Putative mitochondrial intermediate peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial intermediate peptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPW2_LEIBR

TriTrypDb:

LbrM.35.4690 , LBRM2903_350057700

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.487
CLV_C14_Caspase3-7	95	99	PF00656	0.372
CLV_NRD_NRD_1	144	146	PF00675	0.391
CLV_NRD_NRD_1	159	161	PF00675	0.412
CLV_NRD_NRD_1	175	177	PF00675	0.358
CLV_NRD_NRD_1	277	279	PF00675	0.378
CLV_NRD_NRD_1	3	5	PF00675	0.532
CLV_NRD_NRD_1	303	305	PF00675	0.322
CLV_NRD_NRD_1	426	428	PF00675	0.391
CLV_NRD_NRD_1	624	626	PF00675	0.306
CLV_PCSK_KEX2_1	124	126	PF00082	0.475
CLV_PCSK_KEX2_1	144	146	PF00082	0.208
CLV_PCSK_KEX2_1	175	177	PF00082	0.393
CLV_PCSK_KEX2_1	3	5	PF00082	0.532
CLV_PCSK_KEX2_1	303	305	PF00082	0.322
CLV_PCSK_KEX2_1	406	408	PF00082	0.363
CLV_PCSK_KEX2_1	426	428	PF00082	0.123
CLV_PCSK_KEX2_1	514	516	PF00082	0.306
CLV_PCSK_KEX2_1	560	562	PF00082	0.488
CLV_PCSK_KEX2_1	624	626	PF00082	0.306
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.475
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.363
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.306
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.488
CLV_PCSK_SKI1_1	161	165	PF00082	0.567
CLV_PCSK_SKI1_1	206	210	PF00082	0.447
CLV_PCSK_SKI1_1	221	225	PF00082	0.322
CLV_PCSK_SKI1_1	361	365	PF00082	0.323
DEG_APCC_DBOX_1	143	151	PF00400	0.383
DEG_APCC_DBOX_1	226	234	PF00400	0.341
DEG_MDM2_SWIB_1	493	501	PF02201	0.306
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DOC_CKS1_1	60	65	PF01111	0.291
DOC_MAPK_gen_1	124	131	PF00069	0.504
DOC_MAPK_gen_1	190	198	PF00069	0.411
DOC_MAPK_gen_1	361	369	PF00069	0.453
DOC_MAPK_gen_1	403	413	PF00069	0.353
DOC_MAPK_MEF2A_6	361	368	PF00069	0.306
DOC_MAPK_MEF2A_6	406	414	PF00069	0.316
DOC_PP2B_LxvP_1	402	405	PF13499	0.306
DOC_USP7_MATH_1	216	220	PF00917	0.201
DOC_USP7_MATH_1	32	36	PF00917	0.733
DOC_USP7_UBL2_3	82	86	PF12436	0.556
DOC_WW_Pin1_4	153	158	PF00397	0.391
DOC_WW_Pin1_4	38	43	PF00397	0.631
DOC_WW_Pin1_4	59	64	PF00397	0.454
DOC_WW_Pin1_4	86	91	PF00397	0.538
LIG_14-3-3_CanoR_1	125	130	PF00244	0.504
LIG_14-3-3_CanoR_1	160	168	PF00244	0.536
LIG_14-3-3_CanoR_1	190	198	PF00244	0.539
LIG_Actin_WH2_2	53	70	PF00022	0.533
LIG_APCC_ABBA_1	354	359	PF00400	0.341
LIG_APCC_ABBAyCdc20_2	353	359	PF00400	0.306
LIG_BIR_III_2	305	309	PF00653	0.322
LIG_BRCT_BRCA1_1	127	131	PF00533	0.408
LIG_BRCT_BRCA1_1	213	217	PF00533	0.351
LIG_BRCT_BRCA1_1	328	332	PF00533	0.306
LIG_BRCT_BRCA1_1	480	484	PF00533	0.341
LIG_BRCT_BRCA1_1	489	493	PF00533	0.380
LIG_BRCT_BRCA1_2	489	495	PF00533	0.391
LIG_Clathr_ClatBox_1	233	237	PF01394	0.341
LIG_EH_1	214	218	PF12763	0.454
LIG_eIF4E_1	228	234	PF01652	0.341
LIG_FHA_1	383	389	PF00498	0.306
LIG_FHA_1	397	403	PF00498	0.306
LIG_FHA_1	413	419	PF00498	0.196
LIG_FHA_1	71	77	PF00498	0.383
LIG_FHA_1	98	104	PF00498	0.331
