Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/Utp21 specific WD40 associated putative domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPU0_LEIBR

TriTrypDb:

LbrM.35.4460 , LBRM2903_350055200

Length:

987

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HPU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPU0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.420
CLV_C14_Caspase3-7	251	255	PF00656	0.465
CLV_C14_Caspase3-7	331	335	PF00656	0.364
CLV_C14_Caspase3-7	349	353	PF00656	0.292
CLV_C14_Caspase3-7	54	58	PF00656	0.350
CLV_C14_Caspase3-7	614	618	PF00656	0.454
CLV_MEL_PAP_1	942	948	PF00089	0.388
CLV_NRD_NRD_1	343	345	PF00675	0.304
CLV_NRD_NRD_1	759	761	PF00675	0.510
CLV_NRD_NRD_1	832	834	PF00675	0.388
CLV_NRD_NRD_1	920	922	PF00675	0.280
CLV_PCSK_FUR_1	341	345	PF00082	0.322
CLV_PCSK_KEX2_1	116	118	PF00082	0.319
CLV_PCSK_KEX2_1	343	345	PF00082	0.304
CLV_PCSK_KEX2_1	391	393	PF00082	0.371
CLV_PCSK_KEX2_1	758	760	PF00082	0.506
CLV_PCSK_KEX2_1	885	887	PF00082	0.276
CLV_PCSK_KEX2_1	920	922	PF00082	0.302
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.319
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.516
CLV_PCSK_PC1ET2_1	885	887	PF00082	0.276
CLV_PCSK_SKI1_1	152	156	PF00082	0.366
CLV_PCSK_SKI1_1	490	494	PF00082	0.345
CLV_PCSK_SKI1_1	909	913	PF00082	0.336
DEG_APCC_DBOX_1	286	294	PF00400	0.544
DEG_APCC_DBOX_1	964	972	PF00400	0.165
DEG_Nend_UBRbox_3	1	3	PF02207	0.388
DEG_SCF_TRCP1_1	240	246	PF00400	0.245
DEG_SPOP_SBC_1	412	416	PF00917	0.348
DEG_SPOP_SBC_1	611	615	PF00917	0.454
DOC_ANK_TNKS_1	68	75	PF00023	0.287
DOC_CKS1_1	25	30	PF01111	0.469
DOC_CYCLIN_RxL_1	149	159	PF00134	0.444
DOC_CYCLIN_RxL_1	456	465	PF00134	0.443
DOC_CYCLIN_RxL_1	903	916	PF00134	0.340
DOC_CYCLIN_yClb1_LxF_4	783	788	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	803	806	PF00134	0.257
DOC_MAPK_DCC_7	670	679	PF00069	0.463
DOC_MAPK_gen_1	250	258	PF00069	0.469
DOC_MAPK_gen_1	807	813	PF00069	0.257
DOC_MAPK_gen_1	920	927	PF00069	0.276
DOC_MAPK_HePTP_8	872	884	PF00069	0.336
DOC_MAPK_JIP1_4	822	828	PF00069	0.302
DOC_MAPK_MEF2A_6	404	411	PF00069	0.248
DOC_MAPK_MEF2A_6	635	643	PF00069	0.331
DOC_MAPK_MEF2A_6	670	679	PF00069	0.550
DOC_MAPK_MEF2A_6	875	884	PF00069	0.336
DOC_MAPK_MEF2A_6	96	103	PF00069	0.379
DOC_PP1_RVXF_1	115	122	PF00149	0.439
