Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPV2_LEIBR

TriTrypDb:

LbrM.35.4590 , LBRM2903_350056700

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.790
CLV_C14_Caspase3-7	237	241	PF00656	0.673
CLV_C14_Caspase3-7	598	602	PF00656	0.682
CLV_NRD_NRD_1	149	151	PF00675	0.795
CLV_NRD_NRD_1	211	213	PF00675	0.649
CLV_NRD_NRD_1	453	455	PF00675	0.698
CLV_NRD_NRD_1	481	483	PF00675	0.546
CLV_NRD_NRD_1	680	682	PF00675	0.576
CLV_NRD_NRD_1	760	762	PF00675	0.616
CLV_NRD_NRD_1	888	890	PF00675	0.755
CLV_PCSK_KEX2_1	149	151	PF00082	0.795
CLV_PCSK_KEX2_1	211	213	PF00082	0.649
CLV_PCSK_KEX2_1	481	483	PF00082	0.546
CLV_PCSK_KEX2_1	584	586	PF00082	0.714
CLV_PCSK_KEX2_1	682	684	PF00082	0.589
CLV_PCSK_KEX2_1	752	754	PF00082	0.604
CLV_PCSK_KEX2_1	760	762	PF00082	0.621
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.714
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.646
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.604
CLV_PCSK_SKI1_1	340	344	PF00082	0.605
CLV_PCSK_SKI1_1	373	377	PF00082	0.792
CLV_PCSK_SKI1_1	585	589	PF00082	0.715
CLV_PCSK_SKI1_1	696	700	PF00082	0.578
CLV_PCSK_SKI1_1	761	765	PF00082	0.543
CLV_PCSK_SKI1_1	802	806	PF00082	0.539
DEG_APCC_DBOX_1	760	768	PF00400	0.750
DEG_COP1_1	413	425	PF00400	0.552
DEG_Nend_UBRbox_1	1	4	PF02207	0.507
DEG_ODPH_VHL_1	778	790	PF01847	0.531
DEG_SCF_FBW7_1	881	888	PF00400	0.763
DEG_SPOP_SBC_1	769	773	PF00917	0.525
DOC_CKS1_1	24	29	PF01111	0.807
DOC_CKS1_1	41	46	PF01111	0.511
DOC_CKS1_1	875	880	PF01111	0.814
DOC_CKS1_1	94	99	PF01111	0.701
DOC_CYCLIN_RxL_1	368	379	PF00134	0.523
DOC_CYCLIN_RxL_1	578	592	PF00134	0.716
DOC_CYCLIN_yClb1_LxF_4	583	588	PF00134	0.808
DOC_CYCLIN_yCln2_LP_2	84	87	PF00134	0.528
DOC_PP1_RVXF_1	33	40	PF00149	0.805
DOC_PP1_RVXF_1	582	589	PF00149	0.707
DOC_PP2B_LxvP_1	794	797	PF13499	0.514
DOC_PP2B_LxvP_1	84	87	PF13499	0.528
DOC_PP4_FxxP_1	21	24	PF00568	0.822
DOC_PP4_FxxP_1	470	473	PF00568	0.569
DOC_PP4_FxxP_1	509	512	PF00568	0.534
DOC_USP7_MATH_1	15	19	PF00917	0.631
DOC_USP7_MATH_1	159	163	PF00917	0.719
DOC_USP7_MATH_1	215	219	PF00917	0.782
DOC_USP7_MATH_1	247	251	PF00917	0.747
DOC_USP7_MATH_1	265	269	PF00917	0.552
DOC_USP7_MATH_1	313	317	PF00917	0.608
DOC_USP7_MATH_1	410	414	PF00917	0.800
DOC_USP7_MATH_1	425	429	PF00917	0.604
DOC_USP7_MATH_1	439	443	PF00917	0.733
DOC_USP7_MATH_1	453	457	PF00917	0.524
DOC_USP7_MATH_1	512	516	PF00917	0.639
