VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPY3_LEIBR

TriTrypDb:

LbrM.35.4910 , LBRM2903_350059900

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0030139	endocytic vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPY3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:0140678	molecular function inhibitor activity	2	7
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.545
CLV_C14_Caspase3-7	5	9	PF00656	0.537
CLV_NRD_NRD_1	427	429	PF00675	0.545
CLV_NRD_NRD_1	602	604	PF00675	0.312
CLV_NRD_NRD_1	64	66	PF00675	0.497
CLV_PCSK_FUR_1	600	604	PF00082	0.285
CLV_PCSK_KEX2_1	336	338	PF00082	0.495
CLV_PCSK_KEX2_1	427	429	PF00082	0.545
CLV_PCSK_KEX2_1	602	604	PF00082	0.312
CLV_PCSK_KEX2_1	64	66	PF00082	0.497
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.495
CLV_PCSK_SKI1_1	122	126	PF00082	0.384
CLV_PCSK_SKI1_1	232	236	PF00082	0.535
CLV_PCSK_SKI1_1	271	275	PF00082	0.687
CLV_PCSK_SKI1_1	510	514	PF00082	0.363
CLV_PCSK_SKI1_1	898	902	PF00082	0.438
CLV_PCSK_SKI1_1	924	928	PF00082	0.463
CLV_Separin_Metazoa	862	866	PF03568	0.529
DEG_SCF_FBW7_2	233	239	PF00400	0.525
DEG_SCF_TRCP1_1	299	304	PF00400	0.551
DEG_SPOP_SBC_1	721	725	PF00917	0.525
DEG_SPOP_SBC_1	851	855	PF00917	0.546
DOC_CKS1_1	233	238	PF01111	0.596
DOC_CKS1_1	367	372	PF01111	0.498
DOC_CYCLIN_RxL_1	894	903	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.454
DOC_MAPK_FxFP_2	658	661	PF00069	0.231
DOC_MAPK_gen_1	36	44	PF00069	0.422
DOC_MAPK_gen_1	894	902	PF00069	0.517
DOC_MAPK_MEF2A_6	200	209	PF00069	0.360
DOC_MAPK_MEF2A_6	232	240	PF00069	0.517
DOC_MAPK_MEF2A_6	248	256	PF00069	0.520
DOC_MAPK_MEF2A_6	586	595	PF00069	0.312
DOC_PP1_RVXF_1	642	649	PF00149	0.388
DOC_PP2B_LxvP_1	279	282	PF13499	0.684
DOC_PP2B_LxvP_1	42	45	PF13499	0.323
DOC_PP2B_LxvP_1	882	885	PF13499	0.580
DOC_PP2B_LxvP_1	911	914	PF13499	0.353
DOC_PP2B_PxIxI_1	235	241	PF00149	0.539
DOC_PP4_FxxP_1	574	577	PF00568	0.312
DOC_PP4_FxxP_1	658	661	PF00568	0.388
DOC_PP4_MxPP_1	730	733	PF00568	0.544
DOC_USP7_MATH_1	181	185	PF00917	0.582
DOC_USP7_MATH_1	352	356	PF00917	0.617
DOC_USP7_MATH_1	388	392	PF00917	0.604
DOC_USP7_MATH_1	662	666	PF00917	0.341
DOC_USP7_MATH_1	721	725	PF00917	0.598
DOC_USP7_MATH_1	796	800	PF00917	0.535
DOC_USP7_MATH_1	802	806	PF00917	0.669
DOC_USP7_MATH_1	811	815	PF00917	0.650