DOC_PP1_RVXF_1	783	789	PF00149	0.340
DOC_PP2B_LxvP_1	584	587	PF13499	0.399
DOC_PP2B_LxvP_1	803	806	PF13499	0.257
DOC_PP4_FxxP_1	307	310	PF00568	0.459
DOC_PP4_FxxP_1	636	639	PF00568	0.405
DOC_PP4_FxxP_1	813	816	PF00568	0.257
DOC_USP7_MATH_1	243	247	PF00917	0.383
DOC_USP7_MATH_1	502	506	PF00917	0.432
DOC_USP7_MATH_1	714	718	PF00917	0.589
DOC_WW_Pin1_4	17	22	PF00397	0.377
DOC_WW_Pin1_4	24	29	PF00397	0.465
DOC_WW_Pin1_4	593	598	PF00397	0.420
DOC_WW_Pin1_4	635	640	PF00397	0.302
LIG_14-3-3_CanoR_1	192	198	PF00244	0.407
LIG_14-3-3_CanoR_1	379	383	PF00244	0.336
LIG_14-3-3_CanoR_1	715	722	PF00244	0.613
LIG_14-3-3_CanoR_1	965	969	PF00244	0.302
LIG_Actin_WH2_2	523	541	PF00022	0.425
LIG_Actin_WH2_2	808	824	PF00022	0.257
LIG_AP2alpha_2	5	7	PF02296	0.389
LIG_BRCT_BRCA1_1	245	249	PF00533	0.393
LIG_BRCT_BRCA1_1	556	560	PF00533	0.305
LIG_BRCT_BRCA1_1	641	645	PF00533	0.284
LIG_CaM_NSCaTE_8	534	541	PF13499	0.402
LIG_Clathr_ClatBox_1	304	308	PF01394	0.440
LIG_eIF4E_1	149	155	PF01652	0.297
LIG_eIF4E_1	25	31	PF01652	0.315
LIG_eIF4E_1	356	362	PF01652	0.295
LIG_eIF4E_1	419	425	PF01652	0.397
LIG_eIF4E_1	966	972	PF01652	0.217
LIG_FHA_1	123	129	PF00498	0.360
LIG_FHA_1	148	154	PF00498	0.300
LIG_FHA_1	159	165	PF00498	0.365
LIG_FHA_1	243	249	PF00498	0.310
LIG_FHA_1	25	31	PF00498	0.373
LIG_FHA_1	311	317	PF00498	0.417
LIG_FHA_1	349	355	PF00498	0.332
LIG_FHA_1	35	41	PF00498	0.300
LIG_FHA_1	356	362	PF00498	0.310
LIG_FHA_1	515	521	PF00498	0.457
LIG_FHA_1	565	571	PF00498	0.339
LIG_FHA_1	816	822	PF00498	0.306
LIG_FHA_1	914	920	PF00498	0.388
LIG_FHA_1	98	104	PF00498	0.449
LIG_FHA_2	232	238	PF00498	0.349
LIG_FHA_2	249	255	PF00498	0.268
LIG_FHA_2	52	58	PF00498	0.484
LIG_FHA_2	578	584	PF00498	0.499
LIG_FHA_2	612	618	PF00498	0.454
LIG_FHA_2	721	727	PF00498	0.660
LIG_FHA_2	789	795	PF00498	0.257
LIG_FHA_2	815	821	PF00498	0.257
LIG_FHA_2	895	901	PF00498	0.289
LIG_LIR_Apic_2	22	28	PF02991	0.337
LIG_LIR_Apic_2	810	816	PF02991	0.257
LIG_LIR_Gen_1	311	317	PF02991	0.478
LIG_LIR_Gen_1	688	697	PF02991	0.446
LIG_LIR_Gen_1	824	829	PF02991	0.350
LIG_LIR_Gen_1	869	879	PF02991	0.410
LIG_LIR_Nem_3	207	212	PF02991	0.337
LIG_LIR_Nem_3	3	7	PF02991	0.307
LIG_LIR_Nem_3	311	315	PF02991	0.500
LIG_LIR_Nem_3	37	41	PF02991	0.283
LIG_LIR_Nem_3	606	611	PF02991	0.432
LIG_LIR_Nem_3	688	694	PF02991	0.426
