Putative amino acid transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HPW5_LEIBR

TriTrypDb:

LbrM.35.4720 , LBRM2903_350058000

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HPW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW5

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015179	L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.474
CLV_MEL_PAP_1	42	48	PF00089	0.345
CLV_NRD_NRD_1	164	166	PF00675	0.439
CLV_NRD_NRD_1	19	21	PF00675	0.478
CLV_NRD_NRD_1	212	214	PF00675	0.593
CLV_NRD_NRD_1	259	261	PF00675	0.394
CLV_NRD_NRD_1	263	265	PF00675	0.377
CLV_NRD_NRD_1	369	371	PF00675	0.568
CLV_NRD_NRD_1	410	412	PF00675	0.322
CLV_NRD_NRD_1	488	490	PF00675	0.306
CLV_NRD_NRD_1	726	728	PF00675	0.391
CLV_PCSK_FUR_1	260	264	PF00082	0.385
CLV_PCSK_FUR_1	744	748	PF00082	0.289
CLV_PCSK_KEX2_1	164	166	PF00082	0.439
CLV_PCSK_KEX2_1	19	21	PF00082	0.478
CLV_PCSK_KEX2_1	212	214	PF00082	0.592
CLV_PCSK_KEX2_1	258	260	PF00082	0.398
CLV_PCSK_KEX2_1	262	264	PF00082	0.370
CLV_PCSK_KEX2_1	369	371	PF00082	0.574
CLV_PCSK_KEX2_1	410	412	PF00082	0.320
CLV_PCSK_KEX2_1	488	490	PF00082	0.317
CLV_PCSK_KEX2_1	726	728	PF00082	0.391
CLV_PCSK_KEX2_1	746	748	PF00082	0.226
CLV_PCSK_PC1ET2_1	746	748	PF00082	0.226
CLV_PCSK_PC7_1	208	214	PF00082	0.569
CLV_PCSK_PC7_1	254	260	PF00082	0.470
CLV_PCSK_PC7_1	722	728	PF00082	0.383
CLV_PCSK_SKI1_1	131	135	PF00082	0.363
CLV_PCSK_SKI1_1	145	149	PF00082	0.392
CLV_PCSK_SKI1_1	264	268	PF00082	0.317
DEG_APCC_DBOX_1	106	114	PF00400	0.495
DEG_APCC_DBOX_1	487	495	PF00400	0.517
DEG_APCC_DBOX_1	738	746	PF00400	0.687
DEG_Nend_UBRbox_3	1	3	PF02207	0.717
DEG_SCF_FBW7_1	38	44	PF00400	0.587
DOC_CKS1_1	299	304	PF01111	0.226
DOC_CKS1_1	38	43	PF01111	0.588
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.376
DOC_MAPK_gen_1	410	421	PF00069	0.533
DOC_MAPK_gen_1	741	751	PF00069	0.615
DOC_MAPK_MEF2A_6	414	423	PF00069	0.500
DOC_MAPK_RevD_3	731	747	PF00069	0.523
DOC_PP1_RVXF_1	32	38	PF00149	0.605
DOC_PP2B_LxvP_1	118	121	PF13499	0.588
DOC_PP2B_LxvP_1	66	69	PF13499	0.376
DOC_PP2B_PxIxI_1	423	429	PF00149	0.311
DOC_PP4_FxxP_1	237	240	PF00568	0.792
DOC_USP7_MATH_1	295	299	PF00917	0.356
DOC_USP7_MATH_1	512	516	PF00917	0.569
DOC_USP7_MATH_1	599	603	PF00917	0.487
DOC_USP7_MATH_1	672	676	PF00917	0.404
DOC_USP7_MATH_1	710	714	PF00917	0.665
DOC_WW_Pin1_4	171	176	PF00397	0.753
DOC_WW_Pin1_4	232	237	PF00397	0.703
