MTS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial N(5)-glutamine methyltransferase MTQ1, putative

Species:

Leishmania braziliensis

UniProt:

A4HPW6_LEIBR

TriTrypDb:

LbrM.35.4730 , LBRM2903_350058100

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0032259	methylation	2	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008276	protein methyltransferase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.454
CLV_PCSK_KEX2_1	212	214	PF00082	0.438
CLV_PCSK_KEX2_1	216	218	PF00082	0.419
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.528
CLV_PCSK_PC7_1	212	218	PF00082	0.499
CLV_PCSK_SKI1_1	138	142	PF00082	0.528
CLV_PCSK_SKI1_1	158	162	PF00082	0.389
CLV_PCSK_SKI1_1	213	217	PF00082	0.418
CLV_PCSK_SKI1_1	30	34	PF00082	0.642
CLV_PCSK_SKI1_1	35	39	PF00082	0.592
CLV_PCSK_SKI1_1	410	414	PF00082	0.423
CLV_PCSK_SKI1_1	436	440	PF00082	0.472
DEG_APCC_DBOX_1	216	224	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.497
DEG_SCF_FBW7_1	74	80	PF00400	0.510
DEG_SPOP_SBC_1	46	50	PF00917	0.550
DOC_CKS1_1	74	79	PF01111	0.510
DOC_CYCLIN_RxL_1	155	162	PF00134	0.543
DOC_CYCLIN_RxL_1	212	224	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.368
DOC_MAPK_gen_1	419	427	PF00069	0.515
DOC_MAPK_gen_1	471	480	PF00069	0.530
DOC_MAPK_MEF2A_6	35	42	PF00069	0.482
DOC_MAPK_MEF2A_6	449	458	PF00069	0.470
DOC_MAPK_MEF2A_6	473	482	PF00069	0.494
DOC_MAPK_NFAT4_5	35	43	PF00069	0.745
DOC_PP2B_LxvP_1	40	43	PF13499	0.715
DOC_PP2B_PxIxI_1	451	457	PF00149	0.486
DOC_USP7_MATH_1	271	275	PF00917	0.552
DOC_USP7_MATH_1	341	345	PF00917	0.517
DOC_USP7_MATH_1	47	51	PF00917	0.679
DOC_USP7_MATH_2	335	341	PF00917	0.400
DOC_WW_Pin1_4	282	287	PF00397	0.599
DOC_WW_Pin1_4	73	78	PF00397	0.487
LIG_14-3-3_CanoR_1	22	28	PF00244	0.646
LIG_14-3-3_CanoR_1	273	280	PF00244	0.633
LIG_14-3-3_CanoR_1	30	39	PF00244	0.694
LIG_14-3-3_CanoR_1	338	346	PF00244	0.520
LIG_14-3-3_CanoR_1	362	371	PF00244	0.458
LIG_14-3-3_CanoR_1	44	53	PF00244	0.576
LIG_14-3-3_CanoR_1	56	63	PF00244	0.657
LIG_14-3-3_CanoR_1	82	87	PF00244	0.771
LIG_APCC_ABBA_1	478	483	PF00400	0.393
LIG_BRCT_BRCA1_1	234	238	PF00533	0.491
LIG_BRCT_BRCA1_1	343	347	PF00533	0.476
LIG_deltaCOP1_diTrp_1	189	196	PF00928	0.378
LIG_deltaCOP1_diTrp_1	257	262	PF00928	0.380
LIG_deltaCOP1_diTrp_1	54	63	PF00928	0.464
LIG_EH1_1	462	470	PF00400	0.515
LIG_FHA_1	294	300	PF00498	0.476
LIG_FHA_1	307	313	PF00498	0.457
LIG_FHA_1	379	385	PF00498	0.517
LIG_FHA_1	409	415	PF00498	0.526
LIG_FHA_1	46	52	PF00498	0.694
LIG_FHA_1	74	80	PF00498	0.555
LIG_FHA_2	124	130	PF00498	0.665
LIG_FHA_2	311	317	PF00498	0.530
LIG_FHA_2	371	377	PF00498	0.578
LIG_FHA_2	403	409	PF00498	0.463
LIG_LIR_Gen_1	337	347	PF02991	0.468
LIG_LIR_Gen_1	381	390	PF02991	0.415
LIG_LIR_Gen_1	421	432	PF02991	0.446
LIG_LIR_Gen_1	472	482	PF02991	0.302
LIG_LIR_Nem_3	260	265	PF02991	0.486
LIG_LIR_Nem_3	344	350	PF02991	0.504
LIG_LIR_Nem_3	381	385	PF02991	0.363
LIG_LIR_Nem_3	421	427	PF02991	0.448
LIG_LIR_Nem_3	472	478	PF02991	0.403
LIG_MYND_1	248	252	PF01753	0.371
LIG_Pex14_1	57	61	PF04695	0.459
LIG_PTB_Apo_2	385	392	PF02174	0.368
LIG_PTB_Phospho_1	385	391	PF10480	0.366
LIG_SH2_CRK	382	386	PF00017	0.508
LIG_SH2_PTP2	391	394	PF00017	0.409
