Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT9_LEIBR

TriTrypDb:

LbrM.35.4450 , LBRM2903_350055100

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.504
CLV_C14_Caspase3-7	563	567	PF00656	0.582
CLV_C14_Caspase3-7	722	726	PF00656	0.536
CLV_C14_Caspase3-7	816	820	PF00656	0.590
CLV_C14_Caspase3-7	96	100	PF00656	0.605
CLV_NRD_NRD_1	101	103	PF00675	0.682
CLV_NRD_NRD_1	2	4	PF00675	0.693
CLV_NRD_NRD_1	285	287	PF00675	0.652
CLV_NRD_NRD_1	311	313	PF00675	0.593
CLV_NRD_NRD_1	318	320	PF00675	0.556
CLV_NRD_NRD_1	346	348	PF00675	0.685
CLV_NRD_NRD_1	432	434	PF00675	0.735
CLV_NRD_NRD_1	5	7	PF00675	0.654
CLV_NRD_NRD_1	501	503	PF00675	0.781
CLV_NRD_NRD_1	513	515	PF00675	0.634
CLV_NRD_NRD_1	674	676	PF00675	0.625
CLV_NRD_NRD_1	686	688	PF00675	0.620
CLV_NRD_NRD_1	752	754	PF00675	0.612
CLV_PCSK_FUR_1	3	7	PF00082	0.517
CLV_PCSK_FUR_1	510	514	PF00082	0.536
CLV_PCSK_FUR_1	684	688	PF00082	0.461
CLV_PCSK_KEX2_1	101	103	PF00082	0.650
CLV_PCSK_KEX2_1	285	287	PF00082	0.652
CLV_PCSK_KEX2_1	311	313	PF00082	0.586
CLV_PCSK_KEX2_1	317	319	PF00082	0.575
CLV_PCSK_KEX2_1	360	362	PF00082	0.671
CLV_PCSK_KEX2_1	4	6	PF00082	0.680
CLV_PCSK_KEX2_1	432	434	PF00082	0.741
CLV_PCSK_KEX2_1	501	503	PF00082	0.783
CLV_PCSK_KEX2_1	510	512	PF00082	0.727
CLV_PCSK_KEX2_1	513	515	PF00082	0.624
CLV_PCSK_KEX2_1	674	676	PF00082	0.625
CLV_PCSK_KEX2_1	684	686	PF00082	0.606
CLV_PCSK_KEX2_1	752	754	PF00082	0.612
CLV_PCSK_KEX2_1	94	96	PF00082	0.545
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.670
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.562
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.773
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.647
CLV_PCSK_SKI1_1	191	195	PF00082	0.493
CLV_PCSK_SKI1_1	311	315	PF00082	0.413
CLV_PCSK_SKI1_1	539	543	PF00082	0.566
CLV_PCSK_SKI1_1	674	678	PF00082	0.626
CLV_PCSK_SKI1_1	692	696	PF00082	0.678
CLV_PCSK_SKI1_1	718	722	PF00082	0.531
CLV_PCSK_SKI1_1	767	771	PF00082	0.519
DEG_APCC_DBOX_1	544	552	PF00400	0.484
DEG_COP1_1	136	146	PF00400	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SPOP_SBC_1	135	139	PF00917	0.534
DOC_CYCLIN_RxL_1	671	680	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	738	744	PF00134	0.541
DOC_MAPK_DCC_7	217	225	PF00069	0.551
DOC_MAPK_gen_1	285	293	PF00069	0.494
DOC_MAPK_gen_1	534	544	PF00069	0.478
DOC_MAPK_MEF2A_6	217	225	PF00069	0.557
DOC_MAPK_MEF2A_6	534	542	PF00069	0.483
DOC_MAPK_MEF2A_6	545	553	PF00069	0.496