LIG_LIR_Nem_3	824	828	PF02991	0.302
LIG_LIR_Nem_3	869	874	PF02991	0.378
LIG_LRP6_Inhibitor_1	664	670	PF00058	0.358
LIG_MYND_1	802	806	PF01753	0.257
LIG_MYND_3	951	955	PF01753	0.326
LIG_PCNA_yPIPBox_3	903	912	PF02747	0.381
LIG_PCNA_yPIPBox_3	929	937	PF02747	0.314
LIG_PDZ_Class_1	982	987	PF00595	0.406
LIG_Pex14_2	914	918	PF04695	0.276
LIG_PTB_Apo_2	665	672	PF02174	0.460
LIG_PTB_Phospho_1	665	671	PF10480	0.451
LIG_Rb_pABgroove_1	487	495	PF01858	0.381
LIG_SH2_CRK	25	29	PF00017	0.350
LIG_SH2_CRK	312	316	PF00017	0.475
LIG_SH2_CRK	469	473	PF00017	0.410
LIG_SH2_CRK	608	612	PF00017	0.432
LIG_SH2_CRK	634	638	PF00017	0.223
LIG_SH2_CRK	671	675	PF00017	0.365
LIG_SH2_CRK	68	72	PF00017	0.298
LIG_SH2_GRB2like	149	152	PF00017	0.356
LIG_SH2_GRB2like	890	893	PF00017	0.253
LIG_SH2_NCK_1	469	473	PF00017	0.410
LIG_SH2_SRC	80	83	PF00017	0.397
LIG_SH2_SRC	890	893	PF00017	0.351
LIG_SH2_STAP1	149	153	PF00017	0.344
LIG_SH2_STAP1	312	316	PF00017	0.475
LIG_SH2_STAT5	149	152	PF00017	0.356
LIG_SH2_STAT5	312	315	PF00017	0.488
LIG_SH2_STAT5	610	613	PF00017	0.419
LIG_SH2_STAT5	663	666	PF00017	0.380
LIG_SH2_STAT5	673	676	PF00017	0.442
LIG_SH2_STAT5	80	83	PF00017	0.397
LIG_SH2_STAT5	870	873	PF00017	0.299
LIG_SH2_STAT5	890	893	PF00017	0.393
LIG_SH2_STAT5	896	899	PF00017	0.302
LIG_SH3_1	799	805	PF00018	0.257
LIG_SH3_2	802	807	PF14604	0.257
LIG_SH3_3	15	21	PF00018	0.435
LIG_SH3_3	400	406	PF00018	0.486
LIG_SH3_3	675	681	PF00018	0.407
LIG_SH3_3	799	805	PF00018	0.257
LIG_SH3_3	969	975	PF00018	0.302
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.444
LIG_SUMO_SIM_anti_2	753	758	PF11976	0.364
LIG_SUMO_SIM_anti_2	824	831	PF11976	0.165
LIG_SUMO_SIM_par_1	27	34	PF11976	0.301
LIG_SUMO_SIM_par_1	422	429	PF11976	0.200
LIG_SUMO_SIM_par_1	516	521	PF11976	0.483
LIG_SUMO_SIM_par_1	824	831	PF11976	0.307
LIG_TRAF2_1	725	728	PF00917	0.652
LIG_TRAF2_1	817	820	PF00917	0.276
LIG_TRAF2_1	953	956	PF00917	0.388
LIG_TYR_ITIM	669	674	PF00017	0.362
LIG_WRC_WIRS_1	1	6	PF05994	0.364
LIG_WRC_WIRS_1	233	238	PF05994	0.360
LIG_WRC_WIRS_1	911	916	PF05994	0.304
MOD_CK1_1	176	182	PF00069	0.504
MOD_CK1_1	183	189	PF00069	0.617
MOD_CK1_1	191	197	PF00069	0.570
MOD_CK1_1	423	429	PF00069	0.302
MOD_CK1_1	454	460	PF00069	0.396
MOD_CK1_1	596	602	PF00069	0.526
MOD_CK1_1	705	711	PF00069	0.493
