U3 small nucleolar RNA-associated protein 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPX6_LEIBR

TriTrypDb:

LbrM.35.4830 , LBRM2903_350059100

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HPX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.652
CLV_C14_Caspase3-7	88	92	PF00656	0.396
CLV_NRD_NRD_1	16	18	PF00675	0.726
CLV_NRD_NRD_1	218	220	PF00675	0.493
CLV_NRD_NRD_1	295	297	PF00675	0.371
CLV_NRD_NRD_1	74	76	PF00675	0.671
CLV_NRD_NRD_1	95	97	PF00675	0.514
CLV_PCSK_KEX2_1	166	168	PF00082	0.378
CLV_PCSK_KEX2_1	218	220	PF00082	0.493
CLV_PCSK_KEX2_1	74	76	PF00082	0.569
CLV_PCSK_KEX2_1	83	85	PF00082	0.519
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.378
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.491
CLV_PCSK_SKI1_1	289	293	PF00082	0.402
CLV_PCSK_SKI1_1	303	307	PF00082	0.423
CLV_PCSK_SKI1_1	368	372	PF00082	0.350
DEG_SCF_FBW7_1	373	379	PF00400	0.415
DOC_ANK_TNKS_1	328	335	PF00023	0.408
DOC_CDC14_PxL_1	405	413	PF14671	0.368
DOC_CKS1_1	35	40	PF01111	0.526
DOC_CKS1_1	373	378	PF01111	0.443
DOC_CYCLIN_RxL_1	286	294	PF00134	0.417
DOC_MAPK_DCC_7	404	413	PF00069	0.368
DOC_MAPK_gen_1	404	413	PF00069	0.379
DOC_MAPK_MEF2A_6	404	413	PF00069	0.482
DOC_PP1_RVXF_1	125	132	PF00149	0.326
DOC_PP2B_LxvP_1	119	122	PF13499	0.357
DOC_USP7_MATH_1	107	111	PF00917	0.589
DOC_USP7_MATH_1	122	126	PF00917	0.423
DOC_USP7_MATH_1	246	250	PF00917	0.409
DOC_USP7_MATH_1	320	324	PF00917	0.537
DOC_USP7_MATH_1	332	336	PF00917	0.232
DOC_USP7_MATH_1	376	380	PF00917	0.482
DOC_USP7_MATH_1	4	8	PF00917	0.439
DOC_USP7_MATH_1	418	422	PF00917	0.435
DOC_USP7_UBL2_3	161	165	PF12436	0.283
DOC_WW_Pin1_4	316	321	PF00397	0.287
DOC_WW_Pin1_4	34	39	PF00397	0.527
DOC_WW_Pin1_4	359	364	PF00397	0.549
DOC_WW_Pin1_4	372	377	PF00397	0.434
DOC_WW_Pin1_4	67	72	PF00397	0.618
LIG_14-3-3_CanoR_1	247	252	PF00244	0.459
LIG_Actin_WH2_2	335	351	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	378	382	PF00533	0.240
LIG_EH1_1	225	233	PF00400	0.415
LIG_FHA_1	168	174	PF00498	0.505
LIG_FHA_1	195	201	PF00498	0.406
LIG_FHA_1	256	262	PF00498	0.372
LIG_FHA_1	300	306	PF00498	0.411
LIG_FHA_1	308	314	PF00498	0.373
LIG_FHA_1	433	439	PF00498	0.358
LIG_FHA_2	202	208	PF00498	0.470
LIG_FHA_2	220	226	PF00498	0.645
LIG_FHA_2	56	62	PF00498	0.632
LIG_Integrin_isoDGR_2	216	218	PF01839	0.522
LIG_LIR_Nem_3	416	420	PF02991	0.374
LIG_MAD2	114	122	PF02301	0.388
LIG_NRBOX	89	95	PF00104	0.428
LIG_PCNA_yPIPBox_3	83	94	PF02747	0.362
LIG_PDZ_Class_2	447	452	PF00595	0.308
LIG_REV1ctd_RIR_1	224	234	PF16727	0.423
LIG_REV1ctd_RIR_1	38	46	PF16727	0.534
LIG_RPA_C_Fungi	242	254	PF08784	0.383
LIG_SH2_STAP1	147	151	PF00017	0.442
LIG_SH2_STAT3	188	191	PF00017	0.386
LIG_SH2_STAT5	147	150	PF00017	0.302
LIG_SH2_STAT5	188	191	PF00017	0.231
LIG_SH3_3	229	235	PF00018	0.389
LIG_SH3_3	412	418	PF00018	0.352
LIG_SH3_3	431	437	PF00018	0.334
LIG_SUMO_SIM_par_1	268	275	PF11976	0.504
LIG_SUMO_SIM_par_1	337	346	PF11976	0.426
LIG_SUMO_SIM_par_1	437	443	PF11976	0.303
LIG_TRAF2_1	7	10	PF00917	0.562
LIG_UBA3_1	366	371	PF00899	0.501
LIG_WRC_WIRS_1	146	151	PF05994	0.441
