TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPU7_LEIBR

TriTrypDb:

LbrM.35.4530 , LBRM2903_350056000

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0071007	U2-type catalytic step 2 spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HPU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000245	spliceosomal complex assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.666
CLV_C14_Caspase3-7	635	639	PF00656	0.450
CLV_NRD_NRD_1	20	22	PF00675	0.499
CLV_NRD_NRD_1	207	209	PF00675	0.531
CLV_NRD_NRD_1	217	219	PF00675	0.393
CLV_NRD_NRD_1	341	343	PF00675	0.392
CLV_NRD_NRD_1	365	367	PF00675	0.392
CLV_NRD_NRD_1	444	446	PF00675	0.537
CLV_NRD_NRD_1	482	484	PF00675	0.418
CLV_NRD_NRD_1	620	622	PF00675	0.436
CLV_NRD_NRD_1	757	759	PF00675	0.509
CLV_NRD_NRD_1	76	78	PF00675	0.450
CLV_NRD_NRD_1	814	816	PF00675	0.540
CLV_NRD_NRD_1	85	87	PF00675	0.473
CLV_PCSK_FUR_1	363	367	PF00082	0.358
CLV_PCSK_FUR_1	73	77	PF00082	0.451
CLV_PCSK_KEX2_1	19	21	PF00082	0.496
CLV_PCSK_KEX2_1	2	4	PF00082	0.597
CLV_PCSK_KEX2_1	207	209	PF00082	0.531
CLV_PCSK_KEX2_1	217	219	PF00082	0.393
CLV_PCSK_KEX2_1	365	367	PF00082	0.392
CLV_PCSK_KEX2_1	444	446	PF00082	0.538
CLV_PCSK_KEX2_1	482	484	PF00082	0.510
CLV_PCSK_KEX2_1	620	622	PF00082	0.419
CLV_PCSK_KEX2_1	75	77	PF00082	0.448
CLV_PCSK_KEX2_1	757	759	PF00082	0.555
CLV_PCSK_KEX2_1	813	815	PF00082	0.533
CLV_PCSK_KEX2_1	85	87	PF00082	0.318
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.566
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.448
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.552
CLV_PCSK_PC7_1	213	219	PF00082	0.384
CLV_PCSK_PC7_1	753	759	PF00082	0.455
CLV_PCSK_SKI1_1	150	154	PF00082	0.366
CLV_PCSK_SKI1_1	179	183	PF00082	0.335
CLV_PCSK_SKI1_1	245	249	PF00082	0.324
CLV_PCSK_SKI1_1	288	292	PF00082	0.488
CLV_PCSK_SKI1_1	403	407	PF00082	0.497
CLV_PCSK_SKI1_1	423	427	PF00082	0.202
CLV_PCSK_SKI1_1	482	486	PF00082	0.408
CLV_PCSK_SKI1_1	562	566	PF00082	0.471
CLV_PCSK_SKI1_1	742	746	PF00082	0.382
CLV_PCSK_SKI1_1	810	814	PF00082	0.579
CLV_PCSK_SKI1_1	817	821	PF00082	0.556
CLV_PCSK_SKI1_1	86	90	PF00082	0.512
CLV_Separin_Metazoa	572	576	PF03568	0.435
CLV_Separin_Metazoa	652	656	PF03568	0.245
DEG_APCC_DBOX_1	642	650	PF00400	0.380
DEG_APCC_DBOX_1	741	749	PF00400	0.506
DEG_Nend_UBRbox_1	1	4	PF02207	0.572
DEG_SPOP_SBC_1	520	524	PF00917	0.400
DOC_ANK_TNKS_1	316	323	PF00023	0.476
DOC_CKS1_1	223	228	PF01111	0.394
DOC_CKS1_1	731	736	PF01111	0.392
DOC_CYCLIN_RxL_1	479	489	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.433
DOC_MAPK_gen_1	774	783	PF00069	0.493
DOC_PP1_RVXF_1	756	763	PF00149	0.611
