t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPX8_LEIBR

TriTrypDb:

LbrM.35.4860 , LBRM2903_350059300 , LBRM2903_350059400

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HPX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.573
CLV_C14_Caspase3-7	147	151	PF00656	0.702
CLV_C14_Caspase3-7	289	293	PF00656	0.703
CLV_C14_Caspase3-7	385	389	PF00656	0.639
CLV_NRD_NRD_1	219	221	PF00675	0.492
CLV_NRD_NRD_1	29	31	PF00675	0.392
CLV_PCSK_KEX2_1	175	177	PF00082	0.412
CLV_PCSK_KEX2_1	228	230	PF00082	0.453
CLV_PCSK_KEX2_1	31	33	PF00082	0.368
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.396
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.362
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.368
CLV_PCSK_PC7_1	171	177	PF00082	0.403
CLV_PCSK_SKI1_1	135	139	PF00082	0.573
CLV_PCSK_SKI1_1	307	311	PF00082	0.501
CLV_PCSK_SKI1_1	353	357	PF00082	0.492
CLV_PCSK_SKI1_1	375	379	PF00082	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_CYCLIN_RxL_1	303	314	PF00134	0.697
DOC_CYCLIN_RxL_1	369	379	PF00134	0.593
DOC_MAPK_gen_1	175	181	PF00069	0.522
DOC_PP4_FxxP_1	335	338	PF00568	0.614
DOC_PP4_FxxP_1	445	448	PF00568	0.611
DOC_USP7_MATH_1	137	141	PF00917	0.636
DOC_USP7_MATH_1	286	290	PF00917	0.754
DOC_USP7_MATH_1	39	43	PF00917	0.658
DOC_WW_Pin1_4	73	78	PF00397	0.600
LIG_14-3-3_CanoR_1	15	22	PF00244	0.708
LIG_14-3-3_CanoR_1	162	172	PF00244	0.659
LIG_14-3-3_CanoR_1	251	260	PF00244	0.709
LIG_14-3-3_CanoR_1	279	285	PF00244	0.558
LIG_14-3-3_CanoR_1	353	358	PF00244	0.702
LIG_BRCT_BRCA1_1	255	259	PF00533	0.595
LIG_eIF4E_1	5	11	PF01652	0.628
LIG_FHA_1	267	273	PF00498	0.661
LIG_FHA_1	312	318	PF00498	0.690
LIG_FHA_1	38	44	PF00498	0.677
LIG_FHA_1	447	453	PF00498	0.549
LIG_FHA_1	60	66	PF00498	0.638
LIG_FHA_2	217	223	PF00498	0.605
LIG_FHA_2	31	37	PF00498	0.712
LIG_FHA_2	361	367	PF00498	0.669
LIG_GBD_Chelix_1	452	460	PF00786	0.355
LIG_Integrin_RGD_1	229	231	PF01839	0.410
LIG_Integrin_RGD_1	332	334	PF01839	0.394
LIG_LIR_Apic_2	334	338	PF02991	0.650
LIG_LIR_Apic_2	443	448	PF02991	0.648
LIG_LIR_Gen_1	414	421	PF02991	0.559
LIG_LIR_Nem_3	268	273	PF02991	0.668
LIG_LIR_Nem_3	414	420	PF02991	0.561
LIG_NRBOX	451	457	PF00104	0.376
LIG_PCNA_PIPBox_1	154	163	PF02747	0.494
LIG_Pex14_2	266	270	PF04695	0.705
LIG_SH2_SRC	236	239	PF00017	0.581
LIG_SH2_STAT3	250	253	PF00017	0.595
LIG_SH3_3	435	441	PF00018	0.632
LIG_SUMO_SIM_par_1	462	467	PF11976	0.193
LIG_SUMO_SIM_par_1	93	98	PF11976	0.593
LIG_TRAF2_1	182	185	PF00917	0.591
LIG_TRAF2_1	363	366	PF00917	0.579
LIG_Vh1_VBS_1	201	219	PF01044	0.561
LIG_WRC_WIRS_1	320	325	PF05994	0.563
LIG_WRC_WIRS_1	442	447	PF05994	0.514