DOC_USP7_MATH_1	830	834	PF00917	0.533
DOC_USP7_UBL2_3	528	532	PF12436	0.322
DOC_USP7_UBL2_3	606	610	PF12436	0.315
DOC_WW_Pin1_4	232	237	PF00397	0.591
DOC_WW_Pin1_4	242	247	PF00397	0.620
DOC_WW_Pin1_4	280	285	PF00397	0.518
DOC_WW_Pin1_4	318	323	PF00397	0.612
DOC_WW_Pin1_4	366	371	PF00397	0.546
DOC_WW_Pin1_4	542	547	PF00397	0.346
DOC_WW_Pin1_4	573	578	PF00397	0.312
DOC_WW_Pin1_4	601	606	PF00397	0.231
DOC_WW_Pin1_4	611	616	PF00397	0.202
DOC_WW_Pin1_4	782	787	PF00397	0.528
DOC_WW_Pin1_4	842	847	PF00397	0.709
LIG_14-3-3_CanoR_1	151	161	PF00244	0.349
LIG_14-3-3_CanoR_1	261	266	PF00244	0.531
LIG_14-3-3_CanoR_1	46	51	PF00244	0.382
LIG_14-3-3_CanoR_1	483	488	PF00244	0.482
LIG_14-3-3_CanoR_1	493	497	PF00244	0.591
LIG_14-3-3_CanoR_1	510	517	PF00244	0.266
LIG_14-3-3_CanoR_1	644	649	PF00244	0.328
LIG_14-3-3_CanoR_1	749	754	PF00244	0.490
LIG_14-3-3_CanoR_1	812	820	PF00244	0.529
LIG_BRCT_BRCA1_1	668	672	PF00533	0.280
LIG_BRCT_BRCA1_1	677	681	PF00533	0.353
LIG_Clathr_ClatBox_1	133	137	PF01394	0.383
LIG_Clathr_ClatBox_1	538	542	PF01394	0.487
LIG_DLG_GKlike_1	64	72	PF00625	0.510
LIG_DLG_GKlike_1	865	873	PF00625	0.515
LIG_FHA_1	105	111	PF00498	0.576
LIG_FHA_1	153	159	PF00498	0.480
LIG_FHA_1	215	221	PF00498	0.446
LIG_FHA_1	222	228	PF00498	0.405
LIG_FHA_1	233	239	PF00498	0.525
LIG_FHA_1	247	253	PF00498	0.574
LIG_FHA_1	265	271	PF00498	0.492
LIG_FHA_1	306	312	PF00498	0.633
LIG_FHA_1	403	409	PF00498	0.478
LIG_FHA_1	489	495	PF00498	0.482
LIG_FHA_1	511	517	PF00498	0.456
LIG_FHA_1	612	618	PF00498	0.231
LIG_FHA_1	783	789	PF00498	0.514
LIG_FHA_2	151	157	PF00498	0.361
LIG_FHA_2	738	744	PF00498	0.588
LIG_FHA_2	785	791	PF00498	0.580
LIG_FHA_2	910	916	PF00498	0.427
LIG_GBD_Chelix_1	125	133	PF00786	0.341
LIG_Integrin_RGD_1	314	316	PF01839	0.555
LIG_LIR_Apic_2	572	577	PF02991	0.312
LIG_LIR_Apic_2	656	661	PF02991	0.388
LIG_LIR_Gen_1	130	139	PF02991	0.397
LIG_LIR_Gen_1	440	447	PF02991	0.396
LIG_LIR_Gen_1	474	481	PF02991	0.478
LIG_LIR_Gen_1	514	523	PF02991	0.386
LIG_LIR_Gen_1	669	680	PF02991	0.225
LIG_LIR_Nem_3	130	134	PF02991	0.359
LIG_LIR_Nem_3	142	147	PF02991	0.414
LIG_LIR_Nem_3	329	334	PF02991	0.487
LIG_LIR_Nem_3	425	429	PF02991	0.443
LIG_LIR_Nem_3	435	441	PF02991	0.419
LIG_LIR_Nem_3	474	480	PF02991	0.485
LIG_LIR_Nem_3	514	520	PF02991	0.382
LIG_LIR_Nem_3	669	675	PF02991	0.225