DOC_PP2B_LxvP_1	410	413	PF13499	0.556
DOC_PP4_FxxP_1	223	226	PF00568	0.398
DOC_PP4_FxxP_1	49	52	PF00568	0.617
DOC_USP7_MATH_1	154	158	PF00917	0.376
DOC_USP7_MATH_1	190	194	PF00917	0.269
DOC_USP7_MATH_1	379	383	PF00917	0.602
DOC_USP7_MATH_1	385	389	PF00917	0.499
DOC_USP7_MATH_1	399	403	PF00917	0.450
DOC_USP7_MATH_1	52	56	PF00917	0.630
DOC_WW_Pin1_4	222	227	PF00397	0.487
DOC_WW_Pin1_4	391	396	PF00397	0.674
DOC_WW_Pin1_4	397	402	PF00397	0.547
DOC_WW_Pin1_4	48	53	PF00397	0.617
DOC_WW_Pin1_4	701	706	PF00397	0.454
DOC_WW_Pin1_4	730	735	PF00397	0.406
DOC_WW_Pin1_4	781	786	PF00397	0.329
LIG_14-3-3_CanoR_1	116	121	PF00244	0.357
LIG_14-3-3_CanoR_1	150	159	PF00244	0.440
LIG_14-3-3_CanoR_1	342	352	PF00244	0.438
LIG_14-3-3_CanoR_1	365	373	PF00244	0.530
LIG_14-3-3_CanoR_1	444	448	PF00244	0.451
LIG_14-3-3_CanoR_1	507	516	PF00244	0.301
LIG_14-3-3_CanoR_1	593	598	PF00244	0.411
LIG_14-3-3_CanoR_1	709	717	PF00244	0.496
LIG_14-3-3_CanoR_1	757	761	PF00244	0.612
LIG_APCC_ABBA_1	118	123	PF00400	0.505
LIG_APCC_ABBA_1	334	339	PF00400	0.485
LIG_APCC_ABBAyCdc20_2	20	26	PF00400	0.513
LIG_BIR_III_2	189	193	PF00653	0.510
LIG_BRCT_BRCA1_1	136	140	PF00533	0.436
LIG_BRCT_BRCA1_1	452	456	PF00533	0.277
LIG_BRCT_BRCA1_1	676	680	PF00533	0.443
LIG_deltaCOP1_diTrp_1	788	793	PF00928	0.365
LIG_FHA_1	331	337	PF00498	0.457
LIG_FHA_1	508	514	PF00498	0.432
LIG_FHA_2	444	450	PF00498	0.388
LIG_FHA_2	646	652	PF00498	0.466
LIG_FHA_2	765	771	PF00498	0.596
LIG_LIR_Apic_2	221	226	PF02991	0.490
LIG_LIR_Gen_1	106	114	PF02991	0.370
LIG_LIR_Gen_1	130	136	PF02991	0.336
LIG_LIR_Gen_1	310	318	PF02991	0.496
LIG_LIR_Gen_1	349	358	PF02991	0.380
LIG_LIR_Gen_1	766	775	PF02991	0.463
LIG_LIR_Gen_1	788	795	PF02991	0.458
LIG_LIR_Nem_3	126	131	PF02991	0.321
LIG_LIR_Nem_3	160	165	PF02991	0.315
LIG_LIR_Nem_3	228	232	PF02991	0.321
LIG_LIR_Nem_3	310	315	PF02991	0.363
LIG_LIR_Nem_3	345	351	PF02991	0.424
LIG_LIR_Nem_3	353	358	PF02991	0.264
LIG_LIR_Nem_3	663	668	PF02991	0.318
LIG_LIR_Nem_3	766	772	PF02991	0.476
LIG_LIR_Nem_3	777	781	PF02991	0.377
LIG_LIR_Nem_3	788	793	PF02991	0.384
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.472
LIG_MLH1_MIPbox_1	676	680	PF16413	0.443
LIG_PCNA_PIPBox_1	33	42	PF02747	0.483
LIG_PCNA_PIPBox_1	650	659	PF02747	0.448
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.504
LIG_PCNA_yPIPBox_3	643	657	PF02747	0.462
LIG_Pex14_1	559	563	PF04695	0.414
LIG_Pex14_1	675	679	PF04695	0.493
LIG_Pex14_2	555	559	PF04695	0.359
LIG_Pex14_2	676	680	PF04695	0.443
LIG_RPA_C_Fungi	616	628	PF08784	0.425
LIG_SH2_CRK	601	605	PF00017	0.472
LIG_SH2_CRK	657	661	PF00017	0.421
LIG_SH2_GRB2like	546	549	PF00017	0.461
