PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania braziliensis

UniProt:

A4HPX4_LEIBR

TriTrypDb:

LbrM.35.4810 , LBRM2903_350058900

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.438
CLV_NRD_NRD_1	409	411	PF00675	0.420
CLV_NRD_NRD_1	472	474	PF00675	0.519
CLV_NRD_NRD_1	519	521	PF00675	0.296
CLV_PCSK_KEX2_1	409	411	PF00082	0.434
CLV_PCSK_KEX2_1	474	476	PF00082	0.451
CLV_PCSK_KEX2_1	519	521	PF00082	0.306
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.416
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.451
CLV_PCSK_SKI1_1	21	25	PF00082	0.373
CLV_PCSK_SKI1_1	379	383	PF00082	0.495
CLV_PCSK_SKI1_1	411	415	PF00082	0.389
CLV_PCSK_SKI1_1	548	552	PF00082	0.296
CLV_Separin_Metazoa	564	568	PF03568	0.296
DEG_APCC_DBOX_1	11	19	PF00400	0.531
DEG_SCF_FBW7_1	115	122	PF00400	0.534
DEG_SPOP_SBC_1	217	221	PF00917	0.516
DOC_CYCLIN_RxL_1	189	200	PF00134	0.599
DOC_CYCLIN_RxL_1	32	43	PF00134	0.450
DOC_MAPK_gen_1	375	383	PF00069	0.478
DOC_MAPK_gen_1	473	482	PF00069	0.400
DOC_MAPK_gen_1	571	581	PF00069	0.296
DOC_MAPK_JIP1_4	377	383	PF00069	0.476
DOC_MAPK_MEF2A_6	434	442	PF00069	0.338
DOC_MAPK_MEF2A_6	473	482	PF00069	0.400
DOC_PP1_RVXF_1	546	553	PF00149	0.296
DOC_PP2B_LxvP_1	381	384	PF13499	0.397
DOC_PP2B_LxvP_1	92	95	PF13499	0.493
DOC_PP4_MxPP_1	206	209	PF00568	0.599
DOC_USP7_MATH_1	119	123	PF00917	0.579
DOC_USP7_MATH_1	127	131	PF00917	0.643
DOC_USP7_MATH_1	348	352	PF00917	0.569
DOC_USP7_MATH_1	64	68	PF00917	0.530
DOC_WW_Pin1_4	105	110	PF00397	0.650
DOC_WW_Pin1_4	115	120	PF00397	0.555
DOC_WW_Pin1_4	186	191	PF00397	0.582
DOC_WW_Pin1_4	245	250	PF00397	0.635
DOC_WW_Pin1_4	297	302	PF00397	0.606
DOC_WW_Pin1_4	387	392	PF00397	0.478
LIG_14-3-3_CanoR_1	129	138	PF00244	0.510
LIG_14-3-3_CanoR_1	20	30	PF00244	0.419
LIG_14-3-3_CanoR_1	500	507	PF00244	0.296
LIG_Actin_WH2_2	484	502	PF00022	0.415
LIG_BIR_III_4	338	342	PF00653	0.603
LIG_BRCT_BRCA1_1	275	279	PF00533	0.629
LIG_FHA_1	34	40	PF00498	0.420
LIG_FHA_1	481	487	PF00498	0.333
LIG_FHA_2	218	224	PF00498	0.509
LIG_FHA_2	22	28	PF00498	0.375
LIG_FHA_2	511	517	PF00498	0.296
LIG_LIR_Apic_2	418	424	PF02991	0.369
LIG_LIR_Gen_1	278	288	PF02991	0.486
LIG_LIR_Gen_1	40	48	PF02991	0.446
LIG_LIR_Gen_1	426	433	PF02991	0.374
LIG_LIR_LC3C_4	437	442	PF02991	0.316
LIG_LIR_Nem_3	278	284	PF02991	0.525