DOC_USP7_MATH_1	567	571	PF00917	0.496
DOC_USP7_MATH_1	694	698	PF00917	0.555
DOC_USP7_MATH_1	769	773	PF00917	0.525
DOC_USP7_MATH_1	807	811	PF00917	0.650
DOC_USP7_MATH_1	841	845	PF00917	0.790
DOC_USP7_MATH_1	885	889	PF00917	0.851
DOC_WW_Pin1_4	131	136	PF00397	0.688
DOC_WW_Pin1_4	200	205	PF00397	0.621
DOC_WW_Pin1_4	23	28	PF00397	0.813
DOC_WW_Pin1_4	280	285	PF00397	0.709
DOC_WW_Pin1_4	376	381	PF00397	0.739
DOC_WW_Pin1_4	40	45	PF00397	0.513
DOC_WW_Pin1_4	461	466	PF00397	0.679
DOC_WW_Pin1_4	536	541	PF00397	0.714
DOC_WW_Pin1_4	577	582	PF00397	0.682
DOC_WW_Pin1_4	599	604	PF00397	0.670
DOC_WW_Pin1_4	690	695	PF00397	0.516
DOC_WW_Pin1_4	836	841	PF00397	0.800
DOC_WW_Pin1_4	874	879	PF00397	0.812
DOC_WW_Pin1_4	881	886	PF00397	0.729
DOC_WW_Pin1_4	93	98	PF00397	0.690
LIG_14-3-3_CanoR_1	149	155	PF00244	0.708
LIG_14-3-3_CanoR_1	167	171	PF00244	0.624
LIG_14-3-3_CanoR_1	185	193	PF00244	0.480
LIG_14-3-3_CanoR_1	274	284	PF00244	0.742
LIG_14-3-3_CanoR_1	294	299	PF00244	0.683
LIG_14-3-3_CanoR_1	454	458	PF00244	0.568
LIG_14-3-3_CanoR_1	494	500	PF00244	0.538
LIG_14-3-3_CanoR_1	5	12	PF00244	0.513
LIG_14-3-3_CanoR_1	653	659	PF00244	0.731
LIG_14-3-3_CanoR_1	704	713	PF00244	0.633
LIG_14-3-3_CanoR_1	760	764	PF00244	0.460
LIG_Actin_WH2_2	632	650	PF00022	0.538
LIG_BIR_III_4	14	18	PF00653	0.530
LIG_BRCT_BRCA1_1	17	21	PF00533	0.814
LIG_BRCT_BRCA1_1	654	658	PF00533	0.535
LIG_DLG_GKlike_1	150	157	PF00625	0.528
LIG_EH1_1	633	641	PF00400	0.528
LIG_FHA_1	172	178	PF00498	0.736
LIG_FHA_1	185	191	PF00498	0.699
LIG_FHA_1	301	307	PF00498	0.520
LIG_FHA_1	494	500	PF00498	0.700
LIG_FHA_1	642	648	PF00498	0.546
LIG_FHA_1	739	745	PF00498	0.495
LIG_FHA_2	412	418	PF00498	0.678
LIG_FHA_2	46	52	PF00498	0.532
LIG_FHA_2	561	567	PF00498	0.782
LIG_FHA_2	706	712	PF00498	0.734
LIG_FHA_2	725	731	PF00498	0.745
LIG_IRF3_LxIS_1	380	387	PF10401	0.506
LIG_LIR_Apic_2	18	24	PF02991	0.817
LIG_LIR_Apic_2	468	473	PF02991	0.569
LIG_LIR_Gen_1	445	453	PF02991	0.572
LIG_LIR_Gen_1	726	736	PF02991	0.788
LIG_LIR_Gen_1	828	835	PF02991	0.691
LIG_LIR_Nem_3	310	314	PF02991	0.703
LIG_LIR_Nem_3	445	449	PF02991	0.698
LIG_LIR_Nem_3	609	614	PF02991	0.543
LIG_LIR_Nem_3	726	732	PF02991	0.792
LIG_LIR_Nem_3	828	832	PF02991	0.647
LIG_MYND_1	603	607	PF01753	0.807
LIG_Pex14_1	61	65	PF04695	0.525
LIG_Pex14_1	654	658	PF04695	0.802
LIG_Pex14_2	509	513	PF04695	0.538
LIG_Pex14_2	527	531	PF04695	0.515
