Alternative oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alternative oxidase

Gene product:

alternative oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPV5_LEIBR

TriTrypDb:

LbrM.35.4620 , LBRM2903_350057000

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HPV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV5

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010230	alternative respiration	7	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0009916	alternative oxidase activity	5	8
GO:0016491	oxidoreductase activity	2	8
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	8
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.297
CLV_C14_Caspase3-7	23	27	PF00656	0.620
CLV_NRD_NRD_1	163	165	PF00675	0.598
CLV_NRD_NRD_1	20	22	PF00675	0.516
CLV_NRD_NRD_1	33	35	PF00675	0.528
CLV_PCSK_KEX2_1	162	164	PF00082	0.607
CLV_PCSK_KEX2_1	20	22	PF00082	0.516
CLV_PCSK_KEX2_1	33	35	PF00082	0.528
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.426
CLV_PCSK_PC7_1	158	164	PF00082	0.607
CLV_PCSK_SKI1_1	240	244	PF00082	0.496
CLV_PCSK_SKI1_1	390	394	PF00082	0.404
CLV_PCSK_SKI1_1	49	53	PF00082	0.400
DEG_APCC_DBOX_1	471	479	PF00400	0.551
DEG_Nend_UBRbox_1	1	4	PF02207	0.594
DOC_MAPK_DCC_7	339	347	PF00069	0.426
DOC_MAPK_MEF2A_6	108	117	PF00069	0.556
DOC_MAPK_MEF2A_6	136	143	PF00069	0.430
DOC_MAPK_MEF2A_6	6	13	PF00069	0.774
DOC_PP1_RVXF_1	117	124	PF00149	0.517
DOC_PP1_RVXF_1	475	482	PF00149	0.578
DOC_PP4_MxPP_1	84	87	PF00568	0.657
DOC_USP7_MATH_1	149	153	PF00917	0.430
DOC_USP7_MATH_1	180	184	PF00917	0.397
DOC_USP7_MATH_1	188	192	PF00917	0.340
DOC_USP7_MATH_1	202	206	PF00917	0.333
DOC_USP7_MATH_1	211	215	PF00917	0.345
DOC_USP7_MATH_1	300	304	PF00917	0.556
DOC_USP7_MATH_1	348	352	PF00917	0.426
DOC_USP7_MATH_1	47	51	PF00917	0.760
DOC_USP7_MATH_1	61	65	PF00917	0.676
DOC_WW_Pin1_4	102	107	PF00397	0.616
DOC_WW_Pin1_4	181	186	PF00397	0.356
DOC_WW_Pin1_4	189	194	PF00397	0.356
DOC_WW_Pin1_4	378	383	PF00397	0.592
DOC_WW_Pin1_4	391	396	PF00397	0.394
DOC_WW_Pin1_4	50	55	PF00397	0.598
DOC_WW_Pin1_4	57	62	PF00397	0.596
LIG_14-3-3_CanoR_1	136	140	PF00244	0.411
LIG_14-3-3_CanoR_1	20	25	PF00244	0.644
LIG_14-3-3_CanoR_1	206	215	PF00244	0.317
LIG_14-3-3_CanoR_1	228	232	PF00244	0.333
LIG_14-3-3_CanoR_1	33	38	PF00244	0.701
LIG_14-3-3_CanoR_1	390	395	PF00244	0.426
LIG_14-3-3_CanoR_1	90	100	PF00244	0.544
LIG_BRCT_BRCA1_1	182	186	PF00533	0.407
LIG_BRCT_BRCA1_1	204	208	PF00533	0.274
LIG_BRCT_BRCA1_1	402	406	PF00533	0.533
LIG_BRCT_BRCA1_1	77	81	PF00533	0.594