MOD_CK1_1	873	879	PF00069	0.302
MOD_CK1_1	894	900	PF00069	0.386
MOD_CK1_1	913	919	PF00069	0.455
MOD_CK2_1	108	114	PF00069	0.290
MOD_CK2_1	259	265	PF00069	0.303
MOD_CK2_1	285	291	PF00069	0.419
MOD_CK2_1	502	508	PF00069	0.426
MOD_CK2_1	577	583	PF00069	0.465
MOD_CK2_1	720	726	PF00069	0.630
MOD_CK2_1	814	820	PF00069	0.257
MOD_CK2_1	86	92	PF00069	0.506
MOD_CK2_1	894	900	PF00069	0.281
MOD_CMANNOS	531	534	PF00535	0.350
MOD_Cter_Amidation	389	392	PF01082	0.366
MOD_GlcNHglycan	168	171	PF01048	0.389
MOD_GlcNHglycan	180	183	PF01048	0.544
MOD_GlcNHglycan	240	243	PF01048	0.334
MOD_GlcNHglycan	430	433	PF01048	0.350
MOD_GlcNHglycan	448	451	PF01048	0.297
MOD_GlcNHglycan	453	456	PF01048	0.413
MOD_GlcNHglycan	475	478	PF01048	0.324
MOD_GlcNHglycan	534	537	PF01048	0.267
MOD_GlcNHglycan	614	617	PF01048	0.214
MOD_GlcNHglycan	706	710	PF01048	0.703
MOD_GlcNHglycan	716	719	PF01048	0.656
MOD_GlcNHglycan	982	985	PF01048	0.385
MOD_GSK3_1	134	141	PF00069	0.381
MOD_GSK3_1	154	161	PF00069	0.277
MOD_GSK3_1	176	183	PF00069	0.450
MOD_GSK3_1	184	191	PF00069	0.549
MOD_GSK3_1	238	245	PF00069	0.413
MOD_GSK3_1	276	283	PF00069	0.477
MOD_GSK3_1	311	318	PF00069	0.378
MOD_GSK3_1	370	377	PF00069	0.314
MOD_GSK3_1	378	385	PF00069	0.341
MOD_GSK3_1	419	426	PF00069	0.310
MOD_GSK3_1	446	453	PF00069	0.362
MOD_GSK3_1	514	521	PF00069	0.419
MOD_GSK3_1	635	642	PF00069	0.300
MOD_GSK3_1	701	708	PF00069	0.712
MOD_GSK3_1	716	723	PF00069	0.749
MOD_GSK3_1	892	899	PF00069	0.236
MOD_GSK3_1	9	16	PF00069	0.366
MOD_GSK3_1	978	985	PF00069	0.359
MOD_N-GLC_1	485	490	PF02516	0.363
MOD_N-GLC_1	788	793	PF02516	0.302
MOD_N-GLC_1	891	896	PF02516	0.253
MOD_N-GLC_1	97	102	PF02516	0.229
MOD_N-GLC_2	273	275	PF02516	0.366
MOD_NEK2_1	108	113	PF00069	0.415
MOD_NEK2_1	173	178	PF00069	0.451
MOD_NEK2_1	204	209	PF00069	0.365
MOD_NEK2_1	256	261	PF00069	0.378
MOD_NEK2_1	276	281	PF00069	0.199
MOD_NEK2_1	31	36	PF00069	0.311
MOD_NEK2_1	315	320	PF00069	0.372
MOD_NEK2_1	360	365	PF00069	0.272
MOD_NEK2_1	370	375	PF00069	0.292
MOD_NEK2_1	411	416	PF00069	0.269
MOD_NEK2_1	446	451	PF00069	0.474
MOD_NEK2_1	538	543	PF00069	0.346
MOD_NEK2_1	548	553	PF00069	0.362
MOD_NEK2_1	641	646	PF00069	0.320
MOD_NEK2_1	651	656	PF00069	0.254
MOD_NEK2_1	788	793	PF00069	0.276
MOD_NEK2_1	86	91	PF00069	0.399
MOD_NEK2_1	978	983	PF00069	0.405
