Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-tubulin complex component 2

Species:

Leishmania braziliensis

UniProt:

A4HPV6_LEIBR

TriTrypDb:

LbrM.35.4630 , LBRM2903_350057100

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	12
GO:0005737	cytoplasm	2	12
GO:0005815	microtubule organizing center	2	12
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0000923	equatorial microtubule organizing center	3	1
GO:0000930	gamma-tubulin complex	2	1
GO:0005813	centrosome	3	1
GO:0008275	gamma-tubulin small complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HPV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV6

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0007020	microtubule nucleation	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0007051	spindle organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051321	meiotic cell cycle	2	1
GO:0070925	organelle assembly	5	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1904158	axonemal central apparatus assembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043015	gamma-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.483
CLV_C14_Caspase3-7	558	562	PF00656	0.466
CLV_C14_Caspase3-7	61	65	PF00656	0.595
CLV_C14_Caspase3-7	622	626	PF00656	0.555
CLV_NRD_NRD_1	323	325	PF00675	0.255
CLV_NRD_NRD_1	411	413	PF00675	0.305
CLV_NRD_NRD_1	424	426	PF00675	0.192
CLV_NRD_NRD_1	54	56	PF00675	0.353
CLV_NRD_NRD_1	642	644	PF00675	0.294
CLV_NRD_NRD_1	655	657	PF00675	0.334
CLV_NRD_NRD_1	698	700	PF00675	0.277
CLV_PCSK_KEX2_1	16	18	PF00082	0.546
CLV_PCSK_KEX2_1	323	325	PF00082	0.255
CLV_PCSK_KEX2_1	411	413	PF00082	0.303
CLV_PCSK_KEX2_1	424	426	PF00082	0.186
CLV_PCSK_KEX2_1	54	56	PF00082	0.373
CLV_PCSK_KEX2_1	642	644	PF00082	0.316
CLV_PCSK_KEX2_1	655	657	PF00082	0.334
CLV_PCSK_KEX2_1	698	700	PF00082	0.277
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.587
CLV_PCSK_SKI1_1	260	264	PF00082	0.266
CLV_PCSK_SKI1_1	442	446	PF00082	0.265
CLV_PCSK_SKI1_1	542	546	PF00082	0.318
CLV_PCSK_SKI1_1	624	628	PF00082	0.168
CLV_Separin_Metazoa	248	252	PF03568	0.466
DEG_APCC_DBOX_1	654	662	PF00400	0.559
DEG_SCF_TRCP1_1	621	627	PF00400	0.559
DEG_SPOP_SBC_1	279	283	PF00917	0.543
DOC_CKS1_1	150	155	PF01111	0.537
DOC_CKS1_1	437	442	PF01111	0.559
DOC_CYCLIN_RxL_1	653	664	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	667	673	PF00134	0.455
DOC_MAPK_DCC_7	323	332	PF00069	0.496
DOC_MAPK_gen_1	258	267	PF00069	0.541
DOC_MAPK_gen_1	573	581	PF00069	0.541
DOC_MAPK_gen_1	655	663	PF00069	0.532