LIG_FHA_2	245	251	PF00498	0.341
LIG_FHA_2	429	435	PF00498	0.427
LIG_FHA_2	48	54	PF00498	0.540
LIG_FHA_2	560	566	PF00498	0.495
LIG_FHA_2	668	674	PF00498	0.552
LIG_HP1_1	410	414	PF01393	0.306
LIG_LIR_Gen_1	146	154	PF02991	0.401
LIG_LIR_Gen_1	214	224	PF02991	0.201
LIG_LIR_Gen_1	445	455	PF02991	0.307
LIG_LIR_Gen_1	478	488	PF02991	0.306
LIG_LIR_Gen_1	490	501	PF02991	0.306
LIG_LIR_Gen_1	600	611	PF02991	0.306
LIG_LIR_Nem_3	146	151	PF02991	0.394
LIG_LIR_Nem_3	214	220	PF02991	0.366
LIG_LIR_Nem_3	313	317	PF02991	0.308
LIG_LIR_Nem_3	445	451	PF02991	0.307
LIG_LIR_Nem_3	478	483	PF02991	0.306
LIG_LIR_Nem_3	490	496	PF02991	0.306
LIG_LIR_Nem_3	508	512	PF02991	0.306
LIG_LIR_Nem_3	600	606	PF02991	0.306
LIG_LYPXL_yS_3	409	412	PF13949	0.306
LIG_NRBOX	103	109	PF00104	0.340
LIG_NRBOX	219	225	PF00104	0.322
LIG_NRBOX	229	235	PF00104	0.322
LIG_PCNA_PIPBox_1	252	261	PF02747	0.306
LIG_PCNA_TLS_4	658	665	PF02747	0.427
LIG_PCNA_yPIPBox_3	245	259	PF02747	0.306
LIG_PDZ_Class_2	671	676	PF00595	0.435
LIG_PDZ_Wminus1_1	674	676	PF00595	0.409
LIG_Pex14_1	627	631	PF04695	0.306
LIG_Pex14_2	480	484	PF04695	0.322
LIG_Pex14_2	493	497	PF04695	0.360
LIG_PTB_Apo_2	53	60	PF02174	0.464
LIG_SH2_CRK	148	152	PF00017	0.387
LIG_SH2_CRK	614	618	PF00017	0.306
LIG_SH2_GRB2like	372	375	PF00017	0.363
LIG_SH2_NCK_1	228	232	PF00017	0.391
LIG_SH2_NCK_1	28	32	PF00017	0.475
LIG_SH2_SRC	357	360	PF00017	0.427
LIG_SH2_SRC	616	619	PF00017	0.306
LIG_SH2_STAP1	28	32	PF00017	0.550
LIG_SH2_STAP1	618	622	PF00017	0.306
LIG_SH2_STAT3	222	225	PF00017	0.391
LIG_SH2_STAT3	239	242	PF00017	0.341
LIG_SH2_STAT3	266	269	PF00017	0.427
LIG_SH2_STAT5	222	225	PF00017	0.322
LIG_SH2_STAT5	314	317	PF00017	0.306
LIG_SH2_STAT5	378	381	PF00017	0.319
LIG_SH2_STAT5	476	479	PF00017	0.427
LIG_SH2_STAT5	549	552	PF00017	0.482
LIG_SH2_STAT5	616	619	PF00017	0.306
LIG_SH2_STAT5	664	667	PF00017	0.306
LIG_SH3_3	337	343	PF00018	0.371
LIG_SH3_3	49	55	PF00018	0.604
LIG_SH3_3	545	551	PF00018	0.444
LIG_SH3_3	580	586	PF00018	0.404
LIG_Sin3_3	577	584	PF02671	0.502
LIG_SUMO_SIM_par_1	365	370	PF11976	0.306
LIG_SUMO_SIM_par_1	409	415	PF11976	0.306
LIG_SUMO_SIM_par_1	585	591	PF11976	0.414
LIG_SUMO_SIM_par_1	71	79	PF11976	0.387
LIG_TRAF2_1	392	395	PF00917	0.341
LIG_TYR_ITIM	312	317	PF00017	0.427
LIG_UBA3_1	80	86	PF00899	0.407
LIG_WRC_WIRS_1	477	482	PF05994	0.306
MOD_CDK_SPxxK_3	153	160	PF00069	0.327
MOD_CDK_SPxxK_3	38	45	PF00069	0.633
MOD_CDK_SPxxK_3	86	93	PF00069	0.533
MOD_CK1_1	261	267	PF00069	0.427
MOD_CK1_1	41	47	PF00069	0.523
MOD_CK2_1	235	241	PF00069	0.306
MOD_CK2_1	244	250	PF00069	0.306
MOD_CK2_1	265	271	PF00069	0.336
MOD_CK2_1	486	492	PF00069	0.322
MOD_CK2_1	585	591	PF00069	0.405
MOD_Cter_Amidation	158	161	PF01082	0.475
MOD_Cter_Amidation	558	561	PF01082	0.472
MOD_GlcNHglycan	29	32	PF01048	0.703
MOD_GlcNHglycan	34	37	PF01048	0.696
MOD_GlcNHglycan	349	352	PF01048	0.336
MOD_GlcNHglycan	533	536	PF01048	0.233
MOD_GlcNHglycan	606	609	PF01048	0.345
