WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPU3_LEIBR

TriTrypDb:

LbrM.35.4490 , LBRM2903_350055600

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	567	571	PF00656	0.590
CLV_NRD_NRD_1	144	146	PF00675	0.602
CLV_NRD_NRD_1	183	185	PF00675	0.845
CLV_NRD_NRD_1	360	362	PF00675	0.483
CLV_NRD_NRD_1	418	420	PF00675	0.602
CLV_NRD_NRD_1	506	508	PF00675	0.590
CLV_NRD_NRD_1	540	542	PF00675	0.614
CLV_NRD_NRD_1	58	60	PF00675	0.622
CLV_NRD_NRD_1	697	699	PF00675	0.408
CLV_PCSK_KEX2_1	144	146	PF00082	0.702
CLV_PCSK_KEX2_1	183	185	PF00082	0.845
CLV_PCSK_KEX2_1	236	238	PF00082	0.476
CLV_PCSK_KEX2_1	360	362	PF00082	0.483
CLV_PCSK_KEX2_1	418	420	PF00082	0.602
CLV_PCSK_KEX2_1	506	508	PF00082	0.590
CLV_PCSK_KEX2_1	58	60	PF00082	0.622
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.476
CLV_PCSK_SKI1_1	488	492	PF00082	0.598
CLV_PCSK_SKI1_1	506	510	PF00082	0.273
CLV_PCSK_SKI1_1	699	703	PF00082	0.425
DEG_APCC_DBOX_1	685	693	PF00400	0.613
DEG_SCF_FBW7_1	211	218	PF00400	0.448
DEG_SPOP_SBC_1	626	630	PF00917	0.539
DEG_SPOP_SBC_1	656	660	PF00917	0.790
DOC_MAPK_gen_1	541	549	PF00069	0.581
DOC_MAPK_gen_1	58	67	PF00069	0.591
DOC_MAPK_gen_1	605	613	PF00069	0.501
DOC_MAPK_MEF2A_6	250	258	PF00069	0.607
DOC_MAPK_MEF2A_6	430	439	PF00069	0.594
DOC_MAPK_MEF2A_6	605	613	PF00069	0.501
DOC_MAPK_MEF2A_6	686	693	PF00069	0.619
DOC_MAPK_NFAT4_5	686	694	PF00069	0.622
DOC_PP1_RVXF_1	531	537	PF00149	0.352
DOC_PP1_RVXF_1	58	65	PF00149	0.599
DOC_PP2B_LxvP_1	258	261	PF13499	0.453
DOC_PP2B_LxvP_1	283	286	PF13499	0.576
DOC_PP4_FxxP_1	320	323	PF00568	0.561
DOC_PP4_MxPP_1	589	592	PF00568	0.360
DOC_USP7_MATH_1	134	138	PF00917	0.633
DOC_USP7_MATH_1	186	190	PF00917	0.811
DOC_USP7_MATH_1	243	247	PF00917	0.471
DOC_USP7_MATH_1	267	271	PF00917	0.581
DOC_USP7_MATH_1	323	327	PF00917	0.648
DOC_USP7_MATH_1	449	453	PF00917	0.567
DOC_USP7_MATH_1	478	482	PF00917	0.614
DOC_USP7_MATH_1	510	514	PF00917	0.538
DOC_USP7_MATH_1	626	630	PF00917	0.792
DOC_USP7_MATH_1	656	660	PF00917	0.830
DOC_USP7_MATH_1	674	678	PF00917	0.248
DOC_USP7_MATH_1	94	98	PF00917	0.515
DOC_USP7_MATH_2	267	273	PF00917	0.590
DOC_WW_Pin1_4	102	107	PF00397	0.613
DOC_WW_Pin1_4	124	129	PF00397	0.718
DOC_WW_Pin1_4	164	169	PF00397	0.554
DOC_WW_Pin1_4	211	216	PF00397	0.730