DOC_MAPK_HePTP_8	320	332	PF00069	0.455
DOC_MAPK_HePTP_8	675	687	PF00069	0.541
DOC_MAPK_MEF2A_6	323	332	PF00069	0.474
DOC_MAPK_MEF2A_6	430	437	PF00069	0.541
DOC_MAPK_MEF2A_6	575	583	PF00069	0.461
DOC_MAPK_MEF2A_6	678	687	PF00069	0.527
DOC_PP1_RVXF_1	15	22	PF00149	0.458
DOC_PP1_RVXF_1	443	450	PF00149	0.497
DOC_PP1_RVXF_1	543	549	PF00149	0.559
DOC_PP1_RVXF_1	686	693	PF00149	0.516
DOC_PP2B_LxvP_1	88	91	PF13499	0.642
DOC_PP4_FxxP_1	285	288	PF00568	0.530
DOC_USP7_MATH_1	156	160	PF00917	0.542
DOC_USP7_MATH_1	278	282	PF00917	0.521
DOC_USP7_MATH_1	380	384	PF00917	0.532
DOC_USP7_MATH_1	396	400	PF00917	0.521
DOC_USP7_MATH_1	476	480	PF00917	0.546
DOC_USP7_MATH_1	629	633	PF00917	0.514
DOC_USP7_MATH_1	654	658	PF00917	0.541
DOC_USP7_MATH_2	93	99	PF00917	0.511
DOC_WW_Pin1_4	149	154	PF00397	0.538
DOC_WW_Pin1_4	168	173	PF00397	0.528
DOC_WW_Pin1_4	284	289	PF00397	0.561
DOC_WW_Pin1_4	382	387	PF00397	0.433
DOC_WW_Pin1_4	436	441	PF00397	0.559
DOC_WW_Pin1_4	86	91	PF00397	0.561
LIG_14-3-3_CanoR_1	323	327	PF00244	0.473
LIG_14-3-3_CanoR_1	424	429	PF00244	0.447
LIG_14-3-3_CanoR_1	468	473	PF00244	0.471
LIG_14-3-3_CanoR_1	589	595	PF00244	0.518
LIG_14-3-3_CanoR_1	655	659	PF00244	0.537
LIG_14-3-3_CanoR_1	70	78	PF00244	0.722
LIG_14-3-3_CanoR_1	9	15	PF00244	0.361
LIG_Actin_WH2_2	245	262	PF00022	0.502
LIG_BRCT_BRCA1_1	281	285	PF00533	0.530
LIG_Clathr_ClatBox_1	660	664	PF01394	0.455
LIG_deltaCOP1_diTrp_1	554	559	PF00928	0.455
LIG_deltaCOP1_diTrp_1	6	10	PF00928	0.536
LIG_DLG_GKlike_1	424	432	PF00625	0.541
LIG_EH1_1	576	584	PF00400	0.466
LIG_eIF4E_1	203	209	PF01652	0.466
LIG_eIF4E_1	577	583	PF01652	0.397
LIG_FHA_1	133	139	PF00498	0.368
LIG_FHA_1	287	293	PF00498	0.522
LIG_FHA_1	371	377	PF00498	0.492
LIG_FHA_1	38	44	PF00498	0.479
LIG_FHA_1	493	499	PF00498	0.507
LIG_FHA_1	626	632	PF00498	0.546
LIG_FHA_1	634	640	PF00498	0.570
LIG_FHA_1	670	676	PF00498	0.455
LIG_FHA_1	678	684	PF00498	0.455
LIG_FHA_1	704	710	PF00498	0.636
LIG_FHA_2	386	392	PF00498	0.483
LIG_FHA_2	606	612	PF00498	0.522
LIG_Integrin_RGD_1	552	554	PF01839	0.266
LIG_Integrin_RGDW_4	552	555	PF00362	0.266
LIG_LIR_Apic_2	282	288	PF02991	0.530
LIG_LIR_Gen_1	190	198	PF02991	0.466
LIG_LIR_Gen_1	593	604	PF02991	0.480
LIG_LIR_Gen_1	6	14	PF02991	0.440
LIG_LIR_Nem_3	190	195	PF02991	0.511
LIG_LIR_Nem_3	343	349	PF02991	0.489
LIG_LIR_Nem_3	593	599	PF02991	0.480
LIG_LIR_Nem_3	6	10	PF02991	0.425
LIG_MYND_1	86	90	PF01753	0.499
LIG_NRBOX	316	322	PF00104	0.455
LIG_NRBOX	608	614	PF00104	0.541
LIG_PCNA_yPIPBox_3	606	620	PF02747	0.559
