbrM.35.4960 , LBRM2903_350060400

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A4HPY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.389
CLV_C14_Caspase3-7	543	547	PF00656	0.655
CLV_C14_Caspase3-7	646	650	PF00656	0.533
CLV_C14_Caspase3-7	667	671	PF00656	0.667
CLV_NRD_NRD_1	171	173	PF00675	0.657
CLV_NRD_NRD_1	274	276	PF00675	0.422
CLV_NRD_NRD_1	366	368	PF00675	0.422
CLV_NRD_NRD_1	403	405	PF00675	0.557
CLV_NRD_NRD_1	476	478	PF00675	0.467
CLV_NRD_NRD_1	538	540	PF00675	0.675
CLV_NRD_NRD_1	55	57	PF00675	0.425
CLV_NRD_NRD_1	696	698	PF00675	0.528
CLV_NRD_NRD_1	709	711	PF00675	0.406
CLV_PCSK_FUR_1	539	543	PF00082	0.571
CLV_PCSK_FUR_1	707	711	PF00082	0.532
CLV_PCSK_KEX2_1	164	166	PF00082	0.567
CLV_PCSK_KEX2_1	170	172	PF00082	0.575
CLV_PCSK_KEX2_1	274	276	PF00082	0.422
CLV_PCSK_KEX2_1	366	368	PF00082	0.422
CLV_PCSK_KEX2_1	403	405	PF00082	0.542
CLV_PCSK_KEX2_1	476	478	PF00082	0.490
CLV_PCSK_KEX2_1	541	543	PF00082	0.636
CLV_PCSK_KEX2_1	55	57	PF00082	0.501
CLV_PCSK_KEX2_1	579	581	PF00082	0.678
CLV_PCSK_KEX2_1	682	684	PF00082	0.499
CLV_PCSK_KEX2_1	696	698	PF00082	0.530
CLV_PCSK_KEX2_1	706	708	PF00082	0.567
CLV_PCSK_KEX2_1	709	711	PF00082	0.400
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.558
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.636
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.501
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.678
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.499
CLV_PCSK_PC1ET2_1	706	708	PF00082	0.534
CLV_PCSK_SKI1_1	525	529	PF00082	0.574
CLV_PCSK_SKI1_1	690	694	PF00082	0.513
DEG_APCC_DBOX_1	365	373	PF00400	0.391
DEG_Nend_UBRbox_2	1	3	PF02207	0.568
DEG_SPOP_SBC_1	500	504	PF00917	0.610
DOC_MAPK_gen_1	666	674	PF00069	0.515
DOC_MAPK_gen_1	693	702	PF00069	0.494
DOC_PP1_RVXF_1	696	703	PF00149	0.506
DOC_USP7_MATH_1	500	504	PF00917	0.734
DOC_USP7_MATH_1	636	640	PF00917	0.603
DOC_USP7_MATH_1	665	669	PF00917	0.724
DOC_USP7_UBL2_3	628	632	PF12436	0.575
DOC_WW_Pin1_4	300	305	PF00397	0.382
DOC_WW_Pin1_4	592	597	PF00397	0.629
LIG_14-3-3_CanoR_1	121	126	PF00244	0.496
LIG_14-3-3_CanoR_1	413	423	PF00244	0.402
LIG_14-3-3_CanoR_1	456	462	PF00244	0.520
LIG_14-3-3_CanoR_1	56	66	PF00244	0.429
LIG_14-3-3_CanoR_1	568	576	PF00244	0.615
LIG_Actin_WH2_2	119	134	PF00022	0.536
LIG_BRCT_BRCA1_1	103	107	PF00533	0.475
LIG_BRCT_BRCA1_1	339	343	PF00533	0.475
LIG_BRCT_BRCA1_1	72	76	PF00533	0.524
LIG_FHA_1	110	116	PF00498	0.473
LIG_FHA_1	120	126	PF00498	0.512
LIG_FHA_1	13	19	PF00498	0.568
LIG_FHA_1	184	190	PF00498	0.582
LIG_FHA_1	46	52	PF00498	0.454
LIG_FHA_1	571	577	PF00498	0.555
LIG_FHA_2	207	213	PF00498	0.378
