Asparaginase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Asparaginase

Gene product:

asparaginase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPW0_LEIBR

TriTrypDb:

LbrM.35.4670 , LBRM2903_350057500

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPW0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009066	aspartate family amino acid metabolic process	5	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901605	alpha-amino acid metabolic process	4	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004067	asparaginase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	13
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.373
CLV_NRD_NRD_1	350	352	PF00675	0.253
CLV_NRD_NRD_1	53	55	PF00675	0.499
CLV_PCSK_KEX2_1	154	156	PF00082	0.166
CLV_PCSK_KEX2_1	282	284	PF00082	0.260
CLV_PCSK_KEX2_1	53	55	PF00082	0.459
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.179
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.325
CLV_PCSK_SKI1_1	185	189	PF00082	0.226
CLV_PCSK_SKI1_1	217	221	PF00082	0.316
CLV_PCSK_SKI1_1	237	241	PF00082	0.454
CLV_PCSK_SKI1_1	28	32	PF00082	0.427
CLV_PCSK_SKI1_1	282	286	PF00082	0.288
CLV_PCSK_SKI1_1	338	342	PF00082	0.231
CLV_PCSK_SKI1_1	53	57	PF00082	0.397
DEG_APCC_DBOX_1	53	61	PF00400	0.474
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_SPOP_SBC_1	120	124	PF00917	0.319
DOC_CKS1_1	245	250	PF01111	0.149
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.226
DOC_MAPK_gen_1	154	161	PF00069	0.202
DOC_MAPK_gen_1	221	230	PF00069	0.377
DOC_MAPK_gen_1	287	296	PF00069	0.304
DOC_MAPK_gen_1	53	59	PF00069	0.463
DOC_MAPK_MEF2A_6	154	163	PF00069	0.214
DOC_MAPK_MEF2A_6	289	297	PF00069	0.351
DOC_MAPK_NFAT4_5	154	162	PF00069	0.202
DOC_PP1_RVXF_1	133	140	PF00149	0.226
DOC_PP4_FxxP_1	197	200	PF00568	0.215
DOC_SPAK_OSR1_1	73	77	PF12202	0.149
DOC_USP7_MATH_1	162	166	PF00917	0.268
DOC_USP7_MATH_1	204	208	PF00917	0.373
DOC_USP7_MATH_2	20	26	PF00917	0.484
DOC_WW_Pin1_4	16	21	PF00397	0.569
DOC_WW_Pin1_4	196	201	PF00397	0.219
DOC_WW_Pin1_4	244	249	PF00397	0.149
DOC_WW_Pin1_4	361	366	PF00397	0.343
LIG_14-3-3_CanoR_1	148	157	PF00244	0.246
LIG_14-3-3_CanoR_1	185	194	PF00244	0.229
LIG_14-3-3_CanoR_1	351	355	PF00244	0.149
LIG_Actin_WH2_2	70	85	PF00022	0.284
LIG_BRCT_BRCA1_1	198	202	PF00533	0.241
LIG_DCNL_PONY_1	1	4	PF03556	0.485
LIG_FHA_1	138	144	PF00498	0.284
LIG_FHA_1	223	229	PF00498	0.392
LIG_FHA_1	234	240	PF00498	0.212
LIG_FHA_1	79	85	PF00498	0.314
LIG_FHA_2	245	251	PF00498	0.355
LIG_FHA_2	274	280	PF00498	0.237
LIG_FHA_2	87	93	PF00498	0.293
LIG_LIR_Gen_1	147	158	PF02991	0.166
LIG_LIR_Gen_1	247	256	PF02991	0.149
LIG_LIR_Gen_1	92	100	PF02991	0.302
LIG_LIR_LC3C_4	292	295	PF02991	0.368
LIG_LIR_Nem_3	103	107	PF02991	0.291
LIG_LIR_Nem_3	199	205	PF02991	0.226
LIG_LIR_Nem_3	247	252	PF02991	0.149
LIG_LIR_Nem_3	92	96	PF02991	0.298
LIG_MAD2	237	245	PF02301	0.373
LIG_Rb_pABgroove_1	170	178	PF01858	0.259
LIG_SH2_CRK	303	307	PF00017	0.319
LIG_SH2_GRB2like	104	107	PF00017	0.347
LIG_SH2_STAT5	150	153	PF00017	0.242
LIG_SH2_STAT5	3	6	PF00017	0.553
LIG_SH2_STAT5	339	342	PF00017	0.226
LIG_SH3_3	197	203	PF00018	0.226
LIG_SH3_3	239	245	PF00018	0.368
LIG_SH3_3	359	365	PF00018	0.406
LIG_SH3_3	66	72	PF00018	0.435
LIG_SUMO_SIM_anti_2	292	299	PF11976	0.373
LIG_SUMO_SIM_par_1	292	299	PF11976	0.244
LIG_SUMO_SIM_par_1	304	310	PF11976	0.233
LIG_TRAF2_1	19	22	PF00917	0.639
LIG_UBA3_1	129	135	PF00899	0.215
MOD_CDK_SPxxK_3	361	368	PF00069	0.413
MOD_CK1_1	118	124	PF00069	0.213
MOD_CK1_1	190	196	PF00069	0.295
MOD_CK1_1	232	238	PF00069	0.306
MOD_CK1_1	36	42	PF00069	0.459
MOD_CK1_1	363	369	PF00069	0.648
MOD_CK2_1	16	22	PF00069	0.624
MOD_CK2_1	244	250	PF00069	0.355
MOD_GlcNHglycan	113	116	PF01048	0.373
MOD_GlcNHglycan	21	27	PF01048	0.429
MOD_GlcNHglycan	259	262	PF01048	0.340
MOD_GlcNHglycan	323	326	PF01048	0.260
MOD_GlcNHglycan	365	368	PF01048	0.496
MOD_GSK3_1	111	118	PF00069	0.271
MOD_GSK3_1	12	19	PF00069	0.575
MOD_GSK3_1	120	127	PF00069	0.244
MOD_GSK3_1	186	193	PF00069	0.208
MOD_GSK3_1	229	236	PF00069	0.354
MOD_GSK3_1	78	85	PF00069	0.319
MOD_N-GLC_1	257	262	PF02516	0.149
MOD_NEK2_1	119	124	PF00069	0.226
MOD_NEK2_1	139	144	PF00069	0.118
MOD_NEK2_1	42	47	PF00069	0.632
MOD_NEK2_2	204	209	PF00069	0.259
MOD_NEK2_2	211	216	PF00069	0.259
MOD_PIKK_1	164	170	PF00454	0.259
MOD_PIKK_1	296	302	PF00454	0.147
MOD_PIKK_1	326	332	PF00454	0.340
MOD_PIKK_1	42	48	PF00454	0.569
