Elongation factor-2 kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-2 kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPX1_LEIBR

TriTrypDb:

LbrM.35.4780 , LBRM2903_350058600

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0016310	phosphorylation	5	18
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:1901564	organonitrogen compound metabolic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003676	nucleic acid binding	3	6
GO:0003746	translation elongation factor activity	4	6
GO:0003824	catalytic activity	1	18
GO:0004672	protein kinase activity	3	18
GO:0004674	protein serine/threonine kinase activity	4	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0008135	translation factor activity, RNA binding	3	6
GO:0016301	kinase activity	4	18
GO:0016740	transferase activity	2	18
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	18
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0045182	translation regulator activity	1	6
GO:0090079	translation regulator activity, nucleic acid binding	2	6
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0004683	calmodulin-dependent protein kinase activity	5	5
GO:0016905	myosin heavy chain kinase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	162	164	PF00082	0.404
CLV_PCSK_KEX2_1	205	207	PF00082	0.390
CLV_PCSK_KEX2_1	214	216	PF00082	0.389
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.445
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.369
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.375
CLV_PCSK_SKI1_1	137	141	PF00082	0.345
CLV_PCSK_SKI1_1	295	299	PF00082	0.508
DEG_APCC_DBOX_1	136	144	PF00400	0.219
DOC_CYCLIN_RxL_1	159	168	PF00134	0.197
DOC_MAPK_gen_1	213	222	PF00069	0.450
DOC_PP1_RVXF_1	160	167	PF00149	0.197
DOC_PP1_RVXF_1	73	79	PF00149	0.392
DOC_USP7_MATH_1	10	14	PF00917	0.503
DOC_USP7_UBL2_3	201	205	PF12436	0.181
DOC_USP7_UBL2_3	291	295	PF12436	0.529
DOC_WW_Pin1_4	15	20	PF00397	0.678
LIG_14-3-3_CanoR_1	137	143	PF00244	0.303
LIG_14-3-3_CanoR_1	170	178	PF00244	0.425
LIG_14-3-3_CanoR_1	67	76	PF00244	0.459
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BIR_III_1	1	5	PF00653	0.437
LIG_BIR_III_3	1	5	PF00653	0.437
LIG_BRCT_BRCA1_1	106	110	PF00533	0.450
LIG_Clathr_ClatBox_1	178	182	PF01394	0.334
LIG_Clathr_ClatBox_1	219	223	PF01394	0.492
LIG_CSL_BTD_1	16	19	PF09270	0.438
LIG_FHA_1	145	151	PF00498	0.420
LIG_FHA_1	21	27	PF00498	0.500
LIG_FHA_1	71	77	PF00498	0.425
LIG_FHA_2	227	233	PF00498	0.324
LIG_FHA_2	302	308	PF00498	0.395
LIG_LIR_Gen_1	124	132	PF02991	0.492
LIG_LIR_Gen_1	223	231	PF02991	0.309
LIG_LIR_Gen_1	311	320	PF02991	0.520
LIG_LIR_Nem_3	124	129	PF02991	0.433
LIG_LIR_Nem_3	186	192	PF02991	0.360
LIG_LIR_Nem_3	193	199	PF02991	0.332
LIG_LIR_Nem_3	223	228	PF02991	0.309
LIG_LIR_Nem_3	311	316	PF02991	0.567
LIG_MLH1_MIPbox_1	106	110	PF16413	0.392
LIG_NRBOX	352	358	PF00104	0.435
LIG_REV1ctd_RIR_1	164	174	PF16727	0.308
LIG_SH2_CRK	313	317	PF00017	0.424
LIG_SH2_GRB2like	109	112	PF00017	0.401
