Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania braziliensis

UniProt:

A4HPW4_LEIBR

TriTrypDb:

LbrM.35.4710 , LBRM2903_350057900

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.474
CLV_NRD_NRD_1	183	185	PF00675	0.325
CLV_NRD_NRD_1	268	270	PF00675	0.674
CLV_NRD_NRD_1	28	30	PF00675	0.221
CLV_NRD_NRD_1	61	63	PF00675	0.266
CLV_PCSK_KEX2_1	156	158	PF00082	0.491
CLV_PCSK_KEX2_1	183	185	PF00082	0.387
CLV_PCSK_KEX2_1	28	30	PF00082	0.234
CLV_PCSK_KEX2_1	61	63	PF00082	0.264
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.491
CLV_PCSK_SKI1_1	173	177	PF00082	0.403
CLV_PCSK_SKI1_1	263	267	PF00082	0.683
CLV_PCSK_SKI1_1	29	33	PF00082	0.247
DEG_SCF_FBW7_2	160	167	PF00400	0.406
DOC_CYCLIN_RxL_1	170	179	PF00134	0.314
DOC_MAPK_gen_1	128	136	PF00069	0.354
DOC_USP7_MATH_1	165	169	PF00917	0.470
DOC_USP7_MATH_1	244	248	PF00917	0.728
DOC_USP7_MATH_1	256	260	PF00917	0.741
DOC_USP7_UBL2_3	236	240	PF12436	0.577
DOC_USP7_UBL2_3	266	270	PF12436	0.720
DOC_WW_Pin1_4	160	165	PF00397	0.559
DOC_WW_Pin1_4	168	173	PF00397	0.505
LIG_14-3-3_CanoR_1	157	166	PF00244	0.556
LIG_14-3-3_CanoR_1	221	227	PF00244	0.615
LIG_Clathr_ClatBox_1	175	179	PF01394	0.344
LIG_FHA_1	66	72	PF00498	0.428
LIG_FHA_1	9	15	PF00498	0.313
LIG_FHA_2	17	23	PF00498	0.277
LIG_LIR_Gen_1	125	134	PF02991	0.483
LIG_LIR_Gen_1	224	233	PF02991	0.508
LIG_LIR_Gen_1	50	59	PF02991	0.341
LIG_LIR_Nem_3	24	30	PF02991	0.330
LIG_LIR_Nem_3	44	49	PF02991	0.139
LIG_LIR_Nem_3	50	56	PF02991	0.245
LIG_PCNA_yPIPBox_3	121	134	PF02747	0.527
LIG_SH2_CRK	148	152	PF00017	0.258
LIG_SH2_CRK	27	31	PF00017	0.188
LIG_SH2_CRK	53	57	PF00017	0.247
LIG_SH2_CRK	9	13	PF00017	0.280
LIG_SH2_STAP1	226	230	PF00017	0.624
LIG_SH2_STAT5	133	136	PF00017	0.504
LIG_SH2_STAT5	237	240	PF00017	0.530
LIG_TRAF2_1	108	111	PF00917	0.367
LIG_TRAF2_1	205	208	PF00917	0.579
LIG_UBA3_1	175	180	PF00899	0.531
LIG_UBA3_1	229	236	PF00899	0.470
MOD_CDK_SPK_2	168	173	PF00069	0.434
MOD_CK1_1	15	21	PF00069	0.362
MOD_CK1_1	168	174	PF00069	0.553
MOD_CK1_1	201	207	PF00069	0.464
MOD_CK1_1	225	231	PF00069	0.582
MOD_CK1_1	235	241	PF00069	0.548
MOD_CK2_1	105	111	PF00069	0.370
MOD_CK2_1	15	21	PF00069	0.371
MOD_CK2_1	201	207	PF00069	0.568
MOD_CK2_1	221	227	PF00069	0.569
MOD_CK2_1	228	234	PF00069	0.508
MOD_CK2_1	256	262	PF00069	0.492
MOD_CK2_1	54	60	PF00069	0.388
MOD_GlcNHglycan	151	154	PF01048	0.371
MOD_GlcNHglycan	198	201	PF01048	0.606
MOD_GlcNHglycan	203	206	PF01048	0.417
MOD_GlcNHglycan	210	214	PF01048	0.469
MOD_GlcNHglycan	241	244	PF01048	0.587
MOD_GlcNHglycan	258	261	PF01048	0.443
MOD_GlcNHglycan	73	76	PF01048	0.522
MOD_GlcNHglycan	90	93	PF01048	0.345
MOD_GSK3_1	101	108	PF00069	0.407
MOD_GSK3_1	167	174	PF00069	0.465
MOD_GSK3_1	221	228	PF00069	0.542
MOD_GSK3_1	232	239	PF00069	0.513
MOD_GSK3_1	65	72	PF00069	0.495
MOD_GSK3_1	8	15	PF00069	0.263
MOD_NEK2_1	101	106	PF00069	0.417
MOD_NEK2_1	178	183	PF00069	0.546
MOD_NEK2_1	196	201	PF00069	0.555
MOD_NEK2_1	8	13	PF00069	0.407
MOD_PKA_1	269	275	PF00069	0.654
MOD_PKA_2	244	250	PF00069	0.656
MOD_PKA_2	251	257	PF00069	0.584
MOD_PKB_1	219	227	PF00069	0.613
MOD_Plk_1	178	184	PF00069	0.425
MOD_Plk_1	209	215	PF00069	0.556
MOD_Plk_4	171	177	PF00069	0.327
MOD_Plk_4	225	231	PF00069	0.582
MOD_ProDKin_1	160	166	PF00069	0.553
MOD_ProDKin_1	168	174	PF00069	0.499
MOD_SUMO_rev_2	228	238	PF00179	0.512
TRG_ENDOCYTIC_2	133	136	PF00928	0.504
TRG_ENDOCYTIC_2	148	151	PF00928	0.484
TRG_ENDOCYTIC_2	226	229	PF00928	0.575
TRG_ENDOCYTIC_2	27	30	PF00928	0.184
TRG_ENDOCYTIC_2	53	56	PF00928	0.247
TRG_ENDOCYTIC_2	9	12	PF00928	0.261
TRG_ER_diArg_1	182	184	PF00400	0.388
TRG_ER_diArg_1	218	221	PF00400	0.609
TRG_ER_diArg_1	27	29	PF00400	0.234
TRG_NLS_MonoExtC_3	265	270	PF00514	0.640
TRG_NLS_MonoExtN_4	263	270	PF00514	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P699	Leptomonas seymouri	61%	100%
A0A0S4J0E0	Bodo saltans	44%	100%
A0A1X0P0E8	Trypanosomatidae	44%	97%
A0A3Q8IIZ8	Leishmania donovani	76%	100%
A0A3S5ISR2	Trypanosoma rangeli	44%	100%
A4IDM6	Leishmania infantum	76%	100%
D0A4B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ATN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q0W7	Leishmania major	78%	100%
Q8WXX5	Homo sapiens	30%	100%
Q91WN1	Mus musculus	29%	100%
Q9UTQ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	98%
Q9VGR7	Drosophila melanogaster	27%	92%
V5BUT9	Trypanosoma cruzi	47%	100%