LIG_LYPXL_yS_3	660	663	PF13949	0.231
LIG_PCNA_yPIPBox_3	498	512	PF02747	0.459
LIG_Pex14_2	437	441	PF04695	0.468
LIG_Pex14_2	632	636	PF04695	0.312
LIG_PTB_Apo_2	138	145	PF02174	0.527
LIG_PTB_Apo_2	648	655	PF02174	0.312
LIG_PTB_Phospho_1	648	654	PF10480	0.312
LIG_REV1ctd_RIR_1	571	576	PF16727	0.312
LIG_SH2_CRK	131	135	PF00017	0.362
LIG_SH2_CRK	426	430	PF00017	0.429
LIG_SH2_CRK	517	521	PF00017	0.420
LIG_SH2_CRK	843	847	PF00017	0.503
LIG_SH2_NCK_1	331	335	PF00017	0.641
LIG_SH2_SRC	175	178	PF00017	0.346
LIG_SH2_STAP1	175	179	PF00017	0.350
LIG_SH2_STAT5	327	330	PF00017	0.648
LIG_SH2_STAT5	331	334	PF00017	0.598
LIG_SH2_STAT5	460	463	PF00017	0.569
LIG_SH2_STAT5	511	514	PF00017	0.360
LIG_SH2_STAT5	58	61	PF00017	0.490
LIG_SH2_STAT5	654	657	PF00017	0.342
LIG_SH2_STAT5	670	673	PF00017	0.312
LIG_SH3_1	602	608	PF00018	0.231
LIG_SH3_2	605	610	PF14604	0.231
LIG_SH3_3	108	114	PF00018	0.628
LIG_SH3_3	230	236	PF00018	0.454
LIG_SH3_3	249	255	PF00018	0.676
LIG_SH3_3	316	322	PF00018	0.693
LIG_SH3_3	364	370	PF00018	0.511
LIG_SH3_3	602	608	PF00018	0.231
LIG_SH3_3	701	707	PF00018	0.615
LIG_SH3_3	726	732	PF00018	0.575
LIG_SH3_3	768	774	PF00018	0.546
LIG_SH3_3	877	883	PF00018	0.569
LIG_Sin3_3	636	643	PF02671	0.312
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.327
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.449
LIG_SUMO_SIM_anti_2	499	506	PF11976	0.411
LIG_SUMO_SIM_anti_2	787	793	PF11976	0.559
LIG_SUMO_SIM_par_1	307	313	PF11976	0.641
LIG_SUMO_SIM_par_1	362	369	PF11976	0.525
LIG_TRAF2_1	665	668	PF00917	0.312
LIG_TRAF2_1	95	98	PF00917	0.556
LIG_TYR_ITIM	129	134	PF00017	0.352
LIG_WRC_WIRS_1	30	35	PF05994	0.341
MOD_CDC14_SPxK_1	245	248	PF00782	0.511
MOD_CDC14_SPxK_1	283	286	PF00782	0.521
MOD_CDC14_SPxK_1	845	848	PF00782	0.672
MOD_CDK_SPK_2	573	578	PF00069	0.312
MOD_CDK_SPK_2	601	606	PF00069	0.231
MOD_CDK_SPxK_1	242	248	PF00069	0.528
MOD_CDK_SPxK_1	280	286	PF00069	0.522
MOD_CDK_SPxK_1	842	848	PF00069	0.672
MOD_CDK_SPxxK_3	573	580	PF00069	0.312
MOD_CK1_1	142	148	PF00069	0.418
MOD_CK1_1	264	270	PF00069	0.649
MOD_CK1_1	280	286	PF00069	0.653
MOD_CK1_1	395	401	PF00069	0.542
MOD_CK1_1	67	73	PF00069	0.704
MOD_CK1_1	724	730	PF00069	0.577
MOD_CK1_1	765	771	PF00069	0.561
MOD_CK1_1	853	859	PF00069	0.514
MOD_CK1_1	889	895	PF00069	0.697
MOD_CK2_1	150	156	PF00069	0.510
