Paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania braziliensis

UniProt:

A4HPU2_LEIBR

TriTrypDb:

LbrM.35.4480 , LBRM2903_350055500

Length:

1079

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14
GO:0031514	motile cilium	5	3

Expansion

Sequence features

A4HPU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	843	847	PF00656	0.271
CLV_NRD_NRD_1	242	244	PF00675	0.518
CLV_NRD_NRD_1	491	493	PF00675	0.289
CLV_PCSK_KEX2_1	125	127	PF00082	0.438
CLV_PCSK_KEX2_1	288	290	PF00082	0.514
CLV_PCSK_KEX2_1	491	493	PF00082	0.289
CLV_PCSK_KEX2_1	606	608	PF00082	0.427
CLV_PCSK_KEX2_1	755	757	PF00082	0.271
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.507
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.509
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.410
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.271
CLV_PCSK_SKI1_1	1012	1016	PF00082	0.459
CLV_PCSK_SKI1_1	1036	1040	PF00082	0.700
CLV_PCSK_SKI1_1	157	161	PF00082	0.427
CLV_PCSK_SKI1_1	22	26	PF00082	0.560
CLV_PCSK_SKI1_1	447	451	PF00082	0.475
CLV_PCSK_SKI1_1	575	579	PF00082	0.460
CLV_PCSK_SKI1_1	709	713	PF00082	0.310
CLV_PCSK_SKI1_1	812	816	PF00082	0.484
CLV_Separin_Metazoa	964	968	PF03568	0.504
DEG_APCC_DBOX_1	1011	1019	PF00400	0.454
DEG_APCC_DBOX_1	446	454	PF00400	0.537
DOC_CYCLIN_RxL_1	485	499	PF00134	0.434
DOC_CYCLIN_RxL_1	569	582	PF00134	0.285
DOC_CYCLIN_RxL_1	753	762	PF00134	0.488
DOC_CYCLIN_RxL_1	809	820	PF00134	0.397
DOC_CYCLIN_RxL_1	896	905	PF00134	0.438
DOC_CYCLIN_RxL_1	942	951	PF00134	0.319
DOC_MAPK_gen_1	125	133	PF00069	0.289
DOC_MAPK_gen_1	288	294	PF00069	0.497
DOC_MAPK_gen_1	676	685	PF00069	0.266
DOC_MAPK_MEF2A_6	413	421	PF00069	0.517
DOC_MAPK_MEF2A_6	458	465	PF00069	0.558
DOC_MAPK_MEF2A_6	732	741	PF00069	0.421
DOC_MAPK_MEF2A_6	884	893	PF00069	0.538
DOC_PIKK_1	628	636	PF02985	0.316
DOC_USP7_MATH_1	132	136	PF00917	0.487
DOC_USP7_MATH_1	324	328	PF00917	0.385
DOC_USP7_MATH_1	392	396	PF00917	0.361
DOC_USP7_MATH_1	513	517	PF00917	0.432
DOC_USP7_UBL2_3	728	732	PF12436	0.260
DOC_WW_Pin1_4	1024	1029	PF00397	0.526
DOC_WW_Pin1_4	264	269	PF00397	0.507
DOC_WW_Pin1_4	40	45	PF00397	0.456
DOC_WW_Pin1_4	875	880	PF00397	0.284
LIG_14-3-3_CanoR_1	1050	1056	PF00244	0.622
LIG_14-3-3_CanoR_1	134	138	PF00244	0.388
LIG_14-3-3_CanoR_1	224	230	PF00244	0.414
LIG_14-3-3_CanoR_1	295	304	PF00244	0.491
LIG_14-3-3_CanoR_1	445	450	PF00244	0.479
LIG_14-3-3_CanoR_1	485	491	PF00244	0.404