MOD_GSK3_1	206	213	PF00069	0.482
MOD_GSK3_1	261	268	PF00069	0.201
MOD_GSK3_1	32	39	PF00069	0.621
MOD_GSK3_1	66	73	PF00069	0.394
MOD_N-GLC_1	288	293	PF02516	0.311
MOD_N-GLC_1	32	37	PF02516	0.697
MOD_N-GLC_1	347	352	PF02516	0.427
MOD_NEK2_1	244	249	PF00069	0.306
MOD_NEK2_1	258	263	PF00069	0.306
MOD_NEK2_1	459	464	PF00069	0.306
MOD_NEK2_1	467	472	PF00069	0.306
MOD_NEK2_1	47	52	PF00069	0.520
MOD_NEK2_1	96	101	PF00069	0.338
MOD_NEK2_2	216	221	PF00069	0.306
MOD_NEK2_2	454	459	PF00069	0.306
MOD_PIKK_1	265	271	PF00454	0.201
MOD_PIKK_1	459	465	PF00454	0.417
MOD_PIKK_1	478	484	PF00454	0.144
MOD_PK_1	585	591	PF00069	0.514
MOD_PKA_2	244	250	PF00069	0.306
MOD_PKA_2	470	476	PF00069	0.306
MOD_PKA_2	657	663	PF00069	0.453
MOD_Plk_1	433	439	PF00069	0.321
MOD_Plk_1	442	448	PF00069	0.325
MOD_Plk_1	70	76	PF00069	0.268
MOD_Plk_2-3	505	511	PF00069	0.306
MOD_Plk_2-3	667	673	PF00069	0.548
MOD_Plk_4	244	250	PF00069	0.306
MOD_Plk_4	434	440	PF00069	0.322
MOD_Plk_4	443	449	PF00069	0.309
MOD_Plk_4	454	460	PF00069	0.123
MOD_Plk_4	544	550	PF00069	0.450
MOD_Plk_4	76	82	PF00069	0.523
MOD_ProDKin_1	153	159	PF00069	0.386
MOD_ProDKin_1	38	44	PF00069	0.631
MOD_ProDKin_1	59	65	PF00069	0.453
MOD_ProDKin_1	86	92	PF00069	0.536
MOD_SUMO_for_1	334	337	PF00179	0.391
MOD_SUMO_rev_2	358	363	PF00179	0.358
TRG_DiLeu_BaEn_1	229	234	PF01217	0.363
TRG_DiLeu_BaEn_2	358	364	PF01217	0.306
TRG_ENDOCYTIC_2	135	138	PF00928	0.388
TRG_ENDOCYTIC_2	148	151	PF00928	0.354
TRG_ENDOCYTIC_2	314	317	PF00928	0.306
TRG_ENDOCYTIC_2	409	412	PF00928	0.306
TRG_ENDOCYTIC_2	614	617	PF00928	0.306
TRG_ER_diArg_1	174	176	PF00400	0.508
TRG_ER_diArg_1	2	4	PF00400	0.534
TRG_ER_diArg_1	284	287	PF00400	0.309
TRG_ER_diArg_1	294	297	PF00400	0.304
TRG_ER_diArg_1	302	304	PF00400	0.295
TRG_ER_diArg_1	426	428	PF00400	0.391
TRG_ER_diArg_1	624	626	PF00400	0.306
TRG_NES_CRM1_1	325	338	PF08389	0.306
TRG_NES_CRM1_1	64	78	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N6	Leptomonas seymouri	85%	100%
A0A0N1PBM8	Leptomonas seymouri	25%	99%
A0A0N1PDB7	Leptomonas seymouri	23%	100%
A0A0S4JRG5	Bodo saltans	25%	99%
A0A0S4JWM4	Bodo saltans	67%	100%
A0A1X0P0Z5	Trypanosomatidae	77%	98%
A0A3Q8IKU0	Leishmania donovani	91%	100%
A0A3S7WZY5	Leishmania donovani	23%	99%
A0A422MUB5	Trypanosoma rangeli	24%	99%
A0A422P572	Trypanosoma rangeli	77%	99%
A1CTP5	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	26%	84%
A1DMR2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	84%
A2QWM4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	85%
A3LUT4	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	83%
A4HF12	Leishmania braziliensis	24%	100%
A4I291	Leishmania infantum	23%	99%
A4IDM4	Leishmania infantum	91%	100%
A4RF25	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	83%
A5DI46	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	24%	86%
A6H611	Mus musculus	24%	95%
A6SHZ5	Botryotinia fuckeliana (strain B05.10)	27%	89%
