Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPU4_LEIBR

TriTrypDb:

LbrM.35.4500 , LBRM2903_350055700

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.567
CLV_C14_Caspase3-7	547	551	PF00656	0.312
CLV_NRD_NRD_1	108	110	PF00675	0.324
CLV_NRD_NRD_1	365	367	PF00675	0.583
CLV_NRD_NRD_1	388	390	PF00675	0.355
CLV_NRD_NRD_1	482	484	PF00675	0.312
CLV_NRD_NRD_1	501	503	PF00675	0.312
CLV_NRD_NRD_1	523	525	PF00675	0.231
CLV_PCSK_FUR_1	521	525	PF00082	0.231
CLV_PCSK_KEX2_1	108	110	PF00082	0.324
CLV_PCSK_KEX2_1	388	390	PF00082	0.355
CLV_PCSK_KEX2_1	482	484	PF00082	0.312
CLV_PCSK_KEX2_1	523	525	PF00082	0.231
CLV_PCSK_SKI1_1	109	113	PF00082	0.312
CLV_PCSK_SKI1_1	149	153	PF00082	0.312
CLV_PCSK_SKI1_1	18	22	PF00082	0.486
CLV_PCSK_SKI1_1	353	357	PF00082	0.553
CLV_PCSK_SKI1_1	434	438	PF00082	0.312
CLV_PCSK_SKI1_1	458	462	PF00082	0.231
CLV_Separin_Metazoa	153	157	PF03568	0.312
DEG_APCC_DBOX_1	108	116	PF00400	0.312
DEG_APCC_KENBOX_2	121	125	PF00400	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DEG_SPOP_SBC_1	623	627	PF00917	0.723
DOC_CKS1_1	201	206	PF01111	0.457
DOC_CYCLIN_RxL_1	431	440	PF00134	0.327
DOC_CYCLIN_yClb5_NLxxxL_5	146	155	PF00134	0.312
DOC_CYCLIN_yClb5_NLxxxL_5	437	446	PF00134	0.231
DOC_MAPK_DCC_7	5	14	PF00069	0.477
DOC_MAPK_gen_1	156	165	PF00069	0.312
DOC_MAPK_gen_1	5	14	PF00069	0.477
DOC_MAPK_HePTP_8	2	14	PF00069	0.476
DOC_MAPK_MEF2A_6	38	47	PF00069	0.411
DOC_MAPK_MEF2A_6	5	14	PF00069	0.477
DOC_MAPK_MEF2A_6	558	566	PF00069	0.231
DOC_PP2B_LxvP_1	638	641	PF13499	0.657
DOC_PP2B_LxvP_1	683	686	PF13499	0.534
DOC_PP2B_LxvP_1	811	814	PF13499	0.483
DOC_PP4_FxxP_1	470	473	PF00568	0.388
DOC_PP4_MxPP_1	834	837	PF00568	0.453
DOC_USP7_MATH_1	178	182	PF00917	0.388
DOC_USP7_MATH_1	204	208	PF00917	0.663
DOC_USP7_MATH_1	216	220	PF00917	0.592
DOC_USP7_MATH_1	313	317	PF00917	0.766
DOC_USP7_MATH_1	417	421	PF00917	0.312
DOC_USP7_MATH_1	569	573	PF00917	0.418
DOC_USP7_MATH_1	669	673	PF00917	0.627
DOC_USP7_MATH_1	758	762	PF00917	0.555
DOC_USP7_MATH_2	218	224	PF00917	0.560
DOC_WW_Pin1_4	200	205	PF00397	0.545
DOC_WW_Pin1_4	208	213	PF00397	0.587
DOC_WW_Pin1_4	214	219	PF00397	0.582
DOC_WW_Pin1_4	335	340	PF00397	0.525
DOC_WW_Pin1_4	367	372	PF00397	0.503
DOC_WW_Pin1_4	475	480	PF00397	0.247
DOC_WW_Pin1_4	539	544	PF00397	0.388
DOC_WW_Pin1_4	593	598	PF00397	0.567
DOC_WW_Pin1_4	600	605	PF00397	0.618
DOC_WW_Pin1_4	633	638	PF00397	0.607
DOC_WW_Pin1_4	642	647	PF00397	0.579
DOC_WW_Pin1_4	678	683	PF00397	0.524
DOC_WW_Pin1_4	744	749	PF00397	0.583
DOC_WW_Pin1_4	752	757	PF00397	0.583