LIG_14-3-3_CanoR_1	492	500	PF00244	0.395
LIG_14-3-3_CanoR_1	809	815	PF00244	0.467
LIG_14-3-3_CanoR_1	863	870	PF00244	0.393
LIG_14-3-3_CanoR_1	884	891	PF00244	0.528
LIG_Actin_WH2_2	344	360	PF00022	0.448
LIG_Actin_WH2_2	605	622	PF00022	0.336
LIG_Actin_WH2_2	854	870	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	197	201	PF00533	0.236
LIG_BRCT_BRCA1_1	227	231	PF00533	0.412
LIG_BRCT_BRCA1_1	246	250	PF00533	0.413
LIG_BRCT_BRCA1_1	399	403	PF00533	0.356
LIG_BRCT_BRCA1_1	461	465	PF00533	0.283
LIG_BRCT_BRCA1_1	950	954	PF00533	0.343
LIG_Clathr_ClatBox_1	163	167	PF01394	0.418
LIG_Clathr_ClatBox_1	839	843	PF01394	0.387
LIG_FHA_1	1057	1063	PF00498	0.650
LIG_FHA_1	236	242	PF00498	0.432
LIG_FHA_1	255	261	PF00498	0.363
LIG_FHA_1	354	360	PF00498	0.307
LIG_FHA_1	372	378	PF00498	0.356
LIG_FHA_1	403	409	PF00498	0.395
LIG_FHA_1	414	420	PF00498	0.371
LIG_FHA_1	47	53	PF00498	0.383
LIG_FHA_1	543	549	PF00498	0.216
LIG_FHA_1	675	681	PF00498	0.575
LIG_FHA_1	69	75	PF00498	0.507
LIG_FHA_1	703	709	PF00498	0.450
LIG_FHA_1	871	877	PF00498	0.395
LIG_FHA_2	335	341	PF00498	0.423
LIG_FHA_2	36	42	PF00498	0.501
LIG_FHA_2	469	475	PF00498	0.446
LIG_FHA_2	515	521	PF00498	0.383
LIG_FHA_2	571	577	PF00498	0.383
LIG_FHA_2	647	653	PF00498	0.435
LIG_FHA_2	705	711	PF00498	0.493
LIG_FHA_2	925	931	PF00498	0.469
LIG_GBD_Chelix_1	241	249	PF00786	0.387
LIG_IRF3_LxIS_1	328	335	PF10401	0.468
LIG_LIR_Gen_1	374	380	PF02991	0.239
LIG_LIR_Gen_1	649	656	PF02991	0.321
LIG_LIR_Nem_3	1027	1032	PF02991	0.683
LIG_LIR_Nem_3	151	155	PF02991	0.478
LIG_LIR_Nem_3	173	177	PF02991	0.360
LIG_LIR_Nem_3	267	273	PF02991	0.477
LIG_LIR_Nem_3	374	379	PF02991	0.378
LIG_LIR_Nem_3	649	653	PF02991	0.321
LIG_LIR_Nem_3	735	741	PF02991	0.396
LIG_NRBOX	159	165	PF00104	0.484
LIG_NRBOX	560	566	PF00104	0.186
LIG_PCNA_PIPBox_1	184	193	PF02747	0.274
LIG_PCNA_yPIPBox_3	202	215	PF02747	0.483
LIG_Pex14_2	92	96	PF04695	0.334
LIG_PTB_Apo_2	644	651	PF02174	0.186
LIG_PTB_Apo_2	871	878	PF02174	0.272
LIG_Rb_pABgroove_1	244	252	PF01858	0.388
LIG_SH2_CRK	1029	1033	PF00017	0.679
LIG_SH2_CRK	270	274	PF00017	0.319
LIG_SH2_STAT3	1055	1058	PF00017	0.570
LIG_SH2_STAT3	162	165	PF00017	0.245
LIG_SH2_STAT5	1055	1058	PF00017	0.601
LIG_SH2_STAT5	122	125	PF00017	0.395
LIG_SH2_STAT5	162	165	PF00017	0.309
LIG_SH2_STAT5	270	273	PF00017	0.517
LIG_SH2_STAT5	507	510	PF00017	0.349
LIG_SH2_STAT5	511	514	PF00017	0.417
LIG_SH2_STAT5	828	831	PF00017	0.433