A6ZZI7	Saccharomyces cerevisiae (strain YJM789)	24%	88%
A7E7L8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	86%
A7TSL2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	26%	86%
A8N2T3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	29%	87%
A8QB25	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	28%	84%
B0CRC2	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	26%	88%
B0Y7Q2	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	26%	84%
D0A4B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AC74	Leishmania major	23%	100%
E9ATM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AYD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
F4HTQ1	Arabidopsis thaliana	26%	95%
F4KDA5	Arabidopsis thaliana	27%	96%
P0CQ18	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	89%
P0CQ19	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	89%
P0CQ20	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	82%
P0CQ21	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	82%
P24155	Rattus norvegicus	25%	98%
P25375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	95%
P27237	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	99%
P27298	Escherichia coli (strain K12)	27%	99%
P35999	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	88%
P37932	Schizophyllum commune	26%	87%
P44573	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	99%
P47788	Sus scrofa	26%	98%
P52888	Homo sapiens	25%	98%
Q01992	Rattus norvegicus	24%	95%
Q0CI79	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	84%
Q0TXL7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	86%
Q10415	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	89%
Q1E8M9	Coccidioides immitis (strain RS)	26%	85%
Q1JPJ8	Bos taurus	26%	98%
Q2HFL8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	25%	87%
Q2UN31	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	84%
Q4PBS8	Ustilago maydis (strain 521 / FGSC 9021)	26%	76%
Q4Q0W9	Leishmania major	91%	100%
Q4Q937	Leishmania major	24%	100%
Q4WMU9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	84%
Q54DD2	Dictyostelium discoideum	24%	100%
Q59RK9	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	86%
Q5RF14	Pongo abelii	24%	95%
Q6BJ61	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	85%
Q6CHD6	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	87%
Q6CVF7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	87%
Q6FW88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	89%
Q6VMB4	Leucoagaricus gongylophorus	23%	89%
Q6Y5M5	Pleurotus djamor	26%	86%
Q6Y5M6	Coprinellus disseminatus	27%	87%
Q6Y5M7	Coprinopsis scobicola	27%	88%
Q753X4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	87%
Q7SDD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	84%
Q8C1A5	Mus musculus	26%	98%
Q94AM1	Arabidopsis thaliana	24%	85%
Q99797	Homo sapiens	24%	95%
V5B526	Trypanosoma cruzi	78%	99%