LIG_Pex14_1	555	559	PF04695	0.455
LIG_Pex14_2	422	426	PF04695	0.466
LIG_PTB_Apo_2	296	303	PF02174	0.368
LIG_PTB_Phospho_1	296	302	PF10480	0.368
LIG_Rb_LxCxE_1	190	207	PF01857	0.541
LIG_Rb_pABgroove_1	296	304	PF01858	0.368
LIG_REV1ctd_RIR_1	446	456	PF16727	0.541
LIG_SH2_CRK	302	306	PF00017	0.368
LIG_SH2_CRK	453	457	PF00017	0.455
LIG_SH2_GRB2like	705	708	PF00017	0.611
LIG_SH2_NCK_1	302	306	PF00017	0.368
LIG_SH2_STAP1	224	228	PF00017	0.516
LIG_SH2_STAP1	577	581	PF00017	0.397
LIG_SH2_STAP1	705	709	PF00017	0.610
LIG_SH2_STAT3	224	227	PF00017	0.541
LIG_SH2_STAT3	547	550	PF00017	0.516
LIG_SH2_STAT3	577	580	PF00017	0.397
LIG_SH2_STAT5	329	332	PF00017	0.455
LIG_SH2_STAT5	453	456	PF00017	0.449
LIG_SH2_STAT5	547	550	PF00017	0.455
LIG_SH2_STAT5	705	708	PF00017	0.604
LIG_SH3_3	150	156	PF00018	0.559
LIG_SH3_3	169	175	PF00018	0.541
LIG_SH3_3	354	360	PF00018	0.522
LIG_SH3_3	87	93	PF00018	0.750
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.541
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.486
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.422
LIG_SUMO_SIM_anti_2	532	539	PF11976	0.440
LIG_SUMO_SIM_anti_2	657	662	PF11976	0.496
LIG_SUMO_SIM_par_1	671	677	PF11976	0.531
LIG_TRAF2_1	608	611	PF00917	0.541
LIG_UBA3_1	537	545	PF00899	0.455
LIG_UBA3_1	686	694	PF00899	0.469
MOD_CDK_SPxK_1	436	442	PF00069	0.559
MOD_CK1_1	102	108	PF00069	0.606
MOD_CK1_1	155	161	PF00069	0.545
MOD_CK1_1	177	183	PF00069	0.422
MOD_CK1_1	204	210	PF00069	0.559
MOD_CK1_1	281	287	PF00069	0.540
MOD_CK1_1	309	315	PF00069	0.368
MOD_CK1_1	400	406	PF00069	0.504
MOD_CK1_1	438	444	PF00069	0.368
MOD_CK1_1	479	485	PF00069	0.497
MOD_CK1_1	562	568	PF00069	0.535
MOD_CK1_1	590	596	PF00069	0.496
MOD_CK1_1	677	683	PF00069	0.368
MOD_CK1_1	76	82	PF00069	0.715
MOD_CK2_1	177	183	PF00069	0.542
MOD_CK2_1	605	611	PF00069	0.485
MOD_GlcNHglycan	308	311	PF01048	0.268
MOD_GlcNHglycan	338	341	PF01048	0.361
MOD_GlcNHglycan	505	508	PF01048	0.294
MOD_GlcNHglycan	522	525	PF01048	0.179
MOD_GlcNHglycan	561	564	PF01048	0.279
MOD_GlcNHglycan	621	624	PF01048	0.304
MOD_GlcNHglycan	633	636	PF01048	0.217
MOD_GlcNHglycan	712	716	PF01048	0.560
MOD_GlcNHglycan	73	76	PF01048	0.733
MOD_GSK3_1	128	135	PF00069	0.522
MOD_GSK3_1	152	159	PF00069	0.538
MOD_GSK3_1	177	184	PF00069	0.489
MOD_GSK3_1	215	222	PF00069	0.466
MOD_GSK3_1	274	281	PF00069	0.518
MOD_GSK3_1	37	44	PF00069	0.470
MOD_GSK3_1	381	388	PF00069	0.473
MOD_GSK3_1	396	403	PF00069	0.441
MOD_GSK3_1	424	431	PF00069	0.525
MOD_GSK3_1	476	483	PF00069	0.453
MOD_GSK3_1	625	632	PF00069	0.532