DOC_WW_Pin1_4	298	303	PF00397	0.226
DOC_WW_Pin1_4	37	42	PF00397	0.590
DOC_WW_Pin1_4	560	565	PF00397	0.517
DOC_WW_Pin1_4	570	575	PF00397	0.517
DOC_WW_Pin1_4	580	585	PF00397	0.529
DOC_WW_Pin1_4	629	634	PF00397	0.578
DOC_WW_Pin1_4	644	649	PF00397	0.546
DOC_WW_Pin1_4	703	708	PF00397	0.556
LIG_14-3-3_CanoR_1	107	111	PF00244	0.594
LIG_14-3-3_CanoR_1	19	24	PF00244	0.739
LIG_14-3-3_CanoR_1	263	273	PF00244	0.556
LIG_14-3-3_CanoR_1	34	38	PF00244	0.617
LIG_14-3-3_CanoR_1	354	363	PF00244	0.317
LIG_14-3-3_CanoR_1	385	391	PF00244	0.423
LIG_14-3-3_CanoR_1	414	420	PF00244	0.524
LIG_14-3-3_CanoR_1	493	497	PF00244	0.556
LIG_14-3-3_CanoR_1	532	540	PF00244	0.426
LIG_14-3-3_CanoR_1	7	11	PF00244	0.707
LIG_14-3-3_CanoR_1	726	733	PF00244	0.581
LIG_BIR_III_4	103	107	PF00653	0.575
LIG_BIR_III_4	525	529	PF00653	0.426
LIG_BRCT_BRCA1_1	157	161	PF00533	0.620
LIG_BRCT_BRCA1_1	308	312	PF00533	0.444
LIG_BRCT_BRCA1_1	736	740	PF00533	0.621
LIG_BRCT_BRCA1_1	89	93	PF00533	0.425
LIG_CtBP_PxDLS_1	192	198	PF00389	0.667
LIG_deltaCOP1_diTrp_1	331	341	PF00928	0.517
LIG_EH1_1	344	352	PF00400	0.418
LIG_eIF4E_1	458	464	PF01652	0.349
LIG_EVH1_1	237	241	PF00568	0.606
LIG_FHA_1	220	226	PF00498	0.671
LIG_FHA_1	279	285	PF00498	0.346
LIG_FHA_1	301	307	PF00498	0.339
LIG_FHA_1	48	54	PF00498	0.571
LIG_FHA_1	528	534	PF00498	0.558
LIG_FHA_1	560	566	PF00498	0.549
LIG_FHA_1	630	636	PF00498	0.557
LIG_FHA_1	649	655	PF00498	0.544
LIG_FHA_1	664	670	PF00498	0.430
LIG_FHA_2	227	233	PF00498	0.769
LIG_FHA_2	266	272	PF00498	0.249
LIG_FHA_2	299	305	PF00498	0.356
LIG_FHA_2	38	44	PF00498	0.587
LIG_FHA_2	438	444	PF00498	0.274
LIG_FHA_2	498	504	PF00498	0.524
LIG_FHA_2	518	524	PF00498	0.487
LIG_GBD_Chelix_1	77	85	PF00786	0.287
LIG_LIR_Apic_2	105	111	PF02991	0.470
LIG_LIR_Apic_2	235	240	PF02991	0.792
LIG_LIR_Apic_2	298	302	PF02991	0.226
LIG_LIR_Apic_2	395	401	PF02991	0.430
LIG_LIR_Gen_1	332	342	PF02991	0.517
LIG_LIR_Gen_1	343	353	PF02991	0.376
LIG_LIR_Gen_1	380	387	PF02991	0.405
LIG_LIR_Gen_1	461	472	PF02991	0.226
LIG_LIR_Gen_1	573	584	PF02991	0.607
LIG_LIR_Gen_1	686	696	PF02991	0.430
LIG_LIR_Gen_1	94	104	PF02991	0.446
LIG_LIR_LC3C_4	281	284	PF02991	0.249
LIG_LIR_Nem_3	243	248	PF02991	0.629
LIG_LIR_Nem_3	277	282	PF02991	0.451
LIG_LIR_Nem_3	309	315	PF02991	0.385
LIG_LIR_Nem_3	332	338	PF02991	0.556
LIG_LIR_Nem_3	343	349	PF02991	0.367
LIG_LIR_Nem_3	362	366	PF02991	0.319