DOC_WW_Pin1_4	479	484	PF00397	0.474
DOC_WW_Pin1_4	627	632	PF00397	0.642
DOC_WW_Pin1_4	633	638	PF00397	0.699
DOC_WW_Pin1_4	640	645	PF00397	0.772
DOC_WW_Pin1_4	651	656	PF00397	0.623
DOC_WW_Pin1_4	83	88	PF00397	0.656
LIG_14-3-3_CanoR_1	301	307	PF00244	0.556
LIG_14-3-3_CanoR_1	324	333	PF00244	0.568
LIG_14-3-3_CanoR_1	418	424	PF00244	0.485
LIG_14-3-3_CanoR_1	436	440	PF00244	0.295
LIG_14-3-3_CanoR_1	533	539	PF00244	0.352
LIG_14-3-3_CanoR_1	59	65	PF00244	0.596
LIG_14-3-3_CanoR_1	615	625	PF00244	0.513
LIG_14-3-3_CanoR_1	72	82	PF00244	0.454
LIG_14-3-3_CanoR_1	93	99	PF00244	0.636
LIG_14-3-3_CterR_2	698	703	PF00244	0.423
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BIR_III_4	45	49	PF00653	0.572
LIG_BRCT_BRCA1_1	116	120	PF00533	0.572
LIG_BRCT_BRCA1_1	316	320	PF00533	0.575
LIG_BRCT_BRCA1_1	37	41	PF00533	0.601
LIG_BRCT_BRCA1_1	411	415	PF00533	0.656
LIG_CtBP_PxDLS_1	122	126	PF00389	0.646
LIG_FHA_1	185	191	PF00498	0.829
LIG_FHA_1	198	204	PF00498	0.499
LIG_FHA_1	464	470	PF00498	0.511
LIG_FHA_1	560	566	PF00498	0.568
LIG_FHA_1	620	626	PF00498	0.587
LIG_FHA_1	679	685	PF00498	0.563
LIG_FHA_2	292	298	PF00498	0.593
LIG_FHA_2	310	316	PF00498	0.510
LIG_FHA_2	523	529	PF00498	0.398
LIG_FHA_2	581	587	PF00498	0.449
LIG_FHA_2	660	666	PF00498	0.537
LIG_LIR_Apic_2	169	174	PF02991	0.806
LIG_LIR_Apic_2	297	303	PF02991	0.638
LIG_LIR_Apic_2	317	323	PF02991	0.564
LIG_LIR_Gen_1	279	289	PF02991	0.605
LIG_LIR_Gen_1	63	70	PF02991	0.580
LIG_LIR_LC3C_4	688	693	PF02991	0.627
LIG_LIR_Nem_3	117	123	PF02991	0.580
LIG_LIR_Nem_3	279	285	PF02991	0.589
LIG_LIR_Nem_3	63	67	PF02991	0.579
LIG_PDZ_Class_2	698	703	PF00595	0.579
LIG_RPA_C_Fungi	349	361	PF08784	0.566
LIG_RPA_C_Fungi	54	66	PF08784	0.344
LIG_SH2_NCK_1	403	407	PF00017	0.473
LIG_SH2_NCK_1	520	524	PF00017	0.346
LIG_SH2_PTP2	610	613	PF00017	0.504
LIG_SH2_SRC	403	406	PF00017	0.720
LIG_SH2_STAP1	520	524	PF00017	0.599
LIG_SH2_STAT5	222	225	PF00017	0.462
LIG_SH2_STAT5	231	234	PF00017	0.340
LIG_SH2_STAT5	282	285	PF00017	0.578
LIG_SH2_STAT5	610	613	PF00017	0.562
LIG_SH2_STAT5	671	674	PF00017	0.543
LIG_SH3_3	375	381	PF00018	0.569
LIG_SH3_3	472	478	PF00018	0.570
LIG_SH3_3	601	607	PF00018	0.731
LIG_SH3_3	608	614	PF00018	0.575
LIG_SUMO_SIM_par_1	121	127	PF11976	0.650