MOD_CK2_1	28	34	PF00069	0.422
MOD_CK2_1	297	303	PF00069	0.660
MOD_CK2_1	459	465	PF00069	0.342
MOD_CK2_1	573	579	PF00069	0.312
MOD_CK2_1	662	668	PF00069	0.388
MOD_CK2_1	865	871	PF00069	0.528
MOD_CK2_1	909	915	PF00069	0.435
MOD_CK2_1	92	98	PF00069	0.620
MOD_GlcNHglycan	147	150	PF01048	0.503
MOD_GlcNHglycan	183	186	PF01048	0.589
MOD_GlcNHglycan	242	245	PF01048	0.592
MOD_GlcNHglycan	279	282	PF01048	0.657
MOD_GlcNHglycan	299	302	PF01048	0.553
MOD_GlcNHglycan	348	351	PF01048	0.730
MOD_GlcNHglycan	354	357	PF01048	0.700
MOD_GlcNHglycan	395	398	PF01048	0.618
MOD_GlcNHglycan	664	667	PF01048	0.272
MOD_GlcNHglycan	692	695	PF01048	0.556
MOD_GlcNHglycan	726	729	PF01048	0.621
MOD_GlcNHglycan	837	840	PF01048	0.528
MOD_GlcNHglycan	855	858	PF01048	0.699
MOD_GSK3_1	105	112	PF00069	0.607
MOD_GSK3_1	135	142	PF00069	0.373
MOD_GSK3_1	181	188	PF00069	0.575
MOD_GSK3_1	196	203	PF00069	0.447
MOD_GSK3_1	228	235	PF00069	0.694
MOD_GSK3_1	242	249	PF00069	0.612
MOD_GSK3_1	297	304	PF00069	0.660
MOD_GSK3_1	341	348	PF00069	0.684
MOD_GSK3_1	352	359	PF00069	0.595
MOD_GSK3_1	369	376	PF00069	0.759
MOD_GSK3_1	384	391	PF00069	0.586
MOD_GSK3_1	400	407	PF00069	0.555
MOD_GSK3_1	488	495	PF00069	0.479
MOD_GSK3_1	64	71	PF00069	0.628
MOD_GSK3_1	662	669	PF00069	0.388
MOD_GSK3_1	671	678	PF00069	0.422
MOD_GSK3_1	690	697	PF00069	0.605
MOD_GSK3_1	720	727	PF00069	0.528
MOD_GSK3_1	847	854	PF00069	0.594
MOD_GSK3_1	867	874	PF00069	0.543
MOD_GSK3_1	886	893	PF00069	0.630
MOD_GSK3_1	92	99	PF00069	0.613
MOD_N-GLC_1	145	150	PF02516	0.488
MOD_N-GLC_1	240	245	PF02516	0.545
MOD_N-GLC_1	261	266	PF02516	0.520
MOD_N-GLC_1	277	282	PF02516	0.539
MOD_N-GLC_1	290	295	PF02516	0.663
MOD_N-GLC_1	796	801	PF02516	0.490
MOD_N-GLC_1	889	894	PF02516	0.620
MOD_N-GLC_2	522	524	PF02516	0.315
MOD_NEK2_1	20	25	PF00069	0.459
MOD_NEK2_1	277	282	PF00069	0.652
MOD_NEK2_1	373	378	PF00069	0.601
MOD_NEK2_1	393	398	PF00069	0.581
MOD_NEK2_1	488	493	PF00069	0.377
MOD_NEK2_1	59	64	PF00069	0.555
MOD_NEK2_1	675	680	PF00069	0.388
MOD_NEK2_1	68	73	PF00069	0.614
MOD_NEK2_1	847	852	PF00069	0.523
MOD_NEK2_1	900	905	PF00069	0.420
MOD_NEK2_2	356	361	PF00069	0.529
MOD_OFUCOSY	583	588	PF10250	0.388
MOD_PIKK_1	388	394	PF00454	0.530
MOD_PIKK_1	526	532	PF00454	0.360
MOD_PIKK_1	900	906	PF00454	0.415
MOD_PKA_1	64	70	PF00069	0.498