LIG_LIR_Nem_3	380	384	PF02991	0.231
LIG_LIR_Nem_3	43	49	PF02991	0.590
LIG_LIR_Nem_3	433	439	PF02991	0.267
LIG_LIR_Nem_3	461	467	PF02991	0.226
LIG_LIR_Nem_3	573	579	PF02991	0.607
LIG_LIR_Nem_3	686	691	PF02991	0.430
LIG_LIR_Nem_3	737	743	PF02991	0.627
LIG_LIR_Nem_3	90	96	PF02991	0.411
LIG_LYPXL_yS_3	363	366	PF13949	0.356
LIG_MLH1_MIPbox_1	308	312	PF16413	0.421
LIG_NRBOX	80	86	PF00104	0.430
LIG_PCNA_PIPBox_1	293	302	PF02747	0.226
LIG_PCNA_yPIPBox_3	410	420	PF02747	0.426
LIG_PDZ_Class_3	768	773	PF00595	0.365
LIG_Pex14_2	341	345	PF04695	0.311
LIG_Pex14_2	377	381	PF04695	0.335
LIG_Pex14_2	476	480	PF04695	0.376
LIG_SH2_CRK	245	249	PF00017	0.628
LIG_SH2_CRK	279	283	PF00017	0.353
LIG_SH2_CRK	285	289	PF00017	0.359
LIG_SH2_CRK	361	365	PF00017	0.344
LIG_SH2_CRK	371	375	PF00017	0.304
LIG_SH2_CRK	398	402	PF00017	0.499
LIG_SH2_CRK	96	100	PF00017	0.501
LIG_SH2_NCK_1	108	112	PF00017	0.462
LIG_SH2_NCK_1	398	402	PF00017	0.517
LIG_SH2_PTP2	346	349	PF00017	0.365
LIG_SH2_SRC	361	364	PF00017	0.407
LIG_SH2_STAP1	285	289	PF00017	0.376
LIG_SH2_STAP1	576	580	PF00017	0.607
LIG_SH2_STAP1	8	12	PF00017	0.597
LIG_SH2_STAT3	119	122	PF00017	0.612
LIG_SH2_STAT3	355	358	PF00017	0.356
LIG_SH2_STAT5	127	130	PF00017	0.652
LIG_SH2_STAT5	299	302	PF00017	0.383
LIG_SH2_STAT5	311	314	PF00017	0.393
LIG_SH2_STAT5	346	349	PF00017	0.376
LIG_SH2_STAT5	402	405	PF00017	0.517
LIG_SH2_STAT5	438	441	PF00017	0.376
LIG_SH2_STAT5	73	76	PF00017	0.427
LIG_SH2_STAT5	96	99	PF00017	0.430
LIG_SH3_3	235	241	PF00018	0.615
LIG_SH3_3	35	41	PF00018	0.590
LIG_SH3_3	418	424	PF00018	0.517
LIG_SH3_3	442	448	PF00018	0.407
LIG_SH3_3	630	636	PF00018	0.535
LIG_SH3_3	642	648	PF00018	0.508
LIG_SH3_3	701	707	PF00018	0.501
LIG_SUMO_SIM_anti_2	651	659	PF11976	0.556
LIG_SUMO_SIM_par_1	280	286	PF11976	0.326
LIG_SUMO_SIM_par_1	481	487	PF11976	0.430
LIG_SUMO_SIM_par_1	495	500	PF11976	0.556
LIG_SUMO_SIM_par_1	637	642	PF11976	0.556
LIG_SUMO_SIM_par_1	82	88	PF11976	0.373
LIG_TRAF2_1	138	141	PF00917	0.779
LIG_TRAF2_1	253	256	PF00917	0.583
LIG_TRFH_1	116	120	PF08558	0.533
LIG_TYR_ITIM	283	288	PF00017	0.376
LIG_TYR_ITIM	344	349	PF00017	0.365
LIG_UBA3_1	742	746	PF00899	0.608
LIG_WRC_WIRS_1	387	392	PF05994	0.430
LIG_WRC_WIRS_1	438	443	PF05994	0.430
MOD_CDK_SPK_2	703	708	PF00069	0.345
MOD_CK1_1	169	175	PF00069	0.763
MOD_CK1_1	220	226	PF00069	0.853
MOD_CK1_1	298	304	PF00069	0.356
MOD_CK1_1	33	39	PF00069	0.714