LIG_eIF4E_1	281	287	PF01652	0.430
LIG_FHA_1	136	142	PF00498	0.430
LIG_FHA_1	277	283	PF00498	0.430
LIG_FHA_1	306	312	PF00498	0.517
LIG_FHA_2	167	173	PF00498	0.308
LIG_FHA_2	21	27	PF00498	0.618
LIG_FHA_2	261	267	PF00498	0.317
LIG_FHA_2	297	303	PF00498	0.537
LIG_FHA_2	348	354	PF00498	0.524
LIG_FHA_2	359	365	PF00498	0.514
LIG_FHA_2	440	446	PF00498	0.491
LIG_FHA_2	92	98	PF00498	0.525
LIG_HCF-1_HBM_1	232	235	PF13415	0.407
LIG_LIR_Gen_1	183	193	PF02991	0.379
LIG_LIR_Gen_1	250	259	PF02991	0.375
LIG_LIR_Gen_1	279	289	PF02991	0.347
LIG_LIR_Gen_1	304	314	PF02991	0.556
LIG_LIR_Gen_1	68	75	PF02991	0.662
LIG_LIR_Gen_1	78	88	PF02991	0.612
LIG_LIR_Nem_3	183	189	PF02991	0.379
LIG_LIR_Nem_3	250	256	PF02991	0.375
LIG_LIR_Nem_3	279	284	PF02991	0.353
LIG_LIR_Nem_3	39	45	PF02991	0.610
LIG_LIR_Nem_3	454	460	PF02991	0.517
LIG_LIR_Nem_3	68	74	PF02991	0.696
LIG_LYPXL_S_1	287	291	PF13949	0.376
LIG_LYPXL_yS_3	288	291	PF13949	0.517
LIG_NRBOX	268	274	PF00104	0.501
LIG_SH2_CRK	253	257	PF00017	0.407
LIG_SH2_SRC	69	72	PF00017	0.560
LIG_SH2_STAT5	133	136	PF00017	0.540
LIG_SH2_STAT5	156	159	PF00017	0.317
LIG_SH2_STAT5	281	284	PF00017	0.420
LIG_SH2_STAT5	298	301	PF00017	0.471
LIG_SH2_STAT5	69	72	PF00017	0.705
LIG_SH3_3	196	202	PF00018	0.412
LIG_SH3_3	399	405	PF00018	0.607
LIG_SH3_3	48	54	PF00018	0.661
LIG_SH3_3	6	12	PF00018	0.589
LIG_SUMO_SIM_anti_2	445	450	PF11976	0.517
LIG_SUMO_SIM_par_1	439	445	PF11976	0.524
LIG_TRAF2_1	299	302	PF00917	0.556
LIG_TRAF2_1	350	353	PF00917	0.607
LIG_TYR_ITIM	251	256	PF00017	0.356
LIG_TYR_ITIM	329	334	PF00017	0.517
MOD_CDC14_SPxK_1	60	63	PF00782	0.602
MOD_CDK_SPxK_1	102	108	PF00069	0.556
MOD_CDK_SPxK_1	57	63	PF00069	0.607
MOD_CK1_1	166	172	PF00069	0.327
MOD_CK1_1	192	198	PF00069	0.332
MOD_CK1_1	207	213	PF00069	0.339
MOD_CK1_1	218	224	PF00069	0.349
MOD_CK1_1	257	263	PF00069	0.308
MOD_CK1_1	378	384	PF00069	0.571
MOD_CK1_1	388	394	PF00069	0.538
MOD_CK1_1	4	10	PF00069	0.669
MOD_CK1_1	436	442	PF00069	0.521
MOD_CK1_1	50	56	PF00069	0.749
MOD_CK2_1	226	232	PF00069	0.359
MOD_CK2_1	260	266	PF00069	0.325
MOD_CK2_1	296	302	PF00069	0.520
MOD_CK2_1	347	353	PF00069	0.512
MOD_CK2_1	358	364	PF00069	0.456
MOD_CK2_1	408	414	PF00069	0.575
MOD_CK2_1	91	97	PF00069	0.556
MOD_GlcNHglycan	220	223	PF01048	0.571
MOD_GlcNHglycan	26	29	PF01048	0.522
MOD_GlcNHglycan	377	380	PF01048	0.397
MOD_GlcNHglycan	435	438	PF01048	0.226
MOD_GlcNHglycan	45	48	PF01048	0.592
MOD_GSK3_1	135	142	PF00069	0.517
MOD_GSK3_1	164	171	PF00069	0.378
MOD_GSK3_1	188	195	PF00069	0.308
