Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Esterase PHB depolymerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPY1_LEIBR

TriTrypDb:

LbrM.35.4890 , LBRM2903_350059700

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	6
GO:0005576	extracellular region	2	4

Expansion

Sequence features

A4HPY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPY1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008233	peptidase activity	3	2
GO:0008236	serine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	6
GO:0017171	serine hydrolase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0030600	feruloyl esterase activity	5	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.339
CLV_C14_Caspase3-7	416	420	PF00656	0.467
CLV_NRD_NRD_1	157	159	PF00675	0.491
CLV_NRD_NRD_1	370	372	PF00675	0.691
CLV_NRD_NRD_1	435	437	PF00675	0.807
CLV_NRD_NRD_1	497	499	PF00675	0.685
CLV_NRD_NRD_1	509	511	PF00675	0.711
CLV_PCSK_KEX2_1	157	159	PF00082	0.501
CLV_PCSK_KEX2_1	434	436	PF00082	0.768
CLV_PCSK_KEX2_1	453	455	PF00082	0.766
CLV_PCSK_KEX2_1	497	499	PF00082	0.667
CLV_PCSK_KEX2_1	509	511	PF00082	0.711
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.761
CLV_PCSK_SKI1_1	173	177	PF00082	0.527
CLV_PCSK_SKI1_1	23	27	PF00082	0.478
CLV_PCSK_SKI1_1	435	439	PF00082	0.875
CLV_PCSK_SKI1_1	505	509	PF00082	0.713
CLV_Separin_Metazoa	552	556	PF03568	0.407
DEG_APCC_DBOX_1	40	48	PF00400	0.433
DEG_APCC_DBOX_1	420	428	PF00400	0.465
DEG_APCC_KENBOX_2	131	135	PF00400	0.324
DEG_SPOP_SBC_1	296	300	PF00917	0.311
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.415
DOC_MAPK_gen_1	121	129	PF00069	0.401
DOC_MAPK_gen_1	154	164	PF00069	0.280
DOC_MAPK_gen_1	39	47	PF00069	0.478
DOC_MAPK_gen_1	415	424	PF00069	0.467
DOC_MAPK_HePTP_8	151	163	PF00069	0.299
DOC_MAPK_MEF2A_6	154	163	PF00069	0.382
DOC_MAPK_MEF2A_6	39	46	PF00069	0.433
DOC_MAPK_NFAT4_5	39	47	PF00069	0.433
DOC_MAPK_RevD_3	83	98	PF00069	0.290
DOC_PP1_RVXF_1	319	326	PF00149	0.397
DOC_PP2B_LxvP_1	114	117	PF13499	0.348
DOC_PP2B_LxvP_1	141	144	PF13499	0.268
DOC_PP2B_LxvP_1	52	55	PF13499	0.415
DOC_USP7_MATH_1	395	399	PF00917	0.467
DOC_USP7_MATH_1	78	82	PF00917	0.356
DOC_USP7_UBL2_3	449	453	PF12436	0.563
DOC_WW_Pin1_4	370	375	PF00397	0.458
DOC_WW_Pin1_4	387	392	PF00397	0.421
DOC_WW_Pin1_4	487	492	PF00397	0.471
DOC_WW_Pin1_4	515	520	PF00397	0.449
DOC_WW_Pin1_4	76	81	PF00397	0.401
LIG_14-3-3_CanoR_1	123	127	PF00244	0.328
LIG_14-3-3_CanoR_1	267	273	PF00244	0.420
LIG_14-3-3_CanoR_1	301	305	PF00244	0.396
LIG_14-3-3_CanoR_1	35	43	PF00244	0.638
LIG_14-3-3_CanoR_1	434	440	PF00244	0.496
LIG_14-3-3_CanoR_1	481	486	PF00244	0.477
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_4	177	181	PF00653	0.331
LIG_BRCT_BRCA1_1	381	385	PF00533	0.448
LIG_BRCT_BRCA1_1	485	489	PF00533	0.541
LIG_Clathr_ClatBox_1	553	557	PF01394	0.297
LIG_EH1_1	82	90	PF00400	0.419
LIG_FHA_1	263	269	PF00498	0.250
LIG_FHA_1	288	294	PF00498	0.454
LIG_FHA_1	353	359	PF00498	0.288
LIG_FHA_1	570	576	PF00498	0.368
LIG_FHA_1	62	68	PF00498	0.366
LIG_FHA_2	147	153	PF00498	0.333
LIG_FHA_2	361	367	PF00498	0.401
LIG_GBD_Chelix_1	228	236	PF00786	0.433
LIG_LIR_Gen_1	351	360	PF02991	0.433
LIG_LIR_Gen_1	523	528	PF02991	0.443
LIG_LIR_Nem_3	179	184	PF02991	0.379