LIG_PTB_Apo_2	75	82	PF02174	0.554
LIG_PTB_Phospho_1	75	81	PF10480	0.556
LIG_SH2_PTP2	81	84	PF00017	0.547
LIG_SH2_SRC	244	247	PF00017	0.610
LIG_SH2_STAT3	259	262	PF00017	0.790
LIG_SH2_STAT5	244	247	PF00017	0.544
LIG_SH2_STAT5	663	666	PF00017	0.520
LIG_SH2_STAT5	81	84	PF00017	0.547
LIG_SH3_3	21	27	PF00018	0.815
LIG_SH3_3	377	383	PF00018	0.599
LIG_SH3_3	38	44	PF00018	0.518
LIG_SH3_3	544	550	PF00018	0.842
LIG_SH3_3	786	792	PF00018	0.519
LIG_SH3_3	875	881	PF00018	0.702
LIG_SH3_3	91	97	PF00018	0.697
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.519
LIG_SUMO_SIM_par_1	114	120	PF11976	0.548
LIG_SUMO_SIM_par_1	252	258	PF11976	0.519
LIG_TRAF2_1	109	112	PF00917	0.537
LIG_TRAF2_1	234	237	PF00917	0.575
LIG_TRAF2_1	316	319	PF00917	0.526
LIG_TRAF2_1	413	416	PF00917	0.735
LIG_TRAF2_1	57	60	PF00917	0.729
LIG_TRAF2_1	587	590	PF00917	0.716
LIG_TRAF2_1	66	69	PF00917	0.647
MOD_CDK_SPK_2	579	584	PF00069	0.790
MOD_CDK_SPK_2	93	98	PF00069	0.802
MOD_CDK_SPxK_1	579	585	PF00069	0.794
MOD_CDK_SPxK_1	690	696	PF00069	0.522
MOD_CDK_SPxxK_3	536	543	PF00069	0.821
MOD_CDK_SPxxK_3	577	584	PF00069	0.685
MOD_CK1_1	120	126	PF00069	0.779
MOD_CK1_1	127	133	PF00069	0.696
MOD_CK1_1	134	140	PF00069	0.587
MOD_CK1_1	155	161	PF00069	0.788
MOD_CK1_1	22	28	PF00069	0.615
MOD_CK1_1	276	282	PF00069	0.648
MOD_CK1_1	442	448	PF00069	0.758
MOD_CK1_1	519	525	PF00069	0.664
MOD_CK1_1	556	562	PF00069	0.716
MOD_CK1_1	623	629	PF00069	0.620
MOD_CK1_1	635	641	PF00069	0.548
MOD_CK1_1	666	672	PF00069	0.499
MOD_CK1_1	7	13	PF00069	0.731
MOD_CK1_1	728	734	PF00069	0.720
MOD_CK1_1	770	776	PF00069	0.744
MOD_CK1_1	795	801	PF00069	0.650
MOD_CK1_1	830	836	PF00069	0.691
MOD_CK1_1	839	845	PF00069	0.694
MOD_CK1_1	862	868	PF00069	0.652
MOD_CK1_1	93	99	PF00069	0.733
MOD_CK2_1	22	28	PF00069	0.710
MOD_CK2_1	313	319	PF00069	0.531
MOD_CK2_1	388	394	PF00069	0.540
MOD_CK2_1	410	416	PF00069	0.772
MOD_CK2_1	45	51	PF00069	0.634
MOD_CK2_1	465	471	PF00069	0.559
MOD_CK2_1	560	566	PF00069	0.791
MOD_CK2_1	724	730	PF00069	0.815
MOD_CK2_1	770	776	PF00069	0.528
MOD_GlcNHglycan	126	129	PF01048	0.676
MOD_GlcNHglycan	157	160	PF01048	0.787
MOD_GlcNHglycan	17	20	PF01048	0.629
MOD_GlcNHglycan	190	193	PF01048	0.678
MOD_GlcNHglycan	204	207	PF01048	0.635
MOD_GlcNHglycan	247	250	PF01048	0.608
MOD_GlcNHglycan	279	282	PF01048	0.755
MOD_GlcNHglycan	335	338	PF01048	0.665
MOD_GlcNHglycan	388	391	PF01048	0.755
