Serine-rich adhesin for platelets

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPV1_LEIBR

TriTrypDb:

LbrM.35.4580 , LBRM2903_350056600

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.572
CLV_C14_Caspase3-7	62	66	PF00656	0.648
CLV_NRD_NRD_1	119	121	PF00675	0.740
CLV_NRD_NRD_1	157	159	PF00675	0.762
CLV_NRD_NRD_1	207	209	PF00675	0.546
CLV_NRD_NRD_1	277	279	PF00675	0.506
CLV_NRD_NRD_1	30	32	PF00675	0.669
CLV_NRD_NRD_1	347	349	PF00675	0.675
CLV_NRD_NRD_1	350	352	PF00675	0.697
CLV_NRD_NRD_1	489	491	PF00675	0.573
CLV_NRD_NRD_1	499	501	PF00675	0.738
CLV_PCSK_FUR_1	348	352	PF00082	0.444
CLV_PCSK_KEX2_1	119	121	PF00082	0.793
CLV_PCSK_KEX2_1	135	137	PF00082	0.570
CLV_PCSK_KEX2_1	207	209	PF00082	0.599
CLV_PCSK_KEX2_1	277	279	PF00082	0.506
CLV_PCSK_KEX2_1	30	32	PF00082	0.819
CLV_PCSK_KEX2_1	347	349	PF00082	0.503
CLV_PCSK_KEX2_1	350	352	PF00082	0.480
CLV_PCSK_KEX2_1	499	501	PF00082	0.738
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.601
CLV_PCSK_SKI1_1	120	124	PF00082	0.587
CLV_PCSK_SKI1_1	25	29	PF00082	0.704
CLV_PCSK_SKI1_1	283	287	PF00082	0.637
CLV_PCSK_SKI1_1	351	355	PF00082	0.682
CLV_PCSK_SKI1_1	366	370	PF00082	0.493
CLV_PCSK_SKI1_1	535	539	PF00082	0.683
DEG_Nend_UBRbox_1	1	4	PF02207	0.576
DEG_SPOP_SBC_1	255	259	PF00917	0.566
DEG_SPOP_SBC_1	527	531	PF00917	0.529
DOC_CYCLIN_RxL_1	362	373	PF00134	0.481
DOC_CYCLIN_RxL_1	532	541	PF00134	0.685
DOC_MAPK_gen_1	362	369	PF00069	0.602
DOC_PP1_RVXF_1	533	539	PF00149	0.685
DOC_PP2B_LxvP_1	286	289	PF13499	0.630
DOC_PP2B_PxIxI_1	17	23	PF00149	0.573
DOC_PP4_FxxP_1	113	116	PF00568	0.716
DOC_USP7_MATH_1	142	146	PF00917	0.758
DOC_USP7_MATH_1	148	152	PF00917	0.705
DOC_USP7_MATH_1	154	158	PF00917	0.682
DOC_USP7_MATH_1	312	316	PF00917	0.716
DOC_USP7_MATH_1	401	405	PF00917	0.712
DOC_USP7_MATH_1	88	92	PF00917	0.729
DOC_USP7_UBL2_3	381	385	PF12436	0.577
DOC_USP7_UBL2_3	477	481	PF12436	0.572
DOC_WW_Pin1_4	225	230	PF00397	0.774
DOC_WW_Pin1_4	234	239	PF00397	0.668
DOC_WW_Pin1_4	263	268	PF00397	0.641
DOC_WW_Pin1_4	40	45	PF00397	0.727
DOC_WW_Pin1_4	449	454	PF00397	0.744
DOC_WW_Pin1_4	5	10	PF00397	0.558
DOC_WW_Pin1_4	86	91	PF00397	0.578
LIG_14-3-3_CanoR_1	168	176	PF00244	0.751
LIG_14-3-3_CanoR_1	196	204	PF00244	0.688
LIG_14-3-3_CanoR_1	254	260	PF00244	0.685
LIG_14-3-3_CanoR_1	304	313	PF00244	0.517
LIG_14-3-3_CanoR_1	36	44	PF00244	0.645
LIG_14-3-3_CanoR_1	45	51	PF00244	0.616
LIG_14-3-3_CanoR_1	69	78	PF00244	0.546
LIG_14-3-3_CterR_2	546	548	PF00244	0.534
LIG_BRCT_BRCA1_1	528	532	PF00533	0.527
LIG_deltaCOP1_diTrp_1	480	487	PF00928	0.607
LIG_FHA_1	101	107	PF00498	0.555
LIG_FHA_1	184	190	PF00498	0.553
LIG_FHA_1	394	400	PF00498	0.578
