PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPX7_LEIBR

TriTrypDb:

LbrM.35.4840 , LBRM2903_350059200

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.655
CLV_C14_Caspase3-7	50	54	PF00656	0.608
CLV_C14_Caspase3-7	632	636	PF00656	0.593
CLV_NRD_NRD_1	249	251	PF00675	0.589
CLV_NRD_NRD_1	404	406	PF00675	0.480
CLV_NRD_NRD_1	481	483	PF00675	0.271
CLV_NRD_NRD_1	498	500	PF00675	0.271
CLV_NRD_NRD_1	597	599	PF00675	0.569
CLV_NRD_NRD_1	615	617	PF00675	0.378
CLV_NRD_NRD_1	642	644	PF00675	0.592
CLV_NRD_NRD_1	675	677	PF00675	0.418
CLV_NRD_NRD_1	679	681	PF00675	0.470
CLV_NRD_NRD_1	751	753	PF00675	0.587
CLV_NRD_NRD_1	794	796	PF00675	0.459
CLV_NRD_NRD_1	95	97	PF00675	0.691
CLV_PCSK_FUR_1	792	796	PF00082	0.460
CLV_PCSK_KEX2_1	249	251	PF00082	0.591
CLV_PCSK_KEX2_1	386	388	PF00082	0.528
CLV_PCSK_KEX2_1	404	406	PF00082	0.456
CLV_PCSK_KEX2_1	481	483	PF00082	0.293
CLV_PCSK_KEX2_1	498	500	PF00082	0.271
CLV_PCSK_KEX2_1	644	646	PF00082	0.586
CLV_PCSK_KEX2_1	675	677	PF00082	0.418
CLV_PCSK_KEX2_1	679	681	PF00082	0.470
CLV_PCSK_KEX2_1	794	796	PF00082	0.459
CLV_PCSK_KEX2_1	94	96	PF00082	0.650
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.516
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.586
CLV_PCSK_PC7_1	675	681	PF00082	0.446
CLV_PCSK_PC7_1	91	97	PF00082	0.524
CLV_PCSK_SKI1_1	121	125	PF00082	0.530
CLV_PCSK_SKI1_1	181	185	PF00082	0.434
CLV_PCSK_SKI1_1	752	756	PF00082	0.506
DEG_APCC_DBOX_1	481	489	PF00400	0.520
DEG_COP1_1	547	554	PF00400	0.474
DEG_SCF_FBW7_1	574	579	PF00400	0.543
DEG_SCF_TRCP1_1	207	213	PF00400	0.603
DEG_SPOP_SBC_1	189	193	PF00917	0.351
DEG_SPOP_SBC_1	447	451	PF00917	0.496
DOC_CKS1_1	69	74	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.562
DOC_MAPK_gen_1	643	654	PF00069	0.467
DOC_MAPK_gen_1	713	722	PF00069	0.485
DOC_MAPK_gen_1	792	802	PF00069	0.362
DOC_MAPK_HePTP_8	642	654	PF00069	0.470
DOC_MAPK_MEF2A_6	645	654	PF00069	0.459
DOC_MAPK_MEF2A_6	794	802	PF00069	0.364
DOC_PP2B_LxvP_1	333	336	PF13499	0.632
DOC_PP2B_LxvP_1	466	469	PF13499	0.520
DOC_PP2B_LxvP_1	738	741	PF13499	0.546
DOC_PP4_FxxP_1	126	129	PF00568	0.580
DOC_PP4_FxxP_1	310	313	PF00568	0.512
DOC_PP4_FxxP_1	381	384	PF00568	0.504
DOC_USP7_MATH_1	189	193	PF00917	0.420
DOC_USP7_MATH_1	205	209	PF00917	0.614
DOC_USP7_MATH_1	210	214	PF00917	0.603
DOC_USP7_MATH_1	268	272	PF00917	0.527
DOC_USP7_MATH_1	281	285	PF00917	0.587
DOC_USP7_MATH_1	303	307	PF00917	0.679
DOC_USP7_MATH_1	339	343	PF00917	0.688
DOC_USP7_MATH_1	354	358	PF00917	0.672
DOC_USP7_MATH_1	422	426	PF00917	0.452
DOC_USP7_MATH_1	440	444	PF00917	0.566
DOC_USP7_MATH_1	447	451	PF00917	0.514
DOC_USP7_MATH_1	566	570	PF00917	0.608