LIG_SUMO_SIM_par_1	253	259	PF11976	0.602
LIG_SUMO_SIM_par_1	572	578	PF11976	0.613
LIG_TRAF2_1	356	359	PF00917	0.668
LIG_TRAF2_1	664	667	PF00917	0.745
LIG_WRC_WIRS_1	420	425	PF05994	0.582
LIG_WRC_WIRS_1	61	66	PF05994	0.580
MOD_CDC14_SPxK_1	127	130	PF00782	0.518
MOD_CDC14_SPxK_1	643	646	PF00782	0.816
MOD_CDK_SPxK_1	124	130	PF00069	0.477
MOD_CDK_SPxK_1	640	646	PF00069	0.824
MOD_CK1_1	114	120	PF00069	0.571
MOD_CK1_1	124	130	PF00069	0.564
MOD_CK1_1	169	175	PF00069	0.572
MOD_CK1_1	189	195	PF00069	0.714
MOD_CK1_1	2	8	PF00069	0.479
MOD_CK1_1	246	252	PF00069	0.675
MOD_CK1_1	276	282	PF00069	0.490
MOD_CK1_1	314	320	PF00069	0.682
MOD_CK1_1	325	331	PF00069	0.510
MOD_CK1_1	370	376	PF00069	0.654
MOD_CK1_1	390	396	PF00069	0.517
MOD_CK1_1	575	581	PF00069	0.477
MOD_CK1_1	627	633	PF00069	0.672
MOD_CK1_1	651	657	PF00069	0.726
MOD_CK1_1	659	665	PF00069	0.735
MOD_CK2_1	179	185	PF00069	0.595
MOD_CK2_1	291	297	PF00069	0.528
MOD_CK2_1	309	315	PF00069	0.613
MOD_CK2_1	390	396	PF00069	0.809
MOD_CK2_1	522	528	PF00069	0.416
MOD_CK2_1	655	661	PF00069	0.731
MOD_Cter_Amidation	504	507	PF01082	0.613
MOD_GlcNHglycan	135	139	PF01048	0.577
MOD_GlcNHglycan	152	155	PF01048	0.720
MOD_GlcNHglycan	168	171	PF01048	0.546
MOD_GlcNHglycan	205	209	PF01048	0.805
MOD_GlcNHglycan	315	319	PF01048	0.668
MOD_GlcNHglycan	342	345	PF01048	0.495
MOD_GlcNHglycan	372	375	PF01048	0.647
MOD_GlcNHglycan	393	396	PF01048	0.680
MOD_GlcNHglycan	411	414	PF01048	0.343
MOD_GlcNHglycan	42	45	PF01048	0.393
MOD_GlcNHglycan	423	426	PF01048	0.577
MOD_GlcNHglycan	451	454	PF01048	0.577
MOD_GlcNHglycan	496	499	PF01048	0.476
MOD_GlcNHglycan	503	506	PF01048	0.431
MOD_GlcNHglycan	649	653	PF01048	0.654
MOD_GSK3_1	211	218	PF00069	0.700
MOD_GSK3_1	269	276	PF00069	0.514
MOD_GSK3_1	36	43	PF00069	0.461
MOD_GSK3_1	387	394	PF00069	0.594
MOD_GSK3_1	409	416	PF00069	0.595
MOD_GSK3_1	421	428	PF00069	0.532
MOD_GSK3_1	613	620	PF00069	0.653
MOD_GSK3_1	626	633	PF00069	0.604
MOD_GSK3_1	651	658	PF00069	0.779
MOD_GSK3_1	674	681	PF00069	0.412
MOD_N-GLC_1	2	7	PF02516	0.494
MOD_N-GLC_1	309	314	PF02516	0.784
MOD_N-GLC_1	338	343	PF02516	0.609
MOD_N-GLC_1	413	418	PF02516	0.611
MOD_N-GLC_1	488	493	PF02516	0.592
MOD_N-GLC_1	53	58	PF02516	0.460
MOD_N-GLC_1	640	645	PF02516	0.673