DOC_WW_Pin1_4	770	775	PF00397	0.618
DOC_WW_Pin1_4	789	794	PF00397	0.584
LIG_14-3-3_CanoR_1	108	115	PF00244	0.326
LIG_14-3-3_CanoR_1	200	204	PF00244	0.569
LIG_14-3-3_CanoR_1	320	328	PF00244	0.591
LIG_14-3-3_CanoR_1	521	529	PF00244	0.287
LIG_14-3-3_CanoR_1	574	581	PF00244	0.388
LIG_Actin_WH2_2	185	202	PF00022	0.312
LIG_BRCT_BRCA1_1	772	776	PF00533	0.587
LIG_CtBP_PxDLS_1	162	166	PF00389	0.312
LIG_deltaCOP1_diTrp_1	419	428	PF00928	0.312
LIG_eIF4E_1	376	382	PF01652	0.365
LIG_FHA_1	244	250	PF00498	0.577
LIG_FHA_1	270	276	PF00498	0.624
LIG_FHA_1	309	315	PF00498	0.703
LIG_FHA_1	377	383	PF00498	0.402
LIG_FHA_1	38	44	PF00498	0.457
LIG_FHA_1	413	419	PF00498	0.312
LIG_FHA_1	633	639	PF00498	0.558
LIG_FHA_1	710	716	PF00498	0.634
LIG_FHA_1	725	731	PF00498	0.503
LIG_FHA_1	852	858	PF00498	0.607
LIG_FHA_2	17	23	PF00498	0.524
LIG_FHA_2	392	398	PF00498	0.312
LIG_FHA_2	550	556	PF00498	0.255
LIG_FHA_2	88	94	PF00498	0.282
LIG_GBD_Chelix_1	559	567	PF00786	0.255
LIG_IBAR_NPY_1	374	376	PF08397	0.479
LIG_LIR_Apic_2	400	406	PF02991	0.312
LIG_LIR_Apic_2	58	62	PF02991	0.439
LIG_LIR_Gen_1	829	839	PF02991	0.464
LIG_LIR_Nem_3	383	387	PF02991	0.312
LIG_LIR_Nem_3	392	398	PF02991	0.312
LIG_LIR_Nem_3	694	698	PF02991	0.661
LIG_LIR_Nem_3	78	84	PF02991	0.312
LIG_LYPXL_yS_3	698	701	PF13949	0.672
LIG_MYND_1	212	216	PF01753	0.598
LIG_PTB_Apo_2	154	161	PF02174	0.272
LIG_PTB_Apo_2	181	188	PF02174	0.388
LIG_PTB_Phospho_1	181	187	PF10480	0.388
LIG_SH2_CRK	201	205	PF00017	0.447
LIG_SH2_CRK	59	63	PF00017	0.433
LIG_SH2_CRK	753	757	PF00017	0.590
LIG_SH2_CRK	81	85	PF00017	0.312
LIG_SH2_NCK_1	3	7	PF00017	0.469
LIG_SH2_STAP1	414	418	PF00017	0.312
LIG_SH2_STAP1	831	835	PF00017	0.464
LIG_SH2_STAT3	297	300	PF00017	0.714
LIG_SH2_STAT3	396	399	PF00017	0.312
LIG_SH2_STAT5	376	379	PF00017	0.353
LIG_SH2_STAT5	414	417	PF00017	0.348
LIG_SH2_STAT5	600	603	PF00017	0.518
LIG_SH2_STAT5	70	73	PF00017	0.381
LIG_SH2_STAT5	707	710	PF00017	0.720
LIG_SH2_STAT5	753	756	PF00017	0.664
LIG_SH2_STAT5	816	819	PF00017	0.686
LIG_SH2_STAT5	842	845	PF00017	0.598
LIG_SH3_3	210	216	PF00018	0.551
LIG_SH3_3	236	242	PF00018	0.536
LIG_SH3_3	432	438	PF00018	0.312
LIG_SH3_3	450	456	PF00018	0.312
LIG_SH3_3	643	649	PF00018	0.573
LIG_SH3_3	698	704	PF00018	0.513
LIG_SH3_3	834	840	PF00018	0.454
LIG_SH3_3	853	859	PF00018	0.573
LIG_SUMO_SIM_par_1	161	167	PF11976	0.312
LIG_TRAF2_1	552	555	PF00917	0.352
LIG_UBA3_1	118	122	PF00899	0.312
LIG_UBA3_1	427	434	PF00899	0.312
LIG_WRC_WIRS_1	131	136	PF05994	0.312