MOD_CK1_1	484	490	PF00069	0.430
MOD_CK1_1	534	540	PF00069	0.549
MOD_CK1_1	568	574	PF00069	0.477
MOD_CK1_1	601	607	PF00069	0.588
MOD_CK1_1	619	625	PF00069	0.543
MOD_CK1_1	734	740	PF00069	0.639
MOD_CK2_1	106	112	PF00069	0.568
MOD_CK2_1	134	140	PF00069	0.779
MOD_CK2_1	226	232	PF00069	0.741
MOD_CK2_1	265	271	PF00069	0.249
MOD_CK2_1	37	43	PF00069	0.588
MOD_CK2_1	517	523	PF00069	0.527
MOD_CK2_1	591	597	PF00069	0.426
MOD_GlcNHglycan	157	160	PF01048	0.607
MOD_GlcNHglycan	168	171	PF01048	0.615
MOD_GlcNHglycan	219	222	PF01048	0.541
MOD_GlcNHglycan	514	517	PF01048	0.335
MOD_GlcNHglycan	534	537	PF01048	0.171
MOD_GlcNHglycan	541	544	PF01048	0.259
MOD_GlcNHglycan	618	621	PF01048	0.325
MOD_GlcNHglycan	674	677	PF01048	0.556
MOD_GlcNHglycan	712	715	PF01048	0.471
MOD_GlcNHglycan	733	736	PF01048	0.507
MOD_GlcNHglycan	87	90	PF01048	0.265
MOD_GSK3_1	102	109	PF00069	0.589
MOD_GSK3_1	127	134	PF00069	0.578
MOD_GSK3_1	15	22	PF00069	0.744
MOD_GSK3_1	155	162	PF00069	0.809
MOD_GSK3_1	226	233	PF00069	0.802
MOD_GSK3_1	274	281	PF00069	0.346
MOD_GSK3_1	33	40	PF00069	0.715
MOD_GSK3_1	379	386	PF00069	0.335
MOD_GSK3_1	41	48	PF00069	0.646
MOD_GSK3_1	49	56	PF00069	0.531
MOD_GSK3_1	527	534	PF00069	0.593
MOD_GSK3_1	565	572	PF00069	0.523
MOD_GSK3_1	597	604	PF00069	0.514
MOD_GSK3_1	615	622	PF00069	0.556
MOD_GSK3_1	644	651	PF00069	0.488
MOD_GSK3_1	722	729	PF00069	0.608
MOD_GSK3_1	731	738	PF00069	0.688
MOD_GSK3_1	87	94	PF00069	0.354
MOD_N-GLC_1	722	727	PF02516	0.380
MOD_NEK2_1	114	119	PF00069	0.508
MOD_NEK2_1	265	270	PF00069	0.302
MOD_NEK2_1	322	327	PF00069	0.373
MOD_NEK2_1	333	338	PF00069	0.550
MOD_NEK2_1	377	382	PF00069	0.371
MOD_NEK2_1	392	397	PF00069	0.368
MOD_NEK2_1	415	420	PF00069	0.517
MOD_NEK2_1	565	570	PF00069	0.462
MOD_NEK2_1	579	584	PF00069	0.601
MOD_NEK2_1	598	603	PF00069	0.502
MOD_NEK2_1	616	621	PF00069	0.406
MOD_NEK2_1	663	668	PF00069	0.482
MOD_NEK2_1	683	688	PF00069	0.171
MOD_NEK2_1	72	77	PF00069	0.430
MOD_NEK2_1	758	763	PF00069	0.335
MOD_NEK2_1	85	90	PF00069	0.322
MOD_NEK2_2	340	345	PF00069	0.311
MOD_NEK2_2	6	11	PF00069	0.602
MOD_NEK2_2	91	96	PF00069	0.509
MOD_PIKK_1	202	208	PF00454	0.667
MOD_PIKK_1	354	360	PF00454	0.356
MOD_PKA_1	19	25	PF00069	0.748
MOD_PKA_1	726	732	PF00069	0.683
MOD_PKA_2	106	112	PF00069	0.600
MOD_PKA_2	185	191	PF00069	0.841
MOD_PKA_2	19	25	PF00069	0.619
MOD_PKA_2	230	236	PF00069	0.651