MOD_N-GLC_1	656	661	PF02516	0.552
MOD_NEK2_1	123	128	PF00069	0.573
MOD_NEK2_1	179	184	PF00069	0.690
MOD_NEK2_1	195	200	PF00069	0.662
MOD_NEK2_1	204	209	PF00069	0.495
MOD_NEK2_1	278	283	PF00069	0.604
MOD_NEK2_1	387	392	PF00069	0.586
MOD_NEK2_1	435	440	PF00069	0.552
MOD_NEK2_1	494	499	PF00069	0.574
MOD_NEK2_1	534	539	PF00069	0.438
MOD_NEK2_1	617	622	PF00069	0.609
MOD_NEK2_1	672	677	PF00069	0.558
MOD_NEK2_2	413	418	PF00069	0.339
MOD_NEK2_2	536	541	PF00069	0.599
MOD_NEK2_2	543	548	PF00069	0.233
MOD_NEK2_2	559	564	PF00069	0.577
MOD_PIKK_1	189	195	PF00454	0.578
MOD_PIKK_1	379	385	PF00454	0.561
MOD_PIKK_1	630	636	PF00454	0.817
MOD_PIKK_1	75	81	PF00454	0.611
MOD_PK_1	572	578	PF00069	0.613
MOD_PKA_2	179	185	PF00069	0.698
MOD_PKA_2	323	329	PF00069	0.570
MOD_PKA_2	396	402	PF00069	0.615
MOD_PKA_2	435	441	PF00069	0.592
MOD_PKA_2	580	586	PF00069	0.600
MOD_Plk_1	291	297	PF00069	0.592
MOD_Plk_1	35	41	PF00069	0.485
MOD_Plk_1	413	419	PF00069	0.461
MOD_Plk_1	5	11	PF00069	0.672
MOD_Plk_1	559	565	PF00069	0.532
MOD_Plk_1	678	684	PF00069	0.472
MOD_Plk_2-3	661	667	PF00069	0.521
MOD_Plk_4	111	117	PF00069	0.531
MOD_Plk_4	156	162	PF00069	0.557
MOD_Plk_4	291	297	PF00069	0.592
MOD_Plk_4	36	42	PF00069	0.609
MOD_Plk_4	396	402	PF00069	0.662
MOD_Plk_4	430	436	PF00069	0.492
MOD_Plk_4	5	11	PF00069	0.428
MOD_Plk_4	543	549	PF00069	0.402
MOD_Plk_4	572	578	PF00069	0.613
MOD_Plk_4	60	66	PF00069	0.331
MOD_Plk_4	94	100	PF00069	0.548
MOD_ProDKin_1	102	108	PF00069	0.604
MOD_ProDKin_1	124	130	PF00069	0.729
MOD_ProDKin_1	164	170	PF00069	0.555
MOD_ProDKin_1	211	217	PF00069	0.716
MOD_ProDKin_1	479	485	PF00069	0.458
MOD_ProDKin_1	627	633	PF00069	0.644
MOD_ProDKin_1	640	646	PF00069	0.773
MOD_ProDKin_1	651	657	PF00069	0.652
MOD_ProDKin_1	83	89	PF00069	0.657
TRG_DiLeu_BaEn_1	665	670	PF01217	0.516
TRG_DiLeu_BaEn_2	36	42	PF01217	0.609
TRG_ENDOCYTIC_2	282	285	PF00928	0.578
TRG_ENDOCYTIC_2	610	613	PF00928	0.659
TRG_ER_diArg_1	143	145	PF00400	0.608
TRG_ER_diArg_1	176	179	PF00400	0.845
TRG_ER_diArg_1	417	419	PF00400	0.600
TRG_ER_diArg_1	506	508	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGF7	Leishmania donovani	74%	100%
E9AHX8	Leishmania infantum	74%	100%
E9ATK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q0Z0	Leishmania major	73%	100%