Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPV8_LEIBR

TriTrypDb:

LbrM.35.4650 , LBRM2903_350057300

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.569
CLV_NRD_NRD_1	131	133	PF00675	0.507
CLV_NRD_NRD_1	147	149	PF00675	0.463
CLV_NRD_NRD_1	2	4	PF00675	0.620
CLV_NRD_NRD_1	45	47	PF00675	0.586
CLV_NRD_NRD_1	64	66	PF00675	0.474
CLV_NRD_NRD_1	72	74	PF00675	0.427
CLV_PCSK_KEX2_1	108	110	PF00082	0.570
CLV_PCSK_KEX2_1	122	124	PF00082	0.418
CLV_PCSK_KEX2_1	130	132	PF00082	0.460
CLV_PCSK_KEX2_1	2	4	PF00082	0.620
CLV_PCSK_KEX2_1	45	47	PF00082	0.586
CLV_PCSK_KEX2_1	71	73	PF00082	0.455
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.508
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.515
CLV_PCSK_SKI1_1	132	136	PF00082	0.394
DEG_APCC_DBOX_1	2	10	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DOC_PP1_RVXF_1	166	172	PF00149	0.476
DOC_PP1_RVXF_1	56	63	PF00149	0.400
DOC_USP7_MATH_1	15	19	PF00917	0.467
DOC_USP7_MATH_1	30	34	PF00917	0.734
DOC_WW_Pin1_4	24	29	PF00397	0.566
LIG_14-3-3_CanoR_1	163	172	PF00244	0.540
LIG_14-3-3_CanoR_1	46	54	PF00244	0.579
LIG_BRCT_BRCA1_1	50	54	PF00533	0.439
LIG_FHA_1	11	17	PF00498	0.579
LIG_FHA_1	164	170	PF00498	0.716
LIG_FHA_2	149	155	PF00498	0.431
LIG_FHA_2	83	89	PF00498	0.553
LIG_LIR_Apic_2	89	95	PF02991	0.515
LIG_TRAF2_1	94	97	PF00917	0.490
MOD_CK1_1	29	35	PF00069	0.636
MOD_CK1_1	39	45	PF00069	0.641
MOD_CK2_1	148	154	PF00069	0.455
MOD_CK2_1	82	88	PF00069	0.478
MOD_GlcNHglycan	17	20	PF01048	0.553
MOD_GlcNHglycan	187	190	PF01048	0.648
MOD_GlcNHglycan	196	199	PF01048	0.579
MOD_GlcNHglycan	38	41	PF01048	0.602
MOD_GlcNHglycan	50	53	PF01048	0.570
MOD_GSK3_1	26	33	PF00069	0.598
MOD_GSK3_1	5	12	PF00069	0.464
MOD_N-GLC_1	36	41	PF02516	0.498
MOD_NEK2_1	47	52	PF00069	0.637
MOD_NEK2_1	54	59	PF00069	0.592
MOD_OFUCOSY	7	14	PF10250	0.440
MOD_PKA_1	148	154	PF00069	0.428
MOD_PKA_2	10	16	PF00069	0.479
MOD_PKA_2	47	53	PF00069	0.629
MOD_PKB_1	146	154	PF00069	0.425
MOD_PKB_1	46	54	PF00069	0.450
MOD_Plk_1	179	185	PF00069	0.620
MOD_ProDKin_1	24	30	PF00069	0.567
TRG_DiLeu_BaEn_4	96	102	PF01217	0.546
TRG_ENDOCYTIC_2	38	41	PF00928	0.610
TRG_ER_diArg_1	1	3	PF00400	0.637
TRG_ER_diArg_1	129	132	PF00400	0.363
TRG_ER_diArg_1	45	48	PF00400	0.670
TRG_ER_diArg_1	72	75	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGG6	Leishmania donovani	68%	100%
A0A3R7P526	Trypanosoma rangeli	48%	100%
A4IDM0	Leishmania infantum	68%	100%
D0A4A7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q0X3	Leishmania major	67%	97%