LIG_SH2_SRC	546	549	PF00017	0.461
LIG_SH2_STAP1	243	247	PF00017	0.322
LIG_SH2_STAP1	337	341	PF00017	0.442
LIG_SH2_STAP1	657	661	PF00017	0.349
LIG_SH2_STAT3	202	205	PF00017	0.475
LIG_SH2_STAT3	358	361	PF00017	0.456
LIG_SH2_STAT3	418	421	PF00017	0.518
LIG_SH2_STAT5	165	168	PF00017	0.309
LIG_SH2_STAT5	351	354	PF00017	0.378
LIG_SH2_STAT5	538	541	PF00017	0.485
LIG_SH2_STAT5	679	682	PF00017	0.475
LIG_SUMO_SIM_par_1	270	276	PF11976	0.416
LIG_SUMO_SIM_par_1	300	306	PF11976	0.553
LIG_TRAF2_1	470	473	PF00917	0.482
LIG_TRAF2_1	648	651	PF00917	0.484
LIG_TRAF2_1	65	68	PF00917	0.403
LIG_TYR_ITIM	561	566	PF00017	0.456
LIG_WRC_WIRS_1	584	589	PF05994	0.382
LIG_WRC_WIRS_1	594	599	PF05994	0.428
MOD_CDC14_SPxK_1	400	403	PF00782	0.517
MOD_CDK_SPxK_1	397	403	PF00069	0.564
MOD_CK1_1	310	316	PF00069	0.262
MOD_CK1_1	489	495	PF00069	0.517
MOD_CK1_1	701	707	PF00069	0.564
MOD_CK2_1	290	296	PF00069	0.265
MOD_CK2_1	310	316	PF00069	0.376
MOD_CK2_1	443	449	PF00069	0.287
MOD_CK2_1	524	530	PF00069	0.664
MOD_CK2_1	62	68	PF00069	0.401
MOD_CK2_1	645	651	PF00069	0.471
MOD_CK2_1	744	750	PF00069	0.458
MOD_CK2_1	788	794	PF00069	0.455
MOD_GlcNHglycan	135	140	PF01048	0.511
MOD_GlcNHglycan	186	189	PF01048	0.309
MOD_GlcNHglycan	292	295	PF01048	0.393
MOD_GlcNHglycan	367	370	PF01048	0.625
MOD_GlcNHglycan	377	380	PF01048	0.650
MOD_GlcNHglycan	382	385	PF01048	0.566
MOD_GlcNHglycan	387	390	PF01048	0.526
MOD_GlcNHglycan	418	421	PF01048	0.400
MOD_GlcNHglycan	54	57	PF01048	0.636
MOD_GlcNHglycan	634	637	PF01048	0.400
MOD_GlcNHglycan	684	688	PF01048	0.600
MOD_GlcNHglycan	735	738	PF01048	0.358
MOD_GSK3_1	146	153	PF00069	0.372
MOD_GSK3_1	367	374	PF00069	0.570
MOD_GSK3_1	375	382	PF00069	0.587
MOD_GSK3_1	48	55	PF00069	0.575
MOD_GSK3_1	516	523	PF00069	0.554
MOD_GSK3_1	695	702	PF00069	0.617
MOD_GSK3_1	704	711	PF00069	0.493
MOD_GSK3_1	744	751	PF00069	0.444
MOD_GSK3_1	756	763	PF00069	0.534
MOD_GSK3_1	793	800	PF00069	0.478
MOD_N-GLC_1	343	348	PF02516	0.449
MOD_N-GLC_1	52	57	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	134	139	PF00069	0.531
MOD_NEK2_1	367	372	PF00069	0.680
MOD_NEK2_1	516	521	PF00069	0.360
MOD_NEK2_1	793	798	PF00069	0.420
MOD_NEK2_1	80	85	PF00069	0.505
MOD_NEK2_1	818	823	PF00069	0.556
MOD_NEK2_2	350	355	PF00069	0.459
MOD_PIKK_1	476	482	PF00454	0.482
MOD_PIKK_1	486	492	PF00454	0.549
MOD_PIKK_1	521	527	PF00454	0.399
MOD_PIKK_1	764	770	PF00454	0.536
MOD_PK_1	116	122	PF00069	0.305
MOD_PKA_1	342	348	PF00069	0.389
MOD_PKA_1	365	371	PF00069	0.392
MOD_PKA_1	813	819	PF00069	0.556
MOD_PKA_2	365	371	PF00069	0.589
MOD_PKA_2	380	386	PF00069	0.686
MOD_PKA_2	443	449	PF00069	0.450
MOD_PKA_2	592	598	PF00069	0.406