LIG_WRC_WIRS_1	266	271	PF05994	0.531
MOD_CDK_SPxxK_3	475	482	PF00069	0.247
MOD_CK1_1	206	212	PF00069	0.628
MOD_CK1_1	219	225	PF00069	0.714
MOD_CK1_1	227	233	PF00069	0.612
MOD_CK1_1	265	271	PF00069	0.688
MOD_CK1_1	277	283	PF00069	0.618
MOD_CK1_1	287	293	PF00069	0.731
MOD_CK1_1	32	38	PF00069	0.462
MOD_CK1_1	330	336	PF00069	0.524
MOD_CK1_1	370	376	PF00069	0.457
MOD_CK1_1	522	528	PF00069	0.285
MOD_CK1_1	612	618	PF00069	0.647
MOD_CK1_1	636	642	PF00069	0.620
MOD_CK1_1	645	651	PF00069	0.597
MOD_CK1_1	654	660	PF00069	0.573
MOD_CK1_1	681	687	PF00069	0.625
MOD_CK1_1	797	803	PF00069	0.593
MOD_CK1_1	804	810	PF00069	0.507
MOD_CK1_1	820	826	PF00069	0.717
MOD_CK2_1	161	167	PF00069	0.312
MOD_CK2_1	214	220	PF00069	0.557
MOD_CK2_1	489	495	PF00069	0.402
MOD_CK2_1	549	555	PF00069	0.243
MOD_GlcNHglycan	109	112	PF01048	0.352
MOD_GlcNHglycan	114	118	PF01048	0.352
MOD_GlcNHglycan	126	129	PF01048	0.352
MOD_GlcNHglycan	184	187	PF01048	0.329
MOD_GlcNHglycan	223	226	PF01048	0.664
MOD_GlcNHglycan	229	232	PF01048	0.613
MOD_GlcNHglycan	306	309	PF01048	0.740
MOD_GlcNHglycan	315	318	PF01048	0.677
MOD_GlcNHglycan	334	337	PF01048	0.520
MOD_GlcNHglycan	491	494	PF01048	0.291
MOD_GlcNHglycan	611	614	PF01048	0.534
MOD_GlcNHglycan	656	659	PF01048	0.590
MOD_GlcNHglycan	683	686	PF01048	0.570
MOD_GlcNHglycan	767	770	PF01048	0.713
MOD_GlcNHglycan	819	822	PF01048	0.611
MOD_GSK3_1	10	17	PF00069	0.599
MOD_GSK3_1	178	185	PF00069	0.361
MOD_GSK3_1	199	206	PF00069	0.503
MOD_GSK3_1	216	223	PF00069	0.640
MOD_GSK3_1	248	255	PF00069	0.564
MOD_GSK3_1	265	272	PF00069	0.548
MOD_GSK3_1	277	284	PF00069	0.653
MOD_GSK3_1	304	311	PF00069	0.722
MOD_GSK3_1	338	345	PF00069	0.661
MOD_GSK3_1	48	55	PF00069	0.437
MOD_GSK3_1	569	576	PF00069	0.352
MOD_GSK3_1	589	596	PF00069	0.428
MOD_GSK3_1	632	639	PF00069	0.609
MOD_GSK3_1	702	709	PF00069	0.660
MOD_GSK3_1	752	759	PF00069	0.707
MOD_GSK3_1	770	777	PF00069	0.557
MOD_GSK3_1	794	801	PF00069	0.575
MOD_GSK3_1	851	858	PF00069	0.551
MOD_N-GLC_1	220	225	PF02516	0.646
MOD_N-GLC_1	227	232	PF02516	0.618
MOD_N-GLC_1	342	347	PF02516	0.646
MOD_N-GLC_1	678	683	PF02516	0.560
MOD_N-GLC_1	709	714	PF02516	0.645
MOD_N-GLC_1	770	775	PF02516	0.507
MOD_N-GLC_2	344	346	PF02516	0.534
MOD_N-GLC_2	361	363	PF02516	0.486
MOD_NEK2_1	1	6	PF00069	0.478
MOD_NEK2_1	12	17	PF00069	0.468
MOD_NEK2_1	182	187	PF00069	0.388
MOD_NEK2_1	199	204	PF00069	0.376
MOD_NEK2_1	269	274	PF00069	0.631
MOD_NEK2_1	329	334	PF00069	0.611
MOD_NEK2_1	34	39	PF00069	0.478
MOD_NEK2_1	48	53	PF00069	0.509
MOD_NEK2_1	611	616	PF00069	0.590
