Myosin heavy chain kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myosin heavy chain kinase a-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPX3_LEIBR

TriTrypDb:

LbrM.35.4800 , LBRM2903_350058800

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	17
GO:0004683	calmodulin-dependent protein kinase activity	5	6
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0016905	myosin heavy chain kinase activity	6	6
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0003676	nucleic acid binding	3	5
GO:0003746	translation elongation factor activity	4	5
GO:0008135	translation factor activity, RNA binding	3	5
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.329
CLV_C14_Caspase3-7	85	89	PF00656	0.304
CLV_NRD_NRD_1	146	148	PF00675	0.340
CLV_NRD_NRD_1	30	32	PF00675	0.381
CLV_NRD_NRD_1	82	84	PF00675	0.274
CLV_PCSK_KEX2_1	145	147	PF00082	0.345
CLV_PCSK_KEX2_1	250	252	PF00082	0.515
CLV_PCSK_KEX2_1	30	32	PF00082	0.430
CLV_PCSK_KEX2_1	93	95	PF00082	0.423
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.334
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.345
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.459
CLV_PCSK_PC7_1	246	252	PF00082	0.329
CLV_PCSK_SKI1_1	136	140	PF00082	0.371
DEG_APCC_DBOX_1	59	67	PF00400	0.338
DEG_SPOP_SBC_1	138	142	PF00917	0.422
DOC_CYCLIN_RxL_1	215	226	PF00134	0.299
DOC_MAPK_gen_1	248	257	PF00069	0.346
DOC_MAPK_MEF2A_6	236	245	PF00069	0.507
DOC_USP7_MATH_1	138	142	PF00917	0.422
DOC_USP7_MATH_1	82	86	PF00917	0.473
DOC_USP7_UBL2_3	206	210	PF12436	0.372
DOC_USP7_UBL2_3	233	237	PF12436	0.458
DOC_WW_Pin1_4	19	24	PF00397	0.369
LIG_BRCT_BRCA1_1	116	120	PF00533	0.331
LIG_BRCT_BRCA1_2	116	122	PF00533	0.331
LIG_FHA_1	103	109	PF00498	0.300
LIG_FHA_1	20	26	PF00498	0.297
LIG_FHA_2	159	165	PF00498	0.342
LIG_FHA_2	269	275	PF00498	0.443
LIG_IBAR_NPY_1	240	242	PF08397	0.334
LIG_LIR_Gen_1	155	163	PF02991	0.330
LIG_LIR_Nem_3	117	123	PF02991	0.377
LIG_LIR_Nem_3	125	130	PF02991	0.344
LIG_LIR_Nem_3	155	160	PF02991	0.330
LIG_LIR_Nem_3	239	245	PF02991	0.598
LIG_LIR_Nem_3	95	100	PF02991	0.380
LIG_PCNA_yPIPBox_3	201	210	PF02747	0.422
LIG_Pex14_2	54	58	PF04695	0.309
LIG_REV1ctd_RIR_1	95	105	PF16727	0.331
LIG_SH2_GRB2like	41	44	PF00017	0.416
LIG_SH2_GRB2like	90	93	PF00017	0.285
LIG_SH2_STAP1	278	282	PF00017	0.589
LIG_SH2_STAT3	100	103	PF00017	0.422
LIG_SH2_STAT5	242	245	PF00017	0.466
LIG_SH2_STAT5	41	44	PF00017	0.331
LIG_SH2_STAT5	77	80	PF00017	0.422
LIG_SH3_3	108	114	PF00018	0.290
LIG_SH3_3	258	264	PF00018	0.429
LIG_SH3_3	63	69	PF00018	0.362
LIG_SH3_3	76	82	PF00018	0.380
LIG_TRAF2_1	266	269	PF00917	0.514
MOD_CK1_1	158	164	PF00069	0.344
MOD_CK1_1	165	171	PF00069	0.331
MOD_CK1_1	99	105	PF00069	0.333
MOD_CK2_1	137	143	PF00069	0.416
MOD_CK2_1	158	164	PF00069	0.361
MOD_CK2_1	268	274	PF00069	0.483
MOD_GlcNHglycan	116	119	PF01048	0.387
MOD_GlcNHglycan	164	167	PF01048	0.361
MOD_GlcNHglycan	225	228	PF01048	0.351
MOD_GSK3_1	114	121	PF00069	0.326
MOD_GSK3_1	158	165	PF00069	0.337
MOD_GSK3_1	223	230	PF00069	0.376
MOD_GSK3_1	92	99	PF00069	0.409
MOD_N-GLC_1	31	36	PF02516	0.399
MOD_N-GLC_1	69	74	PF02516	0.404
MOD_NEK2_1	162	167	PF00069	0.325
MOD_NEK2_1	280	285	PF00069	0.530
MOD_PIKK_1	145	151	PF00454	0.211
MOD_PIKK_1	280	286	PF00454	0.367
MOD_PIKK_1	99	105	PF00454	0.353
MOD_PKA_1	145	151	PF00069	0.445
MOD_PKA_2	118	124	PF00069	0.489
MOD_PKA_2	145	151	PF00069	0.445
MOD_PKA_2	82	88	PF00069	0.419
MOD_Plk_1	69	75	PF00069	0.422
MOD_Plk_2-3	268	274	PF00069	0.564
MOD_Plk_4	165	171	PF00069	0.325
MOD_ProDKin_1	19	25	PF00069	0.369
MOD_SUMO_rev_2	129	138	PF00179	0.369
MOD_SUMO_rev_2	189	194	PF00179	0.379
MOD_SUMO_rev_2	232	238	PF00179	0.570
MOD_SUMO_rev_2	38	47	PF00179	0.183
TRG_ENDOCYTIC_2	127	130	PF00928	0.354
TRG_ENDOCYTIC_2	242	245	PF00928	0.476
TRG_ER_diArg_1	255	258	PF00400	0.514
TRG_ER_diArg_1	29	31	PF00400	0.430
TRG_NLS_Bipartite_1	135	149	PF00514	0.289
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L4	Leptomonas seymouri	80%	90%
A0A0S4J072	Bodo saltans	60%	67%
A0A1X0NJ27	Trypanosomatidae	59%	82%
A0A3Q8IGH4	Leishmania donovani	88%	86%
A0A3Q8IJS7	Leishmania donovani	57%	78%
A4HPX1	Leishmania braziliensis	58%	100%
A4IDN3	Leishmania infantum	57%	78%
A4IDN5	Leishmania infantum	88%	86%
C9ZME6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	88%
C9ZWN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	88%
E9ATN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	78%
E9ATN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	86%
Q4Q0U3	Leishmania major	87%	100%
Q4Q0W0	Leishmania major	57%	100%
V5AN54	Trypanosoma cruzi	60%	87%