LIG_LIR_Nem_3	40	44	PF02991	0.452
LIG_LIR_Nem_3	426	430	PF02991	0.374
LIG_LIR_Nem_3	561	565	PF02991	0.296
LIG_LIR_Nem_3	78	83	PF02991	0.636
LIG_MYND_1	309	313	PF01753	0.630
LIG_MYND_1	60	64	PF01753	0.517
LIG_MYND_1	77	81	PF01753	0.503
LIG_PCNA_yPIPBox_3	153	162	PF02747	0.651
LIG_SH2_CRK	72	76	PF00017	0.518
LIG_SH2_GRB2like	72	75	PF00017	0.643
LIG_SH2_NCK_1	72	76	PF00017	0.518
LIG_SH2_PTP2	421	424	PF00017	0.356
LIG_SH2_PTP2	427	430	PF00017	0.343
LIG_SH2_SRC	427	430	PF00017	0.343
LIG_SH2_STAP1	304	308	PF00017	0.605
LIG_SH2_STAT3	554	557	PF00017	0.296
LIG_SH2_STAT5	161	164	PF00017	0.639
LIG_SH2_STAT5	304	307	PF00017	0.643
LIG_SH2_STAT5	421	424	PF00017	0.356
LIG_SH2_STAT5	427	430	PF00017	0.343
LIG_SH2_STAT5	443	446	PF00017	0.335
LIG_SH3_3	184	190	PF00018	0.706
LIG_SH3_3	295	301	PF00018	0.631
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.570
LIG_SUMO_SIM_par_1	256	262	PF11976	0.570
LIG_SUMO_SIM_par_1	535	540	PF11976	0.296
LIG_TYR_ITIM	39	44	PF00017	0.453
LIG_WRC_WIRS_1	570	575	PF05994	0.296
MOD_CDC14_SPxK_1	189	192	PF00782	0.521
MOD_CDK_SPK_2	186	191	PF00069	0.514
MOD_CDK_SPxK_1	115	121	PF00069	0.608
MOD_CDK_SPxK_1	186	192	PF00069	0.638
MOD_CDK_SPxK_1	387	393	PF00069	0.539
MOD_CK1_1	130	136	PF00069	0.511
MOD_CK1_1	154	160	PF00069	0.591
MOD_CK1_1	178	184	PF00069	0.700
MOD_CK1_1	197	203	PF00069	0.498
MOD_CK1_1	216	222	PF00069	0.528
MOD_CK1_1	267	273	PF00069	0.725
MOD_CK2_1	253	259	PF00069	0.526
MOD_CK2_1	280	286	PF00069	0.486
MOD_CK2_1	37	43	PF00069	0.454
MOD_CK2_1	397	403	PF00069	0.432
MOD_CK2_1	510	516	PF00069	0.296
MOD_GlcNHglycan	163	166	PF01048	0.566
MOD_GlcNHglycan	215	218	PF01048	0.603
MOD_GlcNHglycan	267	270	PF01048	0.577
MOD_GlcNHglycan	306	309	PF01048	0.538
MOD_GlcNHglycan	451	455	PF01048	0.499
MOD_GlcNHglycan	459	462	PF01048	0.552
MOD_GlcNHglycan	66	69	PF01048	0.570
MOD_GSK3_1	115	122	PF00069	0.584
MOD_GSK3_1	127	134	PF00069	0.513
MOD_GSK3_1	197	204	PF00069	0.540
MOD_GSK3_1	213	220	PF00069	0.481
MOD_GSK3_1	228	235	PF00069	0.556
MOD_GSK3_1	237	244	PF00069	0.686
MOD_GSK3_1	267	274	PF00069	0.627
MOD_GSK3_1	33	40	PF00069	0.418
MOD_GSK3_1	457	464	PF00069	0.546
MOD_GSK3_1	75	82	PF00069	0.603
MOD_N-GLC_1	115	120	PF02516	0.608
MOD_N-GLC_1	154	159	PF02516	0.648
MOD_N-GLC_1	166	171	PF02516	0.466
MOD_N-GLC_1	200	205	PF02516	0.668