MOD_PKA_2	150	156	PF00069	0.510
MOD_PKA_2	492	498	PF00069	0.518
MOD_PKA_2	64	70	PF00069	0.655
MOD_PKA_2	765	771	PF00069	0.581
MOD_PKA_2	811	817	PF00069	0.587
MOD_PKA_2	824	830	PF00069	0.619
MOD_PKA_2	847	853	PF00069	0.655
MOD_PKB_1	337	345	PF00069	0.591
MOD_PKB_1	642	650	PF00069	0.312
MOD_Plk_1	301	307	PF00069	0.552
MOD_Plk_1	356	362	PF00069	0.577
MOD_Plk_1	666	672	PF00069	0.312
MOD_Plk_1	697	703	PF00069	0.619
MOD_Plk_1	796	802	PF00069	0.488
MOD_Plk_1	830	836	PF00069	0.517
MOD_Plk_1	865	871	PF00069	0.601
MOD_Plk_2-3	784	790	PF00069	0.556
MOD_Plk_2-3	909	915	PF00069	0.435
MOD_Plk_4	20	26	PF00069	0.490
MOD_Plk_4	247	253	PF00069	0.677
MOD_Plk_4	305	311	PF00069	0.628
MOD_Plk_4	369	375	PF00069	0.511
MOD_Plk_4	404	410	PF00069	0.583
MOD_Plk_4	483	489	PF00069	0.385
MOD_Plk_4	64	70	PF00069	0.507
MOD_Plk_4	644	650	PF00069	0.312
MOD_Plk_4	675	681	PF00069	0.444
MOD_Plk_4	784	790	PF00069	0.631
MOD_Plk_4	830	836	PF00069	0.517
MOD_Plk_4	847	853	PF00069	0.481
MOD_ProDKin_1	232	238	PF00069	0.597
MOD_ProDKin_1	242	248	PF00069	0.618
MOD_ProDKin_1	280	286	PF00069	0.522
MOD_ProDKin_1	318	324	PF00069	0.607
MOD_ProDKin_1	366	372	PF00069	0.546
MOD_ProDKin_1	542	548	PF00069	0.350
MOD_ProDKin_1	573	579	PF00069	0.312
MOD_ProDKin_1	601	607	PF00069	0.231
MOD_ProDKin_1	611	617	PF00069	0.202
MOD_ProDKin_1	782	788	PF00069	0.523
MOD_ProDKin_1	842	848	PF00069	0.697
MOD_SUMO_rev_2	395	403	PF00179	0.524
MOD_SUMO_rev_2	525	529	PF00179	0.330
MOD_SUMO_rev_2	772	780	PF00179	0.628
TRG_DiLeu_BaEn_1	440	445	PF01217	0.455
TRG_DiLeu_BaEn_1	922	927	PF01217	0.518
TRG_ENDOCYTIC_2	131	134	PF00928	0.349
TRG_ENDOCYTIC_2	331	334	PF00928	0.639
TRG_ENDOCYTIC_2	426	429	PF00928	0.439
TRG_ENDOCYTIC_2	438	441	PF00928	0.382
TRG_ENDOCYTIC_2	477	480	PF00928	0.389
TRG_ENDOCYTIC_2	517	520	PF00928	0.499
TRG_ENDOCYTIC_2	660	663	PF00928	0.243
TRG_ER_diArg_1	426	428	PF00400	0.522
TRG_ER_diArg_1	599	602	PF00400	0.285
TRG_ER_diArg_1	64	66	PF00400	0.497
TRG_ER_diArg_1	641	644	PF00400	0.312
TRG_ER_diArg_1	894	897	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	924	929	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P3	Leptomonas seymouri	44%	92%
A0A3S7XBS1	Leishmania donovani	64%	100%
A4IDP4	Leishmania infantum	64%	100%
E9ATQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q0U8	Leishmania major	64%	100%