DOC_MAPK_MEF2A_6	9	17	PF00069	0.521
DOC_MAPK_RevD_3	81	95	PF00069	0.495
DOC_PP1_RVXF_1	673	680	PF00149	0.614
DOC_PP2B_LxvP_1	132	135	PF13499	0.574
DOC_PP2B_LxvP_1	172	175	PF13499	0.474
DOC_PP2B_LxvP_1	36	39	PF13499	0.340
DOC_PP2B_LxvP_1	612	615	PF13499	0.513
DOC_PP2B_LxvP_1	62	65	PF13499	0.497
DOC_PP2B_LxvP_1	738	741	PF13499	0.539
DOC_PP4_FxxP_1	515	518	PF00568	0.704
DOC_PP4_FxxP_1	804	807	PF00568	0.690
DOC_USP7_MATH_1	111	115	PF00917	0.618
DOC_USP7_MATH_1	135	139	PF00917	0.742
DOC_USP7_MATH_1	198	202	PF00917	0.505
DOC_USP7_MATH_1	299	303	PF00917	0.419
DOC_USP7_MATH_1	39	43	PF00917	0.575
DOC_USP7_MATH_1	421	425	PF00917	0.591
DOC_USP7_MATH_1	490	494	PF00917	0.702
DOC_USP7_MATH_1	742	746	PF00917	0.622
DOC_USP7_MATH_1	817	821	PF00917	0.545
DOC_USP7_UBL2_3	338	342	PF12436	0.614
DOC_WW_Pin1_4	100	105	PF00397	0.499
DOC_WW_Pin1_4	390	395	PF00397	0.678
DOC_WW_Pin1_4	444	449	PF00397	0.786
DOC_WW_Pin1_4	461	466	PF00397	0.588
DOC_WW_Pin1_4	543	548	PF00397	0.485
DOC_WW_Pin1_4	622	627	PF00397	0.522
DOC_WW_Pin1_4	758	763	PF00397	0.575
LIG_14-3-3_CanoR_1	197	203	PF00244	0.297
LIG_14-3-3_CanoR_1	262	270	PF00244	0.695
LIG_14-3-3_CanoR_1	3	13	PF00244	0.484
LIG_14-3-3_CanoR_1	347	355	PF00244	0.563
LIG_14-3-3_CanoR_1	422	428	PF00244	0.635
LIG_14-3-3_CanoR_1	539	545	PF00244	0.532
LIG_14-3-3_CanoR_1	573	579	PF00244	0.507
LIG_14-3-3_CanoR_1	655	664	PF00244	0.523
LIG_14-3-3_CanoR_1	718	727	PF00244	0.538
LIG_14-3-3_CanoR_1	756	764	PF00244	0.668
LIG_Actin_WH2_2	521	536	PF00022	0.521
LIG_Actin_WH2_2	83	100	PF00022	0.374
LIG_APCC_ABBA_1	780	785	PF00400	0.535
LIG_APCC_ABBAyCdc20_2	72	78	PF00400	0.384
LIG_BIR_III_4	153	157	PF00653	0.423
LIG_BRCT_BRCA1_1	166	170	PF00533	0.456
LIG_BRCT_BRCA1_1	679	683	PF00533	0.441
LIG_CSL_BTD_1	115	118	PF09270	0.496
LIG_EH_1	801	805	PF12763	0.682
LIG_FHA_1	129	135	PF00498	0.602
LIG_FHA_1	156	162	PF00498	0.412
LIG_FHA_1	335	341	PF00498	0.672
LIG_FHA_1	449	455	PF00498	0.818
LIG_FHA_1	480	486	PF00498	0.769
LIG_FHA_1	533	539	PF00498	0.612
LIG_FHA_1	548	554	PF00498	0.345
LIG_FHA_1	566	572	PF00498	0.284
LIG_FHA_1	657	663	PF00498	0.466
LIG_FHA_1	698	704	PF00498	0.727
LIG_FHA_1	759	765	PF00498	0.622
LIG_FHA_1	768	774	PF00498	0.553
LIG_FHA_2	137	143	PF00498	0.515
LIG_FHA_2	393	399	PF00498	0.562
LIG_FHA_2	462	468	PF00498	0.578
LIG_FHA_2	470	476	PF00498	0.587
LIG_FHA_2	598	604	PF00498	0.422
LIG_FHA_2	814	820	PF00498	0.557
LIG_LIR_Gen_1	167	178	PF02991	0.489
