Ribosome assembly factor mrt4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPY2_LEIBR

TriTrypDb:

LbrM.35.4900 , LBRM2903_350059800

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0005737	cytoplasm	2	11
GO:0005840	ribosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HPY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPY2

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0022618	ribonucleoprotein complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071826	ribonucleoprotein complex subunit organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044085	cellular component biogenesis	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	224	226	PF00082	0.668
CLV_PCSK_KEX2_1	5	7	PF00082	0.501
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.668
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.501
CLV_PCSK_SKI1_1	111	115	PF00082	0.264
CLV_PCSK_SKI1_1	31	35	PF00082	0.258
CLV_PCSK_SKI1_1	5	9	PF00082	0.530
CLV_PCSK_SKI1_1	65	69	PF00082	0.258
DEG_APCC_KENBOX_2	86	90	PF00400	0.379
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.444
DOC_MAPK_gen_1	162	171	PF00069	0.444
DOC_MAPK_gen_1	3	12	PF00069	0.504
DOC_MAPK_MEF2A_6	156	163	PF00069	0.444
DOC_PP2B_LxvP_1	157	160	PF13499	0.444
DOC_USP7_MATH_1	132	136	PF00917	0.476
DOC_USP7_MATH_1	61	65	PF00917	0.542
DOC_USP7_UBL2_3	110	114	PF12436	0.446
DOC_USP7_UBL2_3	14	18	PF12436	0.520
DOC_USP7_UBL2_3	83	87	PF12436	0.379
DOC_WW_Pin1_4	91	96	PF00397	0.542
LIG_14-3-3_CanoR_1	127	137	PF00244	0.458
LIG_BRCT_BRCA1_1	63	67	PF00533	0.444
LIG_CaM_IQ_9	12	27	PF13499	0.412
LIG_Clathr_ClatBox_1	193	197	PF01394	0.379
LIG_FHA_1	131	137	PF00498	0.448
LIG_FHA_1	208	214	PF00498	0.647
LIG_FHA_1	40	46	PF00498	0.444
LIG_FHA_1	48	54	PF00498	0.444
LIG_FHA_2	129	135	PF00498	0.503
LIG_FHA_2	17	23	PF00498	0.290
LIG_FHA_2	173	179	PF00498	0.458
LIG_LIR_Gen_1	115	125	PF02991	0.656
LIG_LIR_Gen_1	149	159	PF02991	0.444
LIG_LIR_Gen_1	35	45	PF02991	0.458
LIG_LIR_Nem_3	115	120	PF02991	0.449
LIG_LIR_Nem_3	149	154	PF02991	0.444
LIG_LIR_Nem_3	35	40	PF02991	0.444
LIG_SH2_NCK_1	37	41	PF00017	0.458
LIG_SH2_STAP1	37	41	PF00017	0.446
LIG_SH2_STAT3	41	44	PF00017	0.531
LIG_SH2_STAT5	116	119	PF00017	0.444
LIG_SH2_STAT5	37	40	PF00017	0.436
LIG_SH2_STAT5	41	44	PF00017	0.452
LIG_SH3_3	117	123	PF00018	0.687
LIG_SH3_3	141	147	PF00018	0.476
LIG_SH3_3	173	179	PF00018	0.476
LIG_SUMO_SIM_par_1	167	175	PF11976	0.444
LIG_SUMO_SIM_par_1	8	13	PF11976	0.415
LIG_UBA3_1	150	156	PF00899	0.476
LIG_UBA3_1	74	83	PF00899	0.379
LIG_WRC_WIRS_1	40	45	PF05994	0.444
MOD_CK1_1	220	226	PF00069	0.625
MOD_CK2_1	106	112	PF00069	0.532
MOD_CK2_1	128	134	PF00069	0.503
MOD_CK2_1	172	178	PF00069	0.458
MOD_GlcNHglycan	183	186	PF01048	0.263
MOD_GlcNHglycan	219	222	PF01048	0.665
MOD_GlcNHglycan	81	86	PF01048	0.331
MOD_GSK3_1	128	135	PF00069	0.475
MOD_GSK3_1	203	210	PF00069	0.602
MOD_GSK3_1	35	42	PF00069	0.448
MOD_GSK3_1	8	15	PF00069	0.520
MOD_GSK3_1	91	98	PF00069	0.531
MOD_N-GLC_1	106	111	PF02516	0.331
MOD_NEK2_1	103	108	PF00069	0.468
MOD_NEK2_1	12	17	PF00069	0.518
MOD_NEK2_1	171	176	PF00069	0.444
MOD_PIKK_1	12	18	PF00454	0.641
MOD_Plk_1	172	178	PF00069	0.445
MOD_Plk_1	61	67	PF00069	0.412
MOD_Plk_4	132	138	PF00069	0.531
MOD_Plk_4	146	152	PF00069	0.444
MOD_ProDKin_1	91	97	PF00069	0.542
MOD_SUMO_rev_2	197	203	PF00179	0.570
