Putative ABC1 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPX0_LEIBR

TriTrypDb:

LbrM.35.4770 , LBRM2903_350058500

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPX0

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.390
CLV_C14_Caspase3-7	6	10	PF00656	0.430
CLV_NRD_NRD_1	197	199	PF00675	0.190
CLV_NRD_NRD_1	501	503	PF00675	0.358
CLV_PCSK_KEX2_1	197	199	PF00082	0.266
CLV_PCSK_KEX2_1	344	346	PF00082	0.380
CLV_PCSK_KEX2_1	390	392	PF00082	0.321
CLV_PCSK_KEX2_1	501	503	PF00082	0.358
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.380
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.321
CLV_PCSK_SKI1_1	123	127	PF00082	0.419
CLV_PCSK_SKI1_1	198	202	PF00082	0.239
CLV_PCSK_SKI1_1	366	370	PF00082	0.294
CLV_PCSK_SKI1_1	429	433	PF00082	0.318
CLV_PCSK_SKI1_1	81	85	PF00082	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.457
DEG_SPOP_SBC_1	42	46	PF00917	0.659
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.601
DOC_MAPK_gen_1	140	148	PF00069	0.346
DOC_MAPK_gen_1	388	397	PF00069	0.293
DOC_MAPK_gen_1	501	509	PF00069	0.352
DOC_MAPK_HePTP_8	477	489	PF00069	0.291
DOC_MAPK_MEF2A_6	233	242	PF00069	0.295
DOC_MAPK_MEF2A_6	259	266	PF00069	0.213
DOC_MAPK_MEF2A_6	480	489	PF00069	0.297
DOC_MAPK_NFAT4_5	259	267	PF00069	0.228
DOC_PP2B_LxvP_1	489	492	PF13499	0.411
DOC_PP2B_LxvP_1	69	72	PF13499	0.440
DOC_PP4_FxxP_1	176	179	PF00568	0.380
DOC_PP4_FxxP_1	314	317	PF00568	0.253
DOC_USP7_MATH_1	210	214	PF00917	0.266
DOC_USP7_MATH_1	48	52	PF00917	0.656
DOC_WW_Pin1_4	117	122	PF00397	0.415
DOC_WW_Pin1_4	204	209	PF00397	0.437
LIG_14-3-3_CanoR_1	2	12	PF00244	0.681
LIG_14-3-3_CanoR_1	289	293	PF00244	0.380
LIG_14-3-3_CanoR_1	299	304	PF00244	0.380
LIG_14-3-3_CanoR_1	372	378	PF00244	0.266
LIG_Actin_WH2_2	131	149	PF00022	0.380
LIG_Actin_WH2_2	210	225	PF00022	0.380
LIG_BRCT_BRCA1_1	310	314	PF00533	0.380
LIG_BRCT_BRCA1_1	403	407	PF00533	0.291
LIG_EVH1_2	268	272	PF00568	0.248
LIG_FHA_1	323	329	PF00498	0.273
LIG_FHA_1	504	510	PF00498	0.321
LIG_FHA_1	64	70	PF00498	0.561
LIG_FHA_2	362	368	PF00498	0.289
LIG_FHA_2	435	441	PF00498	0.349
LIG_LIR_Apic_2	173	179	PF02991	0.266
LIG_LIR_Apic_2	311	317	PF02991	0.269
LIG_LIR_Gen_1	106	116	PF02991	0.411
LIG_LIR_Gen_1	165	176	PF02991	0.447
LIG_LIR_Gen_1	199	209	PF02991	0.265
LIG_LIR_Gen_1	358	368	PF02991	0.442
LIG_LIR_Gen_1	377	387	PF02991	0.130
LIG_LIR_Gen_1	409	419	PF02991	0.252
LIG_LIR_Nem_3	106	111	PF02991	0.290
LIG_LIR_Nem_3	165	171	PF02991	0.414