LIG_LIR_Gen_1	523	533	PF02991	0.372
LIG_LIR_Gen_1	636	646	PF02991	0.446
LIG_LIR_Gen_1	74	83	PF02991	0.483
LIG_LIR_Nem_3	167	173	PF02991	0.482
LIG_LIR_Nem_3	523	528	PF02991	0.346
LIG_LIR_Nem_3	636	642	PF02991	0.444
LIG_LIR_Nem_3	74	80	PF02991	0.492
LIG_MAD2	539	547	PF02301	0.578
LIG_MLH1_MIPbox_1	679	683	PF16413	0.441
LIG_PCNA_PIPBox_1	284	293	PF02747	0.494
LIG_PCNA_yPIPBox_3	279	291	PF02747	0.499
LIG_PCNA_yPIPBox_3	50	63	PF02747	0.368
LIG_Pex14_1	520	524	PF04695	0.510
LIG_Pex14_1	679	683	PF04695	0.592
LIG_REV1ctd_RIR_1	680	691	PF16727	0.710
LIG_SH2_CRK	166	170	PF00017	0.474
LIG_SH2_CRK	196	200	PF00017	0.422
LIG_SH2_CRK	576	580	PF00017	0.436
LIG_SH2_GRB2like	645	648	PF00017	0.412
LIG_SH2_NCK_1	305	309	PF00017	0.424
LIG_SH2_NCK_1	576	580	PF00017	0.436
LIG_SH2_SRC	305	308	PF00017	0.422
LIG_SH2_SRC	775	778	PF00017	0.788
LIG_SH2_STAP1	305	309	PF00017	0.574
LIG_SH2_STAP1	77	81	PF00017	0.473
LIG_SH2_STAP1	775	779	PF00017	0.789
LIG_SH2_STAT3	591	594	PF00017	0.427
LIG_SH2_STAT3	76	79	PF00017	0.489
LIG_SH2_STAT5	290	293	PF00017	0.528
LIG_SH2_STAT5	583	586	PF00017	0.522
LIG_SH2_STAT5	645	648	PF00017	0.466
LIG_SH2_STAT5	714	717	PF00017	0.552
LIG_SH3_3	388	394	PF00018	0.673
LIG_SH3_3	614	620	PF00018	0.472
LIG_SH3_3	693	699	PF00018	0.535
LIG_SH3_3	776	782	PF00018	0.537
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.601
LIG_SUMO_SIM_anti_2	624	632	PF11976	0.442
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.473
LIG_SUMO_SIM_par_1	32	37	PF11976	0.486
LIG_SUMO_SIM_par_1	42	48	PF11976	0.397
LIG_SUMO_SIM_par_1	457	462	PF11976	0.563
LIG_SUMO_SIM_par_1	540	546	PF11976	0.571
LIG_SUMO_SIM_par_1	624	632	PF11976	0.442
LIG_SUMO_SIM_par_1	659	665	PF11976	0.566
LIG_TRAF2_1	351	354	PF00917	0.510
LIG_TRAF2_1	414	417	PF00917	0.583
LIG_TYR_ITIM	194	199	PF00017	0.433
LIG_TYR_ITIM	574	579	PF00017	0.440
LIG_UBA3_1	58	67	PF00899	0.719
LIG_UBA3_1	90	94	PF00899	0.367
LIG_WRC_WIRS_1	650	655	PF05994	0.514
MOD_CDK_SPxxK_3	100	107	PF00069	0.504
MOD_CDK_SPxxK_3	461	468	PF00069	0.551
MOD_CK1_1	100	106	PF00069	0.625
MOD_CK1_1	136	142	PF00069	0.525
MOD_CK1_1	155	161	PF00069	0.322
MOD_CK1_1	185	191	PF00069	0.415
MOD_CK1_1	255	261	PF00069	0.629
MOD_CK1_1	266	272	PF00069	0.722
MOD_CK1_1	362	368	PF00069	0.682
MOD_CK1_1	503	509	PF00069	0.578
MOD_CK1_1	543	549	PF00069	0.411
MOD_CK1_1	565	571	PF00069	0.544
MOD_CK1_1	577	583	PF00069	0.379
MOD_CK1_1	622	628	PF00069	0.371
MOD_CK1_1	656	662	PF00069	0.475