MOD_PKA_2	190	196	PF00069	0.266
MOD_PKA_2	222	228	PF00069	0.469
MOD_PKA_2	350	356	PF00069	0.149
MOD_PKB_1	227	235	PF00069	0.335
MOD_Plk_4	115	121	PF00069	0.221
MOD_Plk_4	139	145	PF00069	0.257
MOD_Plk_4	237	243	PF00069	0.167
MOD_ProDKin_1	16	22	PF00069	0.565
MOD_ProDKin_1	196	202	PF00069	0.219
MOD_ProDKin_1	244	250	PF00069	0.149
MOD_ProDKin_1	361	367	PF00069	0.356
MOD_SUMO_for_1	100	103	PF00179	0.253
MOD_SUMO_rev_2	309	313	PF00179	0.149
TRG_DiLeu_BaEn_1	95	100	PF01217	0.363
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.237
TRG_ENDOCYTIC_2	107	110	PF00928	0.298
TRG_ENDOCYTIC_2	150	153	PF00928	0.259
TRG_ENDOCYTIC_2	303	306	PF00928	0.215
TRG_ER_diArg_1	220	223	PF00400	0.324
TRG_ER_diArg_1	227	230	PF00400	0.314
TRG_ER_diArg_1	53	55	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.254
TRG_PTS1	366	369	PF00515	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX8	Leptomonas seymouri	31%	94%
A0A0N1PEN4	Leptomonas seymouri	72%	98%
A0A0S4J4T5	Bodo saltans	47%	91%
A0A0S4J8X9	Bodo saltans	45%	100%
A0A0S4JTX6	Bodo saltans	36%	91%
A0A1X0NTQ3	Trypanosomatidae	31%	80%
A0A1X0P1U7	Trypanosomatidae	52%	99%
A0A3Q8IA09	Leishmania donovani	30%	93%
A0A3R7KPG5	Trypanosoma rangeli	51%	100%
A0A3S7XBI7	Leishmania donovani	85%	100%
A1RX40	Thermofilum pendens (strain DSM 2475 / Hrk 5)	26%	82%
A4FWR5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	25%	88%
A4H811	Leishmania braziliensis	28%	100%
A4HWE1	Leishmania infantum	30%	93%
A4IDM2	Leishmania infantum	85%	100%
A4YHH3	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	84%
A5UK11	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	28%	85%
A6UPR4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	25%	87%
A6VGK5	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	26%	88%
A9AA46	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	25%	88%
B0R6H4	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	28%	86%
C3MPS1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	27%	83%
C3MYR5	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	27%	83%
C3N5E7	Sulfolobus islandicus (strain M.16.27)	27%	83%
C3NE01	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	27%	83%
C3NHQ2	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	27%	83%
C4KH13	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	27%	83%
E9AQ41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	93%
E9ATM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O26802	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	85%
O29380	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	88%
O59132	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	84%
P0A962	Escherichia coli (strain K12)	35%	100%
P0A963	Escherichia coli O157:H7	35%	100%
P26900	Bacillus subtilis (strain 168)	32%	100%
P61400	Methanococcus maripaludis (strain S2 / LL)	26%	88%
P61401	Nanoarchaeum equitans (strain Kin4-M)	27%	94%
Q12X65	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	25%	89%
Q18GL3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	28%	83%
Q2NEH1	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	26%	84%
Q46GJ6	Methanosarcina barkeri (strain Fusaro / DSM 804)	25%	87%
Q4J955	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	23%	83%
Q4Q0X1	Leishmania major	85%	100%
Q4QFE1	Leishmania major	29%	100%
Q5JI77	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	84%
Q60331	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	88%
Q8PUM7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	25%	87%
Q8TR66	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	87%
Q8TV84	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	27%	81%
Q8TZE8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	31%	100%
Q8U0X0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	84%
Q8ZY04	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	24%	88%
Q971W5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	82%
Q979L8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	29%	91%
Q97ZH5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	83%
Q9HJJ5	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	90%
Q9HP20	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	28%	86%
Q9RRX9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	27%	100%
Q9V0T9	Pyrococcus abyssi (strain GE5 / Orsay)	29%	84%
Q9Y9T8	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	29%	86%
V5BUU3	Trypanosoma cruzi	49%	100%