MOD_PKA_2	708	714	PF00069	0.485
MOD_PKA_2	756	762	PF00069	0.599
MOD_PKA_2	813	819	PF00069	0.536
MOD_PKB_1	340	348	PF00069	0.449
MOD_PKB_1	363	371	PF00069	0.401
MOD_Plk_1	644	650	PF00069	0.393
MOD_Plk_1	80	86	PF00069	0.496
MOD_Plk_2-3	645	651	PF00069	0.371
MOD_Plk_4	123	129	PF00069	0.266
MOD_Plk_4	225	231	PF00069	0.416
MOD_Plk_4	350	356	PF00069	0.469
MOD_Plk_4	744	750	PF00069	0.420
MOD_ProDKin_1	222	228	PF00069	0.479
MOD_ProDKin_1	391	397	PF00069	0.677
MOD_ProDKin_1	48	54	PF00069	0.618
MOD_ProDKin_1	701	707	PF00069	0.450
MOD_ProDKin_1	730	736	PF00069	0.397
MOD_ProDKin_1	781	787	PF00069	0.331
MOD_SUMO_for_1	564	567	PF00179	0.329
MOD_SUMO_rev_2	449	454	PF00179	0.528
TRG_DiLeu_BaEn_1	777	782	PF01217	0.492
TRG_DiLeu_BaEn_3	135	141	PF01217	0.266
TRG_DiLeu_BaEn_4	651	657	PF01217	0.408
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.497
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.517
TRG_DiLeu_BaLyEn_6	782	787	PF01217	0.457
TRG_ENDOCYTIC_2	131	134	PF00928	0.332
TRG_ENDOCYTIC_2	165	168	PF00928	0.323
TRG_ENDOCYTIC_2	312	315	PF00928	0.363
TRG_ENDOCYTIC_2	351	354	PF00928	0.401
TRG_ENDOCYTIC_2	563	566	PF00928	0.333
TRG_ENDOCYTIC_2	601	604	PF00928	0.331
TRG_ENDOCYTIC_2	657	660	PF00928	0.307
TRG_ER_diArg_1	18	21	PF00400	0.520
TRG_ER_diArg_1	216	218	PF00400	0.382
TRG_ER_diArg_1	365	367	PF00400	0.616
TRG_ER_diArg_1	482	484	PF00400	0.483
TRG_ER_diArg_1	620	623	PF00400	0.451
TRG_ER_diArg_1	756	758	PF00400	0.596
TRG_ER_diArg_1	814	817	PF00400	0.541
TRG_ER_diArg_1	84	86	PF00400	0.511
TRG_NES_CRM1_1	108	123	PF08389	0.429
TRG_NLS_MonoExtC_3	1	7	PF00514	0.603
TRG_NLS_MonoExtC_3	812	817	PF00514	0.532
TRG_NLS_MonoExtN_4	810	817	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P767	Leptomonas seymouri	73%	99%
A0A0S4JKT1	Bodo saltans	28%	94%
A0A1X0P0C5	Trypanosomatidae	42%	100%
A0A3Q8IHN6	Leishmania donovani	88%	100%
A0A3R7P515	Trypanosoma rangeli	43%	100%
A4IE46	Leishmania infantum	88%	100%
D0A493	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P63154	Mus musculus	25%	100%
P63155	Rattus norvegicus	25%	100%
P87312	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4PB37	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4Q0Y6	Leishmania major	87%	100%
Q4WT84	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q5BDX1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5K654	Paracoccidioides brasiliensis	26%	100%
Q6C186	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6CJK2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q7SGD2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9BZJ0	Homo sapiens	25%	97%
V5B545	Trypanosoma cruzi	43%	100%