LIG_LIR_Nem_3	264	269	PF02991	0.333
LIG_LIR_Nem_3	523	527	PF02991	0.442
LIG_LIR_Nem_3	61	65	PF02991	0.354
LIG_PTB_Apo_2	353	360	PF02174	0.408
LIG_PTB_Phospho_1	353	359	PF10480	0.405
LIG_Rb_LxCxE_1	255	271	PF01857	0.233
LIG_SH2_GRB2like	354	357	PF00017	0.406
LIG_SH2_GRB2like	461	464	PF00017	0.460
LIG_SH2_NCK_1	461	465	PF00017	0.461
LIG_SH2_SRC	461	464	PF00017	0.460
LIG_SH2_STAP1	354	358	PF00017	0.296
LIG_SH2_STAT5	100	103	PF00017	0.400
LIG_SH2_STAT5	142	145	PF00017	0.408
LIG_SH2_STAT5	354	357	PF00017	0.427
LIG_SH2_STAT5	43	46	PF00017	0.292
LIG_SH2_STAT5	511	514	PF00017	0.538
LIG_SH2_STAT5	57	60	PF00017	0.528
LIG_SH2_STAT5	574	577	PF00017	0.421
LIG_SH3_3	114	120	PF00018	0.449
LIG_SH3_3	310	316	PF00018	0.307
LIG_SH3_3	407	413	PF00018	0.462
LIG_SUMO_SIM_anti_2	549	555	PF11976	0.410
LIG_TRAF2_1	2	5	PF00917	0.675
LIG_TRAF2_1	429	432	PF00917	0.470
LIG_UBA3_1	164	173	PF00899	0.371
LIG_UBA3_1	88	97	PF00899	0.284
LIG_WRC_WIRS_1	126	131	PF05994	0.402
MOD_CK1_1	146	152	PF00069	0.434
MOD_CK1_1	297	303	PF00069	0.297
MOD_CK1_1	34	40	PF00069	0.609
MOD_CK1_1	350	356	PF00069	0.412
MOD_CK1_1	523	529	PF00069	0.489
MOD_CK1_1	61	67	PF00069	0.409
MOD_CK2_1	360	366	PF00069	0.411
MOD_CK2_1	395	401	PF00069	0.472
MOD_CK2_1	546	552	PF00069	0.506
MOD_CK2_1	76	82	PF00069	0.346
MOD_Cter_Amidation	432	435	PF01082	0.676
MOD_Cter_Amidation	95	98	PF01082	0.495
MOD_GlcNHglycan	36	39	PF01048	0.398
MOD_GlcNHglycan	374	377	PF01048	0.672
MOD_GlcNHglycan	426	430	PF01048	0.664
MOD_GlcNHglycan	445	448	PF01048	0.753
MOD_GlcNHglycan	73	76	PF01048	0.523
MOD_GSK3_1	128	135	PF00069	0.365
MOD_GSK3_1	176	183	PF00069	0.307
MOD_GSK3_1	191	198	PF00069	0.324
MOD_GSK3_1	296	303	PF00069	0.409
MOD_GSK3_1	30	37	PF00069	0.626
MOD_GSK3_1	344	351	PF00069	0.450
MOD_GSK3_1	477	484	PF00069	0.537
MOD_GSK3_1	99	106	PF00069	0.403
MOD_N-GLC_1	481	486	PF02516	0.692
MOD_N-GLC_1	520	525	PF02516	0.647
MOD_N-GLC_2	339	341	PF02516	0.618
MOD_NEK2_1	176	181	PF00069	0.378
MOD_NEK2_1	191	196	PF00069	0.243
MOD_NEK2_1	232	237	PF00069	0.391
MOD_NEK2_1	58	63	PF00069	0.483
MOD_PIKK_1	427	433	PF00454	0.467
MOD_PIKK_1	435	441	PF00454	0.464
MOD_PIKK_1	546	552	PF00454	0.431
MOD_PKA_1	435	441	PF00069	0.558
MOD_PKA_1	509	515	PF00069	0.443
MOD_PKA_2	122	128	PF00069	0.284
MOD_PKA_2	300	306	PF00069	0.395
MOD_PKA_2	31	37	PF00069	0.623
MOD_PKA_2	435	441	PF00069	0.570
MOD_PKA_2	509	515	PF00069	0.443
MOD_PKB_1	415	423	PF00069	0.518
MOD_PKB_1	481	489	PF00069	0.476
MOD_Plk_1	481	487	PF00069	0.477
MOD_Plk_1	520	526	PF00069	0.445
MOD_Plk_4	122	128	PF00069	0.400
MOD_Plk_4	300	306	PF00069	0.395
MOD_ProDKin_1	370	376	PF00069	0.455
MOD_ProDKin_1	387	393	PF00069	0.422
MOD_ProDKin_1	487	493	PF00069	0.467
MOD_ProDKin_1	515	521	PF00069	0.448
MOD_ProDKin_1	76	82	PF00069	0.406
MOD_SUMO_for_1	385	388	PF00179	0.453
MOD_SUMO_rev_2	343	348	PF00179	0.352
TRG_ENDOCYTIC_2	354	357	PF00928	0.360
TRG_ENDOCYTIC_2	43	46	PF00928	0.246
TRG_ER_diArg_1	156	158	PF00400	0.298
TRG_ER_diArg_1	368	371	PF00400	0.431
TRG_ER_diArg_1	434	436	PF00400	0.516
TRG_ER_diArg_1	508	510	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBJ7	Leishmania donovani	56%	100%
A4IDP2	Leishmania infantum	56%	100%
E9ATP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q0V0	Leishmania major	57%	99%