Serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPU5_LEIBR

TriTrypDb:

LbrM.35.4510 , LBRM2903_350055800

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.548
CLV_NRD_NRD_1	125	127	PF00675	0.491
CLV_NRD_NRD_1	198	200	PF00675	0.547
CLV_NRD_NRD_1	310	312	PF00675	0.473
CLV_NRD_NRD_1	333	335	PF00675	0.453
CLV_NRD_NRD_1	340	342	PF00675	0.428
CLV_NRD_NRD_1	356	358	PF00675	0.455
CLV_NRD_NRD_1	380	382	PF00675	0.452
CLV_NRD_NRD_1	406	408	PF00675	0.557
CLV_NRD_NRD_1	90	92	PF00675	0.772
CLV_PCSK_KEX2_1	125	127	PF00082	0.483
CLV_PCSK_KEX2_1	198	200	PF00082	0.547
CLV_PCSK_KEX2_1	310	312	PF00082	0.473
CLV_PCSK_KEX2_1	333	335	PF00082	0.455
CLV_PCSK_KEX2_1	35	37	PF00082	0.751
CLV_PCSK_KEX2_1	356	358	PF00082	0.455
CLV_PCSK_KEX2_1	406	408	PF00082	0.560
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.751
CLV_PCSK_SKI1_1	128	132	PF00082	0.491
CLV_PCSK_SKI1_1	188	192	PF00082	0.481
CLV_PCSK_SKI1_1	198	202	PF00082	0.470
CLV_PCSK_SKI1_1	255	259	PF00082	0.488
CLV_PCSK_SKI1_1	261	265	PF00082	0.463
DEG_APCC_DBOX_1	127	135	PF00400	0.476
DEG_MDM2_SWIB_1	212	220	PF02201	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.516
DOC_CYCLIN_RxL_1	255	266	PF00134	0.467
DOC_MAPK_gen_1	125	131	PF00069	0.528
DOC_MAPK_gen_1	339	349	PF00069	0.453
DOC_MAPK_gen_1	367	375	PF00069	0.509
DOC_MAPK_MEF2A_6	341	349	PF00069	0.448
DOC_USP7_MATH_1	26	30	PF00917	0.739
DOC_USP7_MATH_1	303	307	PF00917	0.599
DOC_USP7_MATH_1	414	418	PF00917	0.662
DOC_USP7_MATH_1	42	46	PF00917	0.659
DOC_USP7_MATH_1	65	69	PF00917	0.762
DOC_WW_Pin1_4	21	26	PF00397	0.735
LIG_14-3-3_CanoR_1	156	164	PF00244	0.327
LIG_14-3-3_CanoR_1	188	195	PF00244	0.579
LIG_14-3-3_CanoR_1	304	308	PF00244	0.587
LIG_14-3-3_CanoR_1	356	360	PF00244	0.544
LIG_14-3-3_CanoR_1	91	97	PF00244	0.531
LIG_AP_GAE_1	117	123	PF02883	0.596
LIG_BRCT_BRCA1_1	396	400	PF00533	0.592
LIG_eIF4E_1	165	171	PF01652	0.442
LIG_FHA_1	368	374	PF00498	0.479
LIG_FHA_1	386	392	PF00498	0.688
LIG_FHA_1	65	71	PF00498	0.527
LIG_FHA_2	134	140	PF00498	0.679
LIG_FHA_2	260	266	PF00498	0.324
LIG_FHA_2	326	332	PF00498	0.491
LIG_Integrin_RGD_1	86	88	PF01839	0.796
LIG_LIR_Apic_2	73	78	PF02991	0.494
LIG_LIR_Gen_1	103	112	PF02991	0.499
LIG_LIR_Gen_1	117	127	PF02991	0.486
LIG_LIR_Gen_1	24	34	PF02991	0.518
LIG_LIR_Nem_3	103	107	PF02991	0.499
LIG_LIR_Nem_3	117	123	PF02991	0.484
LIG_LIR_Nem_3	208	212	PF02991	0.447
LIG_LIR_Nem_3	24	30	PF02991	0.512
LIG_LIR_Nem_3	397	403	PF02991	0.536
LIG_NRBOX	344	350	PF00104	0.479
LIG_PDZ_Class_3	427	432	PF00595	0.506
LIG_Pex14_2	212	216	PF04695	0.426
LIG_SH2_CRK	104	108	PF00017	0.501
LIG_SH2_GRB2like	352	355	PF00017	0.434
LIG_SH2_NCK_1	104	108	PF00017	0.501
LIG_SH2_PTP2	352	355	PF00017	0.340
LIG_SH2_PTP2	75	78	PF00017	0.491
LIG_SH2_SRC	352	355	PF00017	0.459
LIG_SH2_STAP1	259	263	PF00017	0.540
LIG_SH2_STAT3	169	172	PF00017	0.531