LIG_SH2_STAT5	991	994	PF00017	0.494
LIG_SUMO_SIM_anti_2	649	655	PF11976	0.426
LIG_SUMO_SIM_anti_2	927	935	PF11976	0.476
LIG_SUMO_SIM_par_1	129	136	PF11976	0.281
LIG_SUMO_SIM_par_1	459	464	PF11976	0.563
LIG_SUMO_SIM_par_1	48	53	PF11976	0.443
LIG_SUMO_SIM_par_1	547	552	PF11976	0.403
LIG_SUMO_SIM_par_1	652	657	PF11976	0.460
LIG_SUMO_SIM_par_1	770	775	PF11976	0.494
LIG_SUMO_SIM_par_1	828	834	PF11976	0.457
LIG_SUMO_SIM_par_1	838	843	PF11976	0.420
LIG_TRAF2_1	300	303	PF00917	0.478
LIG_TRAF2_1	385	388	PF00917	0.277
LIG_TRAF2_1	429	432	PF00917	0.452
LIG_TYR_ITSM	1025	1032	PF00017	0.545
LIG_UBA3_1	375	383	PF00899	0.404
LIG_UBA3_1	810	815	PF00899	0.519
LIG_WRC_WIRS_1	187	192	PF05994	0.338
LIG_WRC_WIRS_1	226	231	PF05994	0.418
LIG_WRC_WIRS_1	256	261	PF05994	0.312
LIG_WW_3	442	446	PF00397	0.522
MOD_CDK_SPxK_1	1024	1030	PF00069	0.535
MOD_CK1_1	1044	1050	PF00069	0.613
MOD_CK1_1	113	119	PF00069	0.474
MOD_CK1_1	143	149	PF00069	0.445
MOD_CK1_1	197	203	PF00069	0.451
MOD_CK1_1	225	231	PF00069	0.391
MOD_CK1_1	254	260	PF00069	0.347
MOD_CK1_1	426	432	PF00069	0.523
MOD_CK1_1	496	502	PF00069	0.441
MOD_CK1_1	514	520	PF00069	0.258
MOD_CK1_1	524	530	PF00069	0.280
MOD_CK1_1	53	59	PF00069	0.387
MOD_CK1_1	637	643	PF00069	0.353
MOD_CK1_1	674	680	PF00069	0.500
MOD_CK1_1	817	823	PF00069	0.354
MOD_CK1_1	838	844	PF00069	0.428
MOD_CK1_1	878	884	PF00069	0.497
MOD_CK2_1	121	127	PF00069	0.467
MOD_CK2_1	197	203	PF00069	0.250
MOD_CK2_1	35	41	PF00069	0.428
MOD_CK2_1	426	432	PF00069	0.498
MOD_CK2_1	514	520	PF00069	0.418
MOD_CK2_1	570	576	PF00069	0.412
MOD_CK2_1	646	652	PF00069	0.435
MOD_CK2_1	704	710	PF00069	0.524
MOD_CK2_1	91	97	PF00069	0.395
MOD_GlcNHglycan	138	141	PF01048	0.439
MOD_GlcNHglycan	147	150	PF01048	0.340
MOD_GlcNHglycan	173	177	PF01048	0.339
MOD_GlcNHglycan	298	301	PF01048	0.464
MOD_GlcNHglycan	425	428	PF01048	0.433
MOD_GlcNHglycan	464	468	PF01048	0.535
MOD_GlcNHglycan	561	564	PF01048	0.434
MOD_GlcNHglycan	655	659	PF01048	0.374
MOD_GlcNHglycan	822	825	PF01048	0.494
MOD_GlcNHglycan	850	854	PF01048	0.293
MOD_GSK3_1	1044	1051	PF00069	0.570
MOD_GSK3_1	132	139	PF00069	0.421
MOD_GSK3_1	191	198	PF00069	0.402
MOD_GSK3_1	225	232	PF00069	0.430
MOD_GSK3_1	251	258	PF00069	0.444
MOD_GSK3_1	42	49	PF00069	0.381
MOD_GSK3_1	445	452	PF00069	0.408
MOD_GSK3_1	459	466	PF00069	0.277
MOD_GSK3_1	53	60	PF00069	0.277
MOD_GSK3_1	636	643	PF00069	0.466
MOD_GSK3_1	679	686	PF00069	0.365
MOD_GSK3_1	745	752	PF00069	0.531