MOD_GlcNHglycan	406	409	PF01048	0.663
MOD_GlcNHglycan	45	48	PF01048	0.572
MOD_GlcNHglycan	6	9	PF01048	0.781
MOD_GlcNHglycan	625	628	PF01048	0.700
MOD_GlcNHglycan	649	652	PF01048	0.804
MOD_GlcNHglycan	659	663	PF01048	0.642
MOD_GlcNHglycan	672	675	PF01048	0.485
MOD_GlcNHglycan	695	699	PF01048	0.582
MOD_GlcNHglycan	802	805	PF01048	0.719
MOD_GlcNHglycan	809	812	PF01048	0.811
MOD_GlcNHglycan	822	825	PF01048	0.546
MOD_GlcNHglycan	861	864	PF01048	0.693
MOD_GlcNHglycan	89	93	PF01048	0.679
MOD_GSK3_1	120	127	PF00069	0.806
MOD_GSK3_1	134	141	PF00069	0.560
MOD_GSK3_1	15	22	PF00069	0.541
MOD_GSK3_1	155	162	PF00069	0.721
MOD_GSK3_1	179	186	PF00069	0.772
MOD_GSK3_1	215	222	PF00069	0.712
MOD_GSK3_1	273	280	PF00069	0.660
MOD_GSK3_1	384	391	PF00069	0.782
MOD_GSK3_1	411	418	PF00069	0.721
MOD_GSK3_1	453	460	PF00069	0.640
MOD_GSK3_1	461	468	PF00069	0.689
MOD_GSK3_1	512	519	PF00069	0.630
MOD_GSK3_1	532	539	PF00069	0.580
MOD_GSK3_1	553	560	PF00069	0.601
MOD_GSK3_1	573	580	PF00069	0.674
MOD_GSK3_1	595	602	PF00069	0.700
MOD_GSK3_1	654	661	PF00069	0.661
MOD_GSK3_1	666	673	PF00069	0.761
MOD_GSK3_1	690	697	PF00069	0.605
MOD_GSK3_1	705	712	PF00069	0.695
MOD_GSK3_1	719	726	PF00069	0.510
MOD_GSK3_1	827	834	PF00069	0.683
MOD_GSK3_1	839	846	PF00069	0.694
MOD_GSK3_1	881	888	PF00069	0.797
MOD_GSK3_1	96	103	PF00069	0.797
MOD_N-GLC_1	159	164	PF02516	0.544
MOD_N-GLC_1	288	293	PF02516	0.811
MOD_N-GLC_1	442	447	PF02516	0.696
MOD_N-GLC_1	536	541	PF02516	0.548
MOD_N-GLC_1	623	628	PF02516	0.531
MOD_N-GLC_1	706	711	PF02516	0.535
MOD_N-GLC_1	881	886	PF02516	0.713
MOD_N-GLC_2	199	201	PF02516	0.746
MOD_NEK2_1	117	122	PF00069	0.803
MOD_NEK2_1	216	221	PF00069	0.651
MOD_NEK2_1	255	260	PF00069	0.708
MOD_NEK2_1	264	269	PF00069	0.625
MOD_NEK2_1	275	280	PF00069	0.681
MOD_NEK2_1	375	380	PF00069	0.582
MOD_NEK2_1	388	393	PF00069	0.684
MOD_NEK2_1	4	9	PF00069	0.663
MOD_NEK2_1	647	652	PF00069	0.714
MOD_NEK2_1	658	663	PF00069	0.685
MOD_NEK2_1	677	682	PF00069	0.422
MOD_NEK2_1	805	810	PF00069	0.637
MOD_NEK2_1	868	873	PF00069	0.552
MOD_NEK2_2	573	578	PF00069	0.771
MOD_PIKK_1	117	123	PF00454	0.629
MOD_PIKK_1	127	133	PF00454	0.488
MOD_PIKK_1	19	25	PF00454	0.551
MOD_PIKK_1	258	264	PF00454	0.785
MOD_PIKK_1	26	32	PF00454	0.523
MOD_PIKK_1	327	333	PF00454	0.702
MOD_PIKK_1	388	394	PF00454	0.682
MOD_PIKK_1	423	429	PF00454	0.547
MOD_PIKK_1	805	811	PF00454	0.654
MOD_PIKK_1	813	819	PF00454	0.695