MOD_CK1_1	731	737	PF00069	0.701
MOD_CK1_1	758	764	PF00069	0.589
MOD_CK1_1	813	819	PF00069	0.559
MOD_CK1_1	820	826	PF00069	0.514
MOD_CK2_1	136	142	PF00069	0.587
MOD_CK2_1	348	354	PF00069	0.666
MOD_CK2_1	392	398	PF00069	0.741
MOD_CK2_1	4	10	PF00069	0.645
MOD_CK2_1	411	417	PF00069	0.518
MOD_CK2_1	421	427	PF00069	0.638
MOD_CK2_1	461	467	PF00069	0.552
MOD_CK2_1	469	475	PF00069	0.525
MOD_CK2_1	490	496	PF00069	0.805
MOD_CK2_1	583	589	PF00069	0.551
MOD_Cter_Amidation	309	312	PF01082	0.455
MOD_Cter_Amidation	499	502	PF01082	0.552
MOD_GlcNHglycan	153	157	PF01048	0.574
MOD_GlcNHglycan	205	208	PF01048	0.490
MOD_GlcNHglycan	265	268	PF01048	0.774
MOD_GlcNHglycan	301	304	PF01048	0.506
MOD_GlcNHglycan	364	367	PF01048	0.664
MOD_GlcNHglycan	370	373	PF01048	0.561
MOD_GlcNHglycan	529	532	PF01048	0.570
MOD_GlcNHglycan	664	667	PF01048	0.601
MOD_GSK3_1	164	171	PF00069	0.445
MOD_GSK3_1	178	185	PF00069	0.527
MOD_GSK3_1	198	205	PF00069	0.471
MOD_GSK3_1	258	265	PF00069	0.689
MOD_GSK3_1	266	273	PF00069	0.650
MOD_GSK3_1	392	399	PF00069	0.716
MOD_GSK3_1	407	414	PF00069	0.611
MOD_GSK3_1	416	423	PF00069	0.669
MOD_GSK3_1	444	451	PF00069	0.819
MOD_GSK3_1	457	464	PF00069	0.599
MOD_GSK3_1	479	486	PF00069	0.705
MOD_GSK3_1	543	550	PF00069	0.481
MOD_GSK3_1	565	572	PF00069	0.483
MOD_GSK3_1	621	628	PF00069	0.514
MOD_GSK3_1	645	652	PF00069	0.501
MOD_GSK3_1	697	704	PF00069	0.728
MOD_GSK3_1	751	758	PF00069	0.723
MOD_GSK3_1	763	770	PF00069	0.687
MOD_GSK3_1	813	820	PF00069	0.696
MOD_GSK3_1	93	100	PF00069	0.629
MOD_LATS_1	413	419	PF00433	0.577
MOD_N-GLC_1	128	133	PF02516	0.641
MOD_N-GLC_1	327	332	PF02516	0.569
MOD_N-GLC_1	407	412	PF02516	0.581
MOD_N-GLC_1	479	484	PF02516	0.735
MOD_N-GLC_1	646	651	PF02516	0.357
MOD_N-GLC_1	670	675	PF02516	0.594
MOD_N-GLC_1	701	706	PF02516	0.748
MOD_N-GLC_1	731	736	PF02516	0.575
MOD_NEK2_1	128	133	PF00069	0.630
MOD_NEK2_1	146	151	PF00069	0.612
MOD_NEK2_1	202	207	PF00069	0.564
MOD_NEK2_1	263	268	PF00069	0.733
MOD_NEK2_1	532	537	PF00069	0.551
MOD_NEK2_1	653	658	PF00069	0.523
MOD_NEK2_1	670	675	PF00069	0.443
MOD_NEK2_1	677	682	PF00069	0.605
MOD_NEK2_1	751	756	PF00069	0.655
MOD_NEK2_1	93	98	PF00069	0.661
MOD_NEK2_2	407	412	PF00069	0.633
MOD_NEK2_2	71	76	PF00069	0.401
MOD_PIKK_1	348	354	PF00454	0.520
MOD_PIKK_1	751	757	PF00454	0.741
MOD_PKA_1	342	348	PF00069	0.538
MOD_PKA_1	4	10	PF00069	0.730
MOD_PKA_2	111	117	PF00069	0.635
MOD_PKA_2	185	191	PF00069	0.415