MOD_GSK3_1	789	796	PF00069	0.514
MOD_GSK3_1	801	808	PF00069	0.317
MOD_GSK3_1	810	817	PF00069	0.333
MOD_GSK3_1	838	845	PF00069	0.397
MOD_GSK3_1	862	869	PF00069	0.453
MOD_GSK3_1	883	890	PF00069	0.320
MOD_GSK3_1	920	927	PF00069	0.570
MOD_GSK3_1	939	946	PF00069	0.389
MOD_GSK3_1	948	955	PF00069	0.393
MOD_N-GLC_1	1024	1029	PF02516	0.482
MOD_N-GLC_1	1063	1068	PF02516	0.431
MOD_N-GLC_1	295	300	PF02516	0.451
MOD_N-GLC_1	332	337	PF02516	0.386
MOD_N-GLC_1	353	358	PF02516	0.320
MOD_N-GLC_1	392	397	PF02516	0.516
MOD_N-GLC_1	486	491	PF02516	0.374
MOD_N-GLC_1	493	498	PF02516	0.337
MOD_N-GLC_1	514	519	PF02516	0.287
MOD_N-GLC_1	521	526	PF02516	0.266
MOD_N-GLC_1	53	58	PF02516	0.434
MOD_N-GLC_1	542	547	PF02516	0.224
MOD_N-GLC_1	570	575	PF02516	0.312
MOD_N-GLC_1	646	651	PF02516	0.392
MOD_N-GLC_1	683	688	PF02516	0.386
MOD_N-GLC_1	716	721	PF02516	0.432
MOD_N-GLC_1	732	737	PF02516	0.273
MOD_N-GLC_1	952	957	PF02516	0.339
MOD_N-GLC_1	975	980	PF02516	0.315
MOD_N-GLC_2	110	112	PF02516	0.328
MOD_N-GLC_2	253	255	PF02516	0.244
MOD_N-GLC_2	455	457	PF02516	0.298
MOD_N-GLC_2	664	666	PF02516	0.423
MOD_NEK2_1	1005	1010	PF00069	0.401
MOD_NEK2_1	191	196	PF00069	0.418
MOD_NEK2_1	229	234	PF00069	0.403
MOD_NEK2_1	245	250	PF00069	0.269
MOD_NEK2_1	259	264	PF00069	0.373
MOD_NEK2_1	332	337	PF00069	0.437
MOD_NEK2_1	35	40	PF00069	0.469
MOD_NEK2_1	486	491	PF00069	0.294
MOD_NEK2_1	493	498	PF00069	0.261
MOD_NEK2_1	503	508	PF00069	0.212
MOD_NEK2_1	521	526	PF00069	0.304
MOD_NEK2_1	549	554	PF00069	0.342
MOD_NEK2_1	579	584	PF00069	0.415
MOD_NEK2_1	6	11	PF00069	0.484
MOD_NEK2_1	636	641	PF00069	0.462
MOD_NEK2_1	68	73	PF00069	0.342
MOD_NEK2_1	713	718	PF00069	0.385
MOD_NEK2_1	793	798	PF00069	0.433
MOD_NEK2_1	801	806	PF00069	0.387
MOD_NEK2_1	810	815	PF00069	0.300
MOD_NEK2_1	947	952	PF00069	0.336
MOD_NEK2_1	975	980	PF00069	0.286
MOD_NEK2_2	371	376	PF00069	0.186
MOD_PIKK_1	1044	1050	PF00454	0.573
MOD_PIKK_1	140	146	PF00454	0.442
MOD_PIKK_1	191	197	PF00454	0.460
MOD_PIKK_1	671	677	PF00454	0.271
MOD_PK_1	1063	1069	PF00069	0.433
MOD_PK_1	445	451	PF00069	0.508
MOD_PK_1	732	738	PF00069	0.530
MOD_PK_1	98	104	PF00069	0.445
MOD_PKA_2	1049	1055	PF00069	0.598
MOD_PKA_2	133	139	PF00069	0.387
MOD_PKA_2	862	868	PF00069	0.472
MOD_PKA_2	883	889	PF00069	0.527
MOD_Plk_1	1005	1011	PF00069	0.472
MOD_Plk_1	1044	1050	PF00069	0.573
MOD_Plk_1	1063	1069	PF00069	0.554
MOD_Plk_1	202	208	PF00069	0.391
MOD_Plk_1	353	359	PF00069	0.330