MOD_PIKK_1	827	833	PF00454	0.634
MOD_PIKK_1	839	845	PF00454	0.694
MOD_PIKK_1	854	860	PF00454	0.614
MOD_PKA_2	15	21	PF00069	0.774
MOD_PKA_2	166	172	PF00069	0.704
MOD_PKA_2	184	190	PF00069	0.482
MOD_PKA_2	270	276	PF00069	0.681
MOD_PKA_2	293	299	PF00069	0.683
MOD_PKA_2	300	306	PF00069	0.688
MOD_PKA_2	333	339	PF00069	0.632
MOD_PKA_2	4	10	PF00069	0.629
MOD_PKA_2	453	459	PF00069	0.530
MOD_PKA_2	493	499	PF00069	0.538
MOD_PKA_2	595	601	PF00069	0.780
MOD_PKA_2	641	647	PF00069	0.571
MOD_PKA_2	652	658	PF00069	0.569
MOD_PKA_2	705	711	PF00069	0.591
MOD_PKA_2	759	765	PF00069	0.588
MOD_PKA_2	805	811	PF00069	0.632
MOD_PKB_1	150	158	PF00069	0.795
MOD_PKB_1	618	626	PF00069	0.535
MOD_PKB_1	704	712	PF00069	0.541
MOD_Plk_1	159	165	PF00069	0.651
MOD_Plk_1	288	294	PF00069	0.778
MOD_Plk_1	353	359	PF00069	0.815
MOD_Plk_2-3	595	601	PF00069	0.553
MOD_Plk_4	134	140	PF00069	0.687
MOD_Plk_4	240	246	PF00069	0.535
MOD_Plk_4	302	308	PF00069	0.531
MOD_Plk_4	601	607	PF00069	0.771
MOD_Plk_4	635	641	PF00069	0.527
MOD_Plk_4	80	86	PF00069	0.544
MOD_Plk_4	862	868	PF00069	0.524
MOD_ProDKin_1	131	137	PF00069	0.689
MOD_ProDKin_1	200	206	PF00069	0.619
MOD_ProDKin_1	23	29	PF00069	0.810
MOD_ProDKin_1	280	286	PF00069	0.711
MOD_ProDKin_1	376	382	PF00069	0.740
MOD_ProDKin_1	40	46	PF00069	0.513
MOD_ProDKin_1	461	467	PF00069	0.682
MOD_ProDKin_1	536	542	PF00069	0.716
MOD_ProDKin_1	577	583	PF00069	0.682
MOD_ProDKin_1	599	605	PF00069	0.671
MOD_ProDKin_1	690	696	PF00069	0.522
MOD_ProDKin_1	836	842	PF00069	0.798
MOD_ProDKin_1	874	880	PF00069	0.812
MOD_ProDKin_1	881	887	PF00069	0.726
MOD_ProDKin_1	93	99	PF00069	0.691
TRG_DiLeu_BaEn_1	338	343	PF01217	0.546
TRG_DiLeu_BaEn_1	353	358	PF01217	0.752
TRG_DiLeu_BaEn_1	589	594	PF01217	0.781
TRG_DiLeu_BaEn_4	589	595	PF01217	0.591
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.547
TRG_ENDOCYTIC_2	81	84	PF00928	0.547
TRG_ER_diArg_1	148	150	PF00400	0.793
TRG_ER_diArg_1	298	301	PF00400	0.802
TRG_ER_diArg_1	618	621	PF00400	0.664
TRG_ER_diArg_1	678	681	PF00400	0.577
TRG_ER_diArg_1	753	756	PF00400	0.707
TRG_NLS_MonoExtC_3	751	757	PF00514	0.604
TRG_NLS_MonoExtN_4	679	685	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P766	Leptomonas seymouri	31%	100%
A0A3S7XBG5	Leishmania donovani	60%	100%
A4IE39	Leishmania infantum	60%	100%
E9ATL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4Q0X9	Leishmania major	59%	99%