LIG_SH2_STAT3	340	343	PF00017	0.531
LIG_SH2_STAT5	169	172	PF00017	0.446
LIG_SH2_STAT5	279	282	PF00017	0.559
LIG_SH2_STAT5	336	339	PF00017	0.541
LIG_SH2_STAT5	352	355	PF00017	0.434
LIG_SH2_STAT5	423	426	PF00017	0.520
LIG_SH2_STAT5	75	78	PF00017	0.606
LIG_SH3_1	413	419	PF00018	0.489
LIG_SH3_3	105	111	PF00018	0.750
LIG_SH3_3	2	8	PF00018	0.519
LIG_SH3_3	27	33	PF00018	0.711
LIG_SH3_3	413	419	PF00018	0.489
LIG_SUMO_SIM_anti_2	147	154	PF11976	0.526
LIG_SUMO_SIM_anti_2	231	236	PF11976	0.541
LIG_SUMO_SIM_anti_2	344	349	PF11976	0.419
LIG_TRAF2_1	222	225	PF00917	0.491
MOD_CK1_1	103	109	PF00069	0.630
MOD_CK1_1	20	26	PF00069	0.705
MOD_CK1_1	3	9	PF00069	0.764
MOD_CK1_1	358	364	PF00069	0.535
MOD_CK1_1	394	400	PF00069	0.618
MOD_CK1_1	46	52	PF00069	0.755
MOD_CK1_1	68	74	PF00069	0.759
MOD_CK2_1	133	139	PF00069	0.588
MOD_CK2_1	259	265	PF00069	0.528
MOD_CK2_1	26	32	PF00069	0.520
MOD_CK2_1	303	309	PF00069	0.559
MOD_CK2_1	325	331	PF00069	0.501
MOD_GlcNHglycan	36	39	PF01048	0.676
MOD_GlcNHglycan	384	388	PF01048	0.575
MOD_GlcNHglycan	393	396	PF01048	0.548
MOD_GlcNHglycan	45	48	PF01048	0.695
MOD_GlcNHglycan	67	70	PF01048	0.714
MOD_GSK3_1	13	20	PF00069	0.627
MOD_GSK3_1	151	158	PF00069	0.448
MOD_GSK3_1	259	266	PF00069	0.455
MOD_GSK3_1	325	332	PF00069	0.510
MOD_GSK3_1	42	49	PF00069	0.744
MOD_GSK3_1	64	71	PF00069	0.736
MOD_LATS_1	186	192	PF00433	0.480
MOD_N-GLC_1	367	372	PF02516	0.538
MOD_NEK2_1	100	105	PF00069	0.539
MOD_NEK2_1	212	217	PF00069	0.526
MOD_NEK2_1	263	268	PF00069	0.458
MOD_NEK2_1	391	396	PF00069	0.577
MOD_NEK2_1	43	48	PF00069	0.688
MOD_NEK2_1	70	75	PF00069	0.740
MOD_NEK2_2	303	308	PF00069	0.591
MOD_PIKK_1	358	364	PF00454	0.594
MOD_PIKK_1	414	420	PF00454	0.732
MOD_PIKK_1	46	52	PF00454	0.785
MOD_PKA_2	155	161	PF00069	0.323
MOD_PKA_2	303	309	PF00069	0.595
MOD_PKA_2	355	361	PF00069	0.549
MOD_PKA_2	380	386	PF00069	0.465
MOD_PKA_2	90	96	PF00069	0.662
MOD_Plk_4	26	32	PF00069	0.773
MOD_Plk_4	303	309	PF00069	0.595
MOD_Plk_4	369	375	PF00069	0.482
MOD_Plk_4	399	405	PF00069	0.702
MOD_Plk_4	71	77	PF00069	0.506
MOD_ProDKin_1	21	27	PF00069	0.737
TRG_DiLeu_BaEn_1	344	349	PF01217	0.475
TRG_DiLeu_BaEn_4	196	202	PF01217	0.572
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.599
TRG_ENDOCYTIC_2	104	107	PF00928	0.502
TRG_ENDOCYTIC_2	352	355	PF00928	0.321
TRG_ER_diArg_1	125	128	PF00400	0.518
TRG_ER_diArg_1	198	200	PF00400	0.577
TRG_ER_diArg_1	333	335	PF00400	0.479
TRG_ER_diArg_1	355	357	PF00400	0.340
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J8	Leptomonas seymouri	65%	100%
A0A1X0P1T1	Trypanosomatidae	57%	100%
A0A3Q8ILB9	Leishmania donovani	79%	100%
A0A422P583	Trypanosoma rangeli	55%	100%
A4IE48	Leishmania infantum	79%	100%
E9ATL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q0Y8	Leishmania major	79%	100%
V5BQ98	Trypanosoma cruzi	57%	100%