DOC_USP7_MATH_1	580	584	PF00917	0.488
DOC_USP7_MATH_1	74	78	PF00917	0.640
DOC_USP7_UBL2_3	252	256	PF12436	0.525
DOC_WW_Pin1_4	172	177	PF00397	0.383
DOC_WW_Pin1_4	201	206	PF00397	0.649
DOC_WW_Pin1_4	309	314	PF00397	0.668
DOC_WW_Pin1_4	436	441	PF00397	0.616
DOC_WW_Pin1_4	545	550	PF00397	0.512
DOC_WW_Pin1_4	572	577	PF00397	0.559
DOC_WW_Pin1_4	591	596	PF00397	0.508
DOC_WW_Pin1_4	636	641	PF00397	0.575
DOC_WW_Pin1_4	68	73	PF00397	0.719
LIG_14-3-3_CanoR_1	149	157	PF00244	0.460
LIG_14-3-3_CanoR_1	181	186	PF00244	0.429
LIG_14-3-3_CanoR_1	199	205	PF00244	0.605
LIG_14-3-3_CanoR_1	244	248	PF00244	0.654
LIG_14-3-3_CanoR_1	404	412	PF00244	0.411
LIG_14-3-3_CanoR_1	679	686	PF00244	0.448
LIG_14-3-3_CanoR_1	715	723	PF00244	0.475
LIG_14-3-3_CanoR_1	792	802	PF00244	0.443
LIG_14-3-3_CanoR_1	94	101	PF00244	0.676
LIG_Actin_WH2_2	483	500	PF00022	0.520
LIG_Actin_WH2_2	780	796	PF00022	0.461
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BIR_III_3	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	471	475	PF00533	0.415
LIG_deltaCOP1_diTrp_1	543	550	PF00928	0.435
LIG_deltaCOP1_diTrp_1	725	728	PF00928	0.460
LIG_FHA_1	189	195	PF00498	0.457
LIG_FHA_1	325	331	PF00498	0.510
LIG_FHA_1	573	579	PF00498	0.691
LIG_FHA_1	626	632	PF00498	0.470
LIG_FHA_1	636	642	PF00498	0.576
LIG_FHA_1	71	77	PF00498	0.507
LIG_FHA_1	761	767	PF00498	0.543
LIG_FHA_2	107	113	PF00498	0.569
LIG_FHA_2	182	188	PF00498	0.423
LIG_FHA_2	281	287	PF00498	0.554
LIG_FHA_2	32	38	PF00498	0.551
LIG_FHA_2	630	636	PF00498	0.573
LIG_FHA_2	794	800	PF00498	0.415
LIG_GBD_Chelix_1	623	631	PF00786	0.459
LIG_GBD_Chelix_1	686	694	PF00786	0.408
LIG_Integrin_isoDGR_2	242	244	PF01839	0.611
LIG_Integrin_RGD_1	317	319	PF01839	0.517
LIG_LIR_Apic_2	307	313	PF02991	0.520
LIG_LIR_Gen_1	717	724	PF02991	0.511
LIG_LIR_Gen_1	725	734	PF02991	0.439
LIG_LIR_Gen_1	742	751	PF02991	0.608
LIG_LIR_Gen_1	765	775	PF02991	0.503
LIG_LIR_Nem_3	154	159	PF02991	0.518
LIG_LIR_Nem_3	359	365	PF02991	0.351
LIG_LIR_Nem_3	717	722	PF02991	0.513
LIG_LIR_Nem_3	725	731	PF02991	0.432
LIG_LIR_Nem_3	742	748	PF02991	0.604
LIG_NRBOX	626	632	PF00104	0.470
LIG_SH2_CRK	145	149	PF00017	0.547
LIG_SH2_CRK	362	366	PF00017	0.307
LIG_SH2_NCK_1	49	53	PF00017	0.582
LIG_SH2_NCK_1	745	749	PF00017	0.558
LIG_SH2_SRC	20	23	PF00017	0.580
LIG_SH2_SRC	49	52	PF00017	0.579
LIG_SH2_SRC	493	496	PF00017	0.504
LIG_SH2_SRC	603	606	PF00017	0.444
LIG_SH2_SRC	745	748	PF00017	0.562
LIG_SH2_STAP1	190	194	PF00017	0.429
LIG_SH2_STAP1	27	31	PF00017	0.572
LIG_SH2_STAT5	156	159	PF00017	0.546
LIG_SH2_STAT5	185	188	PF00017	0.436
LIG_SH2_STAT5	190	193	PF00017	0.444
LIG_SH2_STAT5	20	23	PF00017	0.580
LIG_SH2_STAT5	326	329	PF00017	0.511