LIG_SH2_SRC	231	234	PF00017	0.374
LIG_SH2_STAP1	382	386	PF00017	0.508
LIG_SH2_STAT3	484	487	PF00017	0.460
LIG_SH2_STAT5	231	234	PF00017	0.349
LIG_SH2_STAT5	391	394	PF00017	0.430
LIG_SH2_STAT5	397	400	PF00017	0.466
LIG_SH2_STAT5	424	427	PF00017	0.378
LIG_SH2_STAT5	71	74	PF00017	0.665
LIG_SH3_3	383	389	PF00018	0.369
LIG_SH3_3	40	46	PF00018	0.474
LIG_SH3_4	439	446	PF00018	0.329
LIG_SUMO_SIM_anti_2	313	320	PF11976	0.537
LIG_TRAF2_1	485	488	PF00917	0.579
LIG_TRAF2_2	394	399	PF00917	0.439
LIG_UBA3_1	160	168	PF00899	0.537
LIG_UBA3_1	219	227	PF00899	0.279
MOD_CDC14_SPxK_1	285	288	PF00782	0.547
MOD_CDK_SPxK_1	282	288	PF00069	0.595
MOD_CK1_1	26	32	PF00069	0.662
MOD_CK1_1	282	288	PF00069	0.550
MOD_CK1_1	308	314	PF00069	0.400
MOD_CK1_1	73	79	PF00069	0.609
MOD_CK1_1	85	91	PF00069	0.749
MOD_CK2_1	128	134	PF00069	0.603
MOD_CK2_1	151	157	PF00069	0.428
MOD_CK2_1	204	210	PF00069	0.599
MOD_CK2_1	215	221	PF00069	0.327
MOD_CK2_1	337	343	PF00069	0.571
MOD_CK2_1	402	408	PF00069	0.466
MOD_CK2_1	81	87	PF00069	0.715
MOD_CMANNOS	259	262	PF00535	0.380
MOD_GlcNHglycan	131	134	PF01048	0.692
MOD_GlcNHglycan	174	178	PF01048	0.416
MOD_GlcNHglycan	25	28	PF01048	0.749
MOD_GlcNHglycan	281	284	PF01048	0.555
MOD_GlcNHglycan	339	342	PF01048	0.383
MOD_GlcNHglycan	355	358	PF01048	0.531
MOD_GlcNHglycan	491	494	PF01048	0.329
MOD_GSK3_1	253	260	PF00069	0.395
MOD_GSK3_1	26	33	PF00069	0.637
MOD_GSK3_1	271	278	PF00069	0.631
MOD_GSK3_1	306	313	PF00069	0.562
MOD_GSK3_1	337	344	PF00069	0.566
MOD_GSK3_1	370	377	PF00069	0.448
MOD_GSK3_1	402	409	PF00069	0.478
MOD_GSK3_1	73	80	PF00069	0.642
MOD_GSK3_1	81	88	PF00069	0.697
MOD_N-GLC_1	278	283	PF02516	0.610
MOD_N-GLC_1	363	368	PF02516	0.669
MOD_N-GLC_1	82	87	PF02516	0.697
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	469	474	PF00069	0.446
MOD_NEK2_2	370	375	PF00069	0.545
MOD_NEK2_2	47	52	PF00069	0.467
MOD_NEK2_2	77	82	PF00069	0.519
MOD_PIKK_1	232	238	PF00454	0.488
MOD_PIKK_1	30	36	PF00454	0.597
MOD_PK_1	82	88	PF00069	0.533
MOD_PKA_2	204	210	PF00069	0.595
MOD_PKA_2	272	278	PF00069	0.605
MOD_PKA_2	322	328	PF00069	0.581
MOD_PKA_2	337	343	PF00069	0.404
MOD_PKA_2	418	424	PF00069	0.502
MOD_PKA_2	81	87	PF00069	0.674
MOD_Plk_1	82	88	PF00069	0.697
MOD_Plk_2-3	204	210	PF00069	0.560
MOD_Plk_4	227	233	PF00069	0.444
MOD_ProDKin_1	282	288	PF00069	0.591
MOD_ProDKin_1	73	79	PF00069	0.489
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.382
TRG_ENDOCYTIC_2	265	268	PF00928	0.518
TRG_ENDOCYTIC_2	339	342	PF00928	0.465
TRG_ENDOCYTIC_2	382	385	PF00928	0.445
TRG_ENDOCYTIC_2	397	400	PF00928	0.336
TRG_ENDOCYTIC_2	424	427	PF00928	0.367
TRG_ENDOCYTIC_2	71	74	PF00928	0.480
TRG_ER_diArg_1	20	23	PF00400	0.704
TRG_ER_diArg_1	200	203	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT0	Leptomonas seymouri	56%	100%
A0A0S4K087	Bodo saltans	49%	100%
A0A1X0P0C0	Trypanosomatidae	50%	100%
A0A3R7N4Z4	Trypanosoma rangeli	52%	100%
A0A3S7XBK9	Leishmania donovani	73%	97%
A4IDM8	Leishmania infantum	72%	97%
D0A4B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ATN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	97%
Q4Q0W5	Leishmania major	73%	100%
V5DLL0	Trypanosoma cruzi	52%	100%