MOD_PKA_2	255	261	PF00069	0.554
MOD_PKA_2	270	276	PF00069	0.542
MOD_PKA_2	4	10	PF00069	0.730
MOD_PKA_2	421	427	PF00069	0.593
MOD_PKA_2	500	506	PF00069	0.748
MOD_PKA_2	677	683	PF00069	0.602
MOD_PKA_2	71	77	PF00069	0.601
MOD_PKA_2	751	757	PF00069	0.678
MOD_PKA_2	97	103	PF00069	0.517
MOD_PKB_1	3	11	PF00069	0.690
MOD_Plk_1	407	413	PF00069	0.818
MOD_Plk_1	415	421	PF00069	0.542
MOD_Plk_1	54	60	PF00069	0.612
MOD_Plk_1	646	652	PF00069	0.357
MOD_Plk_1	692	698	PF00069	0.680
MOD_Plk_1	734	740	PF00069	0.689
MOD_Plk_1	820	826	PF00069	0.542
MOD_Plk_2-3	359	365	PF00069	0.677
MOD_Plk_4	111	117	PF00069	0.513
MOD_Plk_4	146	152	PF00069	0.620
MOD_Plk_4	198	204	PF00069	0.485
MOD_Plk_4	255	261	PF00069	0.524
MOD_Plk_4	327	333	PF00069	0.728
MOD_Plk_4	54	60	PF00069	0.560
MOD_Plk_4	556	562	PF00069	0.565
MOD_Plk_4	574	580	PF00069	0.266
MOD_Plk_4	607	613	PF00069	0.579
MOD_Plk_4	625	631	PF00069	0.500
MOD_Plk_4	635	641	PF00069	0.449
MOD_Plk_4	71	77	PF00069	0.490
MOD_Plk_4	734	740	PF00069	0.577
MOD_ProDKin_1	100	106	PF00069	0.499
MOD_ProDKin_1	390	396	PF00069	0.679
MOD_ProDKin_1	444	450	PF00069	0.786
MOD_ProDKin_1	461	467	PF00069	0.587
MOD_ProDKin_1	543	549	PF00069	0.481
MOD_ProDKin_1	622	628	PF00069	0.517
MOD_ProDKin_1	758	764	PF00069	0.577
MOD_SUMO_rev_2	330	340	PF00179	0.509
MOD_SUMO_rev_2	87	96	PF00179	0.620
TRG_DiLeu_BaEn_1	14	19	PF01217	0.495
TRG_DiLeu_BaEn_1	327	332	PF01217	0.723
TRG_DiLeu_BaEn_2	775	781	PF01217	0.790
TRG_DiLeu_BaLyEn_6	672	677	PF01217	0.611
TRG_ENDOCYTIC_2	196	199	PF00928	0.426
TRG_ENDOCYTIC_2	290	293	PF00928	0.717
TRG_ENDOCYTIC_2	576	579	PF00928	0.436
TRG_ENDOCYTIC_2	77	80	PF00928	0.476
TRG_ER_diArg_1	2	5	PF00400	0.678
TRG_ER_diArg_1	285	287	PF00400	0.652
TRG_ER_diArg_1	318	320	PF00400	0.427
TRG_ER_diArg_1	501	504	PF00400	0.625
TRG_ER_diArg_1	510	513	PF00400	0.641
TRG_ER_diArg_1	674	676	PF00400	0.625
TRG_ER_diArg_1	683	686	PF00400	0.600
TRG_ER_diArg_1	751	753	PF00400	0.695
TRG_NLS_MonoCore_2	2	7	PF00514	0.522
TRG_NLS_MonoExtC_3	316	322	PF00514	0.679
TRG_NLS_MonoExtN_4	3	8	PF00514	0.508
TRG_NLS_MonoExtN_4	314	321	PF00514	0.662
TRG_NLS_MonoExtN_4	432	437	PF00514	0.807
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	771	776	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I967	Leptomonas seymouri	44%	98%
A0A3S7XBE9	Leishmania donovani	67%	100%
A4IE53	Leishmania infantum	67%	100%
E9ATK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q0Z4	Leishmania major	66%	98%