TRG_DiLeu_BaEn_1	186	191	PF01217	0.444
TRG_ENDOCYTIC_2	37	40	PF00928	0.444
TRG_NLS_MonoExtN_4	2	9	PF00514	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P819	Leptomonas seymouri	90%	100%
A0A0S4JL62	Bodo saltans	76%	100%
A0A1X0P0H0	Trypanosomatidae	78%	100%
A0A3S7XBL0	Leishmania donovani	91%	100%
A0A422P595	Trypanosoma rangeli	77%	99%
A3DNI2	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	26%	67%
A4FV84	Bos taurus	47%	95%
A4FZS8	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	22%	68%
A4HFR5	Leishmania braziliensis	24%	70%
A4HFR6	Leishmania braziliensis	24%	70%
A4IDP3	Leishmania infantum	91%	100%
A5UKU8	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	24%	68%
A6UTF8	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	24%	67%
A9A838	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	23%	68%
B6YSX9	Thermococcus onnurineus (strain NA1)	23%	67%
C3MXH4	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	23%	67%
C4KIJ9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	23%	67%
C6A1F5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	23%	67%
D0A4D2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ATP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
G0S616	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	32%	84%
O04204	Arabidopsis thaliana	26%	72%
O24573	Zea mays	26%	71%
O27717	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	68%
O74109	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	25%	66%
O74864	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	73%
P05317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	73%
P05388	Homo sapiens	26%	72%
P14869	Mus musculus	26%	72%
P19889	Drosophila melanogaster	25%	72%
P19945	Rattus norvegicus	26%	72%
P29764	Oxybasis rubra	25%	71%
P33201	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	96%
P35023	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	68%
P41095	Oryza sativa subsp. japonica	27%	71%
P47826	Gallus gallus	26%	72%
P50345	Lupinus luteus	26%	70%
P50346	Glycine max	27%	71%
P57691	Arabidopsis thaliana	26%	70%
P96039	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	23%	67%
Q29214	Sus scrofa	26%	71%
Q2NEW2	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	23%	68%
Q42112	Arabidopsis thaliana	26%	71%
Q4Q0U9	Leishmania major	89%	100%
Q5JH36	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	20%	67%
Q6FJ04	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	95%
Q6L1X8	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	25%	72%
Q75DK9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	96%
Q7S302	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	90%
Q86HD3	Dictyostelium discoideum	39%	100%
Q8NHW5	Homo sapiens	26%	72%
Q8TZJ8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	67%
Q90YX1	Ictalurus punctatus	27%	72%
Q95140	Bos taurus	26%	71%
Q96TJ5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	73%
Q971J2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	68%
Q9C3Z6	Podospora anserina	22%	72%
Q9D0I8	Mus musculus	47%	95%
Q9DG68	Lithobates sylvaticus	27%	72%
Q9PV90	Danio rerio	27%	71%
Q9U3U0	Ceratitis capitata	26%	72%
Q9UKD2	Homo sapiens	47%	95%
Q9USZ6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	94%
Q9UXS5	Pyrococcus abyssi (strain GE5 / Orsay)	25%	67%
Q9Y8J3	Methanococcus voltae	25%	76%