LIG_FHA_2	27	33	PF00498	0.292
LIG_FHA_2	458	464	PF00498	0.481
LIG_FHA_2	484	490	PF00498	0.528
LIG_FHA_2	582	588	PF00498	0.579
LIG_FHA_2	644	650	PF00498	0.541
LIG_Integrin_RGD_1	580	582	PF01839	0.557
LIG_LIR_Apic_2	315	319	PF02991	0.404
LIG_LIR_Gen_1	433	440	PF02991	0.387
LIG_LIR_Gen_1	595	604	PF02991	0.595
LIG_LIR_Nem_3	433	437	PF02991	0.376
LIG_LIR_Nem_3	595	600	PF02991	0.659
LIG_Pex14_1	316	320	PF04695	0.405
LIG_PTB_Apo_2	222	229	PF02174	0.340
LIG_PTB_Apo_2	289	296	PF02174	0.474
LIG_PTB_Phospho_1	222	228	PF10480	0.340
LIG_SH2_CRK	597	601	PF00017	0.544
LIG_SH2_STAP1	261	265	PF00017	0.426
LIG_SH2_STAT3	236	239	PF00017	0.366
LIG_SH2_STAT3	89	92	PF00017	0.570
LIG_SH2_STAT5	113	116	PF00017	0.475
LIG_SH2_STAT5	145	148	PF00017	0.480
LIG_SH2_STAT5	236	239	PF00017	0.389
LIG_SH2_STAT5	242	245	PF00017	0.445
LIG_SH2_STAT5	377	380	PF00017	0.529
LIG_SH2_STAT5	400	403	PF00017	0.516
LIG_SH3_2	188	193	PF14604	0.447
LIG_SH3_3	15	21	PF00018	0.657
LIG_SH3_3	185	191	PF00018	0.496
LIG_SH3_3	220	226	PF00018	0.369
LIG_SH3_3	34	40	PF00018	0.265
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.475
LIG_SUMO_SIM_anti_2	211	220	PF11976	0.367
LIG_SUMO_SIM_par_1	118	127	PF11976	0.518
LIG_SUMO_SIM_par_1	211	220	PF11976	0.393
LIG_SUMO_SIM_par_1	421	426	PF11976	0.375
LIG_WRC_WIRS_1	333	338	PF05994	0.406
MOD_CK1_1	116	122	PF00069	0.321
MOD_CK1_1	179	185	PF00069	0.569
MOD_CK1_1	253	259	PF00069	0.362
MOD_CK1_1	288	294	PF00069	0.481
MOD_CK1_1	380	386	PF00069	0.552
MOD_CK1_1	498	504	PF00069	0.689
MOD_CK1_1	505	511	PF00069	0.689
MOD_CK1_1	545	551	PF00069	0.609
MOD_CK1_1	570	576	PF00069	0.670
MOD_CK1_1	641	647	PF00069	0.686
MOD_CK1_1	668	674	PF00069	0.669
MOD_CK2_1	100	106	PF00069	0.312
MOD_CK2_1	483	489	PF00069	0.573
MOD_CK2_1	500	506	PF00069	0.731
MOD_CK2_1	55	61	PF00069	0.433
MOD_CK2_1	581	587	PF00069	0.557
MOD_CK2_1	658	664	PF00069	0.662
MOD_Cter_Amidation	147	150	PF01082	0.644
MOD_Cter_Amidation	577	580	PF01082	0.677
MOD_GlcNHglycan	115	118	PF01048	0.407
MOD_GlcNHglycan	179	182	PF01048	0.735
MOD_GlcNHglycan	252	255	PF01048	0.355
MOD_GlcNHglycan	26	29	PF01048	0.398
MOD_GlcNHglycan	287	290	PF01048	0.454
MOD_GlcNHglycan	372	375	PF01048	0.402
MOD_GlcNHglycan	425	428	PF01048	0.382
MOD_GlcNHglycan	497	500	PF01048	0.668
MOD_GlcNHglycan	561	564	PF01048	0.752
MOD_GlcNHglycan	576	579	PF01048	0.593
MOD_GlcNHglycan	638	641	PF01048	0.667
MOD_GlcNHglycan	98	101	PF01048	0.324
MOD_GSK3_1	105	112	PF00069	0.363
MOD_GSK3_1	115	122	PF00069	0.454
MOD_GSK3_1	12	19	PF00069	0.512
MOD_GSK3_1	173	180	PF00069	0.633
MOD_GSK3_1	249	256	PF00069	0.352
MOD_GSK3_1	284	291	PF00069	0.420
MOD_GSK3_1	375	382	PF00069	0.470