MOD_N-GLC_1	237	242	PF02516	0.627
MOD_N-GLC_1	264	269	PF02516	0.597
MOD_N-GLC_1	271	276	PF02516	0.591
MOD_N-GLC_1	302	307	PF02516	0.590
MOD_N-GLC_1	494	499	PF02516	0.393
MOD_NEK2_1	131	136	PF00069	0.578
MOD_NEK2_1	166	171	PF00069	0.506
MOD_NEK2_1	183	188	PF00069	0.568
MOD_NEK2_1	194	199	PF00069	0.589
MOD_NEK2_1	229	234	PF00069	0.653
MOD_NEK2_1	264	269	PF00069	0.570
MOD_NEK2_1	365	370	PF00069	0.418
MOD_NEK2_1	37	42	PF00069	0.454
MOD_NEK2_1	465	470	PF00069	0.471
MOD_NEK2_1	482	487	PF00069	0.393
MOD_NEK2_1	510	515	PF00069	0.296
MOD_NEK2_1	530	535	PF00069	0.306
MOD_NEK2_1	569	574	PF00069	0.296
MOD_NEK2_2	353	358	PF00069	0.488
MOD_PIKK_1	194	200	PF00454	0.604
MOD_PIKK_1	312	318	PF00454	0.543
MOD_PIKK_1	4	10	PF00454	0.529
MOD_PIKK_1	510	516	PF00454	0.329
MOD_PKA_1	548	554	PF00069	0.296
MOD_Plk_1	221	227	PF00069	0.553
MOD_Plk_1	241	247	PF00069	0.655
MOD_Plk_1	274	280	PF00069	0.496
MOD_Plk_1	465	471	PF00069	0.439
MOD_Plk_1	530	536	PF00069	0.296
MOD_Plk_4	14	20	PF00069	0.457
MOD_Plk_4	202	208	PF00069	0.552
MOD_Plk_4	241	247	PF00069	0.602
MOD_Plk_4	253	259	PF00069	0.526
MOD_Plk_4	280	286	PF00069	0.486
MOD_Plk_4	423	429	PF00069	0.408
MOD_Plk_4	482	488	PF00069	0.442
MOD_Plk_4	494	500	PF00069	0.282
MOD_Plk_4	548	554	PF00069	0.296
MOD_Plk_4	75	81	PF00069	0.609
MOD_ProDKin_1	105	111	PF00069	0.652
MOD_ProDKin_1	115	121	PF00069	0.555
MOD_ProDKin_1	186	192	PF00069	0.587
MOD_ProDKin_1	245	251	PF00069	0.631
MOD_ProDKin_1	297	303	PF00069	0.606
MOD_ProDKin_1	387	393	PF00069	0.480
MOD_SUMO_rev_2	540	550	PF00179	0.296
TRG_DiLeu_BaEn_1	436	441	PF01217	0.322
TRG_ENDOCYTIC_2	285	288	PF00928	0.484
TRG_ENDOCYTIC_2	41	44	PF00928	0.455
TRG_ENDOCYTIC_2	427	430	PF00928	0.343
TRG_ENDOCYTIC_2	570	573	PF00928	0.296
TRG_ENDOCYTIC_2	72	75	PF00928	0.585
TRG_ER_diArg_1	375	378	PF00400	0.457
TRG_ER_diArg_1	410	413	PF00400	0.412
TRG_ER_diArg_1	472	475	PF00400	0.421
TRG_ER_diArg_1	573	576	PF00400	0.296
TRG_NES_CRM1_1	43	57	PF08389	0.464
TRG_NLS_MonoCore_2	408	413	PF00514	0.354
TRG_NLS_MonoCore_2	472	477	PF00514	0.478
TRG_NLS_MonoExtN_4	409	414	PF00514	0.358
TRG_NLS_MonoExtN_4	473	478	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P823	Leptomonas seymouri	59%	95%
A0A3Q8ILF1	Leishmania donovani	80%	100%
E9ATP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q0V8	Leishmania major	78%	100%