LIG_LIR_Nem_3	199	204	PF02991	0.273
LIG_LIR_Nem_3	358	363	PF02991	0.442
LIG_LIR_Nem_3	377	383	PF02991	0.130
LIG_LIR_Nem_3	409	414	PF02991	0.252
LIG_LIR_Nem_3	87	93	PF02991	0.487
LIG_LYPXL_yS_3	244	247	PF13949	0.248
LIG_Pex14_2	104	108	PF04695	0.377
LIG_Pex14_2	369	373	PF04695	0.248
LIG_PTB_Apo_2	379	386	PF02174	0.248
LIG_PTB_Phospho_1	379	385	PF10480	0.380
LIG_SH2_CRK	300	304	PF00017	0.242
LIG_SH2_NCK_1	320	324	PF00017	0.170
LIG_SH2_SRC	333	336	PF00017	0.170
LIG_SH2_SRC	411	414	PF00017	0.266
LIG_SH2_STAP1	290	294	PF00017	0.278
LIG_SH2_STAP1	403	407	PF00017	0.266
LIG_SH2_STAT5	290	293	PF00017	0.365
LIG_SH2_STAT5	315	318	PF00017	0.347
LIG_SH2_STAT5	333	336	PF00017	0.358
LIG_SH2_STAT5	355	358	PF00017	0.266
LIG_SH2_STAT5	393	396	PF00017	0.361
LIG_SH2_STAT5	411	414	PF00017	0.150
LIG_SH3_1	488	494	PF00018	0.299
LIG_SH3_3	228	234	PF00018	0.380
LIG_SH3_3	239	245	PF00018	0.248
LIG_SH3_3	263	269	PF00018	0.326
LIG_SH3_3	488	494	PF00018	0.413
LIG_SH3_3	79	85	PF00018	0.551
LIG_SUMO_SIM_anti_2	409	416	PF11976	0.271
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.295
LIG_SUMO_SIM_par_1	150	157	PF11976	0.427
LIG_SUMO_SIM_par_1	504	511	PF11976	0.285
LIG_SUMO_SIM_par_1	70	78	PF11976	0.440
LIG_TRAF2_1	437	440	PF00917	0.411
LIG_TYR_ITIM	242	247	PF00017	0.248
LIG_UBA3_1	107	115	PF00899	0.519
LIG_WRC_WIRS_1	201	206	PF05994	0.345
LIG_WW_1	494	497	PF00397	0.307
MOD_CDK_SPxK_1	117	123	PF00069	0.423
MOD_CK1_1	250	256	PF00069	0.276
MOD_CK1_1	43	49	PF00069	0.616
MOD_CK1_1	55	61	PF00069	0.644
MOD_CK1_1	67	73	PF00069	0.491
MOD_CK2_1	356	362	PF00069	0.254
MOD_CK2_1	434	440	PF00069	0.342
MOD_CK2_1	71	77	PF00069	0.303
MOD_Cter_Amidation	342	345	PF01082	0.321
MOD_GlcNHglycan	283	287	PF01048	0.364
MOD_GlcNHglycan	310	313	PF01048	0.170
MOD_GlcNHglycan	36	39	PF01048	0.660
MOD_GlcNHglycan	50	53	PF01048	0.569
MOD_GlcNHglycan	503	506	PF01048	0.309
MOD_GlcNHglycan	518	521	PF01048	0.307
MOD_GlcNHglycan	57	60	PF01048	0.482
MOD_GSK3_1	200	207	PF00069	0.349
MOD_GSK3_1	397	404	PF00069	0.423
MOD_GSK3_1	413	420	PF00069	0.161
MOD_GSK3_1	472	479	PF00069	0.458
MOD_GSK3_1	48	55	PF00069	0.637
MOD_GSK3_1	63	70	PF00069	0.561
MOD_N-GLC_1	378	383	PF02516	0.266
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	183	188	PF00069	0.263
MOD_NEK2_1	26	31	PF00069	0.581
MOD_NEK2_1	260	265	PF00069	0.291
MOD_NEK2_1	361	366	PF00069	0.274
MOD_NEK2_1	476	481	PF00069	0.372
MOD_NEK2_1	503	508	PF00069	0.310
MOD_NEK2_1	513	518	PF00069	0.296