MOD_GSK3_1	485	492	PF00069	0.737
MOD_GSK3_1	495	502	PF00069	0.659
MOD_GSK3_1	540	547	PF00069	0.591
MOD_GSK3_1	549	556	PF00069	0.651
MOD_GSK3_1	570	577	PF00069	0.592
MOD_GSK3_1	613	620	PF00069	0.677
MOD_GSK3_1	644	651	PF00069	0.601
MOD_GSK3_1	654	661	PF00069	0.616
MOD_GSK3_1	70	77	PF00069	0.586
MOD_GSK3_1	96	103	PF00069	0.339
MOD_N-GLC_1	285	290	PF02516	0.417
MOD_N-GLC_1	291	296	PF02516	0.486
MOD_N-GLC_1	386	391	PF02516	0.566
MOD_N-GLC_1	700	705	PF02516	0.531
MOD_N-GLC_2	200	202	PF02516	0.374
MOD_N-GLC_2	368	370	PF02516	0.381
MOD_NEK2_1	249	254	PF00069	0.345
MOD_NEK2_1	284	289	PF00069	0.397
MOD_NEK2_1	347	352	PF00069	0.355
MOD_NEK2_1	423	428	PF00069	0.375
MOD_NEK2_2	332	337	PF00069	0.468
MOD_PIKK_1	235	241	PF00454	0.377
MOD_PK_1	121	127	PF00069	0.312
MOD_PK_1	269	275	PF00069	0.403
MOD_PK_1	55	61	PF00069	0.509
MOD_PKA_1	540	546	PF00069	0.634
MOD_PKA_1	55	61	PF00069	0.509
MOD_PKA_2	177	183	PF00069	0.687
MOD_PKA_2	55	61	PF00069	0.433
MOD_PKA_2	567	573	PF00069	0.556
MOD_PKA_2	665	671	PF00069	0.579
MOD_Plk_1	119	125	PF00069	0.312
MOD_Plk_1	16	22	PF00069	0.453
MOD_Plk_1	269	275	PF00069	0.403
MOD_Plk_1	291	297	PF00069	0.470
MOD_Plk_1	338	344	PF00069	0.468
MOD_Plk_1	375	381	PF00069	0.447
MOD_Plk_1	69	75	PF00069	0.499
MOD_Plk_1	700	706	PF00069	0.530
MOD_Plk_4	109	115	PF00069	0.291
MOD_Plk_4	26	32	PF00069	0.373
MOD_Plk_4	291	297	PF00069	0.470
MOD_Plk_4	380	386	PF00069	0.498
MOD_Plk_4	70	76	PF00069	0.508
MOD_ProDKin_1	300	306	PF00069	0.383
MOD_ProDKin_1	592	598	PF00069	0.629
MOD_SUMO_for_1	163	166	PF00179	0.553
MOD_SUMO_for_1	6	9	PF00179	0.446
MOD_SUMO_for_1	692	695	PF00179	0.469
MOD_SUMO_rev_2	488	496	PF00179	0.588
MOD_SUMO_rev_2	523	533	PF00179	0.497
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.491
TRG_ENDOCYTIC_2	320	323	PF00928	0.402
TRG_ENDOCYTIC_2	597	600	PF00928	0.546
TRG_ER_diArg_1	170	172	PF00400	0.562
TRG_ER_diArg_1	221	224	PF00400	0.372
TRG_ER_diArg_1	273	275	PF00400	0.538
TRG_ER_diArg_1	365	367	PF00400	0.428
TRG_ER_diArg_1	402	404	PF00400	0.539
TRG_ER_diArg_1	449	452	PF00400	0.439
TRG_ER_diArg_1	476	478	PF00400	0.467
TRG_ER_diArg_1	707	710	PF00400	0.541
TRG_NES_CRM1_1	2	14	PF08389	0.515
TRG_NLS_Bipartite_1	681	701	PF00514	0.491
TRG_NLS_MonoCore_2	538	543	PF00514	0.563
TRG_NLS_MonoExtN_4	539	544	PF00514	0.634
TRG_NLS_MonoExtN_4	628	634	PF00514	0.646
TRG_NLS_MonoExtN_4	696	701	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Z8	Leptomonas seymouri	66%	100%
A0A3S7XBM3	Leishmania donovani	74%	100%
A4IDP9	Leishmania infantum	74%	100%
E9ATQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q0U2	Leishmania major	75%	99%