Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPV7_LEIBR

TriTrypDb:

LbrM.35.4640 , LBRM2903_350057200

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003724	RNA helicase activity	3	8
GO:0003743	translation initiation factor activity	4	8
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0008186	ATP-dependent activity, acting on RNA	2	8
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	887	891	PF00656	0.644
CLV_NRD_NRD_1	120	122	PF00675	0.770
CLV_NRD_NRD_1	234	236	PF00675	0.528
CLV_NRD_NRD_1	29	31	PF00675	0.731
CLV_NRD_NRD_1	35	37	PF00675	0.708
CLV_NRD_NRD_1	412	414	PF00675	0.406
CLV_NRD_NRD_1	516	518	PF00675	0.610
CLV_NRD_NRD_1	535	537	PF00675	0.763
CLV_NRD_NRD_1	595	597	PF00675	0.760
CLV_NRD_NRD_1	632	634	PF00675	0.752
CLV_NRD_NRD_1	637	639	PF00675	0.740
CLV_NRD_NRD_1	718	720	PF00675	0.367
CLV_NRD_NRD_1	74	76	PF00675	0.557
CLV_NRD_NRD_1	816	818	PF00675	0.581
CLV_NRD_NRD_1	824	826	PF00675	0.631
CLV_NRD_NRD_1	911	913	PF00675	0.702
CLV_NRD_NRD_1	970	972	PF00675	0.869
CLV_PCSK_FUR_1	968	972	PF00082	0.621
CLV_PCSK_KEX2_1	119	121	PF00082	0.867
CLV_PCSK_KEX2_1	243	245	PF00082	0.751
CLV_PCSK_KEX2_1	249	251	PF00082	0.824
CLV_PCSK_KEX2_1	28	30	PF00082	0.687
CLV_PCSK_KEX2_1	330	332	PF00082	0.365
CLV_PCSK_KEX2_1	35	37	PF00082	0.704
CLV_PCSK_KEX2_1	412	414	PF00082	0.406
CLV_PCSK_KEX2_1	515	517	PF00082	0.803
CLV_PCSK_KEX2_1	534	536	PF00082	0.650
CLV_PCSK_KEX2_1	548	550	PF00082	0.583
CLV_PCSK_KEX2_1	594	596	PF00082	0.682
CLV_PCSK_KEX2_1	632	634	PF00082	0.752
CLV_PCSK_KEX2_1	718	720	PF00082	0.367
CLV_PCSK_KEX2_1	74	76	PF00082	0.557
CLV_PCSK_KEX2_1	751	753	PF00082	0.276
CLV_PCSK_KEX2_1	970	972	PF00082	0.798
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.828
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.751
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.824
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.361
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.803
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.679
CLV_PCSK_PC1ET2_1	751	753	PF00082	0.276
CLV_PCSK_PC7_1	590	596	PF00082	0.706
CLV_PCSK_SKI1_1	353	357	PF00082	0.384
CLV_PCSK_SKI1_1	491	495	PF00082	0.596
CLV_PCSK_SKI1_1	6	10	PF00082	0.795
CLV_PCSK_SKI1_1	614	618	PF00082	0.608
CLV_PCSK_SKI1_1	719	723	PF00082	0.377
CLV_PCSK_SKI1_1	74	78	PF00082	0.733
CLV_PCSK_SKI1_1	912	916	PF00082	0.664
CLV_PCSK_SKI1_1	921	925	PF00082	0.743
DEG_APCC_DBOX_1	740	748	PF00400	0.606
DEG_APCC_KENBOX_2	176	180	PF00400	0.608
DEG_SCF_FBW7_2	214	219	PF00400	0.604
DEG_SPOP_SBC_1	106	110	PF00917	0.847
DOC_CKS1_1	295	300	PF01111	0.476
DOC_CKS1_1	388	393	PF01111	0.567
DOC_CYCLIN_RxL_1	204	215	PF00134	0.592
DOC_CYCLIN_RxL_1	339	349	PF00134	0.577
DOC_MAPK_DCC_7	595	605	PF00069	0.805
DOC_MAPK_gen_1	18	25	PF00069	0.611
DOC_MAPK_gen_1	287	295	PF00069	0.521
DOC_MAPK_gen_1	330	338	PF00069	0.565