MOD_NEK2_2	870	875	PF00069	0.388
MOD_PIKK_1	382	388	PF00454	0.340
MOD_PIKK_1	748	754	PF00454	0.582
MOD_PIKK_1	815	821	PF00454	0.267
MOD_PKA_2	191	197	PF00069	0.646
MOD_PKA_2	370	376	PF00069	0.303
MOD_PKA_2	378	384	PF00069	0.329
MOD_PKA_2	714	720	PF00069	0.614
MOD_PKA_2	821	827	PF00069	0.257
MOD_PKA_2	964	970	PF00069	0.276
MOD_Plk_1	310	316	PF00069	0.498
MOD_Plk_1	485	491	PF00069	0.350
MOD_Plk_1	503	509	PF00069	0.368
MOD_Plk_1	554	560	PF00069	0.427
MOD_Plk_1	788	794	PF00069	0.257
MOD_Plk_1	97	103	PF00069	0.229
MOD_Plk_2-3	378	384	PF00069	0.329
MOD_Plk_4	124	130	PF00069	0.397
MOD_Plk_4	19	25	PF00069	0.355
MOD_Plk_4	243	249	PF00069	0.336
MOD_Plk_4	300	306	PF00069	0.290
MOD_Plk_4	311	317	PF00069	0.333
MOD_Plk_4	420	426	PF00069	0.298
MOD_Plk_4	514	520	PF00069	0.434
MOD_Plk_4	555	561	PF00069	0.319
MOD_Plk_4	788	794	PF00069	0.263
MOD_Plk_4	821	827	PF00069	0.298
MOD_Plk_4	910	916	PF00069	0.338
MOD_ProDKin_1	17	23	PF00069	0.386
MOD_ProDKin_1	24	30	PF00069	0.456
MOD_ProDKin_1	593	599	PF00069	0.420
MOD_ProDKin_1	635	641	PF00069	0.304
MOD_SUMO_rev_2	111	118	PF00179	0.416
MOD_SUMO_rev_2	440	449	PF00179	0.324
MOD_SUMO_rev_2	881	887	PF00179	0.280
TRG_DiLeu_BaEn_1	311	316	PF01217	0.487
TRG_DiLeu_BaEn_1	863	868	PF01217	0.271
TRG_DiLeu_BaLyEn_6	799	804	PF01217	0.257
TRG_ENDOCYTIC_2	209	212	PF00928	0.340
TRG_ENDOCYTIC_2	312	315	PF00928	0.488
TRG_ENDOCYTIC_2	469	472	PF00928	0.411
TRG_ENDOCYTIC_2	608	611	PF00928	0.432
TRG_ENDOCYTIC_2	634	637	PF00928	0.223
TRG_ENDOCYTIC_2	663	666	PF00928	0.320
TRG_ENDOCYTIC_2	671	674	PF00928	0.328
TRG_ENDOCYTIC_2	68	71	PF00928	0.300
TRG_ER_diArg_1	757	760	PF00400	0.550
TRG_ER_diArg_1	919	921	PF00400	0.336
TRG_NES_CRM1_1	850	863	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H8	Leptomonas seymouri	82%	100%
A0A0S4IK94	Bodo saltans	51%	100%
A0A1X0P3D2	Trypanosomatidae	62%	100%
A0A3R7KJ70	Trypanosoma rangeli	63%	100%
A0A3S7XBK1	Leishmania donovani	91%	100%
A4IE52	Leishmania infantum	91%	100%
D0A8Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	89%
E9ATK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O14053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q06078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q0Z3	Leishmania major	88%	99%
Q8NI36	Homo sapiens	24%	100%
V5BS01	Trypanosoma cruzi	62%	100%