LIG_SH2_STAT5	423	426	PF00017	0.440
LIG_SH2_STAT5	493	496	PF00017	0.471
LIG_SH2_STAT5	596	599	PF00017	0.495
LIG_SH3_3	199	205	PF00018	0.672
LIG_SH3_3	332	338	PF00018	0.518
LIG_SH3_3	382	388	PF00018	0.434
LIG_SH3_3	416	422	PF00018	0.373
LIG_SH3_3	434	440	PF00018	0.610
LIG_SH3_3	497	503	PF00018	0.473
LIG_SH3_3	546	552	PF00018	0.583
LIG_SH3_3	574	580	PF00018	0.541
LIG_SH3_3	66	72	PF00018	0.534
LIG_SUMO_SIM_par_1	31	38	PF11976	0.555
LIG_SUMO_SIM_par_1	729	735	PF11976	0.489
LIG_TRAF2_1	109	112	PF00917	0.569
LIG_TRAF2_1	741	744	PF00917	0.552
LIG_TYR_ITIM	360	365	PF00017	0.337
LIG_WRC_WIRS_1	554	559	PF05994	0.507
LIG_WW_2	335	338	PF00397	0.517
MOD_CDK_SPK_2	201	206	PF00069	0.654
MOD_CDK_SPxxK_3	591	598	PF00069	0.565
MOD_CDK_SPxxK_3	636	643	PF00069	0.578
MOD_CK1_1	175	181	PF00069	0.384
MOD_CK1_1	215	221	PF00069	0.610
MOD_CK1_1	228	234	PF00069	0.677
MOD_CK1_1	556	562	PF00069	0.562
MOD_CK1_1	579	585	PF00069	0.591
MOD_CK1_1	586	592	PF00069	0.474
MOD_CK1_1	608	614	PF00069	0.653
MOD_CK1_1	61	67	PF00069	0.630
MOD_CK1_1	760	766	PF00069	0.545
MOD_CK1_1	77	83	PF00069	0.488
MOD_CK2_1	106	112	PF00069	0.674
MOD_CK2_1	148	154	PF00069	0.448
MOD_CK2_1	181	187	PF00069	0.428
MOD_CK2_1	280	286	PF00069	0.508
MOD_CK2_1	292	298	PF00069	0.509
MOD_CK2_1	31	37	PF00069	0.607
MOD_CK2_1	464	470	PF00069	0.375
MOD_CK2_1	793	799	PF00069	0.418
MOD_Cter_Amidation	614	617	PF01082	0.428
MOD_GlcNHglycan	207	210	PF01048	0.657
MOD_GlcNHglycan	235	238	PF01048	0.688
MOD_GlcNHglycan	257	260	PF01048	0.607
MOD_GlcNHglycan	283	286	PF01048	0.652
MOD_GlcNHglycan	330	333	PF01048	0.604
MOD_GlcNHglycan	405	408	PF01048	0.439
MOD_GlcNHglycan	425	428	PF01048	0.396
MOD_GlcNHglycan	450	453	PF01048	0.586
MOD_GlcNHglycan	515	518	PF01048	0.250
MOD_GlcNHglycan	560	563	PF01048	0.618
MOD_GlcNHglycan	610	613	PF01048	0.517
MOD_GlcNHglycan	682	685	PF01048	0.494
MOD_GlcNHglycan	709	712	PF01048	0.485
MOD_GlcNHglycan	759	762	PF01048	0.566
MOD_GlcNHglycan	76	79	PF01048	0.625
MOD_GlcNHglycan	772	775	PF01048	0.484
MOD_GlcNHglycan	808	811	PF01048	0.521
MOD_GlcNHglycan	98	101	PF01048	0.654
MOD_GSK3_1	148	155	PF00069	0.450
MOD_GSK3_1	201	208	PF00069	0.681
MOD_GSK3_1	224	231	PF00069	0.681
MOD_GSK3_1	276	283	PF00069	0.592
MOD_GSK3_1	304	311	PF00069	0.661
MOD_GSK3_1	324	331	PF00069	0.546
MOD_GSK3_1	436	443	PF00069	0.609
MOD_GSK3_1	553	560	PF00069	0.646
MOD_GSK3_1	568	575	PF00069	0.675
MOD_GSK3_1	576	583	PF00069	0.569
MOD_GSK3_1	584	591	PF00069	0.542
MOD_GSK3_1	625	632	PF00069	0.467
MOD_GSK3_1	64	71	PF00069	0.586
MOD_GSK3_1	714	721	PF00069	0.486
MOD_GSK3_1	90	97	PF00069	0.529
MOD_N-GLC_1	567	572	PF02516	0.552
MOD_NEK2_1	124	129	PF00069	0.521