DOC_MAPK_gen_1	412	419	PF00069	0.606
DOC_MAPK_gen_1	494	503	PF00069	0.592
DOC_MAPK_gen_1	718	729	PF00069	0.559
DOC_MAPK_gen_1	74	81	PF00069	0.558
DOC_MAPK_gen_1	749	759	PF00069	0.606
DOC_MAPK_gen_1	894	902	PF00069	0.603
DOC_MAPK_gen_1	943	951	PF00069	0.689
DOC_MAPK_MEF2A_6	138	145	PF00069	0.809
DOC_MAPK_MEF2A_6	722	731	PF00069	0.606
DOC_MAPK_MEF2A_6	751	759	PF00069	0.606
DOC_PP1_RVXF_1	205	212	PF00149	0.611
DOC_PP1_RVXF_1	270	277	PF00149	0.606
DOC_PP1_RVXF_1	704	711	PF00149	0.606
DOC_PP1_RVXF_1	741	747	PF00149	0.606
DOC_PP1_RVXF_1	846	852	PF00149	0.621
DOC_PP2B_LxvP_1	151	154	PF13499	0.792
DOC_PP2B_PxIxI_1	359	365	PF00149	0.476
DOC_PP2B_PxIxI_1	383	389	PF00149	0.606
DOC_PP4_FxxP_1	211	214	PF00568	0.541
DOC_PP4_FxxP_1	276	279	PF00568	0.567
DOC_USP7_MATH_1	100	104	PF00917	0.788
DOC_USP7_MATH_1	105	109	PF00917	0.820
DOC_USP7_MATH_1	557	561	PF00917	0.837
DOC_USP7_MATH_1	63	67	PF00917	0.830
DOC_USP7_MATH_1	637	641	PF00917	0.681
DOC_USP7_MATH_1	687	691	PF00917	0.566
DOC_USP7_UBL2_3	243	247	PF12436	0.740
DOC_USP7_UBL2_3	5	9	PF12436	0.725
DOC_USP7_UBL2_3	745	749	PF12436	0.606
DOC_USP7_UBL2_3	858	862	PF12436	0.593
DOC_USP7_UBL2_3	955	959	PF12436	0.572
DOC_WW_Pin1_4	111	116	PF00397	0.571
DOC_WW_Pin1_4	212	217	PF00397	0.574
DOC_WW_Pin1_4	294	299	PF00397	0.633
DOC_WW_Pin1_4	336	341	PF00397	0.606
DOC_WW_Pin1_4	387	392	PF00397	0.579
DOC_WW_Pin1_4	83	88	PF00397	0.736
DOC_WW_Pin1_4	98	103	PF00397	0.596
LIG_14-3-3_CanoR_1	120	124	PF00244	0.760
LIG_14-3-3_CanoR_1	331	337	PF00244	0.606
LIG_14-3-3_CanoR_1	353	362	PF00244	0.504
LIG_14-3-3_CanoR_1	549	556	PF00244	0.616
LIG_14-3-3_CanoR_1	614	619	PF00244	0.602
LIG_14-3-3_CanoR_1	638	642	PF00244	0.617
LIG_14-3-3_CanoR_1	74	83	PF00244	0.746
LIG_14-3-3_CanoR_1	783	789	PF00244	0.606
LIG_14-3-3_CanoR_1	925	931	PF00244	0.704
LIG_Actin_WH2_2	731	747	PF00022	0.606
LIG_Actin_WH2_2	832	850	PF00022	0.655
LIG_AP2alpha_1	746	750	PF02296	0.606
LIG_BRCT_BRCA1_1	427	431	PF00533	0.606
LIG_BRCT_BRCA1_1	706	710	PF00533	0.476
LIG_FHA_1	339	345	PF00498	0.601
LIG_FHA_1	621	627	PF00498	0.643
LIG_FHA_1	75	81	PF00498	0.738
LIG_FHA_1	946	952	PF00498	0.691
LIG_FHA_2	284	290	PF00498	0.585
LIG_FHA_2	540	546	PF00498	0.622
LIG_FHA_2	626	632	PF00498	0.717
LIG_GBD_Chelix_1	839	847	PF00786	0.539
LIG_Integrin_RGD_1	752	754	PF01839	0.276
LIG_IRF3_LxIS_1	332	339	PF10401	0.657
LIG_LIR_Apic_2	273	279	PF02991	0.567
LIG_LIR_Gen_1	428	439	PF02991	0.606
LIG_LIR_Nem_3	428	434	PF02991	0.606
LIG_LIR_Nem_3	474	480	PF02991	0.734
LIG_LIR_Nem_3	692	697	PF02991	0.606
LIG_LIR_Nem_3	815	819	PF02991	0.532
LIG_NRBOX	280	286	PF00104	0.606
LIG_NRBOX	433	439	PF00104	0.567
LIG_NRBOX	719	725	PF00104	0.606
LIG_NRBOX	75	81	PF00104	0.738
LIG_NRBOX	802	808	PF00104	0.536
LIG_PCNA_yPIPBox_3	361	375	PF02747	0.610
LIG_Pex14_2	746	750	PF04695	0.567
LIG_Rb_LxCxE_1	681	701	PF01857	0.361