MOD_NEK2_2	103	108	PF00069	0.373
MOD_NEK2_2	3	8	PF00069	0.439
MOD_NEK2_2	495	500	PF00069	0.360
MOD_PKA_1	501	507	PF00069	0.310
MOD_PKA_2	1	7	PF00069	0.599
MOD_PKA_2	288	294	PF00069	0.326
MOD_PKA_2	501	507	PF00069	0.310
MOD_Plk_1	156	162	PF00069	0.535
MOD_Plk_1	183	189	PF00069	0.164
MOD_Plk_1	361	367	PF00069	0.170
MOD_Plk_4	103	109	PF00069	0.363
MOD_Plk_4	356	362	PF00069	0.448
MOD_Plk_4	448	454	PF00069	0.311
MOD_Plk_4	472	478	PF00069	0.376
MOD_Plk_4	480	486	PF00069	0.352
MOD_Plk_4	503	509	PF00069	0.367
MOD_ProDKin_1	117	123	PF00069	0.423
MOD_ProDKin_1	204	210	PF00069	0.437
TRG_ENDOCYTIC_2	244	247	PF00928	0.248
TRG_ENDOCYTIC_2	300	303	PF00928	0.248
TRG_ENDOCYTIC_2	320	323	PF00928	0.309
TRG_ENDOCYTIC_2	411	414	PF00928	0.248
TRG_ENDOCYTIC_2	90	93	PF00928	0.446
TRG_ER_diArg_1	196	198	PF00400	0.266
TRG_ER_diArg_1	462	465	PF00400	0.327
TRG_ER_diArg_1	487	490	PF00400	0.387
TRG_ER_diArg_1	501	503	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.239
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U2	Leptomonas seymouri	72%	100%
A0A0S4KEI7	Bodo saltans	25%	100%
A0A1X0P0M1	Trypanosomatidae	56%	94%
A0A1X0P192	Trypanosomatidae	24%	84%
A0A3Q8IPG5	Leishmania donovani	85%	100%
A0A3R7KBH2	Trypanosoma rangeli	26%	82%
A0A3R7RTW5	Trypanosoma rangeli	58%	100%
A1W4D7	Acidovorax sp. (strain JS42)	29%	100%
A3QJU3	Danio rerio	40%	85%
A4IDN2	Leishmania infantum	85%	100%
A9BP42	Delftia acidovorans (strain DSM 14801 / SPH-1)	27%	100%
B9DGY1	Arabidopsis thaliana	25%	77%
D0A4C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	94%
P27697	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P73121	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	94%
P73627	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	91%
Q18486	Caenorhabditis elegans	43%	70%
Q29RI0	Bos taurus	42%	82%
Q4Q0W1	Leishmania major	86%	100%
Q54IH6	Dictyostelium discoideum	38%	94%
Q55680	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	78%
Q566J8	Mus musculus	43%	100%
Q5BJQ0	Rattus norvegicus	42%	82%
Q5M7P6	Xenopus tropicalis	24%	100%
Q5RGU1	Danio rerio	38%	86%
Q60936	Mus musculus	42%	82%
Q6AY19	Rattus norvegicus	43%	100%
Q8NI60	Homo sapiens	42%	82%
Q8RWG1	Arabidopsis thaliana	25%	78%
Q92338	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	87%
Q94BU1	Arabidopsis thaliana	25%	77%
Q96D53	Homo sapiens	43%	98%
Q9SBB2	Arabidopsis thaliana	40%	85%
V5BCS0	Trypanosoma cruzi	26%	84%
V5BQ67	Trypanosoma cruzi	61%	100%