MOD_GSK3_1	76	83	PF00069	0.683
MOD_GSK3_1	95	102	PF00069	0.735
MOD_N-GLC_1	220	225	PF02516	0.322
MOD_N-GLC_1	428	433	PF02516	0.341
MOD_N-GLC_1	605	610	PF02516	0.314
MOD_NEK2_1	128	133	PF00069	0.535
MOD_NEK2_1	181	186	PF00069	0.500
MOD_NEK2_1	267	272	PF00069	0.514
MOD_NEK2_1	322	327	PF00069	0.541
MOD_NEK2_1	370	375	PF00069	0.437
MOD_NEK2_1	381	386	PF00069	0.476
MOD_NEK2_1	428	433	PF00069	0.487
MOD_NEK2_1	503	508	PF00069	0.474
MOD_NEK2_1	529	534	PF00069	0.579
MOD_NEK2_1	73	78	PF00069	0.620
MOD_PIKK_1	116	122	PF00454	0.600
MOD_PIKK_1	400	406	PF00454	0.559
MOD_PKA_1	424	430	PF00069	0.436
MOD_PKA_1	54	60	PF00069	0.535
MOD_PKA_2	102	108	PF00069	0.750
MOD_PKA_2	322	328	PF00069	0.491
MOD_PKA_2	34	40	PF00069	0.562
MOD_PKA_2	370	376	PF00069	0.441
MOD_PKA_2	424	430	PF00069	0.424
MOD_PKA_2	54	60	PF00069	0.342
MOD_PKA_2	619	625	PF00069	0.541
MOD_PKA_2	654	660	PF00069	0.541
MOD_Plk_1	116	122	PF00069	0.577
MOD_Plk_1	220	226	PF00069	0.541
MOD_Plk_1	428	434	PF00069	0.514
MOD_Plk_1	605	611	PF00069	0.479
MOD_Plk_4	128	134	PF00069	0.490
MOD_Plk_4	181	187	PF00069	0.466
MOD_Plk_4	428	434	PF00069	0.504
MOD_Plk_4	562	568	PF00069	0.535
MOD_Plk_4	669	675	PF00069	0.455
MOD_ProDKin_1	149	155	PF00069	0.538
MOD_ProDKin_1	168	174	PF00069	0.528
MOD_ProDKin_1	284	290	PF00069	0.561
MOD_ProDKin_1	382	388	PF00069	0.433
MOD_ProDKin_1	436	442	PF00069	0.559
MOD_ProDKin_1	86	92	PF00069	0.560
TRG_DiLeu_BaEn_1	313	318	PF01217	0.466
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.506
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.748
TRG_ENDOCYTIC_2	302	305	PF00928	0.368
TRG_ENDOCYTIC_2	329	332	PF00928	0.455
TRG_ENDOCYTIC_2	346	349	PF00928	0.455
TRG_ENDOCYTIC_2	453	456	PF00928	0.447
TRG_ENDOCYTIC_2	596	599	PF00928	0.479
TRG_ER_diArg_1	257	260	PF00400	0.466
TRG_ER_diArg_1	322	324	PF00400	0.455
TRG_ER_diArg_1	424	426	PF00400	0.462
TRG_ER_diArg_1	641	643	PF00400	0.397
TRG_ER_diArg_1	698	700	PF00400	0.482
TRG_NES_CRM1_1	536	550	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I635	Leptomonas seymouri	66%	82%
A0A0S4J3M1	Bodo saltans	38%	82%
A0A1X0P0Y3	Trypanosomatidae	45%	91%
A0A3R7RTV6	Trypanosoma rangeli	43%	94%
A0A3S7XBK0	Leishmania donovani	83%	84%
A4IDL8	Leishmania infantum	83%	84%
D0A4A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	92%
E9ATM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	84%
Q4Q0X5	Leishmania major	82%	100%
Q5R5J6	Pongo abelii	22%	80%
Q9BSJ2	Homo sapiens	22%	80%
Q9C5H9	Arabidopsis thaliana	21%	100%
V5DLM1	Trypanosoma cruzi	45%	95%