LIG_FHA_2	123	129	PF00498	0.850
LIG_FHA_2	196	202	PF00498	0.479
LIG_FHA_2	341	347	PF00498	0.697
LIG_FHA_2	50	56	PF00498	0.613
LIG_FHA_2	60	66	PF00498	0.637
LIG_LIR_Apic_2	110	116	PF02991	0.561
LIG_LIR_Apic_2	233	238	PF02991	0.700
LIG_LIR_Apic_2	46	51	PF02991	0.504
LIG_LIR_Apic_2	480	485	PF02991	0.700
LIG_LIR_Gen_1	179	189	PF02991	0.733
LIG_LIR_Gen_1	407	417	PF02991	0.573
LIG_LIR_Nem_3	179	185	PF02991	0.649
LIG_LIR_Nem_3	335	340	PF02991	0.650
LIG_LIR_Nem_3	407	413	PF02991	0.576
LIG_LIR_Nem_3	76	81	PF02991	0.807
LIG_Rb_pABgroove_1	532	540	PF01858	0.532
LIG_SH2_NCK_1	182	186	PF00017	0.724
LIG_SH2_NCK_1	4	8	PF00017	0.566
LIG_SH2_PTP2	339	342	PF00017	0.617
LIG_SH2_SRC	182	185	PF00017	0.749
LIG_SH2_SRC	293	296	PF00017	0.617
LIG_SH2_SRC	339	342	PF00017	0.617
LIG_SH2_STAP1	293	297	PF00017	0.612
LIG_SH2_STAP1	406	410	PF00017	0.697
LIG_SH2_STAT3	140	143	PF00017	0.576
LIG_SH2_STAT5	339	342	PF00017	0.501
LIG_SH3_1	41	47	PF00018	0.564
LIG_SH3_2	160	165	PF14604	0.732
LIG_SH3_3	157	163	PF00018	0.694
LIG_SH3_3	41	47	PF00018	0.642
LIG_SH3_3	537	543	PF00018	0.562
LIG_SH3_5	221	225	PF00018	0.568
LIG_TRAF2_1	357	360	PF00917	0.475
LIG_TRAF2_2	417	422	PF00917	0.566
LIG_TRAF2_2	467	472	PF00917	0.610
LIG_TRFH_1	225	229	PF08558	0.560
MOD_CDK_SPK_2	225	230	PF00069	0.815
MOD_CDK_SPK_2	40	45	PF00069	0.694
MOD_CDK_SPxxK_3	449	456	PF00069	0.822
MOD_CK1_1	167	173	PF00069	0.843
MOD_CK1_1	211	217	PF00069	0.828
MOD_CK1_1	228	234	PF00069	0.528
MOD_CK1_1	236	242	PF00069	0.677
MOD_CK1_1	256	262	PF00069	0.690
MOD_CK1_1	3	9	PF00069	0.686
MOD_CK1_1	316	322	PF00069	0.689
MOD_CK1_1	35	41	PF00069	0.673
MOD_CK1_1	404	410	PF00069	0.607
MOD_CK1_1	412	418	PF00069	0.599
MOD_CK1_1	442	448	PF00069	0.745
MOD_CK1_1	449	455	PF00069	0.666
MOD_CK1_1	46	52	PF00069	0.614
MOD_CK1_1	493	499	PF00069	0.656
MOD_CK1_1	510	516	PF00069	0.680
MOD_CK1_1	526	532	PF00069	0.455
MOD_CK1_1	541	547	PF00069	0.466
MOD_CK2_1	122	128	PF00069	0.849
MOD_CK2_1	195	201	PF00069	0.583
MOD_CK2_1	340	346	PF00069	0.600
MOD_CK2_1	49	55	PF00069	0.625
MOD_GlcNHglycan	144	147	PF01048	0.646
MOD_GlcNHglycan	170	173	PF01048	0.638
MOD_GlcNHglycan	213	216	PF01048	0.809
MOD_GlcNHglycan	230	233	PF01048	0.685
MOD_GlcNHglycan	238	241	PF01048	0.614
MOD_GlcNHglycan	278	281	PF01048	0.507
MOD_GlcNHglycan	306	309	PF01048	0.714
MOD_GlcNHglycan	370	373	PF01048	0.766
MOD_GlcNHglycan	38	41	PF01048	0.750
MOD_GlcNHglycan	406	409	PF01048	0.711
MOD_GlcNHglycan	441	444	PF01048	0.839
MOD_GlcNHglycan	448	451	PF01048	0.732
MOD_GlcNHglycan	492	495	PF01048	0.792
MOD_GlcNHglycan	5	8	PF01048	0.698
MOD_GlcNHglycan	519	522	PF01048	0.802
MOD_GlcNHglycan	539	543	PF01048	0.446
