Sld5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GINS complex protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT8_LEIBR

TriTrypDb:

LbrM.35.4440 , LBRM2903_350055000

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	9
GO:0005694	chromosome	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HPT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	52	58	PF00089	0.344
CLV_NRD_NRD_1	344	346	PF00675	0.572
CLV_PCSK_KEX2_1	343	345	PF00082	0.578
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.578
CLV_PCSK_SKI1_1	132	136	PF00082	0.325
CLV_Separin_Metazoa	165	169	PF03568	0.438
DEG_APCC_DBOX_1	230	238	PF00400	0.543
DOC_MAPK_gen_1	177	187	PF00069	0.442
DOC_MAPK_gen_1	229	237	PF00069	0.586
DOC_USP7_MATH_1	25	29	PF00917	0.595
DOC_USP7_MATH_1	318	322	PF00917	0.674
DOC_WW_Pin1_4	190	195	PF00397	0.442
DOC_WW_Pin1_4	272	277	PF00397	0.743
DOC_WW_Pin1_4	331	336	PF00397	0.636
LIG_14-3-3_CanoR_1	214	218	PF00244	0.380
LIG_14-3-3_CanoR_1	247	253	PF00244	0.680
LIG_14-3-3_CanoR_1	265	271	PF00244	0.702
LIG_14-3-3_CanoR_1	278	285	PF00244	0.619
LIG_14-3-3_CanoR_1	344	348	PF00244	0.572
LIG_14-3-3_CanoR_1	55	59	PF00244	0.294
LIG_14-3-3_CanoR_1	88	95	PF00244	0.442
LIG_14-3-3_CterR_2	348	350	PF00244	0.590
LIG_Actin_WH2_2	198	216	PF00022	0.442
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	121	125	PF00533	0.525
LIG_BRCT_BRCA1_1	192	196	PF00533	0.484
LIG_deltaCOP1_diTrp_1	31	35	PF00928	0.531
LIG_FHA_1	201	207	PF00498	0.481
LIG_FHA_1	256	262	PF00498	0.705
LIG_FHA_1	265	271	PF00498	0.778
LIG_FHA_1	90	96	PF00498	0.442
LIG_FHA_2	184	190	PF00498	0.518
LIG_FHA_2	269	275	PF00498	0.542
LIG_LIR_Gen_1	117	128	PF02991	0.382
LIG_LIR_Gen_1	41	50	PF02991	0.356
LIG_LIR_Gen_1	99	106	PF02991	0.541
LIG_LIR_Nem_3	117	123	PF02991	0.382
LIG_LIR_Nem_3	215	220	PF02991	0.406
LIG_LIR_Nem_3	32	38	PF02991	0.459
LIG_LIR_Nem_3	67	71	PF02991	0.433
LIG_LIR_Nem_3	99	103	PF02991	0.541
LIG_PCNA_yPIPBox_3	177	185	PF02747	0.525
LIG_Pex14_1	82	86	PF04695	0.525
LIG_Rb_LxCxE_1	203	216	PF01857	0.574
LIG_SH2_STAT3	86	89	PF00017	0.525
LIG_SH2_STAT5	100	103	PF00017	0.457
LIG_SH2_STAT5	105	108	PF00017	0.464
LIG_SH2_STAT5	126	129	PF00017	0.442
LIG_SH2_STAT5	86	89	PF00017	0.523
LIG_SH3_3	67	73	PF00018	0.348
LIG_WRC_WIRS_1	40	45	PF05994	0.315
LIG_WW_1	97	100	PF00397	0.484
MOD_CDK_SPxK_1	272	278	PF00069	0.492
MOD_CK1_1	16	22	PF00069	0.672
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	241	247	PF00069	0.654
MOD_CK1_1	259	265	PF00069	0.572
MOD_CK1_1	272	278	PF00069	0.642
MOD_CK1_1	302	308	PF00069	0.650
MOD_CK1_1	312	318	PF00069	0.555
MOD_CK1_1	331	337	PF00069	0.618
MOD_CK2_1	183	189	PF00069	0.485
MOD_GlcNHglycan	148	151	PF01048	0.265
MOD_GlcNHglycan	18	21	PF01048	0.575
MOD_GlcNHglycan	240	243	PF01048	0.667
MOD_GlcNHglycan	258	261	PF01048	0.563
MOD_GlcNHglycan	280	283	PF01048	0.716
MOD_GlcNHglycan	304	307	PF01048	0.666
MOD_GlcNHglycan	320	323	PF01048	0.643
MOD_GlcNHglycan	47	51	PF01048	0.275
MOD_GSK3_1	16	23	PF00069	0.573
MOD_GSK3_1	248	255	PF00069	0.645
MOD_GSK3_1	256	263	PF00069	0.607
MOD_GSK3_1	264	271	PF00069	0.533
MOD_GSK3_1	302	309	PF00069	0.588
MOD_GSK3_1	318	325	PF00069	0.618
MOD_GSK3_1	327	334	PF00069	0.572
MOD_GSK3_1	343	350	PF00069	0.707
MOD_GSK3_1	87	94	PF00069	0.383
MOD_N-GLC_1	327	332	PF02516	0.523
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	212	217	PF00069	0.372
MOD_NEK2_1	283	288	PF00069	0.660
MOD_NEK2_1	317	322	PF00069	0.660
MOD_NEK2_1	46	51	PF00069	0.289
MOD_NEK2_1	64	69	PF00069	0.432
MOD_PIKK_1	299	305	PF00454	0.682
MOD_PIKK_1	322	328	PF00454	0.787
MOD_PKA_1	132	138	PF00069	0.525
MOD_PKA_1	343	349	PF00069	0.572
MOD_PKA_2	213	219	PF00069	0.377
MOD_PKA_2	264	270	PF00069	0.796
MOD_PKA_2	277	283	PF00069	0.620
MOD_PKA_2	343	349	PF00069	0.572
MOD_PKA_2	54	60	PF00069	0.286
MOD_PKA_2	87	93	PF00069	0.442
MOD_Plk_4	183	189	PF00069	0.454
MOD_Plk_4	290	296	PF00069	0.678
MOD_Plk_4	39	45	PF00069	0.472
MOD_Plk_4	48	54	PF00069	0.335
MOD_ProDKin_1	190	196	PF00069	0.442
MOD_ProDKin_1	272	278	PF00069	0.742
MOD_ProDKin_1	331	337	PF00069	0.633
TRG_DiLeu_BaEn_1	165	170	PF01217	0.442
TRG_ENDOCYTIC_2	100	103	PF00928	0.518
TRG_ENDOCYTIC_2	68	71	PF00928	0.386
TRG_NES_CRM1_1	158	172	PF08389	0.386
TRG_NES_CRM1_1	209	223	PF08389	0.432
TRG_NLS_MonoCore_2	341	346	PF00514	0.575
TRG_NLS_MonoExtN_4	339	346	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H9	Leptomonas seymouri	70%	100%
A0A3Q8IPD7	Leishmania donovani	83%	100%
A0A3R7KS72	Trypanosoma rangeli	43%	100%
A4IE54	Leishmania infantum	83%	100%
D0A8Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q0Z5	Leishmania major	81%	98%
V5BMD4	Trypanosoma cruzi	46%	85%