MOD_GSK3_1	20	27	PF00069	0.757
MOD_GSK3_1	207	214	PF00069	0.384
MOD_GSK3_1	227	234	PF00069	0.287
MOD_GSK3_1	296	303	PF00069	0.537
MOD_GSK3_1	32	39	PF00069	0.812
MOD_GSK3_1	368	375	PF00069	0.535
MOD_GSK3_1	400	407	PF00069	0.486
MOD_GSK3_1	408	415	PF00069	0.525
MOD_GSK3_1	43	50	PF00069	0.740
MOD_GSK3_1	57	64	PF00069	0.685
MOD_N-GLC_1	24	29	PF02516	0.613
MOD_N-GLC_1	388	393	PF02516	0.243
MOD_N-GLC_2	8	10	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	101	106	PF00069	0.607
MOD_NEK2_1	117	122	PF00069	0.383
MOD_NEK2_1	139	144	PF00069	0.353
MOD_NEK2_1	215	220	PF00069	0.360
MOD_NEK2_1	231	236	PF00069	0.334
MOD_NEK2_1	24	29	PF00069	0.732
MOD_NEK2_1	347	352	PF00069	0.451
MOD_NEK2_1	37	42	PF00069	0.721
MOD_NEK2_1	372	377	PF00069	0.426
MOD_NEK2_1	45	50	PF00069	0.711
MOD_NEK2_1	75	80	PF00069	0.561
MOD_NEK2_2	14	19	PF00069	0.602
MOD_PIKK_1	305	311	PF00454	0.556
MOD_PIKK_1	337	343	PF00454	0.471
MOD_PIKK_1	348	354	PF00454	0.471
MOD_PIKK_1	467	473	PF00454	0.651
MOD_PIKK_1	91	97	PF00454	0.607
MOD_PKA_1	163	169	PF00069	0.226
MOD_PKA_1	20	26	PF00069	0.617
MOD_PKA_1	33	39	PF00069	0.616
MOD_PKA_2	1	7	PF00069	0.590
MOD_PKA_2	135	141	PF00069	0.517
MOD_PKA_2	163	169	PF00069	0.352
MOD_PKA_2	19	25	PF00069	0.601
MOD_PKA_2	211	217	PF00069	0.397
MOD_PKA_2	227	233	PF00069	0.274
MOD_PKA_2	32	38	PF00069	0.725
MOD_Plk_1	231	237	PF00069	0.358
MOD_Plk_1	260	266	PF00069	0.317
MOD_Plk_1	300	306	PF00069	0.514
MOD_Plk_2-3	368	374	PF00069	0.426
MOD_Plk_4	135	141	PF00069	0.517
MOD_Plk_4	301	307	PF00069	0.517
MOD_Plk_4	436	442	PF00069	0.607
MOD_Plk_4	47	53	PF00069	0.792
MOD_Plk_4	65	71	PF00069	0.704
MOD_ProDKin_1	102	108	PF00069	0.616
MOD_ProDKin_1	181	187	PF00069	0.356
MOD_ProDKin_1	189	195	PF00069	0.356
MOD_ProDKin_1	378	384	PF00069	0.592
MOD_ProDKin_1	391	397	PF00069	0.394
MOD_ProDKin_1	50	56	PF00069	0.601
MOD_ProDKin_1	57	63	PF00069	0.596
MOD_SUMO_rev_2	413	422	PF00179	0.557
TRG_ENDOCYTIC_2	156	159	PF00928	0.317
TRG_ENDOCYTIC_2	253	256	PF00928	0.349
TRG_ENDOCYTIC_2	281	284	PF00928	0.392
TRG_ENDOCYTIC_2	288	291	PF00928	0.503
TRG_ENDOCYTIC_2	331	334	PF00928	0.517
TRG_ENDOCYTIC_2	71	74	PF00928	0.685
TRG_ER_diArg_1	32	34	PF00400	0.701
TRG_NES_CRM1_1	315	326	PF08389	0.426
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P770	Leptomonas seymouri	55%	100%
A0A1X0P0D1	Trypanosomatidae	36%	100%
A0A3Q8IWB1	Leishmania donovani	69%	100%
A4IDL7	Leishmania infantum	69%	100%
E9ATM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q0X6	Leishmania major	69%	100%