MOD_GlcNHglycan	71	74	PF01048	0.630
MOD_GSK3_1	107	114	PF00069	0.818
MOD_GSK3_1	118	125	PF00069	0.613
MOD_GSK3_1	148	155	PF00069	0.623
MOD_GSK3_1	164	171	PF00069	0.693
MOD_GSK3_1	249	256	PF00069	0.705
MOD_GSK3_1	259	266	PF00069	0.600
MOD_GSK3_1	30	37	PF00069	0.718
MOD_GSK3_1	312	319	PF00069	0.723
MOD_GSK3_1	387	394	PF00069	0.700
MOD_GSK3_1	402	409	PF00069	0.558
MOD_GSK3_1	442	449	PF00069	0.849
MOD_GSK3_1	486	493	PF00069	0.609
MOD_GSK3_1	501	508	PF00069	0.707
MOD_GSK3_1	523	530	PF00069	0.633
MOD_GSK3_1	541	548	PF00069	0.460
MOD_GSK3_1	86	93	PF00069	0.605
MOD_LATS_1	23	29	PF00433	0.703
MOD_N-GLC_1	211	216	PF02516	0.825
MOD_N-GLC_1	249	254	PF02516	0.700
MOD_N-GLC_1	319	324	PF02516	0.795
MOD_N-GLC_1	501	506	PF02516	0.587
MOD_N-GLC_1	527	532	PF02516	0.530
MOD_N-GLC_1	74	79	PF02516	0.698
MOD_NEK2_1	107	112	PF00069	0.599
MOD_NEK2_1	506	511	PF00069	0.688
MOD_NEK2_1	538	543	PF00069	0.557
MOD_NEK2_2	242	247	PF00069	0.553
MOD_NEK2_2	90	95	PF00069	0.579
MOD_PIKK_1	130	136	PF00454	0.716
MOD_PIKK_1	171	177	PF00454	0.775
MOD_PIKK_1	213	219	PF00454	0.766
MOD_PIKK_1	393	399	PF00454	0.734
MOD_PKA_1	30	36	PF00069	0.585
MOD_PKA_1	490	496	PF00069	0.578
MOD_PKA_2	118	124	PF00069	0.705
MOD_PKA_2	164	170	PF00069	0.819
MOD_PKA_2	195	201	PF00069	0.674
MOD_PKA_2	206	212	PF00069	0.542
MOD_PKA_2	253	259	PF00069	0.724
MOD_PKA_2	276	282	PF00069	0.625
MOD_PKA_2	30	36	PF00069	0.713
MOD_PKA_2	303	309	PF00069	0.554
MOD_PKA_2	445	451	PF00069	0.807
MOD_PKA_2	506	512	PF00069	0.682
MOD_PKB_1	247	255	PF00069	0.808
MOD_PKB_1	444	452	PF00069	0.594
MOD_Plk_1	223	229	PF00069	0.645
MOD_Plk_1	249	255	PF00069	0.555
MOD_Plk_1	351	357	PF00069	0.581
MOD_Plk_1	527	533	PF00069	0.579
MOD_Plk_1	74	80	PF00069	0.564
MOD_Plk_2-3	423	429	PF00069	0.574
MOD_Plk_4	184	190	PF00069	0.585
MOD_ProDKin_1	225	231	PF00069	0.773
MOD_ProDKin_1	234	240	PF00069	0.669
MOD_ProDKin_1	263	269	PF00069	0.637
MOD_ProDKin_1	40	46	PF00069	0.721
MOD_ProDKin_1	449	455	PF00069	0.744
MOD_ProDKin_1	5	11	PF00069	0.553
MOD_ProDKin_1	86	92	PF00069	0.580
MOD_SUMO_rev_2	452	460	PF00179	0.591
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.544
TRG_ENDOCYTIC_2	182	185	PF00928	0.647
TRG_ENDOCYTIC_2	410	413	PF00928	0.580
TRG_ER_diArg_1	206	208	PF00400	0.531
TRG_ER_diArg_1	246	249	PF00400	0.648
TRG_ER_diArg_1	260	263	PF00400	0.526
TRG_ER_diArg_1	276	278	PF00400	0.515
TRG_ER_diArg_1	347	350	PF00400	0.674
TRG_ER_diArg_1	364	367	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U4	Leptomonas seymouri	37%	100%
A0A3Q8IPF2	Leishmania donovani	57%	99%
A4IE40	Leishmania infantum	57%	99%
E9ATL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q0Y0	Leishmania major	54%	97%