MOD_PKA_2	33	39	PF00069	0.622
MOD_PKA_2	492	498	PF00069	0.556
MOD_PKA_2	512	518	PF00069	0.607
MOD_PKA_2	531	537	PF00069	0.383
MOD_PKA_2	6	12	PF00069	0.719
MOD_PKA_2	616	622	PF00069	0.517
MOD_PKA_2	726	732	PF00069	0.582
MOD_PKB_1	262	270	PF00069	0.426
MOD_Plk_1	202	208	PF00069	0.838
MOD_Plk_1	502	508	PF00069	0.556
MOD_Plk_1	549	555	PF00069	0.426
MOD_Plk_1	648	654	PF00069	0.607
MOD_Plk_4	265	271	PF00069	0.329
MOD_Plk_4	278	284	PF00069	0.415
MOD_Plk_4	295	301	PF00069	0.342
MOD_Plk_4	33	39	PF00069	0.714
MOD_Plk_4	334	340	PF00069	0.517
MOD_Plk_4	415	421	PF00069	0.477
MOD_Plk_4	49	55	PF00069	0.523
MOD_Plk_4	492	498	PF00069	0.556
MOD_Plk_4	502	508	PF00069	0.556
MOD_Plk_4	56	62	PF00069	0.367
MOD_Plk_4	649	655	PF00069	0.583
MOD_Plk_4	664	670	PF00069	0.262
MOD_Plk_4	683	689	PF00069	0.376
MOD_Plk_4	73	79	PF00069	0.262
MOD_ProDKin_1	171	177	PF00069	0.754
MOD_ProDKin_1	232	238	PF00069	0.700
MOD_ProDKin_1	298	304	PF00069	0.226
MOD_ProDKin_1	37	43	PF00069	0.588
MOD_ProDKin_1	560	566	PF00069	0.517
MOD_ProDKin_1	570	576	PF00069	0.517
MOD_ProDKin_1	580	586	PF00069	0.529
MOD_ProDKin_1	629	635	PF00069	0.578
MOD_ProDKin_1	644	650	PF00069	0.546
MOD_ProDKin_1	703	709	PF00069	0.556
MOD_SUMO_rev_2	331	336	PF00179	0.517
TRG_DiLeu_BaEn_1	659	664	PF01217	0.430
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.488
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.665
TRG_DiLeu_LyEn_5	561	566	PF01217	0.556
TRG_ENDOCYTIC_2	245	248	PF00928	0.627
TRG_ENDOCYTIC_2	279	282	PF00928	0.376
TRG_ENDOCYTIC_2	285	288	PF00928	0.430
TRG_ENDOCYTIC_2	311	314	PF00928	0.430
TRG_ENDOCYTIC_2	346	349	PF00928	0.341
TRG_ENDOCYTIC_2	363	366	PF00928	0.329
TRG_ENDOCYTIC_2	371	374	PF00928	0.337
TRG_ENDOCYTIC_2	404	407	PF00928	0.492
TRG_ENDOCYTIC_2	438	441	PF00928	0.395
TRG_ENDOCYTIC_2	576	579	PF00928	0.607
TRG_ENDOCYTIC_2	770	773	PF00928	0.503
TRG_ENDOCYTIC_2	96	99	PF00928	0.430
TRG_ER_diArg_1	211	213	PF00400	0.788
TRG_ER_diArg_1	257	260	PF00400	0.594
TRG_ER_diArg_1	262	264	PF00400	0.570
TRG_ER_diArg_1	368	370	PF00400	0.368
TRG_ER_diArg_1	410	412	PF00400	0.522
TRG_ER_diArg_1	726	728	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ5	Leptomonas seymouri	55%	97%
A0A0S4JW15	Bodo saltans	37%	100%
A0A3S7XBM8	Leishmania donovani	69%	98%
A4IDM7	Leishmania infantum	68%	98%
E9ATN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
Q4Q0W6	Leishmania major	68%	100%