LIG_SH2_CRK	779	783	PF00017	0.657
LIG_SH2_GRB2like	702	705	PF00017	0.476
LIG_SH2_NCK_1	41	45	PF00017	0.823
LIG_SH2_STAP1	885	889	PF00017	0.524
LIG_SH2_STAT5	190	193	PF00017	0.598
LIG_SH2_STAT5	405	408	PF00017	0.606
LIG_SH2_STAT5	618	621	PF00017	0.550
LIG_SH2_STAT5	683	686	PF00017	0.511
LIG_SH2_STAT5	694	697	PF00017	0.501
LIG_SH2_STAT5	775	778	PF00017	0.601
LIG_SH2_STAT5	788	791	PF00017	0.527
LIG_SH3_1	138	144	PF00018	0.733
LIG_SH3_2	115	120	PF14604	0.607
LIG_SH3_3	112	118	PF00018	0.614
LIG_SH3_3	138	144	PF00018	0.740
LIG_SH3_3	292	298	PF00018	0.547
LIG_SH3_3	601	607	PF00018	0.802
LIG_SUMO_SIM_anti_2	728	733	PF11976	0.476
LIG_SUMO_SIM_anti_2	801	807	PF11976	0.553
LIG_SUMO_SIM_par_1	148	156	PF11976	0.714
LIG_SUMO_SIM_par_1	620	628	PF11976	0.644
LIG_SUMO_SIM_par_1	722	728	PF11976	0.476
LIG_TRAF2_1	216	219	PF00917	0.607
LIG_TRAF2_1	565	568	PF00917	0.752
LIG_TRAF2_1	65	68	PF00917	0.771
LIG_UBA3_1	280	287	PF00899	0.521
LIG_UBA3_1	716	722	PF00899	0.584
LIG_UBA3_1	819	826	PF00899	0.682
LIG_WRC_WIRS_1	830	835	PF05994	0.613
MOD_CDC14_SPxK_1	339	342	PF00782	0.606
MOD_CDK_SPxK_1	336	342	PF00069	0.606
MOD_CDK_SPxK_1	387	393	PF00069	0.567
MOD_CK1_1	110	116	PF00069	0.820
MOD_CK1_1	265	271	PF00069	0.561
MOD_CK1_1	294	300	PF00069	0.591
MOD_CK1_1	464	470	PF00069	0.675
MOD_CK1_1	529	535	PF00069	0.851
MOD_CK1_1	625	631	PF00069	0.706
MOD_CK1_1	863	869	PF00069	0.510
MOD_CK2_1	236	242	PF00069	0.752
MOD_CK2_1	539	545	PF00069	0.628
MOD_CK2_1	625	631	PF00069	0.706
MOD_CK2_1	665	671	PF00069	0.640
MOD_CK2_1	825	831	PF00069	0.626
MOD_Cter_Amidation	513	516	PF01082	0.871
MOD_Cter_Amidation	823	826	PF01082	0.622
MOD_Cter_Amidation	910	913	PF01082	0.699
MOD_GlcNHglycan	103	106	PF01048	0.799
MOD_GlcNHglycan	125	128	PF01048	0.684
MOD_GlcNHglycan	185	188	PF01048	0.725
MOD_GlcNHglycan	251	254	PF01048	0.771
MOD_GlcNHglycan	264	267	PF01048	0.331
MOD_GlcNHglycan	269	272	PF01048	0.290
MOD_GlcNHglycan	427	430	PF01048	0.370
MOD_GlcNHglycan	466	469	PF01048	0.710
MOD_GlcNHglycan	545	548	PF01048	0.664
MOD_GlcNHglycan	558	562	PF01048	0.753
MOD_GlcNHglycan	620	623	PF01048	0.546
MOD_GlcNHglycan	634	638	PF01048	0.737
MOD_GlcNHglycan	671	674	PF01048	0.648
MOD_GlcNHglycan	91	94	PF01048	0.807
MOD_GlcNHglycan	926	929	PF01048	0.692
MOD_GSK3_1	101	108	PF00069	0.824
MOD_GSK3_1	119	126	PF00069	0.770
MOD_GSK3_1	231	238	PF00069	0.543
MOD_GSK3_1	332	339	PF00069	0.574
MOD_GSK3_1	539	546	PF00069	0.773
MOD_GSK3_1	59	66	PF00069	0.801
MOD_GSK3_1	614	621	PF00069	0.582
MOD_GSK3_1	633	640	PF00069	0.712
MOD_GSK3_1	665	672	PF00069	0.651
MOD_GSK3_1	758	765	PF00069	0.582
MOD_GSK3_1	825	832	PF00069	0.596
MOD_N-GLC_1	110	115	PF02516	0.813
MOD_N-GLC_1	679	684	PF02516	0.571
MOD_NEK2_1	209	214	PF00069	0.630
MOD_NEK2_1	406	411	PF00069	0.606
MOD_NEK2_1	425	430	PF00069	0.569
MOD_NEK2_1	669	674	PF00069	0.686
MOD_NEK2_1	698	703	PF00069	0.606