MOD_NEK2_1	226	231	PF00069	0.654
MOD_NEK2_1	448	453	PF00069	0.534
MOD_NEK2_1	475	480	PF00069	0.289
MOD_NEK2_1	531	536	PF00069	0.307
MOD_NEK2_1	557	562	PF00069	0.543
MOD_NEK2_1	584	589	PF00069	0.509
MOD_NEK2_1	625	630	PF00069	0.460
MOD_NEK2_1	770	775	PF00069	0.466
MOD_NEK2_1	793	798	PF00069	0.553
MOD_NEK2_2	469	474	PF00069	0.228
MOD_PIKK_1	276	282	PF00454	0.568
MOD_PIKK_1	354	360	PF00454	0.473
MOD_PK_1	794	800	PF00069	0.516
MOD_PKA_1	14	20	PF00069	0.582
MOD_PKA_1	679	685	PF00069	0.484
MOD_PKA_1	752	758	PF00069	0.505
MOD_PKA_1	794	800	PF00069	0.448
MOD_PKA_1	94	100	PF00069	0.533
MOD_PKA_2	127	133	PF00069	0.593
MOD_PKA_2	148	154	PF00069	0.455
MOD_PKA_2	243	249	PF00069	0.801
MOD_PKA_2	324	330	PF00069	0.575
MOD_PKA_2	403	409	PF00069	0.422
MOD_PKA_2	679	685	PF00069	0.484
MOD_PKA_2	714	720	PF00069	0.486
MOD_PKA_2	757	763	PF00069	0.570
MOD_PKA_2	793	799	PF00069	0.449
MOD_PKA_2	90	96	PF00069	0.615
MOD_PKB_1	792	800	PF00069	0.451
MOD_PKB_1	94	102	PF00069	0.655
MOD_Plk_1	469	475	PF00069	0.228
MOD_Plk_1	61	67	PF00069	0.534
MOD_Plk_1	698	704	PF00069	0.448
MOD_Plk_2-3	538	544	PF00069	0.307
MOD_Plk_4	152	158	PF00069	0.436
MOD_Plk_4	181	187	PF00069	0.480
MOD_Plk_4	190	196	PF00069	0.431
MOD_Plk_4	212	218	PF00069	0.730
MOD_Plk_4	31	37	PF00069	0.558
MOD_Plk_4	475	481	PF00069	0.296
MOD_Plk_4	580	586	PF00069	0.528
MOD_Plk_4	718	724	PF00069	0.472
MOD_ProDKin_1	172	178	PF00069	0.378
MOD_ProDKin_1	201	207	PF00069	0.651
MOD_ProDKin_1	309	315	PF00069	0.669
MOD_ProDKin_1	436	442	PF00069	0.614
MOD_ProDKin_1	545	551	PF00069	0.517
MOD_ProDKin_1	572	578	PF00069	0.557
MOD_ProDKin_1	591	597	PF00069	0.501
MOD_ProDKin_1	636	642	PF00069	0.576
MOD_ProDKin_1	68	74	PF00069	0.718
MOD_SUMO_for_1	101	104	PF00179	0.657
MOD_SUMO_rev_2	430	440	PF00179	0.522
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.504
TRG_ENDOCYTIC_2	145	148	PF00928	0.550
TRG_ENDOCYTIC_2	362	365	PF00928	0.304
TRG_ENDOCYTIC_2	49	52	PF00928	0.579
TRG_ENDOCYTIC_2	745	748	PF00928	0.562
TRG_ENDOCYTIC_2	767	770	PF00928	0.655
TRG_ER_diArg_1	480	482	PF00400	0.307
TRG_ER_diArg_1	497	499	PF00400	0.307
TRG_ER_diArg_1	642	645	PF00400	0.591
TRG_ER_diArg_1	647	650	PF00400	0.554
TRG_ER_diArg_1	693	696	PF00400	0.610
TRG_ER_diArg_1	792	795	PF00400	0.466
TRG_ER_diArg_1	94	96	PF00400	0.650
TRG_NES_CRM1_1	729	744	PF08389	0.510
TRG_NLS_MonoExtC_3	642	647	PF00514	0.587
TRG_NLS_MonoExtN_4	640	647	PF00514	0.588
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA05	Leptomonas seymouri	54%	97%
A0A3Q8IHQ6	Leishmania donovani	71%	100%
A4IDN8	Leishmania infantum	71%	100%
E9ATP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q0V5	Leishmania major	71%	99%