MOD_CK1_1	152	158	PF00069	0.559
MOD_CK1_1	400	406	PF00069	0.550
MOD_CK1_1	42	48	PF00069	0.692
MOD_CK1_1	59	65	PF00069	0.493
MOD_CK2_1	163	169	PF00069	0.511
MOD_CK2_1	216	222	PF00069	0.603
MOD_CK2_1	30	36	PF00069	0.685
MOD_CK2_1	313	319	PF00069	0.692
MOD_CK2_1	360	366	PF00069	0.595
MOD_CK2_1	392	398	PF00069	0.477
MOD_CK2_1	6	12	PF00069	0.640
MOD_CK2_1	87	93	PF00069	0.560
MOD_Cter_Amidation	226	229	PF01082	0.414
MOD_GlcNHglycan	128	131	PF01048	0.574
MOD_GlcNHglycan	150	154	PF01048	0.476
MOD_GlcNHglycan	263	266	PF01048	0.586
MOD_GlcNHglycan	292	295	PF01048	0.439
MOD_GlcNHglycan	334	338	PF01048	0.460
MOD_GlcNHglycan	383	387	PF01048	0.384
MOD_GlcNHglycan	65	68	PF01048	0.413
MOD_GlcNHglycan	97	100	PF01048	0.324
MOD_GSK3_1	11	18	PF00069	0.653
MOD_GSK3_1	145	152	PF00069	0.622
MOD_GSK3_1	216	223	PF00069	0.641
MOD_GSK3_1	22	29	PF00069	0.725
MOD_GSK3_1	236	243	PF00069	0.749
MOD_GSK3_1	254	261	PF00069	0.749
MOD_GSK3_1	286	293	PF00069	0.675
MOD_GSK3_1	39	46	PF00069	0.651
MOD_GSK3_1	397	404	PF00069	0.551
MOD_GSK3_1	411	418	PF00069	0.632
MOD_GSK3_1	59	66	PF00069	0.470
MOD_GSK3_1	83	90	PF00069	0.568
MOD_GSK3_1	93	100	PF00069	0.566
MOD_N-GLC_2	213	215	PF02516	0.330
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	104	109	PF00069	0.520
MOD_NEK2_1	124	129	PF00069	0.641
MOD_NEK2_1	216	221	PF00069	0.697
MOD_NEK2_1	266	271	PF00069	0.706
MOD_NEK2_1	411	416	PF00069	0.488
MOD_NEK2_1	43	48	PF00069	0.596
MOD_NEK2_1	56	61	PF00069	0.565
MOD_NEK2_1	83	88	PF00069	0.558
MOD_NEK2_1	95	100	PF00069	0.556
MOD_NEK2_2	280	285	PF00069	0.696
MOD_PIKK_1	145	151	PF00454	0.569
MOD_PIKK_1	397	403	PF00454	0.547
MOD_PKA_1	220	226	PF00069	0.583
MOD_PKA_1	30	36	PF00069	0.566
MOD_PKA_2	14	20	PF00069	0.765
MOD_PKA_2	421	427	PF00069	0.579
MOD_Plk_1	1	7	PF00069	0.641
MOD_Plk_1	392	398	PF00069	0.552
MOD_Plk_2-3	240	246	PF00069	0.584
MOD_Plk_4	39	45	PF00069	0.661
MOD_Plk_4	401	407	PF00069	0.580
MOD_Plk_4	441	447	PF00069	0.580
MOD_Plk_4	83	89	PF00069	0.590
MOD_ProDKin_1	73	79	PF00069	0.595
MOD_SUMO_for_1	182	185	PF00179	0.584
MOD_SUMO_rev_2	128	137	PF00179	0.632
MOD_SUMO_rev_2	383	392	PF00179	0.556
TRG_DiLeu_BaEn_4	365	371	PF01217	0.568
TRG_ER_diArg_1	121	124	PF00400	0.664
TRG_NLS_MonoExtN_4	27	34	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ6	Leptomonas seymouri	53%	100%
A0A3Q8IJ09	Leishmania donovani	72%	100%
A0A422P578	Trypanosoma rangeli	34%	100%
A4IDP0	Leishmania infantum	72%	100%
D0A4C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ATP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q0V3	Leishmania major	71%	100%
V5BUS9	Trypanosoma cruzi	37%	100%