TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPW1_LEIBR

TriTrypDb:

LbrM.35.4680 , LBRM2903_350057600

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.403
CLV_NRD_NRD_1	152	154	PF00675	0.473
CLV_NRD_NRD_1	199	201	PF00675	0.552
CLV_NRD_NRD_1	240	242	PF00675	0.414
CLV_PCSK_KEX2_1	152	154	PF00082	0.305
CLV_PCSK_KEX2_1	199	201	PF00082	0.546
CLV_PCSK_KEX2_1	240	242	PF00082	0.414
CLV_PCSK_SKI1_1	136	140	PF00082	0.527
CLV_PCSK_SKI1_1	153	157	PF00082	0.441
CLV_PCSK_SKI1_1	199	203	PF00082	0.485
CLV_PCSK_SKI1_1	56	60	PF00082	0.594
DEG_APCC_DBOX_1	151	159	PF00400	0.300
DEG_SPOP_SBC_1	25	29	PF00917	0.645
DOC_CYCLIN_RxL_1	196	205	PF00134	0.292
DOC_MAPK_gen_1	152	160	PF00069	0.412
DOC_MAPK_gen_1	199	206	PF00069	0.502
DOC_MAPK_gen_1	240	246	PF00069	0.511
DOC_MAPK_gen_1	274	281	PF00069	0.662
DOC_MAPK_gen_1	36	44	PF00069	0.413
DOC_MAPK_MEF2A_6	199	208	PF00069	0.505
DOC_MAPK_NFAT4_5	199	207	PF00069	0.290
DOC_PP4_FxxP_1	272	275	PF00568	0.609
DOC_USP7_MATH_1	176	180	PF00917	0.382
DOC_USP7_UBL2_3	207	211	PF12436	0.418
DOC_USP7_UBL2_3	80	84	PF12436	0.447
DOC_WW_Pin1_4	6	11	PF00397	0.727
DOC_WW_Pin1_4	61	66	PF00397	0.458
LIG_14-3-3_CanoR_1	177	181	PF00244	0.383
LIG_14-3-3_CanoR_1	56	65	PF00244	0.333
LIG_BRCT_BRCA1_1	204	208	PF00533	0.462
LIG_BRCT_BRCA1_1	268	272	PF00533	0.436
LIG_BRCT_BRCA1_2	204	210	PF00533	0.464
LIG_BRCT_BRCA1_2	268	274	PF00533	0.476
LIG_FHA_1	13	19	PF00498	0.704
LIG_FHA_1	268	274	PF00498	0.569
LIG_FHA_1	52	58	PF00498	0.567
LIG_FHA_1	72	78	PF00498	0.384
LIG_FHA_2	161	167	PF00498	0.479
LIG_FHA_2	18	24	PF00498	0.581
LIG_LIR_Apic_2	179	185	PF02991	0.447
LIG_LIR_Apic_2	269	275	PF02991	0.503
LIG_LIR_Gen_1	145	155	PF02991	0.402
LIG_LIR_Nem_3	145	150	PF02991	0.404
LIG_LIR_Nem_3	179	183	PF02991	0.520
LIG_LIR_Nem_3	186	192	PF02991	0.564
LIG_LIR_Nem_3	257	263	PF02991	0.475
LIG_LIR_Nem_3	28	34	PF02991	0.483
LIG_Pex14_1	277	281	PF04695	0.550
LIG_SH2_CRK	147	151	PF00017	0.388
LIG_SH2_CRK	193	197	PF00017	0.527
LIG_SH2_PTP2	243	246	PF00017	0.518
LIG_SH2_SRC	183	186	PF00017	0.536
LIG_SH2_STAP1	189	193	PF00017	0.544
LIG_SH2_STAP1	222	226	PF00017	0.378
LIG_SH2_STAP1	53	57	PF00017	0.425
LIG_SH2_STAT5	121	124	PF00017	0.342
LIG_SH2_STAT5	230	233	PF00017	0.473
LIG_SH2_STAT5	243	246	PF00017	0.479
LIG_SH2_STAT5	34	37	PF00017	0.564
LIG_SH2_STAT5	53	56	PF00017	0.260
LIG_SH3_3	59	65	PF00018	0.448
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.406
LIG_SUMO_SIM_par_1	200	205	PF11976	0.279
LIG_TRAF2_1	20	23	PF00917	0.614
LIG_TRAF2_1	251	254	PF00917	0.632
LIG_TRFH_1	193	197	PF08558	0.404
LIG_UBA3_1	201	207	PF00899	0.280
MOD_CK1_1	6	12	PF00069	0.639
MOD_CK2_1	160	166	PF00069	0.524
MOD_CK2_1	17	23	PF00069	0.564
MOD_CK2_1	24	30	PF00069	0.528
MOD_GlcNHglycan	10	13	PF01048	0.676
MOD_GlcNHglycan	48	51	PF01048	0.395
MOD_GSK3_1	2	9	PF00069	0.690
MOD_GSK3_1	263	270	PF00069	0.427
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	202	207	PF00069	0.412
MOD_NEK2_1	46	51	PF00069	0.432
MOD_NEK2_1	71	76	PF00069	0.378
MOD_NEK2_2	176	181	PF00069	0.387
MOD_NMyristoyl	1	7	PF02799	0.637
MOD_PIKK_1	263	269	PF00454	0.538
MOD_PIKK_1	56	62	PF00454	0.336
MOD_PKA_2	176	182	PF00069	0.427
MOD_Plk_1	202	208	PF00069	0.502
MOD_ProDKin_1	6	12	PF00069	0.726
MOD_ProDKin_1	61	67	PF00069	0.451
MOD_SUMO_for_1	255	258	PF00179	0.496
TRG_DiLeu_BaEn_1	66	71	PF01217	0.388
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.482
TRG_ENDOCYTIC_2	147	150	PF00928	0.391
TRG_ENDOCYTIC_2	192	195	PF00928	0.502
TRG_ENDOCYTIC_2	230	233	PF00928	0.472
TRG_ENDOCYTIC_2	243	246	PF00928	0.350
TRG_ENDOCYTIC_2	34	37	PF00928	0.420
TRG_ER_diArg_1	151	153	PF00400	0.360
TRG_ER_diArg_1	199	201	PF00400	0.565
TRG_ER_diArg_1	240	242	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P695	Leptomonas seymouri	77%	96%
A0A1X0P0E3	Trypanosomatidae	73%	97%
A0A3R7MCL3	Trypanosoma rangeli	65%	97%
A0A3S7XBK2	Leishmania donovani	88%	100%
A4IDM3	Leishmania infantum	88%	100%
D0A4A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	94%
E9ATM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0X0	Leishmania major	89%	100%
V5DLL6	Trypanosoma cruzi	66%	97%