MOD_CDK_SPxK_1	359	365	PF00069	0.505
MOD_CDK_SPxxK_3	67	74	PF00069	0.567
MOD_CK1_1	125	131	PF00069	0.385
MOD_CK1_1	249	255	PF00069	0.321
MOD_CK1_1	257	263	PF00069	0.340
MOD_CK1_1	299	305	PF00069	0.504
MOD_CK1_1	350	356	PF00069	0.460
MOD_CK1_1	378	384	PF00069	0.270
MOD_CK2_1	219	225	PF00069	0.596
MOD_CK2_1	275	281	PF00069	0.407
MOD_CK2_1	378	384	PF00069	0.296
MOD_CK2_1	4	10	PF00069	0.563
MOD_CK2_1	437	443	PF00069	0.303
MOD_CK2_1	92	98	PF00069	0.503
MOD_Cter_Amidation	216	219	PF01082	0.513
MOD_GlcNHglycan	109	112	PF01048	0.550
MOD_GlcNHglycan	124	127	PF01048	0.413
MOD_GlcNHglycan	268	271	PF01048	0.382
MOD_GlcNHglycan	320	323	PF01048	0.500
MOD_GlcNHglycan	334	337	PF01048	0.320
MOD_GlcNHglycan	349	352	PF01048	0.476
MOD_GlcNHglycan	356	359	PF01048	0.493
MOD_GlcNHglycan	6	9	PF01048	0.502
MOD_GSK3_1	167	174	PF00069	0.495
MOD_GSK3_1	201	208	PF00069	0.428
MOD_GSK3_1	272	279	PF00069	0.448
MOD_GSK3_1	299	306	PF00069	0.412
MOD_GSK3_1	307	314	PF00069	0.407
MOD_GSK3_1	316	323	PF00069	0.420
MOD_GSK3_1	334	341	PF00069	0.322
MOD_GSK3_1	343	350	PF00069	0.365
MOD_GSK3_1	372	379	PF00069	0.331
MOD_GSK3_1	383	390	PF00069	0.399
MOD_GSK3_1	48	55	PF00069	0.438
MOD_GSK3_1	74	81	PF00069	0.422
MOD_N-GLC_1	307	312	PF02516	0.324
MOD_NEK2_1	100	105	PF00069	0.485
MOD_NEK2_1	205	210	PF00069	0.423
MOD_NEK2_1	226	231	PF00069	0.337
MOD_NEK2_1	343	348	PF00069	0.539
MOD_NEK2_1	41	46	PF00069	0.653
MOD_NEK2_1	426	431	PF00069	0.326
MOD_NEK2_1	52	57	PF00069	0.565
MOD_NEK2_2	338	343	PF00069	0.351
MOD_PIKK_1	100	106	PF00454	0.402
MOD_PIKK_1	260	266	PF00454	0.288
MOD_PIKK_1	383	389	PF00454	0.471
MOD_PK_1	114	120	PF00069	0.392
MOD_PK_1	247	253	PF00069	0.385
MOD_PKA_1	296	302	PF00069	0.476
MOD_PKA_1	74	80	PF00069	0.426
MOD_PKA_2	122	128	PF00069	0.403
MOD_PKA_2	208	214	PF00069	0.459
MOD_PKA_2	246	252	PF00069	0.443
MOD_PKA_2	299	305	PF00069	0.350
MOD_PKA_2	74	80	PF00069	0.515
MOD_Plk_1	168	174	PF00069	0.419
MOD_Plk_1	272	278	PF00069	0.341
MOD_Plk_1	343	349	PF00069	0.388
MOD_Plk_4	114	120	PF00069	0.373
MOD_Plk_4	201	207	PF00069	0.438
MOD_Plk_4	257	263	PF00069	0.406
MOD_Plk_4	272	278	PF00069	0.317
MOD_Plk_4	338	344	PF00069	0.358
MOD_Plk_4	387	393	PF00069	0.406
MOD_ProDKin_1	316	322	PF00069	0.296
MOD_ProDKin_1	34	40	PF00069	0.529
MOD_ProDKin_1	359	365	PF00069	0.541
MOD_ProDKin_1	372	378	PF00069	0.434
MOD_ProDKin_1	67	73	PF00069	0.616
MOD_SUMO_rev_2	54	63	PF00179	0.630
TRG_DiLeu_BaEn_1	369	374	PF01217	0.484
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.485
TRG_ER_diArg_1	327	330	PF00400	0.315
TRG_NLS_MonoExtC_3	16	21	PF00514	0.429
TRG_NLS_MonoExtC_3	82	88	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A9	Leptomonas seymouri	73%	100%
A0A0S4JN39	Bodo saltans	43%	100%
A0A1X0P106	Trypanosomatidae	51%	100%
A0A3Q8IKV5	Leishmania donovani	80%	100%
A0A422P581	Trypanosoma rangeli	52%	100%
A4IDN7	Leishmania infantum	80%	100%
D0A4C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0V6	Leishmania major	80%	100%
Q5SSI6	Mus musculus	25%	82%
Q9Y5J1	Homo sapiens	23%	81%
V5B517	Trypanosoma cruzi	50%	100%