MOD_NEK2_1	734	739	PF00069	0.606
MOD_NEK2_1	819	824	PF00069	0.607
MOD_NEK2_1	835	840	PF00069	0.397
MOD_NEK2_1	924	929	PF00069	0.711
MOD_PIKK_1	236	242	PF00454	0.678
MOD_PIKK_1	509	515	PF00454	0.614
MOD_PIKK_1	529	535	PF00454	0.611
MOD_PIKK_1	63	69	PF00454	0.834
MOD_PK_1	40	46	PF00069	0.824
MOD_PKA_1	119	125	PF00069	0.796
MOD_PKA_1	235	241	PF00069	0.620
MOD_PKA_1	249	255	PF00069	0.672
MOD_PKA_1	4	10	PF00069	0.717
MOD_PKA_1	74	80	PF00069	0.557
MOD_PKA_1	825	831	PF00069	0.626
MOD_PKA_1	912	918	PF00069	0.680
MOD_PKA_2	119	125	PF00069	0.846
MOD_PKA_2	183	189	PF00069	0.799
MOD_PKA_2	249	255	PF00069	0.810
MOD_PKA_2	637	643	PF00069	0.736
MOD_PKA_2	74	80	PF00069	0.557
MOD_PKA_2	782	788	PF00069	0.606
MOD_PKA_2	81	87	PF00069	0.565
MOD_PKA_2	863	869	PF00069	0.570
MOD_PKA_2	871	877	PF00069	0.642
MOD_PKA_2	924	930	PF00069	0.705
MOD_PKA_2	945	951	PF00069	0.687
MOD_Plk_1	291	297	PF00069	0.476
MOD_Plk_1	461	467	PF00069	0.713
MOD_Plk_1	679	685	PF00069	0.576
MOD_Plk_1	704	710	PF00069	0.521
MOD_Plk_2-3	878	884	PF00069	0.698
MOD_Plk_4	270	276	PF00069	0.606
MOD_Plk_4	332	338	PF00069	0.567
MOD_Plk_4	433	439	PF00069	0.657
MOD_Plk_4	473	479	PF00069	0.795
MOD_Plk_4	637	643	PF00069	0.682
MOD_Plk_4	679	685	PF00069	0.573
MOD_Plk_4	801	807	PF00069	0.494
MOD_Plk_4	835	841	PF00069	0.580
MOD_ProDKin_1	111	117	PF00069	0.571
MOD_ProDKin_1	212	218	PF00069	0.567
MOD_ProDKin_1	294	300	PF00069	0.633
MOD_ProDKin_1	336	342	PF00069	0.606
MOD_ProDKin_1	387	393	PF00069	0.579
MOD_ProDKin_1	83	89	PF00069	0.735
MOD_ProDKin_1	98	104	PF00069	0.596
TRG_DiLeu_BaEn_1	433	438	PF01217	0.572
TRG_DiLeu_BaEn_2	472	478	PF01217	0.605
TRG_ENDOCYTIC_2	41	44	PF00928	0.821
TRG_ENDOCYTIC_2	696	699	PF00928	0.606
TRG_ER_diArg_1	27	30	PF00400	0.690
TRG_ER_diArg_1	35	37	PF00400	0.705
TRG_ER_diArg_1	412	414	PF00400	0.569
TRG_ER_diArg_1	486	489	PF00400	0.598
TRG_ER_diArg_1	516	519	PF00400	0.611
TRG_ER_diArg_1	534	536	PF00400	0.713
TRG_ER_diArg_1	594	596	PF00400	0.711
TRG_ER_diArg_1	717	719	PF00400	0.567
TRG_ER_diArg_1	73	75	PF00400	0.563
TRG_ER_diArg_1	741	744	PF00400	0.606
TRG_ER_diArg_1	967	970	PF00400	0.620
TRG_NLS_Bipartite_1	235	250	PF00514	0.644
TRG_NLS_Bipartite_1	534	552	PF00514	0.706
TRG_NLS_MonoExtC_3	245	250	PF00514	0.745
TRG_NLS_MonoExtC_3	514	519	PF00514	0.842
TRG_NLS_MonoExtN_4	118	123	PF00514	0.709
TRG_NLS_MonoExtN_4	243	250	PF00514	0.755
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.733
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	817	821	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	901	906	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ87	Leptomonas seymouri	68%	100%
A0A0S4II81	Bodo saltans	26%	100%
A0A3S7XBG9	Leishmania donovani	79%	100%
A4IDL9	Leishmania infantum	79%	100%
E9ATM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q0X4	Leishmania major	80%	100%