MOD_Plk_1	392	398	PF00069	0.390
MOD_Plk_1	468	474	PF00069	0.502
MOD_Plk_1	486	492	PF00069	0.356
MOD_Plk_1	514	520	PF00069	0.291
MOD_Plk_1	53	59	PF00069	0.387
MOD_Plk_1	542	548	PF00069	0.192
MOD_Plk_1	570	576	PF00069	0.439
MOD_Plk_1	579	585	PF00069	0.418
MOD_Plk_1	615	621	PF00069	0.473
MOD_Plk_1	634	640	PF00069	0.368
MOD_Plk_1	646	652	PF00069	0.280
MOD_Plk_1	732	738	PF00069	0.383
MOD_Plk_1	789	795	PF00069	0.467
MOD_Plk_1	939	945	PF00069	0.385
MOD_Plk_1	98	104	PF00069	0.428
MOD_Plk_2-3	1041	1047	PF00069	0.455
MOD_Plk_2-3	459	465	PF00069	0.289
MOD_Plk_2-3	46	52	PF00069	0.296
MOD_Plk_2-3	570	576	PF00069	0.277
MOD_Plk_4	1017	1023	PF00069	0.437
MOD_Plk_4	133	139	PF00069	0.410
MOD_Plk_4	186	192	PF00069	0.431
MOD_Plk_4	245	251	PF00069	0.270
MOD_Plk_4	255	261	PF00069	0.320
MOD_Plk_4	324	330	PF00069	0.388
MOD_Plk_4	334	340	PF00069	0.396
MOD_Plk_4	371	377	PF00069	0.198
MOD_Plk_4	434	440	PF00069	0.444
MOD_Plk_4	473	479	PF00069	0.480
MOD_Plk_4	503	509	PF00069	0.374
MOD_Plk_4	514	520	PF00069	0.266
MOD_Plk_4	646	652	PF00069	0.333
MOD_Plk_4	732	738	PF00069	0.465
MOD_Plk_4	749	755	PF00069	0.440
MOD_Plk_4	801	807	PF00069	0.359
MOD_Plk_4	835	841	PF00069	0.387
MOD_Plk_4	91	97	PF00069	0.423
MOD_Plk_4	939	945	PF00069	0.352
MOD_ProDKin_1	1024	1030	PF00069	0.535
MOD_ProDKin_1	264	270	PF00069	0.507
MOD_ProDKin_1	40	46	PF00069	0.463
MOD_ProDKin_1	875	881	PF00069	0.277
MOD_SUMO_for_1	1062	1065	PF00179	0.421
MOD_SUMO_for_1	577	580	PF00179	0.441
MOD_SUMO_rev_2	1034	1040	PF00179	0.449
MOD_SUMO_rev_2	41	50	PF00179	0.307
MOD_SUMO_rev_2	570	579	PF00179	0.432
TRG_ENDOCYTIC_2	1029	1032	PF00928	0.676
TRG_ENDOCYTIC_2	152	155	PF00928	0.451
TRG_ENDOCYTIC_2	270	273	PF00928	0.422
TRG_ENDOCYTIC_2	991	994	PF00928	0.399
TRG_ER_diArg_1	444	447	PF00400	0.481
TRG_ER_diArg_1	490	492	PF00400	0.274
TRG_ER_diArg_1	581	584	PF00400	0.596
TRG_NES_CRM1_1	1013	1026	PF08389	0.437
TRG_NES_CRM1_1	834	846	PF08389	0.283
TRG_Pf-PMV_PEXEL_1	1012	1016	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA2	Leptomonas seymouri	54%	100%
A0A0S4J1S9	Bodo saltans	23%	100%
A0A0S4JCL5	Bodo saltans	24%	90%
A0A0S4JML5	Bodo saltans	31%	99%
A0A1X0P080	Trypanosomatidae	37%	100%
A0A3Q8IWA4	Leishmania donovani	73%	96%
A0A422MVT9	Trypanosoma rangeli	34%	100%
A4IE50	Leishmania infantum	73%	96%
D0A481	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q0Z1	Leishmania major	73%	100%
V5DLP2	Trypanosoma cruzi	36%	100%