MOD_NEK2_1	622	627	PF00069	0.594
MOD_NEK2_1	632	637	PF00069	0.618
MOD_NEK2_1	741	746	PF00069	0.660
MOD_NEK2_2	178	183	PF00069	0.388
MOD_NEK2_2	243	248	PF00069	0.552
MOD_NEK2_2	52	57	PF00069	0.436
MOD_PIKK_1	274	280	PF00454	0.551
MOD_PIKK_1	295	301	PF00454	0.580
MOD_PIKK_1	569	575	PF00454	0.312
MOD_PIKK_1	684	690	PF00454	0.651
MOD_PIKK_1	721	727	PF00454	0.655
MOD_PIKK_1	742	748	PF00454	0.524
MOD_PIKK_1	758	764	PF00454	0.633
MOD_PKA_2	107	113	PF00069	0.388
MOD_PKA_2	199	205	PF00069	0.491
MOD_PKA_2	281	287	PF00069	0.631
MOD_PKA_2	304	310	PF00069	0.702
MOD_PKA_2	319	325	PF00069	0.586
MOD_PKA_2	37	43	PF00069	0.418
MOD_PKA_2	522	528	PF00069	0.310
MOD_PKA_2	573	579	PF00069	0.352
MOD_Plk_1	10	16	PF00069	0.515
MOD_Plk_1	113	119	PF00069	0.312
MOD_Plk_1	391	397	PF00069	0.312
MOD_Plk_2-3	262	268	PF00069	0.525
MOD_Plk_2-3	550	556	PF00069	0.312
MOD_Plk_2-3	89	95	PF00069	0.231
MOD_Plk_4	29	35	PF00069	0.488
MOD_Plk_4	391	397	PF00069	0.312
MOD_Plk_4	444	450	PF00069	0.312
MOD_Plk_4	669	675	PF00069	0.662
MOD_Plk_4	702	708	PF00069	0.668
MOD_Plk_4	812	818	PF00069	0.558
MOD_Plk_4	852	858	PF00069	0.567
MOD_ProDKin_1	200	206	PF00069	0.556
MOD_ProDKin_1	208	214	PF00069	0.590
MOD_ProDKin_1	335	341	PF00069	0.528
MOD_ProDKin_1	367	373	PF00069	0.487
MOD_ProDKin_1	475	481	PF00069	0.247
MOD_ProDKin_1	539	545	PF00069	0.388
MOD_ProDKin_1	593	599	PF00069	0.563
MOD_ProDKin_1	600	606	PF00069	0.618
MOD_ProDKin_1	633	639	PF00069	0.603
MOD_ProDKin_1	642	648	PF00069	0.578
MOD_ProDKin_1	678	684	PF00069	0.526
MOD_ProDKin_1	744	750	PF00069	0.585
MOD_ProDKin_1	752	758	PF00069	0.581
MOD_ProDKin_1	770	776	PF00069	0.618
MOD_ProDKin_1	789	795	PF00069	0.585
MOD_SUMO_for_1	192	195	PF00179	0.312
MOD_SUMO_for_1	531	534	PF00179	0.255
MOD_SUMO_rev_2	185	194	PF00179	0.388
TRG_DiLeu_BaEn_1	114	119	PF01217	0.312
TRG_DiLeu_BaEn_1	534	539	PF01217	0.388
TRG_DiLeu_BaEn_1	555	560	PF01217	0.313
TRG_DiLeu_BaEn_4	534	540	PF01217	0.388
TRG_ENDOCYTIC_2	395	398	PF00928	0.312
TRG_ENDOCYTIC_2	698	701	PF00928	0.672
TRG_ENDOCYTIC_2	81	84	PF00928	0.381
TRG_ENDOCYTIC_2	831	834	PF00928	0.471
TRG_ER_diArg_1	107	109	PF00400	0.312
TRG_ER_diArg_1	155	158	PF00400	0.312
TRG_ER_diArg_1	387	389	PF00400	0.298
TRG_ER_diArg_1	520	523	PF00400	0.227
TRG_NES_CRM1_1	554	570	PF08389	0.231
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR0	Leptomonas seymouri	55%	100%
A0A3S7XBF4	Leishmania donovani	79%	100%
A4IE49	Leishmania infantum	78%	100%
E9ATK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q0Y9	Leishmania major	79%	100%