LIG_SH2_STAP1	192	196	PF00017	0.259
LIG_SH2_STAP1	349	353	PF00017	0.603
LIG_SH2_STAP1	46	50	PF00017	0.285
LIG_SH2_STAT3	349	352	PF00017	0.433
LIG_SH2_STAT5	109	112	PF00017	0.295
LIG_SH2_STAT5	192	195	PF00017	0.350
LIG_SH2_STAT5	44	47	PF00017	0.359
LIG_SH3_3	126	132	PF00018	0.380
LIG_SH3_3	34	40	PF00018	0.436
LIG_SH3_3	59	65	PF00018	0.322
LIG_SH3_4	291	298	PF00018	0.342
LIG_TRAF2_1	208	211	PF00917	0.392
LIG_TRAF2_1	342	345	PF00917	0.459
LIG_TRAF2_1	79	82	PF00917	0.259
LIG_TRAF2_2	325	330	PF00917	0.388
LIG_UBA3_1	331	336	PF00899	0.451
LIG_WRC_WIRS_1	139	144	PF05994	0.284
MOD_CK1_1	168	174	PF00069	0.311
MOD_CK1_1	226	232	PF00069	0.295
MOD_CK1_1	233	239	PF00069	0.295
MOD_CK1_1	308	314	PF00069	0.560
MOD_CK1_1	339	345	PF00069	0.494
MOD_CK1_1	70	76	PF00069	0.262
MOD_CK2_1	19	25	PF00069	0.509
MOD_CK2_1	205	211	PF00069	0.413
MOD_CK2_1	226	232	PF00069	0.344
MOD_CK2_1	301	307	PF00069	0.461
MOD_CK2_1	339	345	PF00069	0.499
MOD_GlcNHglycan	173	176	PF01048	0.306
MOD_GlcNHglycan	207	210	PF01048	0.278
MOD_GlcNHglycan	232	235	PF01048	0.344
MOD_GlcNHglycan	353	356	PF01048	0.479
MOD_GSK3_1	15	22	PF00069	0.591
MOD_GSK3_1	165	172	PF00069	0.270
MOD_GSK3_1	187	194	PF00069	0.281
MOD_GSK3_1	226	233	PF00069	0.307
MOD_GSK3_1	301	308	PF00069	0.406
MOD_GSK3_1	315	322	PF00069	0.548
MOD_GSK3_1	332	339	PF00069	0.441
MOD_GSK3_1	351	358	PF00069	0.355
MOD_GSK3_1	83	90	PF00069	0.469
MOD_N-GLC_1	187	192	PF02516	0.401
MOD_N-GLC_1	305	310	PF02516	0.441
MOD_N-GLC_1	99	104	PF02516	0.381
MOD_NEK2_1	230	235	PF00069	0.295
MOD_NEK2_1	293	298	PF00069	0.354
MOD_NEK2_1	319	324	PF00069	0.562
MOD_NEK2_1	351	356	PF00069	0.550
MOD_NEK2_1	83	88	PF00069	0.433
MOD_PIKK_1	319	325	PF00454	0.560
MOD_PIKK_1	67	73	PF00454	0.360
MOD_PKA_1	205	211	PF00069	0.259
MOD_PKA_2	169	175	PF00069	0.425
MOD_PKA_2	205	211	PF00069	0.259
MOD_PKA_2	301	307	PF00069	0.554
MOD_PKA_2	308	314	PF00069	0.571
MOD_Plk_1	99	105	PF00069	0.239
MOD_Plk_4	138	144	PF00069	0.392
MOD_Plk_4	233	239	PF00069	0.308
MOD_Plk_4	308	314	PF00069	0.433
MOD_Plk_4	55	61	PF00069	0.451
MOD_ProDKin_1	15	21	PF00069	0.681
MOD_SUMO_rev_2	257	262	PF00179	0.362
TRG_DiLeu_BaEn_1	34	39	PF01217	0.349
TRG_ENDOCYTIC_2	200	203	PF00928	0.371
TRG_ENDOCYTIC_2	312	315	PF00928	0.466
TRG_ER_diArg_1	215	218	PF00400	0.360
TRG_NLS_MonoExtN_4	213	218	PF00514	0.351
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L4	Leptomonas seymouri	53%	100%
A0A0S4IVQ7	Bodo saltans	33%	82%
A0A0S4J072	Bodo saltans	52%	84%
A0A1X0NJ27	Trypanosomatidae	46%	100%
A0A3Q8IGH4	Leishmania donovani	55%	100%
A0A3Q8IJS7	Leishmania donovani	80%	97%
A4HPX3	Leishmania braziliensis	58%	100%
A4IDN3	Leishmania infantum	80%	97%
A4IDN5	Leishmania infantum	55%	100%
C9ZME6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZWN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%
E9ATN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q0U3	Leishmania major	54%	100%
Q4Q0W0	Leishmania major	82%	100%
V5AN54	Trypanosoma cruzi	49%	100%